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| 1 | Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling显示文摘Bone remodeling is precisely coordinated by bone resorption and formation.Apoptotic osteoclasts generate large amounts of apoptotic bodies(ABs)marking the end of the bone resorption phase,whereas the functions of osteoclast-derived ABs remain largely unknown.Here,we identified the molecular profile of ABs derived from osteoclasts at distinct differentiation stages and investigated their corresponding functions.ABs were isolated from apoptotic bone marrow macrophages,preosteoclasts,and mature osteoclasts induced by staurosporine.Proteomic signature analysis with liquid chromatography-tandem mass spectrometry suggested marked protein cargo differences among the different ABs.Further bioinformatic analysis showed that the proteomic signatures of the ABs were highly similar to those of their parental cells.Functionally,pOC-ABs induced endothelial progenitor cell differentiation and increased CD31hiEmcnhi endothelial cell formation in a murine bone defect model via their PDGF-BB cargo.mOC-ABs induced osteogenic differentiation of mesenchymal stem cells and facilitated osteogenesis via RANKL reverse signaling.In summary,we mapped the detailed proteomic landscapes of ABs derived from osteoclasts and showed that their potential biological roles are important in coupling bone formation with resorption during bone remodeling. | Qinyu Ma Mengmeng Liang Yutong Wu Fei Luo Zaisong Ma Shiwu Dong Jianzhong Xu Ce Dou | 2021 | Bone Research2021，9，1： | 8 |
| 2 | Control Effect of Bacillus cereus CGMCC4348 against Botrytis cinerea and Its Mechanism显示文摘[Objective]The paper was to study antifungal activity and control mechanism of Bacillus cereus CGMCC4348 against Botrytis cinerea,and further find new methods against the disease.[Method]By quantitative bioassay,in vitro experiment and pot test,the antagonistic protein was extracted with ammonium sulfate precipitation fractionation to determine the control efficiency.EC50of B.cereus CGMCC4348 was 6.19 mg/L.Average controlling effect of B.cereus CGMCC4348 on B.cinerea was 75.8%,equal to the control group which was treated by 50 mg/L pyrimethanil.Bacillus cereus CGMCC4348 had good inhibitory effect against B.cinerea.[Conclusion]The paper provides scientific basis for green control technology against solanaceous vegetable diseases. | Liang Mengmeng Hu Yonghong Yin Jingjing Yang Wenge Tang Rongrong Zhang Yong Liu Youzhou | 2013 | Plant Diseases and Pests2013，4，5： | 3 |
| 3 | Lipogenic metabolism: a viable target for prostate cancer treatment?显示文摘癌症房间经常与他们由奥托·瓦堡,在 1924 观察了的正常 counterparts.1,2,3,4 相比取决于改变的新陈代谢当正常房间通常假定 mitochondrial 时,癌症房间通过氧气的 glycolysis 显示出优先的葡萄糖消费氧化 phosphorylation.4 carcinogenesis 的另一个新陈代谢的特点被改变类脂化合物新陈代谢,癌症房间由此可以采用,提高了生产( lipogenesis ) .1,2,3 提高了的 de novo | Mengmeng Liang David J Mulholland | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 4 | Changes of gut microbiome and metabolome in the AOM/DSS mouse model of colorectal cancer with FLASH radiation显示文摘Objective:To investigate the differences in small intestinal toxicity and taxonomic composition,diversity,and functional pathways of gut microbiome and metabolome after different radiotherapies in mouse colorectal cancer(CRC)model.Methods:Azoxymethane/dextran sodium sulfate(AOM/DSS)-induced mouse CRC model was treated with single pulse FLASH-RT(dose rate 100 Gy/s)or CONV-RT(dose rate 2 Gy/min)at whole abdomen.At 12 d after radiotherapy,sections of small intestinal tract tissue were dissected for hematoxylin and eosin(HE)staining and the fresh feces were collected for 16S ribosomal RNA(rRNA)microbiome sequencing and liquid chromatography and mass spectrometry(LC-MS)metabolomics sequencing to assess changes in the gut microbiota and metabolites.Microbial high-throughput 16S rRNA data was analyzed with QIIME2 and LEfSe softwares.ProteoWizard,XCMS and Ropls softwares were used for LC-MS analysis.Results:HE staining showed that FLASH-RT maintained small intestinal integrity and reduced the radiotherapyinduced injury.Sequencing analysis of gut fecal microbiome showed that phylum Bacteroidetes and genera Prevotella and Lactobacillus of microbial community were increased after FLASH-RT.Metabolomics sequencing analysis revealed that the metabolites after FLASH-RT were enriched in amino acid metabolism,while cholesterol metabolism was top enriched after CONV-RT.Conclusions:FLASH-RT significantly mitigates the small intestine tissue damage compared with CONV-RT.FLASHRT and CONV-RT have different impact on gut microbiota and its metabolites.Our results provide a theoretical basis for the early evaluation,prediction and individualized treatment of the irradiation effect after novel FLASHRT on tumors through the evaluation of intestinal microbiota and metabolites. | Mengmeng Xu Xinyu Qiu Qiu Chen Tianyu Yang Jingze Xu Liang Chen Lixiong Shuai Zhiming Xu Xinyang Cheng Yongsheng Zhang Zhifei Cao | 2023 | Radiation Medicine and Protection2023，4，1： | 2 |
| 5 | Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South Korea.Hubei Province is one of the major SFTS epidemic areas in the central part of China.This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017.Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains.It was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously recognized.Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions.Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1.Subsequently,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/genotypes.In conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution.It provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies. | Xiaoli Wu Mingyue Li Yanfang Zhang Boyun Liang Junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li Wenjing Zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao Zhang Cheng Peng Xin Zheng Fei Deng Shu Shen | 2021 | Virologica Sinica2021，36，2： | 2 |
| 6 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 7 | Coherent Chemical Variation Trends of the 55-25 Ma Magmatic Rocks in SE Tibet:N-S Direction Lithospheric Stretching of Eurasia during Early Stage of India-Eurasia Collision显示文摘The progressive indentation of India into Eurasia generated an E-W-trending orthogonal collision belt and a N-S-trending oblique collision belt.Compiling available data reveals that~70%of the Cenozoic igneous rocks in eastern and southeastern Tibet are concentrated within an ENE-trending,~550-km long and~250-km wide magmatic zone(CMZ)that once separated the orthogonal and oblique collision belts.The Latitude 26°N Line is now its southern boundary.The onset timing of magmatism of the CMZ varies gradually from~55 Ma in the westernmost part to~27 Ma in the easternmost.Then the magmatism successively occurred and suddenly stopped at~25 Ma.The segmented and coherent chemical variation trends found suggest that the CMZ magmatic rocks were formed due to partial melting of the heterogeneous upper mantle and crusts of Eurasia.Subduction of Paleo-and Neotethyan oceanic plates generated this compositional and mineralogical heterogeneity.Combined with available geophysical data,the CMZ was diachronously formed in response to asthenosphere upwelling induced by NNW-SSE-direction lithosphere stretching.The difference in responses of the orthogonal and oblique collision belts to the indentation of the Indian continent has led to this lithosphere stretching. | YANG Tiannan DONG Mengmeng XUE Chuandong XIN Di LIANG Mingjuan | 2023 | Acta Geologica Sinica(English Edition)2023，97，5： | 1 |
| 8 | Research on Indoor Thermal Environment in Winter and Retrofit Requirement in Existing Residential Buildings in China's Northern Heating Region显示文摘 | Chuanzhi Liang Mengmeng Lu Yong Wu | | Energy Procedia0，16，： | 1 |
| 9 | Improving the surveillance and response system to achieve and maintain malaria elimination:a retrospective analysis in Jiangsu Province,China显示文摘Background:Following initiation of China’s National Malaria Elimination Action Plan(NMEAP)in 2010,the'1-3-7’approach was developed and rolled out in China to facilitate the malaria elimination programme and accelerate malaria elimination.This study aims to summarize and condense these experiences through a retrospective analysis in Jiangsu Province,which could be adapted and applied in other malaria elimination settings worldwide.Methods:A retrospective analysis of imported malaria cases into China identified through an improved surveillance and response system in Jiangsu Province was carried out for the period of 2001-2020.To improve the malaria surveillance and response system,Centers for Diseases Control and Prevention from the prefectures and counties in Jiangsu province conducted population-level health education to improve healthcare seeking behavior,strengthened capacity of health facilities to improve performance of malaria diagnosis and treatment,and raised the capacity of public health providers to improve implementation of the'1-3-7’approach.Categorical variables were carried out by Chi square tests with Fisher’s exact correction.Results:From 2001 to 2020,a total of 9,879 malaria cases were reported in Jiangsu Province.Since 2012,no indigenous malaria cases have been reported in Jiangsu Province.However,in recent years,there has been a substantial increase of imported falciparum malaria cases.Between 2012 and 2020,an estimated 61.57 million individuals have benefited from population-level health education in Jiangsu Province.For healthcare-seeking services among the 2,423 imported malaria cases,687(28.4%)and 1,104(45.6%)cases visited hospitals on the first day and the second day from symptom onset,respectively.A total of 1,502(61.9%)cases were diagnosed on the first day at medical facilities.Jiangsu Province achieved 100%,99.4%and 98.3%completion rate in terms of case detection and notification(within one day),case investigation(within three days)and foci response and disposition(within seven days),respectively.The improved surveillance and response system in Jiangsu Province plays an important role in preventing the re-introduction of malaria and maintaining the malaria-free status.Conclusions:Jiangsu Province has maintained its malaria-free status since 2012.The continuous improvement of a surveillance and response system plays an important role in the early detection and rapid response of potential malaria-related outbreaks in Jiangsu,China,and has important lessons for other malaria eliminating settings.Remaining vigilant in the detection of imported malaria cases and maintaining an active surveillance and response system is critical to sustain the success of malaria elimination. | Yuanyuan Cao Guangyu Lu Chris Cotter Weiming Wang Mengmeng Yang Yaobao Liu Cheng Liang Huayun Zhou Yan Lu Jun Yan Guoding Zhu Jun Cao | 2022 | Infectious Diseases of Poverty2022，11，1： | 1 |
| 10 | Synthesis and electromagnetic wave absorption performances of a novel(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)high-entropy MAX phase显示文摘Herein,a novel kind of high-entropy MAX phases,(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)powders were success-fully synthesized by a newly proposed two-step solid state reaction process.The oxidation experiments demonstrate that the oxidation products of Al_(2)Mo_(3)O_(12) and rutile TiO 2 are formed at about 600 and 800℃,respectively.Besides,the dielectric and electromagnetic(EM)wave absorption properties of(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)powders and those after oxidation at different temperatures were also exam-ined.The results show that the as-synthesized(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)powders possess excellent EM wave absorption performances with the minimum reflection loss(RL)of-45.80 dB(at 1.7 mm thickness)and the maximum effective absorption bandwidth(E AB)of 3.6 GHz(at 1.5 mm thickness).After oxidation at 400-800℃,due to the coupling of conductivity loss and polarization loss,(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)powders can retain good EM wave absorption properties in a certain frequency range.In this paper,the effects of oxidation on EM wave absorption properties of high-entropy MAX phases were systematically investigated for the first time.This work manifests that high-entropy MAX phases are promising EM wave absorbing candidates and can maintain good EM wave absorption performances after oxidation. | Linjing Qiao Jianqiang Bi Guandong Liang Chen Liu Zhuangzhuang Yin Yao Yang Hongyi Wang Shaoyin Wang Mengmeng Shang Weili Wang | 2023 | Journal of Materials Science & Technology2023，，6： | 1 |
| 11 | Plant functional trait diversity and structural diversity co-underpin ecosystem multifunctionality in subtropical forests显示文摘Tree species diversity is assumed to be an important component in managing forest ecosystems because of effects on multiple functions or ecosystem multifunctionality.However,the importance of tree diversity in determining multifunctionality in structurally complex subtropical forests relative to other regulators(e.g.,soil microbial diversity,stand structure,and environmental conditions)remains uncertain.In this study,effects of aboveground(species richness and functional and structural diversity)and belowground(bacterial and fungal diversity)biodiversity,functional composition(community-weighted means of species traits),stand structure(diameter at breast height and stand density),and soil factors(pH and bulk density)on multifunctionality(including biomass production,carbon stock,and nutrient cycling)were examined along a tree diversity gradient in subtropical forests.The community-weighted mean of tree maximum height was the best predictor of ecosystem multifunctionality.Functional diversity explained a higher proportion of the variation in multifunctionality than that of species richness and fungal diversity.Stand structure-played an important role in modulating the effects of tree diversity on multifunctionality.The work highlights that species composition and maximizing forest structural complexity are effective strategies to increase forest multifunctionality while also conserving biodiversity in the management of multifunctional forests under global environmental changes. | Shuai Ouyang Mengmeng Gou Pifeng Lei Yue Liu Liang Chen Xiangwen Deng Zhonghui Zhao Yelin Zeng Yanting Hu Changhui Peng Wenhua Xiang | 2023 | Forest Ecosystems2023，10，2： | 0 |
| 12 | The Anatomy of Shallow Water Sandy Braided River Reservoir Architecture显示文摘1 Introduction Reservoir architecture refers to pattern,scale,direction and overlapping relationship of different levels of architecture units.The research of architecture in fluvial phase began in the 1980s(Miall,1985).The braided | CHEN Liang YIN Taiju SU Yangling WANG Mengmeng SHEN Chunsheng LI Menglu | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 13 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 14 | MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non-small cell lung cancer显示文摘Background:Angiogenesis plays an important role in the occurrence and development of non-small cell lung cancer(NSCLC).The atypical mitogen-activated protein kinase 4(MAPK4)has been shown to be involved in the pathogenesis of various diseases.However,the potential role of MAPK4 in the tumor angiogenesis of NSCLC remains unclear.Methods:Adult male C57BL/6 wild-type mice were randomly divided into the control group and p-siMAPK4 intervention group,respectively.The cell proliferation was analyzed with flow cytometry and immunofluorescence staining.The vascular density in tumor mass was analyzed by immuno-fluorescence staining.The expressions of MAPK4 and related signaling molecules were detected by western blot analysis and immunofluorescence staining,and so on.Results:We found that the expression of MAPK4,which was dominantly expressed in local endothelial cells(ECs),was correlated with tumor angiogenesis of NSCLC.Furthermore,MAPK4 silencing inhibited the proliferation and migration abilities of human umbilical vein ECs(HUVECs).QKHZC-2020-4Y156,QKH-JC-2018-1428,QKH-RC-2019-5612;Collaborative Innovation Center of Chinese Ministry of Education,Grant/Award Number:2020-39;Program for Science and Technology Joint Fund Project in Zunyi Science and Technology Bureau and Zunyi Medical University,Grant/Award Numbers:ZSKH-RPT-2020-6,ZSKH-HZ-2021-193;Graduate Research Fund of Zunyi Medical University,Grant/Award Number:2023-ZYK-171 Global gene analysis showed that MAPK4 silencing altered the expression of multiple genes related to cell cycle and angiogenesis pathways,and that MAPK4 silencing increased transduction of the extracellular regulated protein kinases 1/2(ERK1/2)pathway but not Akt and c-Jun n-terminal kinase pathways.Further analysis showed that MAPK4 silencing inhibited the proliferation and migration abilities of HUVECs cultured in tumor cell supernatant,which was accompanied with increased transduction of the ERK1/2 pathway.Clinical data analysis suggested that the higher expression of MAPK4 and CD34 were associated with poor prognosis of patients with NSCLC.Targeted silencing of MAPK4 in ECs using small interfering RNA driven by the CD34 promoter effectively inhibited tumor angiogenesis and growth of NSCLC in vivo.Conclusion:Our results reveal that MAPK4 plays an important role in the angiogenesis and development of NSCLC.MAPK4 may thus represent a new target for NSCLC. | Jing Chen Jing Yang Yufang Liu Xu Zhao Juanjuan Zhao Lin Tang Mengmeng Guo Ya Zhou Chao Chen Dongmei Li Zhenke Wen Guiyou Liang Lin Xu | 2024 | Cancer Innovation2024，3，3： | 0 |
| 15 | Petrogenesis of the Late Eocene to Early Oligocene Yao'an Shoshonitic Complex,Southeastern Tibet:Partial Melting of an Ancient Continental Lithospheric Mantle beneath the Yangtze Block显示文摘Cenozoic potassic-ultrapotassic igneous rocks are widespread in the southeastern Tibetan Plateau.Their petrogenesis and magmatic processes remain subject to debate in spite of numerous publications.Almost all of the Cenozoic extrusive and intrusive rocks in the Yao’an area,western Yunnan Province,SW China,are geochemically shoshonitic,collectively termed here the Yao’an Shoshonitic Complex(YSC).The YSC is located in the(south)easternmost part of the ENE-WSW-trending,~550 km-long and~250 km-wide Cenozoic magmatic zone;the latter separates the orthogonal and oblique collision belts of the India-Eurasia collision orogen.Previously published geochronological and thermochronological data revealed that the rocks of the YSC were emplaced over a short timespan of 34-32 Ma.This and our new data suggest that the primary magma of the YSC likely was formed by partial melting of ancient continental lithospheric mantle beneath the Yangtze Block.This part of the continental lithospheric mantle had likely not been modified by any oceanic subduction.Fractionation crystallization of an Mg-and Ca-bearing mineral and TiFe oxides during the magmatic evolution probably account for the variable lithologies of the YSC. | DONG Mengmeng YANG Tiannan XUE Chuandong XIN Di LIANG Mingjuan YAN Qinggao | 2023 | Acta Geologica Sinica(English Edition)2023，97，6： | 0 |
| 16 | Porous heterostructure of graphene/hexagonal boron nitride as an efficient electrocatalyst for hydrogen peroxide generation显示文摘Compared with the traditional heteroatom doping,employing heterostructure is a new modulating approach for carbon-based electrocatalysts.Herein,a facile ball milling-assisted route is proposed to synthesize porous carbon materials composed of abundant graphene/hexagonal boron nitride(G/h-BN)heterostructures.Metal Ni powder and nanoscale h-BN sheets are used as a catalytic substrate/hard template and“nucleation seed”for the formation of the heterostructure,respectively.As-prepared G/h-BN heterostructures exhibit enhanced electrocatalytic activity toward H_(2)O_(2) generation with 86%-95%selectivity at the range of 0.45-0.75 V versus reversible hydrogen electrode(RHE)and a positive onset potential of 0.79 versus RHE(defined at a ring current density of 0.3 mA cm^(-2))in the alkaline solution.In a flow cell,G/h-BN heterostructured electrocatalyst has a H_(2)O_(2) production rate of up to 762 mmol g_(catalyst)^(-1) h^(-1) and Faradaic efficiency of over 75%during 12 h testing,superior to the reported carbon-based electrocatalysts.The density functional theory simulation suggests that the B atoms at the interface of the G/h-BN heterostructure are the key active sites.This research provides a new route to activate carbon catalysts toward highly active and selective O_(2)-to-H_(2)O_(2) conversion. | Mengmeng Fan Zeming Wang Yuying Zhao Qixin Yuan Jian Cui Jithu Raj Kang Sun Ao Wang Jingjie Wu Hao Sun Bei Li Liang Wang Jianchun Jiang | 2023 | Carbon Energy2023，5，5： | 0 |
| 17 | Multifaceted roles of LhWRKY44 in promoting anthocyanin accumulation in Asiatic hybrid lilies (Lilium spp.)显示文摘The Asiatic hybrid lily(Lilium spp.)is a horticultural crop with high commercial value and diverse anthocyanin pigmentation patterns.However,the regulatory mechanism underlying lily flower color has been largely unexplored.Here,we identified a WRKY transcription factor from lily tepals,LhWRKY44,whose expression was closely associated with anthocyanin accumulation.Functional verification indicated that LhWRKY44 positively regulated anthocyanin accumulation.LhWRKY44 physically interacted with LhMYBSPLATTER and directly bound to the LhMYBSPLATTER promoter,which enhanced the effect of the LhMYBSPLATTER-LhbHLH2 MBW complex activator on anthocyanin accumulation.Moreover,EMSA and dual-luciferase assays revealed that LhWRKY44 activated and bound to the promoters of gene LhF3H and the intracellular anthocyanin-related glutathione S-transferase gene LhGST.Interestingly,our further results showed that LhWRKY44 participated in light and drought-induced anthocyanin accumulation,and improved the drought tolerance in lily via activating stress-related genes.These results generated a multifaceted regulatory mechanism for the LhWRKY44-meditaed enhancement by the environmental signal pathway of anthocyanin accumulation and expanded our understanding of the WRKY-mediated transcriptional regulatory hierarchy modulating anthocyanin accumulation in Asiatic hybrid lilies. | Mengmeng Bi Rui Liang Jiawen Wang Yuxiao Qu Xin Liu Yuwei Cao Guoren He Yue Yang Panpan Yang Leifeng Xu Jun Ming | 2023 | Horticulture Research2023，10，9： | 0 |
| 18 | Protective efficacy evaluation of immunogenic protein AHA_3793 of Aeromonas hydrophila as vaccine candidate for largemouth bass Micropterus salmoides显示文摘Aeromonas hydrophila is a Gram-negative pathogen that can infect various fish,including largemouth bass(Micropterus salmoides),which have caused huge economic losses.In present study,largemouth bass anti-A.hydrophila antibodies were produced,then a highly immunogenic outer membrane proteins,AHA_3793,was identified by combined western blotting and mass spectrometry analysis.Moreover,AHA_3793 was expressed,and its immunogenicity was further verified by western blotting.Subsequently,the protective efficacy of AHA_3793 were evaluated in largemouth bass.The results showed that rAHA_3793 could produce a relative percentage survival(RPS)of 61.76% for largemouth bass against A.hydrophila challenge.ELISA analysis showed the specific serum antibodies of largemouth bass against rAHA_3793 and A.hydrophila in vaccinated group in weeks 4 and 5 after immunization were significantly higher than those in control group,which suggested that rAHA_3793 induced production of specific serum antibodies against rAHA_3793 and A.hydrophila.The qRT-PCR analysis showed that expressions of CD4-2 and MHC Ⅱα were also significantly up-regulated after immunization.These results collectively demonstrated that rAHA_3793 could induce a strong humoral immune response of largemouth bass,and then produce high immune protection ef fects against A.hydrophila infection. | Shun YANG Idefonce MKINGULE Long LIU Wenqi CHEN Xiangyu YUAN Zixuan MA Liang LIANG Shichao QIAN Mengmeng HUANG Hui FEI | 2023 | Journal of Oceanology and Limnology2023，41，1： | 0 |
| 19 | Simulating soil erodibility in southeastern China using a sequential Gaussian algorithm显示文摘Soil erodibility(K)is a key factor of soil erosion,and its appropriate quantification and interpolation are vitally important for soil and water conservation.The traditional point-represent-polygon approaches and common kriging method for the estimation of K,however,do not sufficiently represent the original data.The objectives of this study were to simulate the spatial distribution of K using a sequential Gaussian algorithm and analyze the uncertainty in evaluating the risk of soil erodibility in southeastern China.We determined 101 sampling points in the area and collected disturbed soil samples from the 0-20 cm layer at each point.Soil properties were determined,and K was calculated using five common models:the EPIC(Erosion/Productivity Impact Calculator),approximate nomograph,Torri,Shirazi,and Wang models.Among the chosen models,the EPIC model performed the best at estimating K(KEPIC),which ranged from 0.019 to 0.060 t ha h(ha MJ mm)^(-1),with a mean of 0.043 t ha h(ha MJ mm)^(-1).The KEPIC was moderately spatially variable and had a limited spatial structure,increasing from south to north in our study area,and all spatial simulations using the cooperative kriging(CK)interpolation and the sequential Gaussian simulation(SGS)with 10,25,50,100,200,and 500 realizations had acceptable accuracies.The CK interpolation narrowed the range,and the SGS maintained the original characteristics of the calculated data.The proportions of the risk area were 38.0% and 10.1%,when the risk probability for K was 60% and 80%,respectively,and high risk areas were mostly located in the north.The results provide scientific guidance for managing the risk of soil erodibility in southeastern China. | Xuchao ZHU Yin LIANG Zhiyuan TIAN Yi ZHANG Yugang ZHANG Jing DU Xin WANG Yu LI Lili QU Mengmeng DAI | 2021 | Pedosphere2021，31，5： | 0 |
| 20 | Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor显示文摘The adoptive transfer of chimeric antigen receptor-T(CAR-T)cells has shown remarkable clinical responses in hematologic malignancies.However,unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.Herein we develop a click CAR-T cell engineering strategy via cell glycometabolic labeling for robustly boosting their antitumor effects and safety in vivo.Briefly,paired chemical groups(N3/BCN)are separately incorporated into CAR-T cell and tumor via nondestructive intrinsic glycometabolism of exogenous Ac4GalNAz and Ac4ManNBCN,serving as an artificial ligand-receptor.Functional groups anchored on cell surface strengthen the interaction of CAR-T cell and tumor via bioorthogonal click chemistry,further enhancing specific recognition,migration and selective antitumor effects of CAR-T cells.In vivo,click CAR-T cell completely removes lymphoma cells and minimizes off-target toxicity via selective and efficient bioorthogonal targeting in blood cancer.Surprisingly,compared to unlabeled cells,artificial bioorthogonal targeting significantly promotes the accumulation,deep penetration and homing of CAR-T cells into tumor tissues,ultimately improving its curative effect for solid tumor.Click CAR-T cell engineering robustly boosts selective recognition and antitumor capabilities of CAR T cells in vitro and in vivo,thereby holding a great potential for effective clinical cell immunotherapy with avoiding adverse events in patients. | Hong Pan Wenjun Li Ze Chen Yingmei Luo Wei He Mengmeng Wang Xiaofan Tang Huamei He Lanlan Liu Mingbin Zheng Xin Jiang Ting Yin Ruijing Liang Yifan Ma Lintao Cai | 2021 | Bioactive Materials2021，6，4： | 0 |
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