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| 1 | Research and application of methods for effectiveness evaluation of mine cooling system显示文摘Regarding the complexity and inconsistency of results in existing evaluation methods of mine cooling system, this paper clarifies the advantages, disadvantages and application of various mine cooling systems through principle analysis, and divides all the cooling systems into air-cooling, ice-cooling and water-cooling according to the transportation of cold energy. On this basis, the paper proposes a simple and efficient evaluation method for mine cooling system. The first index of this method is the air temperature at point C which is 15 m away from the return wind corner at working face. A cooling system will be judged ineligible if the air temperature at point C is above 30 °C during operation, because in this case, the combustible gases in coal will sharply overflow, inducing gas incidents. Based on the preliminary judgment of the first index, another two evaluation indexes are proposed based on the cooling ability and dehumidification of an airflow volume of 1000 m3/min at point C to evaluate the investment and operation cost of mine cooling system. This evaluation method has already been successfully applied in the cooling system design of Zhangshuanglou coal mine. | Guo Pingye Wang Yanwei Duan Mengmeng Pang Dongyang Li Nan | 2015 | International Journal of Mining Science and Technology2015，25，4： | 7 |
| 2 | Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier显示文摘Multidrug 抵抗蛋白质(MDRP ) 在肿瘤在 multidrug 抵抗的调停被含有,代表主要障碍到成功的化疗。当 curcumin (杂种狗) 在 MDRP 的表示和功能上施加禁止的效果,为杂种狗和 doxorubicin (纪录影片) 的合作交货的 nanocarrier 被准备通过他们的 synergistic 效果克服 MDR 肿瘤。由于在肿瘤的 legumain 的 overexpression,从这 nanocarrier 的纪录影片的版本侧面被设计是调制的 legumain,它被与 legumain 敏感的肽衔接纪录影片到基本材料(chitosan ) 完成。与 nanoparticles 相比仅仅包含纪录影片,纪录影片和杂种狗的 coadministration 显著地禁止了 multidrug 抵抗(P < 0.05 ) 在一个 multidrug 抵抗的癌症房间模型(MCF-7/ADR 房间线) ,与到正常房间(L929 房间线) 的 cytotoxicity。如此的抑制能在 MCF-7/ADR 原子核被归功于到增加的纪录影片累积。合作交货系统整个延长发行量时间,改进指向肿瘤的效率,肿瘤抑制活动的举起,和 MDRP 表示的抑制展出了好 anticancer 效果。这些数据为癌症治疗揭示了这个合作交货系统的庞大的潜力,特别在 multidrug 抵抗可以发展的以后的阶段。 | Sen Lin Peiling Xie Mengmeng Luo Qing Li Ling Li Jinzhao Zhang Qinxiang Zheng Hao Chen Kaihui Nan | 2018 | Nano Research2018，11，7： | 2 |
| 3 | Adverse Effect of Nonalcoholic Fatty Liver Disease on the Therapeutic Response in Patients with Chronic Hepatitis B显示文摘Background and Aims:The impact of nonalcoholic fatty liver disease(NAFLD)on the treatment outcome of chronic hepatitis B(CHB)is undefined and deserves an in-depth investigation.Methods:Histologically-proven CHB receiving first-line antiviral regimens as initial therapy was enrolled and grouped by the concurrence of NAFLD,and followed up at six monthly intervals.Therapeutic response related data were recorded and compared at multiple time points.Kaplan-Meier and Cox regression analyses were utilized to estimate the impact of NAFLD on complete virological response(CVR).Results:We enrolled 267 patients(CHB:164;CHB with NAFLD:103)with comparable follow-up durations.They were also comparable in baseline HBV DNA levels and HBeAg positivity.Patients with concomitant NAFLD showed less significant decline in HBV DNA,qHBsAg,pgRNA,and liver enzyme levels over time;moreover,their cumulative incidences of CVR were significantly lower and that of low-level viremia(LLV)were significantly higher at 6,12,18,24 months.First CVR of CHB was delayed with the presence NAFLD(11.0 vs.7.0 months,p<0.001)and further prolonged with higher grade of liver steatosis(Grade 2–3 vs.1:13.0 vs.9.0 months).On multivariate analysis,HBeAg positivity(HR:0.650,p=0.036),grade of steatosis(G2[HR:0.447,p=0.004];G3[HR:0.085,p=0.002])and HBV DNA(log10 IU/mL)(HR:0.687,p<0.001)were significantly associated with delayed CVR,whereas grade of necroinflammation(HR:1.758,p<0.001)accelerated the CVR.Conclusions:In CHB patients receiving initial antiviral therapy,NAFLD was associated with higher levels of HBV DNA,pgRNA,and liver enzymes,and higher incidence of LLV and delayed CVR. | Siyu Zhang Xiaoxiao Zhang Huiming Jin Yao Dou Lu Li Xiwei Yuan Chen Dong Mengmeng Hou Yue-min Nan Jia Shang | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 1 |
| 4 | Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months显示文摘Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd immunity.This retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to convalescence.Antibodies in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CLIA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the convalescence.However,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th week.The titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values respectively.In contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of observation.Dynamic behavior of antibodies and their correlation in age,gender and severity groups were investigated.In general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent patients.Only a few patients with antibody reducing to an undetectable level which needs further attention.The humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity. | Yang Zheng Qing Zhang Ashaq Ali Ke Li Nan Shao Xiaoli Zhou Zhiqin Ye Xiaomin Chen Shanshan Cao Jing Cui Juan Zhou Dianbing Wang Baidong Hou Min Li Mengmeng Cui Lihua Deng Xinyi Sun Qian Zhang Qinfang Yang Yong li Hui Wang Yake Lei Bo Yu Yegang Cheng Xiaolin Tong Dong Men Xian-En Zhang | 2021 | Virologica Sinica2021，36，5： | 1 |
| 5 | Common variants in PERK, JNK, BIP and XBP1 genes are associated with the risk of prediabetes or diabetes-related phenotypes in a Chinese population显示文摘 | Feng Nan Ma Xiaowei Wei Xiaowei Zhang Junqing Dong Aimei Jin Mengmeng Zhang Hong Guo Xiaohui | 2014 | Chinese Medical Journal2014，，13： | 0 |
| 6 | Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure显示文摘Tebuconazole exposure has been described as an increasing hazard to human health.An increasing number of recent studies have shown a positive association between tebuconazole exposure and cardiovascular disease risk,which is characterized by the reduction of adenosine triphosphate(ATP)synthesis.However,researches on the damage of tebuconazole exposure to energy metabolism and the related molecular mechanisms are limited.In the present study,male C57BL/6 mice were treated with tebuconazole at different low concentrations for 4 weeks.The results indicated that tebuconazole could accumulate in the heart and further induce the decrease of ATP content in the mouse heart.Importantly,tebuconazole induced an obvious shift in substrate utilization of fatty acid and glucose by disrupting their corresponding transporters(GLUT1,GLUT4,CD36,FABP3 and FATP1)expression,and significantly repressed the expression of mitochondrial biogenesis(Gabpa and Tfam)and oxidative phosphorylation(CS,Ndufa4,Sdhb,Cox5a and Atp5b)related genes in a dosedependent manner.Further investigation revealed that these alterations were related to the IRS1/AKT and PPARγ/RXRαpathways.These findings contribute to a better understanding of triazole fungicide-induced cardiovascular disease by revealing the key indicators associated with this phenomenon. | Tingting Ku Jindong Hu Mengmeng Zhou Yuanyuan Xie Yutong Liu Xin Tan Lin Guo Guangke Li Nan Sang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 7 | Influence of nitrogen status on fermentation performances of non-Saccharomyces yeasts:a review显示文摘Nitrogen,one of the most crucial nutrients present in grapes and musts,plays a key role in yeast activities during alcoholic fermentation.Such influences are imposed on yeast growth and fermentation performances including the formation of secondary metabolites.Saccharomyces cerevisiae,the main yeast responsible for fermentation,has been studied extensively regarding nitrogen impacts.On the other hand,a similar study for non-Saccharomyces yeasts,whose contributions to winemaking have gradually been acknowledged,remains to be fully explored,with a few studies being reported.This review starts by discussing nitrogen impacts on non-Saccharomyces yeast growth and fermentation kinetics in different case scenarios,then proceeds to summarize the nitrogen preferences of individual yeast strains with regulation mechanisms elucidated by recent studies.Detailed discussions on the influences on the production of volatile compounds and proposed pathways therein are made,followed by future work suggested as the final section.In summarizing the nitrogen impacts on non-Saccharomyces yeasts throughout alcoholic fermentation,this review will be helpful in obtaining a more comprehensive view on these non-conventional wine yeasts in terms of nutrient requirements and corresponding volatile production.Research gaps will therefore be elucidated for future research. | Jinchen Li Mengmeng Yuan Nan Meng Hehe Li Jinyuan Sun Baoguo Sun | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 8 | 单细胞技术揭示肝癌免疫图谱与动态特征显示文摘文章简介肝细胞癌是世界范围内死亡率排名第三的癌症,其中中国的肝癌发病率居世界之先。肿瘤存在多种免疫逃逸机制,提出了研究肿瘤微环境中不同免疫细胞状态的重要性。而不同类型的单细胞测序技术则是研究不同类型免疫细胞的状态和动态的有力手段。本研究结合了两种单细胞测序技术,充分发挥不同数据类型的优势,获得高分辨率的肝癌免疫图谱。肿瘤中的树突状细胞是重要的抗原呈递细胞,除传统的树突状细胞外。 | Qiming Zhang Yao He Nan Luo Shashank J.Patel Yanjie Han Ranran Gao Madhura Modak Sebastian Carotta Christian Haslinger David Kind Gregory W.Peet Guojie Zhong Shuangjia Lu Weihua Zhu Yilei Mao Mengmeng Xiao Michael Bergmann Xueda Hu Sid P.Kerkar Anne B.Vogt Stefan Pflanz Kang Liu 彭吉润 任仙文 张泽民 | 2020 | 科学新闻2020，，2： | 0 |
| 9 | Recent Progress of Fuel-Driven Temporary Materials显示文摘Fuel-driven dissipative self-assembly,which is a well-established concept in recent years,refers to out-of-equilibrium molecular self-assembly initiated and supported by the addition of active molecules (chemical fuel).It widely exists in nature since many temporary,active micro- or nanostructures in living bodies are generated by the dissipative self-assembly of biomolecules.Therefore,the study on dissipative self-assembly provides a good opportunity to have an insight into the microscopic mechanism of living organisms.In the meantime,dissipative assembly is thought to be a potential pathway to achieve dynamic,temporary supramolecular materials.Recently,a number of temporary materials have been developed with the aid of strategies for realizing dissipative self-assembly.Some of their properties,including solubility,stiffness,turbidity,color,or self-healing ability,change upon the addition of chemical fuel but spontaneously restore with chemical fuel consumption.The dynamic of these materials brings them various unprecedented functions.In this review,the principles of fabricating a fuel-driven temporary material are first reviewed.Subsequently,recent examples of fuel-driven temporary materials are emphatically summarized,including gels,self-erased inks,nanoreactors,self-healing materials,nanochannels,and droplets.Finally,the challenges of developing fuel-driven temporary materials and some perspectives on the function and application of such kind of materials are discussed. | Guangtong Wang Mengmeng Nan Kangle Guo Yaqi Pan Tao Jia Shaoqin Liu | 2023 | Chinese Journal of Chemistry2023，41，23： | 0 |
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