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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | Structural characterisation of polysaccharides from Tricholoma matsutake and their antioxidant and antitumour activities显示文摘 | Lijun You Qing Gao Mengying Feng Bao Yang Jiaoyan Ren Longjian Gu Chun Cui Mouming Zhao | 2013 | Food Chemistry2013，，4： | 2 |
| 3 | SbMYB3 transcription factor promotes root-specific f lavone biosynthesis in Scutellaria baicalensis显示文摘Scutellaria baicalensis Georgi produces abundant root-specific f lavones(RSFs),which provide various benefits to human health.We have elucidated the complete biosynthetic pathways of baicalein and wogonin.However,the transcriptional regulation of f lavone biosynthesis in S.baicalensis remains unclear.We show that the SbMYB3 transcription factor functions as a transcriptional activator involved in the biosynthesis of RSFs in S.baicalensis.Yeast one-hybrid and transcriptional activation assays showed that SbMYB3 binds to the promoter of flavone synthase II-2(SbFNSII-2)and enhances its transcription.In S.baicalensis hairy roots,RNAi of SbMYB3 reduced the accumulation of baicalin and wogonoside,and SbMYB3 knockout decreased the biosynthesis of baicalein,baicalin,wogonin,and wogonoside,whereas SbMYB3 overexpression enhanced the contents of baicalein,baicalin,wogonin,and wogonoside.Transcript profiling by qRT–PCR demonstrated that SbMYB3 activates SbFNSII-2 expression directly,thus leading to more abundant accumulation of RSFs.This study provides a potential target for metabolic engineering of RSFs. | Yumin Fang Jie Liu Minmin Zheng Sanming Zhu Tianlin Pei Mengying Cui Lijing Chang Hanwen Xiao Jun Yang Cathie Martin Qing Zhao | 2023 | Horticulture Research2023，10，2： | 2 |
| 4 | Effects of shape and particle size on the photocatalytic kinetics and mechanism of nano-CeO_(2)显示文摘Nanomaterials have been widely applied to many fields because of their excellent photocatalytic performance.The performance is closely related to the catalytic kinetics,but it is not completely clear about the influencing regularities of shape and particle size on the photocatalytic kinetics of nanomaterials and the photocatalytic kinetic mechanism.In this paper,nano-CeO_(2)with different shapes and particle sizes were prepared,the kinetic parameters of adsorption and photocatalytic degradation were determined,and the effects of shape and particle size on the kinetics of adsorption and photocatalysis and photocatalytic mechanism were discussed.The results show that the shape and particle size have significant influences.With the decreases of diameter,the performances of adsorption and photocatalysis of nano-CeO_(2)are improved;and these performances of spherical nano-CeO_(2)are greater than those of linear nano-CeO_(2).The shape and particle size have no effects on the kinetic order and mechanism of the whole photocatalytic process.Then a generalized mechanism of photocatalytic kinetics of nanomaterials was proposed and the mechanism rate equation was derived.Finally,the conclusion can be drawn:the desorption of photodegradation products is the control step of photocatalytic kinetics,and the kinetic order of photocatalytic degradation reaction is 1.The mechanism is universal and all nanomaterials have the same photocatalytic kinetic mechanism and order. | Zixiang Cui Lu Zhang Yongqiang Xue Ya’nan Feng Mengying Wang Jiaojiao Chen Boteng Ji Chenyu Wang Yidi Xue | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，12： | 1 |
| 5 | Mesoporous H-ZSM-5 nanocrystals with programmable number of acid sites as "solid ligands" to activate Pd nanoparticles for C-C coupling reactions显示文摘在这个工作,我们描述了一个 proof-of-concept 方法为异构的催化作用支持 Pd nanoparticles 的活动和选择(由联合反应的 C-C 例示) 由在一个沸石框架以内使用酸地点。Pd nanoparticles 在导致混合样品的 mesoporous H-ZSM-5 的水晶的墙内被包含(作为 Pd@mZ-x-H 表示了) 与酸地点的控制数字。在沸石 nanocrystals 的酸地点和在器官的反应的 Pd nanoparticles 的催化活动的数字之间的一种线性关系被建立。而且,当最后的活动被提高时, Pd@mZ-x-H 的形状依赖者选择没被牺牲。 | Wenyu Ke Tianlu Cui Qiuying Yu Mengying Wang Libing Lv Honghui Wang Zhidong Jiang XinhHao Li Jiesheng Chen | 2018 | Nano Research2018，11，2： | 1 |
| 6 | Developments in diagnostic applications of saliva in human organ diseases显示文摘Saliva is one of the important body fluids that reflects normal internal characteristics and disease state of an individual.As a multi-composition oral fluid,has high potential for the surveillance of general health and disease,which contains various disease signal biomarkers and is non-invasive,convenient,fast and easy to be accepted by patients.At present,saliva is increasingly used as a biological fluid for diagnosis,monitoring systemic disease states and predicting disease progression,which has been verified.In this review,the molecular compositions and effectiveness of saliva as reliable biological fluid were discussed.Besides the latest research progress in the diagnosis of saliva related to 14 organs were reviewed.The factors affecting saliva diagnosis were discussed.The method to improve the accuracy of prediction through artificial intelligence combined with microfluidic chip was proposed,which laid the foundation for dealing with the prevention,diagnosis,and treatment of related diseases through saliva with great and long-term significance. | Yangyang Cui Mengying Yang Jia Zhu Hangkun Zhang Zhili Duan Song Wang Zhenhua Liao Weiqiang Liu | 2022 | Medicine in Novel Technology and Devices2022，，1： | 0 |
| 7 | Expressive and functional characterization of transient receptor potentialvanilloid 4 in the DRG and spinal cord in rat with diabetic mechanical allodynia显示文摘Diabetic mechanical allodynia(DMA)remains no effective treatment currently.TRPV4 is involved in mechanical sensation of varying etiologies,but expression feature and the whether it contributes to the DMA are so far unclear. | Cui Yuanyuan Li Mengying Shi Juan Li Yunqing | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 8 | Gap-free genome assembly and CYP450 gene family analysis reveal the biosynthesis of anthocyanins in Scutellaria baicalensis显示文摘Scutellaria baicalensis Georgi,a member of the Lamiaceae family,is a widely utilized medicinal plant.The flavones extracted from S.baicalensis contribute to numerous health benefits,including anti-inflammatory,antiviral,and anti-tumor activities.However,the incomplete genome assembly hinders biological studies on S.baicalensis.This study presents the first telomere-to-telomere(T2T)gap-free genome assembly of S.baicalensis through the integration of Pacbio HiFi,Nanopore ultra-long and Hi-C technologies.A total of 384.59 Mb of genome size with a contig N50 of 42.44 Mb was obtained,and all sequences were anchored into nine pseudochromosomes without any gap or mismatch.In addition,we analysed the major cyanidin-and delphinidin-based anthocyanins involved in the determination of blue-purple flower using a widely-targeted metabolome approach.Based on the genome-wide identification of Cytochrome P450(CYP450)gene family,three genes(SbFBH1,2,and 5)encoding flavonoid 3′-hydroxylases(F3′Hs)and one gene(SbFBH7)encoding flavonoid 3′5′-hydroxylase(F3′5′H)were found to hydroxylate the B-ring of flavonoids.Our studies enrich the genomic information available for the Lamiaceae family and provide a toolkit for discovering CYP450 genes involved in the flavonoid decoration. | Tianlin Pei Sanming Zhu Weizhi Liao Yumin Fang Jie Liu Yu Kong Mengxiao Yan Mengying Cui Qing Zhao | 2023 | Horticulture Research2023，10，12： | 0 |
| 9 | Quantitative Characterization of the Elasticity,Net Creep,and Swelling of the Intervertebral Disc:An In Vitro Experiment显示文摘During the in vitro creep of intervertebral discs,both applied loads and osmosis of solution influence their biomechanical behaviors.More specifically,the total displacement can be attributed to three parts:the elastic response during the loading period that results from instant tissue deformation;the nonlinear displacement during the creep period that is due to the poro-elastic fluid flow and visco-elastic deformation;and the swelling of discs that are affected by the osmolality.However,their respective contributions to the total displacement are unknown.To this end,this study aims to discern contributions of the above three parts in ex vivo experiments quantitively.Specimens were compressed for 4 h after 0.5 h preload.Displacement and strain were recorded and curve-fitted.The instant elastic displacement was positively related to the applied load,and its proportion rose from 18.09 to 21.46% as the load elevated.While the contribution of the net creep was inversely related to the applied load,dropping from 74.49 to 60.16%.An increase of 0.74 MPa of the osmolality induced a rise in displacement by 7.42-18.38%.Moreover,with the help of the non-contact measurement,researchers are able to know the contribution of each part quantitatively,which is of importance in understanding the creep mechanisms and developing biomaterials with mechanical mimicry of natural discs. | Mengying Yang Yangyang Cui Yu Zhang Huakai Wu Beibei Hu Song Wang Weiqiang Liu | 2022 | Journal of Bionic Engineering2022，19，4： | 0 |
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