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| 1 | Targeted mutagenesis in rice using CRISPR-Cas system显示文摘 | Jin Miao Dongshu Guo Jinzhe Zhang Qingpei Huang Genji Qin Xin Zhang Jianmin Wan Hongya Gu Li-Jia Qu | 2013 | Cell Research2013，23，10： | 103 |
| 2 | Multicenter case-control study of the risk factors for ulcerative colitis in China显示文摘AIM:To evaluate potential risk factors in the development of ulcerative colitis(UC) in China.METHODS:A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China.The UC cases were collected from 17 hospitals in China from April 2007 to April 2010.Uniform questionnaires were designed to investigate risk factors including smoking,appendectomy,stress,socio-economic conditions,nonsteroidal antiinflammatory drugs(NSAIDs),oral contraceptives,diet,breastfeeding,infections and family sanitary conditions.Group comparisons by each factor were done using simple logistic regression analysis.Conditional logistic regression was used for multivariate analysis.RESULTS:By univariate analysis,the variables predictive of UC included feeling stress,light and heavy alcoholic drinking,spicy food,sugar consumption and infectious diarrhea,while heavy tea intake and tap water consumption were protective against UC.On multivariate analysis,the protective factor for UC was tap water consumption [odds ratios(OR) = 0.424,95%CI:0.302-0.594,P < 0.001];while the potential risk factors for UC were heavy sugar consumption(OR = 1.632,95%CI:1.156-2.305,P < 0.001),spicy food(light intake:OR = 3.329,95%CI:2.282-4.857,P < 0.001;heavy intake:OR = 3.979,95%CI:2.700-5.863,P < 0.001),and often feeling stress(OR = 1.981,95%CI:1.447-2.711,P < 0.001).Other factors,such as smoking habit,appendectomy,breastfeeding,a history of measles,rural or urban residence,education,oral contraceptives,and NSAID use have not been found to have a significant association with the development of UC in the present study.CONCLUSION:Our study showed tap water consumption was a protective factor for UC,while spicy food,heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population. | Yu-Fang Wang Qin Ou-yang Bing Xia Li-Na Liu Fang Gu Kai-Fang Zhou Qiao Mei Rui-Hua Shi Zhi-Hua Ran Xiao-Di Wang Pin-Jin Hu Kai-Chun Wu Xin-Guang Liu Ying-Lei Miao Ying Han Xiao-Ping Wu Guo-Bing He Jie Zhong Guan-Jian Liu | 2013 | World Journal of Gastroenterology2013，19，11： | 24 |
| 3 | Age-related changes of serum tartrate-resistant acid phosphatase 5b and the relationship with bone mineral density in Chinese women显示文摘瞄准:Osteoclastic 活动被尿标记的测量主要估计(例如类型的 C 终端 cross-linked telopeptides 我骨胶原,类型的 N 终端 cross-linked telopeptides 我骨胶原等等,其层次能被肾的清理经常影响。最近,浆液酒石酸盐抵抗的酸磷酸酶 5b (TRACP5b ) 被用作一个其他的浆液标记评估 osteoclastic 活动。我们在中国女人与骨头矿物质密度(BMD ) 调查了 TRACP5b 水平和它的协会的年龄相关的变化。方法:七 -- 20 79 年的 122 个中国大陆女人在学习被招募。浆液 TRACP5b 水平用免疫分析被测量评估骨头再吞的状态。骨头矿物质密度(BMD )( 在腰部的脊骨的 g/cm 2) 1 4 并且近似腿节被决斗精力 X 光检查 absorptiometry 测量。结果:浆液 TRACP5b 水平在绝经前的女人到达了底部价值 30 39,逐渐地在女人增加了 40 49,很快,在女人的玫瑰变老 50 59,并且在女人与最大的价值达到顶点 60 69 在在女人的慢落下前变老 70 79。TRACP5b 的平均水平在绝经后的女人是显著地更高的[(3.29 ± 1 .07 ) U/L ] 比在绝经前的女人([1.70 ± 0 .59 ] U/L ) 。TRACP5b 的层次相反地与根本测量的 BMD 被相关地点(P<0.001 ) 。而且, TRACP5b 的水平比有正常骨头质量(P<0.001 ) 的那些在有骨质疏松症和 osteopenia 的女人显然是更高的。结论:我们在中国大陆女人建立了浆液 TRACP5b 的参考价值,并且发现绝经后的女人比更年轻的女人有更高的 TRACP5b 集中。结果证明浆液 TRACP5b 是为骨头吸收的年龄相关的变化的评估的一个敏感、有用的参数。 | Yue-juan QIN Zhen-lin ZHANG Hao ZHANG Wei-wei HU Yu-juan LIU Yun-qiu HU Miao LI Jie-mei GU Jin-wei HE | 2008 | Acta Pharmacologica Sinica2008，29，12： | 19 |
| 4 | Gene therapy for human colorectal carcinoma using human CEA promoter controlled bacterial ADP-ribosylating toxin genes:PEA and DTA gene transfer显示文摘INTRODUCTIONAmajorrequirementforinvivogenetherapyforcanceristotargetthetherapeuticgeneexpresiontomalignanttissuesbyselectingp... | CAO Guang Wen 1, QI Zhong Tian 1, PAN Xin 1, ZHANG Xiao Qin 1, MIAO Xiao Hui 1, FENG Yan 1, LU Xin Hua 1, Shigeki Kuriyama 2 and DU Ping 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 18 |
| 5 | Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis显示文摘1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR ) 是涉及 2-C-methyl-D-erythritol-4-phosphate (MEP ) 的重要的酶为 isoprenoid 生合成提供基本五碳的单位的小径。在植物开发和新陈代谢调查 MEP 小径的角色,我们在 dxr 异种(GK_215C01 ) 和二根 DXR 转基因的合作抑制线上执行了详细分析, OX-DXR-L2 和 OX-DXR-L7。我们发现 dxr 异种是白化体和矮子。它从来没跑,显著地减少了毛状体的数字,大多数 stomata 不能在叶子通常关门。二根合作抑制线没有毛状体生产了更黄的开花期和白化体萼片。涉及毛状体开始的基因的抄写层次被发现强烈被假装,包括 GLABRA1,透明种皮光洁 1, TRIPTYCHON 并且细长纤弱,哪个被 gibberellic 酸(气体) 调整的表示。而 abscisic 酸(骆驼毛的织物) 的外长的申请能救 stomata 闭合缺点, GA3 的外长的申请能部分救矮子显型和 dxr 的毛状体开始,建议 GA 和骆驼毛的织物的底层贡献在 dxr 异种的显型。我们进一步发现涉及 GA 和骆驼毛的织物的 biosynthetic 小径的基因并列地被调整。这些结果显示 plastidial MEP 小径的那混乱导致光合的颜料,气体和骆驼毛的织物的 biosynthetic 缺乏,并且这样发展畸形,并且从细胞质的 mevalonate 小径的流动不是足够的救缺乏,这由 plastidial MEP 小径的阻塞引起了。这些结果在控制 isoprenoids 的生合成为 MEP biosynthetic 小径揭示一个关键角色。 | Shufan Xing Jin Miao Shuang Li Genji Qin Si Tang Haoni Li Hongya Gu Li-Jia Qu | 2010 | Cell Research2010，20，6： | 17 |
| 6 | Research progress on synergistic anti-tumor mechanisms of compounds inTraditional Chinese Medicine显示文摘The curative effects of Chinese herbal compounds result from the coordination of numerous natural compounds.We aimed to review the mechanism of action of Traditional Chinese Medicine(TCM)compounds(TCMC),explore the rationality of formulation theory and synergistic effects in TCM compounds,and analyze the effectiveness of drug compatibility of TCMC in molecular biology.This literature review covers the mechanisms of the anti-tumor effects of compounds,and their synergistic antitumor mechanisms.We aim to provide reference for the effective development and use of natural resources and the organic combination of TCM and modern medicine using molecular biology. | Jing Zhou Tianyao Zhou Meijuan Chen Miao Jiang Xiaoxia Wang Qin Liu Zhen Zhan Xu Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 15 |
| 7 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 8 | The effects of autophagy on vascular endothelial cells induced by airborne PM2.5显示文摘The purpose of this study was to examine the direct toxicity of PM2.5 collected from Beijing on human umbilical vein endothelial cells(HUVEC). A Cell Counting Kit 8(CCK8) assay demonstrated that PM2.5 exposure decreased the proliferation of HUVECs in a dosedependent manner. We also found that PM2.5 exposure induced autophagy in HUVECs, as evidenced by:(1) an increased number of double-membrane vesicles;(2) enhanced conversion and punctuation of the microtubule-associated protein light chain 3(LC3); and(3) decreased levels of the selective autophagy substrate p62 in a time-dependent manner.Furthermore, promoting autophagy in PM2.5-exposed HUVECs with rapamycin increased the cell survival rate, whereas inhibiting autophagy via 3-methyladenine significantly decreased cell survival. These results demonstrate that PM2.5 exposure can induce cytotoxicity and autophagy in HUVECs and that autophagy play a protective role against PM2.5-induced cytotoxicity. The findings of the present study imply a direct toxic effect of PM2.5 on HUVECs and provide novel insight into the mechanism of cardiovascular diseases caused by PM2.5 exposure. | Zhixiang Zhou Tong Shao Mengnan Qin Xiaoyan Miao Yu Chang Wang Sheng Fengshang Wu Yunjiang Yu | 2018 | Journal of Environmental Sciences2018，30，4： | 11 |
| 9 | Association of polymorphisms in low-density lipoprotein receptor-related protein 5 gene with bone mineral density in postmenopausal Chinese women显示文摘瞄准:在低密度的脂蛋白调查 Q89R, N740N 和 A1330V 多型性的可能的协会受体相关的蛋白质 5 (LRP5 ) 有在绝经后的中国女人的骨头矿物质密度(BMD ) 的基因。方法:Q89R, N740N 和 A1330V 遗传型被聚合酶链反应限制碎片长度多型性(PCR-RFLP ) 在上海 43-76 年在 647 个无关的健康的绝经后的汉中国女人决定。在包括大腿骨的颈,转子和沃德的腰椎 1-4 和左近似腿节的 BMD 是三角被双精力的 X 光检查 absorptionmetry 在所有题目测量。结果:在这张人口的 Q89R, N740N 和 A1330V 遗传型的分发如下:QQ 80.5% , QR 18.7% ,和 RR 0.8% ;TT 66.9% , TC 31.1% ,和 CC 2.0% ;AA 68.0% , AV 29.7% ,和 VV 2.3% 。Q89R, N740N 和 A1330V 遗传型和等位基因的频率没从 Hardy-Weinberg 平衡背离。我们发现 Q89R 和 A1330V 多型性在在我们的人口的连接不平衡(kappa2=13.50, | Zhen-lin ZHANG Yue-juan QIN Jin-wei HE Qi-ren HUANG Miao LI Yun-qiu HU Yu-juan LIU | 2005 | Acta Pharmacologica Sinica2005，26，9： | 11 |
| 10 | Prevalence and Genotypes of Rotavirus A and Human Adenovirus among Hospitalized Children with Acute Gastroenteritis in Fujian, China, 2009-2017显示文摘Gastroenteritis is an infectious diarrhea that has been considered as an important cause of hospitalizations and death in children aged < 5 years, particularly in developing countries. Unsanitary water, contaminated food, poor hygiene, and inadequate disposal of waste and feces are all risk factors for gastroenteritis, resulting in the higher incidence in developing countries. Gastroenteritis is generally caused by viral infections, among which rotavirus (RV) infections have been reported to be the most common, especially among young children aged < 5 years with acute gastroenteritis in Asia and Africa[1]. Other viruses associated with acute gastroenteritis include human Adenovirus (HAdV), Norovirus, Sapovirus (SaV), human Astrovirus (HAstV), and Aichi virus. Recent research has reported that adenovirus types 40 and 41, belonging to species F, cause gastroenteritis and were therefore termed as enteric adenoviruses. In addition, non-enteric HAdV species such as A, B, C, and D have been associated with diarrheal. | WU Bing Shan HUANG Zhi Miao WENG Yu Wei CHEN Feng Qin ZHANG Yun Lin LIN Wei Dong YU Ting Ting | 2019 | Biomedical and Environmental Sciences2019，32，3： | 10 |
| 11 | Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis Georgi in PC12 cells.显示文摘 | Shang YZ Qin BW Cheng JJ Miao H | 2006 | 中国生物学文摘2006，20，10： | 9 |
| 12 | Simultaneous regulation of cations and anions in an electrolyte for high-capacity, high-stability aqueous zinc–vanadium batteries显示文摘Safe,inexpensive aqueous zinc-ion batteries(AZIBs)are regarded as promising energy storage devices.However,they still face issues,including dissolution and collapse of the cathode as well as H_(2)evolution and the growth of Zn dendrites on the Zn anode.Herein,we simultaneously regulate the cations and anions in the electrolyte for high-capacity,high-stability aqueous zinc–vanadium(Zn–V)batteries based on a bimetallic cation-doped Na_(0.33)K_(0.1)V_(2)O_(5)·nH_(2)O cathode.We demonstrate that Na^(+) cations suppress cathode dissolution and restrain Zn dendrite growth on the anode via an electrostatic shield effect.We also illustrate that ClO_(4)^(-) anions participate in energy storage at the cathode and are reduced to Cl^(-),generating a protective layer on the Zn anode surface and providing a stable interface to decrease Zn dendrites and H_(2)evolution during long-term cycling.When Na^(+) and ClO_(4)^(-) are introduced into an aqueous ZnSO_(4) electrolyte,a Zn/Zn symmetric cell shows durable and reversible Zn stripping/plating for 1500 h at a current density of 1 mA cm^(-2) and with an area capacity of 1 mAh cm^(-2).Zn/Na_(0.33)K_(0.1)V_(2)O_(5)·nH_(2)O full batteries exhibit a high capacity of 600 mAh g^(-1)at 0.1 A g^(-1) and long-term cycling performance for 5000 cycles,with a capacity of 200 mAh g^(-1) at 20 Ag^(-1). | Ziqing Wang Miao Zhou Liping Qin Minghui Chen Zixian Chen Shan Guo Liangbing Wang Guozhao Fang Shuquan Liang | 2022 | eScience2022，2，2： | 8 |
| 13 | Association between SNP and haplotypes in PPARGC1 and adiponectin genes and bone mineral density in Chinese nuclear families显示文摘估计单个核苷酸多型性( SNP )的贡献在 peroxisome 的 andhaplotypes 激活proliferator 的 receptor-gamma co-activator-1 ( PPARGCl ) andadiponectin 基因到正常在健康中国女人 andmen.Methods 的骨头矿物质密度( BMD )变化:我们表演了基于人口( ANOVA )并且基于家庭(量的特点 locustransmission 不平衡测试)协会学习在 2genes 的 PPARGC1 和 adiponectin genes.SNP 是 genotyped.BMD | Zhen-lin ZHANG Jin-wei HE Yue-juan QIN Yun-qiu HU Miao LI Yu-juan LIU Hao ZHANG Wei-wei HU | 2007 | Acta Pharmacologica Sinica2007，28，2： | 8 |
| 14 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 15 | Development and Validation of a Model for Predicting Diabetic Nephropathy in Chinese People显示文摘Objective To develop a risk model for predicting later development of diabetic nephropathy(DN)in Chinese people with type 2 diabetes mellitus(T2DM)and evaluate its performance with independent validation.Methods We used data collected from the project‘Comprehensive Research on the Prevention and Control of Diabetes’,which was a community-based study conducted by the Jiangsu Center for Disease Control and Prevention in 2013.A total of 11,771 eligible participants were included in our study.The endpoint was a clear diagnosis of DN.Data was divided into two components:a training set for model development and a test set for validation.The Cox proportional hazard regression was used for survival analysis in men and women.The model’s performance was evaluated by discrimination and calibration.Results The incidence(cases per 10,000 person-years)of DN was 9.95(95%CI;8.66-11.43)in women and 11.28(95%CI;9.77-13.03)in men.Factors including diagnosis age,location,body mass index,high-density-lipoprotein cholesterol,creatinine,hypertension,dyslipidemia,retinopathy,diet control,and physical activity were significant in the final model.The model showed high discrimination and good calibration.Conclusion The risk model for predicting DN in people with T2DM can be used in clinical practice for improving the quality of risk management and intervention. | MIAO Dan Dan PAN En Chun ZHANG Qin SUN Zhong Ming QIN Yu WU Ming | 2017 | Biomedical and Environmental Sciences2017，30，2： | 8 |
| 16 | DNA Immobilization on Nano-Gold Modified Glassy Carbon Electrode显示文摘CT-DNA were electrochemically immobilized on the surfaces of both nano-goldmodified glassy carbon electrode and bare glassy carbon electrode. The cyclic voltammetricbehavior of Co (phen)33+adsorbed on the immobilized DNA was studied. Increase in the peakcurrent of Co (phen)33+ redox reaction was obtained on nano-gold modified glassy carbon electrode.The result suggests that more DNA molecules were immobilized on this electrode and nano-goldmodification can enhance the heterogeneous electron transfer rate constant of the Co (phen)33+. | Xiang Qin LIN Qian MIAO Bao Kang JIN(Department of Chemistry. University of Science and Technology of China, Hefei 230026)(Department of Chemistry. AnHui University. Hefei 230039) | 1999 | Chinese Chemical Letters1999，10，2： | 7 |
| 17 | Division of diagenesis reservoir facies and its control——Case study of Chang-3 reservoir in Yangchang formation of Fuxian exploration area in northern Shaanxi显示文摘By dividing the diagenetic reservoir facies and studying its distribution,we can effectively evaluate reservoirs.Using an analytical method for mutual relationships among diagenesis of reservoirs,structural characteristics and the origin of types of sand,we classified the diagenetic reservoir of the Yanchang formation Chang-3 oil layer into different types and analyzed the factors controlling this high quality reservoir.The results show that:1) the catagenesis of the Chang-3 oil layer in the Fuxian region is complex and variable;2) mechanical compaction,pressure solutions and cementation of all kinds of authogenous minerals decreases porosity by 28.13% and 3) corrosion increases porosity by 3.39%.Cementation and corrosion of laumontite is a kind of catagenesis which makes this region different from other exploratory regions.The original amount and rate of corrosion of laumontite are the main factors for the increase in laumontite porosity.The Chang-3 oil layer developed four kinds of diagenetic reservoir facies,of which the weak compaction facies,i.e.,laumontite corrosion and overgrowth,of the original pore reservoir facies has the most promising diagenesis.Its distribution is controlled by a sedimentary facies zone and is widely developed in the original truncated tributary channel facies belt of the delta plain.The development of this high quality reservoir is controlled by the distribution of sedimentary sand bodies and secondarily-eroded porosity of laumontite in the Chang-3 oil layer of the Fuxian exploratory region. | FU Guo-min QIN Xiao-li MIAO Qing ZHANG Tian-jin YANG Jian-peng | 2009 | Mining Science and Technology2009，19，4： | 6 |
| 18 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 19 | AR mutations in 28 patients with androgen insensitivity syndrome(Prader grade 0–3)显示文摘We investigated the androgen receptor(AR) gene mutation profiles of Chinese patients exhibiting severe androgen insensitivity syndrome(AIS) phenotypes. The present study enrolled 28 patients with genetically diagnosed AIS, who presented with severe phenotypes(Prader grade 0–3). Patients and some family members were screened via amplification and sequencing of their AR exons 1–8, including the corresponding intronic flanking regions. Luteinizing(LH), follicle-stimulating(FSH), and testosterone(T) hormone levels were found to be slightly, but not significantly, higher in patients with complete androgen insensitivity syndrome(CAIS) than in patients with partial androgen insensitivity syndrome(PAIS)(P>0.05). We identified 24 different AR mutations, including 12 that were novel. Ten patients(cases 2, 3, 10, 28, 11, 12, 19, 20, 24, and 25) were found to carry five recurrent mutations(p.Y572 S, p.P914 S, p.S176 R, p.Y782 N, and p.R841H); of these, p.Y572 S, p.S176 R, and p.Y782 N were novel. Among the mutations identified in patients with CAIS, six(66.7%) were characterized as single-nucleotide missense mutations, and six(66.7%) were found to be located in the AR ligand-binding domain(LBD). Among the mutations identified in patients with PAIS, 15(93.8%) were found to be missense, and 11(68.8%) were found to be located in the LBD. Patients 10 and 28 were determined to harbor the same missense mutation(p.P914S), but were diagnosed with CAIS and PAIS, respectively.Sex hormone levels were slightly, but not significantly, elevated in patients with CAIS compared to those with PAIS. Missense mutations spanning AR exons 1–8 were the predominant form of identified mutations, and these were mostly located in the AR LBD. Approximately 50% of the identified mutations were novel, and have enriched the AR gene-mutation database. Patients harboring identical mutations were in some instances found to exhibit divergent phenotypes. | Yi Wang Chunxiu Gong Xiou Wang Miao Qin | 2017 | Science China(Life Sciences)2017，60，7： | 6 |
| 20 | A network security entity recognition method based on feature template and CNN-BiLSTM-CRF显示文摘By network security threat intelligence analysis based on a security knowledge graph(SKG), multi-source threat intelligence data can be analyzed in a fine-grained manner. This has received extensive attention. It is difficult for traditional named entity recognition methods to identify mixed security entities in Chinese and English in the field of network security, and there are difficulties in accurately identifying network security entities because of insufficient features extracted. In this paper, we propose a novel FT-CNN-BiLSTM-CRF security entity recognition method based on a neural network CNN-BiLSTM-CRF model combined with a feature template(FT). The feature template is used to extract local context features, and a neural network model is used to automatically extract character features and text global features. Experimental results showed that our method can achieve an F-score of 86% on a large-scale network security dataset and outperforms other methods. | Ya QIN Guo-wei SHEN Wen-bo ZHAO Yan-ping CHEN Miao YU Xin JIN | 2019 | Frontiers of Information Technology & Electronic Engineering2019，20，6： | 5 |
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