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| 1 | Emergency department procedural sedation for primary electrical cardioversion — a comparison with procedural sedations for other reasons显示文摘BACKGROUND: Atrial fibrillation(AF) is the most common arrhythmia treated in the emergency department(ED), with primary electrical cardioversion(PEC) the preferred method of rhythm control. Anecdotally, patients undergoing ED procedural sedation(EDPS) for PEC differ from those requiring EDPS for other procedures: they are at higher risk of adverse events, and require fewer drugs and lower doses. We attempt to verify this using an EDPS registry at a Canadian, tertiary care teaching hospital.METHODS: This is a retrospective review of patients that underwent EDPS for the period of June 2006 to September 2014. We compared demographics, medication use and intra-procedural adverse events between those receiving EDPS for PEC for AF compared to that for other indications. We report the asssociation between AEs and predictors using logistic regression.RESULTS: A total of 4 867 patients were included, 714 for PEC for AF and 4 153 for other indications. PEC patients were more likely male(58.5% vs. 47.1%), older(59.5 years vs. 48.1 years), and less likely to be ASA I(46.6% vs. 69.0%). PEC patients received smaller doses of propofol and less likely to receive adjuvant analgesic therapy(11.5% vs. 78.2%). PEC patients were more likely to experience hypotension(27.6% vs. 16.5%) but respiratory AEs(apnea, hypoxia and airway intervention) were not different.CONCLUSION: EDPS for PEC differs from that conducted for other purposes: patients tend to be less healthy, receive smaller doses of medication and more likely to suffer hypotension without an increase in respiratory AEs. These factors should be considered when performing EDPS. | Michael Butler Patrick Froese Peter Zed George Kovacs Robert Mac Kinley Kirk Magee Mary-Lynn Watson Samuel G.Campbell | 2017 | World Journal of Emergency Medicine2017，8，3： | 6 |
| 2 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 3 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 5 |
| 4 | 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society显示文摘 | Craig T. January L. Samuel Wann Joseph S. Alpert Hugh Calkins Joaquin E. Cigarroa Joseph C. Cleveland Jamie B. Conti Patrick T. Ellinor Michael D. Ezekowitz Michael E. Field Katherine T. Murray Ralph L. Sacco William G. Stevenson Patrick J. Tchou Cynthia | 2014 | Circulation2014，，23： | 4 |
| 5 | Electrocardiographic markers of cardiac resynchronization therapy response:delayed time to intrinsicoid deflection onset in lateral leads显示文摘Cardiac resynchronization therapy(CRT)has emerged as an important intervention for patients with heart failure(HF)with reduced ejection fraction and delayed ventricular activation.In these patients,CRT has demonstrated to improve quality of life,promote reverse left ventricular(LV)remodeling,reduce HF hospitalizations,and extend survival.However,despite advancements in our understanding of CRT,a significant number of patients do not respond to this therapy.Several invasive and non-invasive parameters have been assessed to predict response to CRT,but the electrocardiogram(ECG)has remained as the prevailing screening method albeit with limitations.Ideally,an accurate,simple,and reproducible ECG marker or set of markers would dramatically overcome the current limitations.We describe the clinical utility of an old ECG parameter that can estimate ventricular activation delay:the onset to intrinsicoid deflection(ID).Based on the concept of direct measurement of ventricular activation time(intrinsic deflection onset),time to ID onset measures on the surface ECG the time that the electrical activation time takes to reach the area subtended by the corresponding surface ECG lead.Based on this principle,the time to ID on the lateral leads can estimate the delay activation to the lateral LV wall and can be used as a predictor for CRT response,particularly in patients with non-specific intraventricular conduction delay or in patients with left bundle branch block and QRS<150 ms.The aim of this review is to present the current evidence and potential use of this ECG parameter to estimate LV activation and predict CRT response. | Rubén KA Tapia-Orihuela S Michael Gharacholou Samuel J Asirvatham Freddy Del-Carpio Munoz | 2022 | Journal of Geriatric Cardiology2022，19，1： | 3 |
| 6 | Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension: A Scientific Statement From the American Heart Association显示文摘 | Michael R. Jaff M. Sean McMurtry Stephen L. Archer Mary Cushman Neil Goldenberg Samuel Z. Goldhaber J. Stephen Jenkins Jeffrey A. Kline Andrew D. Michaels Patricia Thistlethwaite Suresh Vedantham R. James White Brenda K. Zierler | 2011 | Circulation2011，，16： | 3 |
| 7 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 8 | In vitro activity and in vivo efficacy of a combination therapy of diminazene and chloroquine against murine visceral leishmaniasis显示文摘The present study evaluated the in vitro activity and in vivo efficacy of diminazene combined with chloroquine as a potential drug against Leishmania donovani.Amphotericin B was used as a positive control drug.In vitro activity involved incubation of various drug concentrations with promastigotes or vero cells in culture before determination of parasite growth inhibition or cell death while in vivo evaluations involved infection of various mice groups with virulent L.donovani parasites and treatment with test drug compounds following disease establishment.Weight changes in experimental mice were also evaluated before infection and throughout the experiment.The results indicated that the diminazene-chloroquine combination was at least nine times more efficacious than individual drugs in killing promastigotes in culture.The diminazene-chloroquine combination was safer(Ld_(50)=0.03±0.04) than Amphotericin B(Ld_(50)=0.02±0.01).Body weight in infected mice increased significantly(P=0.0007) from day7 to day 37 following infection(P=0.026).However,body weight remained comparable in all mice groups during treatment(P=0.16).The diminazene-chloroquine combination significantly reduced splenic parasite numbers as compared to individual drug therapies(P=0.0001) although Amphotericin B was still more efficacious than any other treatment(P=0.0001).Amongst the test compounds,the diminazene-chloroquine combination showed the lowest level of IgG antibody responses with results indicating significant negative correlation between antileishmanial antibody responses and protection against disease.These findings demonstrate the positive advantage and the potential use of a combined therapy of diminazene-chloroquine over the constituent drugs.Further evaluation is recommended to determine the most efficacious combination ratio of the two compounds. | Samuel W.Mwololo Joshua M.Mutiso John C.Macharia Alain J.Bourdichon Michael M.Gicheru | 2015 | The Journal of Biomedical Research2015，29，3： | 3 |
| 9 | BACTERIAL TRANSLOCATION IN CLINICAL INTESTINAL TRANSPLANTATION显示文摘 | Luca Cicalese Pierpaolo Sileri Michael Green Kareem Abu-Elmagd Samuel Kocoshis Jorge Reyes | 2001 | Transplantation2001，，10： | 3 |
| 10 | Risk for Immune-Mediated Graft Dysfunction in Liver Transplant Recipients With Recurrent HCV Infection Treated With Pegylated Interferon显示文摘 | Josh Levitsky Maria Isabel Fiel John P. Norvell Edward Wang Kymberly D. Watt Michael P. Curry Sumeet Tewani Timothy M. McCashland Maarouf A. Hoteit Abraham Shaked Samuel Saab Amanda C. Chi Amy Tien Thomas D. Schiano | 2012 | Gastroenterology2012，，5： | 3 |
| 11 | Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR显示文摘 | Janin Riedelsberger Tripti Sharma Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt Ingo Dreyer | 2010 | Molecular Plant2010，3，1： | 2 |
| 12 | 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society显示文摘 | Craig T. January L. Samuel Wann Joseph S. Alpert Hugh Calkins Joaquin E. Cigarroa Joseph C. Cleveland Jamie B. Conti Patrick T. Ellinor Michael D. Ezekowitz Michael E. Field Katherine T. Murray Ralph L. Sacco William G. Stevenson Patrick J. Tchou Cynthia | 2014 | Circulation2014，，23： | 2 |
| 13 | The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly显示文摘 | Amir A. Zeki Michael Schivo Andrew Chan Timothy E. Albertson Samuel Louie Nicola Scichilone | 2011 | Journal of Allergy2011，，： | 2 |
| 14 | HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma显示文摘 | Anne Nguyen Kovochich Michael Arensman Anna R. Lay Nagesh P. Rao Timothy Donahue Xinmin Li Samuel W. French David W. Dawson | 2012 | Cancer2012，，3： | 2 |
| 15 | Biochar and biochar-compost as soil amendments to a vineyard soil: Influences on plant growth, nutrient uptake, plant health and grape quality显示文摘 | Hans-Peter Schmidt Claudia Kammann Claudio Niggli Michael W.H. Evangelou Kathleen A. Mackie Samuel Abiven | 2014 | Agriculture, Ecosystems and Environment2014，，： | 2 |
| 16 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 2 |
| 17 | Xanthogranulomatous cholecystitis: Diagnostic performance of CT to differentiate from gallbladder cancer显示文摘 | Satoshi Goshima Samuel Chang Jin Hong Wang Masayuki Kanematsu Kyongtae T. Bae Michael P. Federle | 2009 | European Journal of Radiology2009，，3： | 2 |
| 18 | A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis显示文摘 | Matthew Walker Barry R. Campbell Karim Azer Christopher Tong Kaijie Fang Jacquelynn J. Cook Michael J. Forrest Kimberly Kempadoo Samuel D. Wright Jeffrey S. Saltzman Euan MacIntyre Richard Hargreaves | 2009 | Atherosclerosis2009，，1： | 1 |
| 19 | Thoracic aorta imaging with multisclice CT显示文摘 | Michael B. Gotway Samuel K. Dawn | 2003 | Radiologic Clinics of North America2003，，： | 1 |
| 20 | Critical dialogues with self: developing teacher identities and roles — a case study of South African student teachers显示文摘 | Michael Samuel David Stephens | 2000 | International Journal of Educational Research2000，，5： | 1 |
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