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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Emerging radiotherapy technologies and trends in nasopharyngeal cancer显示文摘AbTechnology has always driven advances in radiotherapy treatment.In this review,we describe the main technological advances in radiotherapy over the past decades for the treatment of nasopharyngeal cancer(NPC)and highlight some of the pressing issues and challenges that remain.We aim to identify emerging trends in radiation medicine.These include advances in personalized medicine and advanced imaging modalities,standardization of planning and delineation,assessment of treatment response and adaptive re-planning,impact of particle therapy,and role of artificial intelligence or automation in clinical care.In conclusion,we expect significant improvement in the therapeutic ratio of radiotherapy treatment for NPC over the next decade. | Michelle Tseng Francis Ho Yiat Horng Leong Lea ChoungWong Ivan WK Tham Timothy Cheo Anne WM Lee | 2020 | Cancer Communications2020，40，9： | 5 |
| 3 | Pre‐ and post‐training session evaluation for interobserver agreement and diagnostic accuracy of probe‐based confocal laser endomicroscopy for biliary strictures显示文摘 | Jayant P. Talreja Brian G. Turner Frank G. Gress Sammy Ho Savreet Sarkaria Naveen Paddu Nikola Natov Sheila Bharmal Monica Gaidhane Amrita Sethi Michel Kahaleh | 2014 | Digestive Endoscopy2014，，4： | 2 |
| 4 | LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease显示文摘Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD. | Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 5 | Congenital and childhood myotonic dystrophy:Current aspects of disease and future directions显示文摘Myotonic dystrophy type 1(DM1) is multisystem disease arising from mutant CTG expansion in the nontranslating region of the dystrophia myotonica protein kinase gene. While DM1 is the most common adult muscular dystrophy, with a worldwide prevalence of one in eight thousand, age of onset varies from before birth to adulthood. There is a broad spectrum of clinical severity, ranging from mild to severe, which correlates with number of DNA repeats. Importantly, the early clinical manifestations and management in congenital and childhood DM1 differ from classic adult DM1. In neonates and children, DM1 predominantly affects muscle strength, cognition, respiratory, central nervous and gastrointestinal systems. Sleep disorders are often under recognised yet a significant morbidity. No effective disease modifying treatment is currently available and neonates and children with DM1 may experience severe physical and intellectual disability, which may be life limiting in the most severe forms. Management is currently supportive, incorporating regular surveillance and treatment of manifestations. Novel therapies, which target the gene and the pathogenic mechanism of abnormal splicing are emerging. Genetic counselling is critical in this autosomal dominant genetic disease with variable penetrance and potential maternal anticipation, as is assisting with family planning and undertaking cascade testing to instigate health surveillance in affected family members. This review incorporates discussion of the clinical manifestations and management of congenital and childhood DM1, with a particular focus on hypersomnolence and sleep disorders. In addition, the molecular genetics, mechanisms of disease pathogenesis and development of novel treatment strategies in DM1 will be summarised. | Genevieve Ho Michael Cardamone Michelle Farrar | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 2 |
| 6 | Management of Complications Associated with Partially Covered Biliary Metal Stents显示文摘 | Henry Ho Anshu Mahajan Sonia Gosain Animesh Jain Andrew Brock Michele E. Rehan Kristi Ellen Vanessa M. Shami Michel Kahaleh | 2010 | Digestive Diseases and Sciences2010，，2： | 2 |
| 7 | 140 Endoscopic Ultrasound (EUS) Guided Biliary Drainage: What Have We Learned?显示文摘 | Michel Kahaleh Manuel Perez-Miranda Everson L. Artifon Kapil Gupta Do Hyun Park Jong Ho Moon Hyun Jong Choi Carlos De La Serna Jose-Guillermo De La Mora-Levy Juan Octavio Alonso-Larraga Miguel a. Ramirez Raj J. Shah Brian C. Brauer Norio Fukami Monica Gai | 2013 | Gastrointestinal Endoscopy2013，，5： | 1 |
| 8 | 200nm bandwidth fiber optical amplifier combing parametric and Raman gain显示文摘 | HO Min-Chen KATSUMI Uesaka MICHEL Marhic | 2001 | Lightwave Technology2001，19，7： | 1 |
| 9 | Mortality in patients undergoing covered self-expandable metal stent revisions in malignant biliary stricture: Does pathology matter?显示文摘 | Anshu Mahajan Henry Ho Animesh Jain Michele E. Rehan Patrick G. Northup Melissa S. Phillips Kristi Ellen Vanessa M. Shami Michel Kahaleh | 2010 | Digestive and Liver Disease2010，，11： | 1 |
| 10 | Towards a stability theory of general hybrid dynamical systems显示文摘 | Michel A N Bo Ho | 1999 | Automatica1999，35，3： | 1 |
| 11 | Effect of Margin Width on Local Recurrence in Triple-Negative Breast Cancer Patients Treated with Breast-Conserving Therapy显示文摘 | Melissa Pilewskie Alice Ho Emily Orell Michelle Stempel Yu Chen Anne Eaton Sujata Patil Monica Morrow | 2014 | Annals of Surgical Oncology2014，，4： | 1 |
| 12 | Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice显示文摘 | Debbie J. Mustacich Kishorchandra Gohil Richard S. Bruno Michelle Yan Scott W. Leonard Emily Ho Carroll E. Cross Maret G. Traber | 2009 | The Journal of Nutritional Biochemistry2009，，： | 1 |
| 13 | Gallbladder Stent Placement for Prevention of Cholecystitis in Patients Receiving Covered Metal Stent for Malignant Obstructive Jaundice: A Feasibility Study显示文摘 | Sonia Gosain Hugo Bonatti LaVone Smith Michele E. Rehan Andrew Brock Anshu Mahajan Melissa Phillips Henry C. Ho Kristi Ellen Vanessa M. Shami Michel Kahaleh | 2010 | Digestive Diseases and Sciences2010，，8： | 1 |
| 14 | A randomized trial of nursing interventions supporting recovery of the postmastectomy patient显示文摘 | Ho Soon Michelle Cho Gail C Davis Jae Eun Paek | 2012 | Journal of Clinical Nursing2012，22，10： | 1 |
| 15 | Optimizing road network daily maintenance operations with stochastic service and travel times显示文摘 | Lu Chen Minh Hoàng Hà André Langevin Michel Gendreau | 2014 | Transportation Research Part E2014，，： | 1 |
| 16 | Anti‐VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models显示文摘 | Mallika Singh Suzana S Couto William F Forrest Anthony Lima Jason H Cheng Rafael Molina Jason E Long Patricia Hamilton Angela McNutt Ian Kasman Michelle A Nannini Hani Bou Reslan Tim C Cao Calvin CK Ho Kai H Barck Richard AD Carano Oded Foreman Jeffrey Ea | 2012 | J Pathol2012，，4： | 1 |
| 17 | Fat grafting to improve severe tuberous breast 显示文摘 | Ho Quoc C Piat JM Michel G | 2015 | J Gynecol Obstet Biol Reprod (Paris)2015，44，6： | 1 |
| 18 | 槟城——贸易争端的赢家显示文摘槟城色调柔和的殖民时代建筑诉说着马来西亚作为东印度公司重要贸易基地的历史,那时各种香料充斥了这里的仓库,英国人和荷兰人争夺着在这个地区的主导权。如今,在这里争夺经济霸权和槟城电子工业的变成了美国和中国,而这里的电子工业正在得益。马来西亚约有四分之一的人口是华裔,而更大比例的人精通英语。2019年上半年,槟城吸纳的外商直接投资增长了134%,达到92亿马来西亚林吉特(约合22亿美元)。 | Michelle Jamrisko Anisah Shukry Yantoultra Ngui Yudith Ho 竹西(译) | 2020 | 商业周刊(中文版)2020，0，2： | 0 |
| 19 | Fluctuating temperature modifies heat-mortality association around the globe显示文摘Studies have investigated the effects of heat and temperature variability(TV)on mortality.However,few assessed whether TV modifies the heat-mortality association.Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries.TV was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures. | Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo | 2022 | The Innovation2022，3，2： | 0 |
| 20 | Effects of illness perception on negative emotions and fatigue in chronic rheumatic diseases:Rumination as a possible mediator显示文摘BACKGROUND Illness perception has long been hypothesized to be linked to psychological well-b eing in patients with rheumatic diseases,although substantial evidence is lacking,and the contribution of ruminative coping style to this relationship is unclear.AIM To investigate the roles of illness perception and rumination in predicting fatigue and negative emotions in patients with chronic rheumatic diseases.METHODS Illness perception,rumination,fatigue and negative emotions(i.e.depression,anxiety and stress)were assessed by the Illness Perception Questionnaire-Revised,Stress Reactive Rumination Scale,Multidimensional Assessment of Fatigue,and the Depression,Anxiety and Stress Scale respectively.Multivariate regression analysis,the Sobel test,and the bootstrap were used to identify the mediating effect of rumination.RESULTS All five subscales of illness perception,including perceived illness identity,chronicity,cyclical nature,consequences and coherence of illness,were significantly associated with fatigue and negative emotions.In mediational analysis,rumination was found to mediate three components of illness perception(the identity,cyclical nature and consequences of illness)and negative emotions/fatigue.CONCLUSION Perceived identity,cyclical nature,and consequences of illness are significantly associated with fatigue and negative emotions in patients with chronic rheumatic diseases and these associations are mediated by rumination.Our findings suggest that psychological intervention should target rumination to improve physical and emotional well-being of patients with chronic rheumatic diseases. | Yanxia Lu Xia Jin Li-Wei Feng CSK Tang Michelle Neo Roger C Ho | 2022 | World Journal of Clinical Cases2022，10，34： | 0 |
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