|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | Isolation and culture of hepatic stellate cells from mouse liver显示文摘肝的星形的房间(HSC ) 是在肝以内的主要细胞外的生产矩阵的房间并且有众多的 vitalfunctions。为 HSC 的隔离和文化的一个柔韧的协议是重要的因为房间 functionsand 的进一步的调查在肝疾病联系了机制。鼠标肝的卷比老鼠肝的小得多,哪个对更困难的 makesit 比老鼠 HSC 孤立鼠标 HSC (mHSCs ) 。目前,孤立 mHSCs 仍然是挑战 becausethere 不是有效、柔韧的方法孤立并且文化这些房间。在现在的学习, C57BL/6J 老鼠是有包含 liposome 的 dichloromethylene diphosphate (CL2MDP ) 的 intravenouslyinjected 有选择地从 theliver 消除 Kupffer 房间。老鼠肝然后在 situ 被酒,并且 mHSCs 与一种优化密度坡度 centrifugation 技术被孤立。在磷酸盐缓冲区答案(PBS )-liposome 组, mHSCs 的收益是(1. | Wenj u Chang Mengxuan Yang Lujun Song Kuntang Shen Hongshan Wang Xiaodong Gao Min Li Weixin Niu Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 6 |
| 3 | Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily: Identification of novel antitumor drug binding site显示文摘The studies of novel inhibitors of DNA topoisomerase I (Topo I) have already be-come very promising in cancer chemotherapy. Identifying the new drug-binding residues is playing an important role in the design and optimization of Topo I inhibitors. The designed com-pounds may have novel scaffolds, thus will be helpful to overcome the toxicities of current camptothecin (CPT) drugs and may provide a solution to cross resistance with these drugs. Mul-tiple sequence alignments were performed on eukaryotic DNA topoisomerase I superfamily and thus the evolutionary tree was constructed. The Evolutionary Trace method was applied to iden-tify functionally important residues of human Topo I. It has been demonstrated that class-specific hydrophobic residues Ala351, Met428, Pro431 are located around the 7,9-position of CPT, indi-cating suitable substitution of hydrophobic group on CPT will increase antitumor activity. The conservative residue Lys436 in the superfamily is of particular interest and new CPT derivatives designed based on this residue may greatly increase water solubility of such drugs. It has also been demonstrated that the residues Asn352 and Arg364 were conservative in the superfamily, whose mutation will render CPT resistance. As our molecular docking studies demonstrated they did not make any direct interaction with CPT, they are important drug-binding site residues for future design of novel non-camptothecin lead compounds. This work provided a strong basis for the design and synthesis of novel highly potent CPT derivatives and virtual screening for novel lead compounds. | SONG Yunlong QI Yunpeng ZHANG Wannian SHENG Chunquan ZHANG Min YAO Jianzhong YU Jianxin MIAO Zhenyuan ZHOU Youjun ZHU Ju L(U) Jiaguo | 2005 | Science China(Life Sciences)2005，48，4： | 5 |
| 4 | Effect of Perched Water Tables on Aluminosilicate Stability and Soil Genesis显示文摘The mineral stability and solute activities of soil solution extracted from selected horizons of seven studied pedons of Alfisols in Kentucky, USA, and the relationship between distribution of iron-manganese concretions and the restrictive layers were investigated. The results showed that the genesis and development of these soils and mineral weathering trends were strongly influenced by the depth of bedrock and the presence of perched water tables at lithic (limestone) interfaces due to the dissolution and buffering effect of limestone bedrock. The extractable Mg/Ca ratio as depth function and soil depth above bedrock could be used as indices of weathering and degree of soil development. Maximum iron-manganese concretion accumulation was found to occur in the horizon overlying clay horizon (>40% clay) with a sharp increase in clay content (>10%), which suggested that zones of Fe-Mn concretion accumulation in soils of the Inner Bluegrass Region appeared to be a sensitive genetic indicator of argillic horizons with restrictive permeability. | ZHANG MIN , GONG ZITONG and A. D. KARATHANASIS College of Resources and Environment, Shandong Agricultural University, Tai’an 271018 (China) Institute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China) College of Agriculture, U | 2000 | Pedosphere2000，10，3： | 4 |
| 5 | Increased circulating level of interleukin-6 and CD8+T cell exhaustion are associated with progression of COVID-19显示文摘Background: Coronavirus disease 2019(COVID-19)is pandemic.It is critical to identify COVID-19 patients who are most likely to develop a severe disease.This study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease progression.Methods:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,2020.Differences in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of COVID-19.Results: The mean incubation was 8.67(95%confidence interval,6.78–10.56)days.Mean duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)days.Compared to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(<190/µl)of CD8+T cells,and neutrophil/lymphocyte ratio.Thirteen patients deteriorated during hospitalization.Cox regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of COVID-19.During hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumonia-free patients.CD8+lymphocyte count in pneumonia patients did not recover when discharged.Conclusions: Older age and higher levels of C-reactive protein,procalcitionin,interleukin-6,and lactate might predict COVID-19 progression.T lymphocyte,especially CD8+cell-mediated immunity is critical in recovery of COVID-19.This study may help in predicting disease progression and designing immunotherapy for COVID-19. | Peng-Hui Yang Yi-Bo Ding Zhe Xu Rui Pu Ping U Jin Yan Ji-Luo Liu Fan-Ping Meng Lei Huang Lei Shi Tian-Jun Jiang En-Qiang Qin Min Zhao Da-Wei Zhang Peng Zhao Ling-Xiang Yu Zhao-Hai Wang Zhi-Xian Hong Zhao-Hui Xiao Qing Xi De-Xi Zhao Peng Yu Cai-Zhong Zhu Zhu Chen Shao-Geng Zhang Jun-Sheng Ji Fu-Sheng Wang Guang-Wen Cao | 2020 | Infectious Diseases of Poverty2020，9，6： | 3 |
| 6 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 7 | Micro Manipulation Using Magnetic Microrobots显示文摘 | Hoyeon Kim Jamel Ali U Kei Cheang Jinwoo Jeong din Seok Kim Min dun Kim | 2016 | Journal of Bionic Engineering2016，13，4： | 2 |
| 8 | Cough variant asthma is associated with a highter wheezing threshold than classic asthma 显示文摘 | Koh Y Y Chae S A Min K U | 1993 | Clin Exp Allergy1993，23，8： | 1 |
| 9 | Effects of oleoresin-tocopherol combinations on lipid oxidation, off-odor, and color of irradiated raw and cooked pork patties 显示文摘 | Nam K C Ko K Y Min B R Ismail H Lee E J Cordray J Ahn D U | 2007 | Meat Science2007，，： | 1 |
| 10 | Rejection of the component tissues of limb al ografts in rats immunosuppressed with FK-506 and cyclosporine显示文摘 | Büttemeyer R Jones NF Min Z Rao U | | 0，，01： | 1 |
| 11 | Cough variant asthma is associated with a higher threshold than classic asthma显示文摘 | Chae S A Min K U | 1993 | Clin Experimental Allergy1993，23，： | 1 |
| 12 | Effect of cordycepinpurified from cordyceps militaris on Th1 and Th2 cytokinesin mouse splenocytes 显示文摘 | JEONG M H MIN J S PARK J U | 2012 | J Microbiol Biotechnol2012，22，8： | 1 |
| 13 | Ammonia removal in bubble column by ozonation in the presence of bromide显示文摘 | Min Y Kazuya U Haruki M | 1999 | Water Res1999，33，8： | 1 |
| 14 | Cytotoxic Compounds from the Stem Bark of Magnolia obovata 显示文摘 | Min B S Youn U J Bae K H | 2008 | Natur Prodt Sci2008，14，： | 1 |
| 15 | Comparison of scaling methods for waveform inversion显示文摘 | Jang U Min D J Shin C | 2009 | Geophysical Prospecting2009，57，： | 1 |
| 16 | N^(6)-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19显示文摘N^(6)-methyladenosine(m6A),a m ethylation in the N6 position of adenosine especially in the mRNA,exerts diverse physiological and pathological functions.However,the precise role of m 6A methylation in hypoxic preconditioning(HPC)is still unknown.Here,we observed that HPC treatm ent protected H9c2 cells against H2O2-induced injury,upregulated the m 6A level in the total RNA and the expression of methyltransferase like 3(METTL3),methyltransferase like 14(METTL14),and long noncoding RNA(lncRNA)H19.Either knockdown of METTL3 or METTL14 notably reversed the HPC-induced enhancement of cell viability,anti-apoptosis ability,and H19 expression.M ethylated RNA im m unoprecipitation(IP)indicated that knockdown of METTL3 or METTL14 decreased m 6A level in the lncRNA H19.Gain-of-function assay dem onstrated that H19 overexpression could partially rescue the decreased protection mediated by METTL3 or METTL14 knockdown in HPCtreated H9c2 cells.RNA binding protein im m unoprecipitation(RIP)assay showed that METTL3 and METTL14 could directly bind w ith H19.Our study identified a novel pattern of posttranscriptional regulation in HPC treatm ent.Since METTL3,METTL14,and lncRNA H19 were involved in HPC protection,they could be considered as potential biomarkers and therapeutic targets in HPC-derived cardiac rehabilitation and therapeutic approaches. | Yamin Su Rongfeng X u Rui Zhang Yangyang Qu Wenjie Zuo Zhenjun Ji Haihua Geng Min Pan Genshan Ma | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 1 |
| 17 | Reactive oxygen species and their detoxification in healing skin wounds显示文摘 | auf dem Keller U Kümin A Braun S | | 0，，： | 1 |
| 18 | Physical characteristics of fish oil encapsulated by β-cyclodextrin using an aggregation method or polycaprolactone using an emulsion-diffusion method显示文摘 | CHOI M J RUKTANONCHAI U MIN S G | 2010 | Food Chemistry2010，119，4： | 1 |
| 19 | Landslide susceptibility mapping by correlation between topography and geological structure:the Janghung area,Korea显示文摘 | Lee S Chwae U Min K D | 2002 | Geomorphology2002，46，34： | 1 |
| 20 | Transparent Polyimide Nanocomposite Films : Thermo-Optical Properties, Morphology, and Gas Permeability 显示文摘 | Min U Kim J C Chang J H | 2011 | Polymer engineering and science2011，10，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员