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| 1 | Early Serum HBsAg Kinetics as Predictor of HBsAg Loss in Patients with HBeAg-Negative Chronic Hepatitis B after Treatment with Pegylated Interferonα-2a显示文摘Hepatitis B surface antigen(HBsAg)loss is an ideal treatment endpoint for patients with chronic hepatitis B(CHB).We investigated the predictive value of on-treatment HBsAg levels for HBsAg loss in hepatitis B e antigen(HBe Ag)-negative CHB patients who received 120-week PEG-IFNα-2a treatment.Serum HBV DNA,HBsAg,and anti-HBs levels were assayed at baseline and every 3 months during the treatment.Of 81 patients,12 achieved HBsAg loss,20 achieved HBsAg\100 IU/mL,and 49 maintained HBs Ag C 100 IU/mL.HBsAg loss rate was only 3.7%at 48 weeks,while it reached to 11.1%and 14.8%after treatment of 96 weeks and 120 weeks.The cutoff HBs Ag levels at 12 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 400 IU/mL and 750 IU/mL,with AUC 0.725 and 0.722,positive predictive value(PPV)29.41%and 30.56%,and negative predictive value(NPV)93.75%and 97.78%,respectively.The cutoff HBsAg levels at 24 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 174 IU/m L and 236 IU/mL respectively,with AUC 0.925 and 0.922,PPV 40.0%and 46.15%,and both NPV 100%.The predictive ability of the cutoff HBsAg levels at 24 weeks was better than that at 12 weeks for HBs Ag loss at either 96 or 120 weeks(χ~2=3.880,P=0.049 andχ~2=4.412,P=0.036).These results indicate that extended therapy is critical to HBsAg loss in HBe Ag-negative CHB patients during PEG-IFN treatment,and the HBsAg level at 24 weeks can be used to predict HBsAg loss during tailoring PEG-IFN therapy. | Minghui Li Lu Zhang Yao Lu Qiqi Chen Huihui Lu Fangfang Sun Zhan Zeng Gang Wan Linqing Zhao Yao Xie | 2021 | Virologica Sinica2021，36，2： | 15 |
| 2 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 3 | Study on the relative radiometric correction of CBERS satellite CCD image显示文摘The main payload on CBERS-01/02 of China-Brazil Earth Resources Satellite (CBERS) is a push-broom CCD camera with moderate spatial and radiant resolution. Because at lab the data for calibration at satellite assembly stage were unable to be collected, and also because the onboard calibrator after launch was in a different state from imaging, the calibration of CCD image got a series of difficulties involved. In practice, two methods are used in the processing on the ground station: One is extracting calibration data by statistics from the image itself, and the other is the method of histogram match. It was proved that the latter can calibrate the image much better, because it can remove the effect of unstable response of the camera largely and also can overcome the nonlinearity of the camera basically by using Look-Up Table (LUT) calculated from histogram statistics of different temporal images. Considering the problems of CBERS-01, a lot of calibration tests were done before the launch of CBERS-02, in which a set of lab coefficients for relative calibration was formulated after the data collection by using integration-hemisphere in the stage of satellite assembly test. During the on-orbit test, it was found that the calibration result from such coefficients was not satisfying, especially there being response difference between 3 detector arrays, which was attributed to the unstable dark currents of the CCD camera. This paper comes up with a statistic method to remove such response difference. In this method the middle detector array was used as reference to find the response differences of adjacent similar features between these arrays and it was proved to have a broad adaptability. | GUO Jianning, YU Jin, ZENG Yong, XU Jianyan, PAN Zhiqiang & HOU Minghui China Center for Resource Satellite Data and Application, Beijing 100830, China | 2005 | Science China(Technological Sciences)2005，48，S2： | 6 |
| 4 | One-Step Preparation of Green Fabric for Continuous Antibacterial Applications显示文摘Polypropylene(PP)scaffolds are the most commonly used biomedical scaffolds despite their disadvan-tages,which include problems with adhesion,infection,and inflammatory responses.Here,we report on the successful development of a facile one-step method to fabricate a series of novel triclosan poly-dopamine polypropylene(TPP)composite scaffolds and thereby effectively improve the biocompatibility and long-term antibacterial properties of PP scaffolds.The antibacterial triclosan can effectively interact with dopamine during biocompatible polydopamine formation on the PP scaffold by one-step green fab-rication.Thanks to the sustained release of triclosan from the biocompatible polydopamine coating,a 5mm×5mm sample of TPP-coated scaffold made with a triclosan concentration of 8 mg-mL^(-1)(referredto herein as TPP-8)exhibited a continuous antibacterial effect against both Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)for more than 15d,at maximum antibacterial volumes of 2 and 5mL,respectively.Our study establishes a new direction for facile long-term antibacterial studies for medical applications. | Rongkang Huang Minghui Hu Weiwen Liang Juanjuan Zheng Yang Du Yanhuan Lin Huaiming Wang Wentai Guo Zhantao Zeng Chuangkun Li Ming Li Hui Wang Xingcai Zhang | 2021 | Engineering2021，7，3： | 3 |
| 5 | Non-symmetrical levee breaching processes in a channel bend due to overtopping显示文摘A series of experiments were done to reveal the overtopping breaching process of non-cohesive and cohesive levees in a U-bend flume. The flood hydrograph and breaching geometry were measured and analyzed in detail. The results show that the levee breaching processes can be briefly divided into four stages: slope erosion, longitudinal headward gully-cutting, lateral erosion, and relative stabilization. For non-cohesive levees, non-symmetrical lateral development of the breach occurs throughout the four stages, and the final non-symmetrical coefficient is approximately 2.2-2.6. Larger flow discharge or higher water level can accelerate the breaching process, while coarser sands tend to accelerate the process initially but depress the process at the end. The fluvial erosion rate of a non-cohesive breach shows a power-function relation with the excess wall shear stress. For cohesive levees, a plateau forms in the breach partially blocking the flow in the first two stages. The breach flow is approximately perpendicular to the levee body, and, thus, the erosion rates of the two breach sides are almost the same.Non-symmetrical lateral development mainly occurs in the third stage when the deep gully forms. The final non-symmetrical coefficient is approximately 2.7-3.3. It is expected that these findings can provide a valuable experimental dataset and a theoretical basis for breach closure and flood alleviation. | Songbai Wu Minghui Yu Hongyan Wei Yanjie Liang Jing Zeng | 2018 | International Journal of Sediment Research2018，33，2： | 2 |
| 6 | Ferroelectricity in dopant-free HfO_(2) thin films prepared by pulsed laser deposition显示文摘As a high-k material,hafnium oxide(HfO_(2))has been used in gate dielectrics for decades.Since the discovery of polar phase in Si-doped HfO_(2) films,chemical doping has been widely demonstrated as an effective approach to stabilize the ferroelectric phase in HfO_(2) based thin films.However,the extra capping layer deposition,post-growth annealing and wake-up effect are usually required to arouse the ferroelectricity in HfO_(2) based thin films,resulting in the increase of complexity for sample synthesis and the impediment of device application.In this study,the ferroelectricity is observed in non-capped dopant-free HfO_(2) thin films prepared by pulsed laser deposition(PLD)without post-growth annealing.By adjusting the deposited temperature,oxygen pressure and thickness,the maximum polarization up to 14.7 m C/cm^(2) was obtained in 7.4 nm-thick film.The fraction of orthorhombic phase,concentrations of defects and size effects are considered as possible mechanisms for the influences of ferroelectric prop-erties.This study indicates that PLD is an effective technique to fabricate high-quality ferroelectric HfO_(2) thin films in the absence of chemical doping,capping layer deposition and post-growth annealing,which may boost the process of nonvolatile memory device application. | Yongjian Luo Zhenxun Tang Xiaozhe Yin Chao Chen Zhen Fan Minghui Qin Min Zeng Guofu Zhou Xingsen Gao Xubing Lu Jiyan Dai Deyang Chen Jun-Ming Liu | 2022 | Journal of Materiomics2022，8，2： | 1 |
| 7 | Cata- lytic oxidation of formaldehyde on surface of H-TiOz / H-C-TiO2 without light illumination at room tempera- ture显示文摘 | ZENG Lei SONG Wu-lin LI Minghui | 2014 | Applied Catalysis B: Environmental2014，147，： | 1 |
| 8 | Characterization of a chromosomal toxin–antitoxin, Rv1102c–Rv1103c system in Mycobacterium tuberculosis显示文摘 | Jeong-Sun Han Jae Jin Lee Tripti Anandan Minghui Zeng Srinivas Sripathi Wan Jin Jahng Sang Hee Lee Joo-Won Suh Choong-Min Kang | 2010 | Biochemical and Biophysical Research Communications2010，，3： | 1 |
| 9 | Tuning the crystallite size of monoclinic ZrO_(2) to reveal critical roles of surface defects on m–ZrO_(2) catalyst for direct synthesis of isobutene from syngas显示文摘The effects of crystallite size on the physicochemical properties and surface defects of pure monoclinic ZrO_(2) catalysts for isobutene synthesis were studied.We prepared a series of monoclinic ZrO_(2) catalysts with different crystallite size by changing calcination temperature and evaluated their catalytic performance for isobutene synthesis from syngas.ZrO_(2) with small crystalline size showed higher CO conversion and isobutene selectivity,while samples with large crystalline size preferred to form dimethyl ether(DME)instead of hydrocarbons,much less to isobutene.Oxygen defects(ODefects)analyzed by X-ray photoelectron spectroscopy(XPS)provided evidence that more ODefectsoccupied on the surface of ZrO_(2) catalysts with smaller crystalline size.Electron paramagnetic resonance(EPR)and ultraviolet–visible diffuse reflectance(UV–vis DRS)confirmed the presence of high concentration of surface defects and Zr3+on mZrO_(2)-5.9 sample,respectively.In situ diffuse reflectance infrared Fourier transform spectroscopy(in situ DRIFTS)analysis indicated that the adsorption strength of formed formate species on catalyst reduced as the crystalline size decreased.These results suggested that surface defects were responsible for CO activation and further influenced the adsorption strength of surface species,and thus the products distribution changed.This study provides an in-depth insight for active sites regulation of ZrO_(2) catalyst in CO hydrogenation reaction. | Xuemei Wu Minghui Tan Bing Xu Shengying Zhao Qingxiang Ma Yingluo He Chunyang Zeng Guohui Yang Noritatsu Tsubaki Yisheng Tan | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 1 |
| 10 | Domino free radical photopolymerization based on phototriggered base proliferation reaction and redox initiation显示文摘 | Minghui He Shun Jiang Ruixin Xu Jianwen Yang Zhaohua Zeng Guangxue Chen | 2014 | J Polym Sci Part A: Polym Chem2014，，11： | 1 |
| 11 | Photo‐triggered redox frontal polymerization: A new tool for synthesizing thermally sensitive materials显示文摘 | Minghui He Xun Huang Zhaohua Zeng Jianwen Yang | 2013 | J Polym Sci Part A: Polym Chem2013，，21： | 1 |
| 12 | Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy显示文摘Chronic hepatitis B virus(HBV)infection is a global public health problem,which can cause chronic hepatitis,liver cirrhosis,hepatocellular carcinoma(HCC),and other diseases.Antiviral therapy is the most critical measure to slow down the progression of chronic hepatitis B,prevent or delay cirrhosis,HCC,and other kinds of liver decompensation events.At present,the anti-hepatitis B virus drugs are mainly nucleoside(acid)analogues(NAs)and interferon.Each kind of antiviral drug has different effects on the clinical outcome of hepatitis B patients(such as HCC).In this paper,we discussed the biological characteristics,natural course and prognosis of HBV infection,the mechanism of HBV-related HCC,the effect of different antiviral drugs on patients’outcome,predictive biomarkers and model for HBV clinical outcome,predictors of sustained response and recurrence after withdrawal of antiviral therapy,consideration of expanding therapeutic indications and antiviral therapy,hoping to give a hand to the clinical diagnosis and treatment of HBV. | Huihui Lu Wei Yi Fangfang Sun Zhan Zeng Lu Zhang Minghui Li Yao Xie | 2021 | Biosafety and Health2021，3，4： | 1 |
| 13 | Photoinduced redox initiation for fast polymerization of acrylaytes based on latent superbase and peroxides显示文摘 | Minghui He Xun Huang Yugang Huang Zhaohua Zeng Jianwen Yang | 2012 | Polymer2012，，15： | 1 |
| 14 | Systematic Evaluation of Pharmacognostic Identification of Polygonum capitatum显示文摘[Objectives] To investigate the systematic evaluation of pharmacognostic identification of Polygonum capitatum . [Methods] 10 batches of P. capitatum cultivated in Guizhou were chosen for plant samples. Macroscopical identification was conducted on plant roots, stems, leaves, flowers and fruits. The P. capitatum powder was processed for physical and chemical distinction by FeCl 3 chromogenic reaction, hydrochloric acid magnesium powder reaction, AlCl 3 color development reaction and thin-layer chromatography.Microscope identification was carried out on the powder. Plant genome DNeasy Plant Kit was adopted for DNA molecular marker identification. [Results] The results showed that the stem of P. capitatum was tufted, the leaves were oval, 2 to 5 cm long, and 1 to 2 cm wide;the leaf apex was acute and cuneate at the base, the inflorescence was capitate, paired or solitary;the raceme was erect and nearly spherical, and the perianth was light red. Furthermore, for the chromogenic reaction of FeCl 3 ethanol extract of P. capitatum , appeared blue and turned to dark blue after long time storing at room temperature. For the reaction of hydrochloric acid magnesium powder, the alcohol extract of P. capitatum , exhibited deep red. In the color reaction of AlCl 3, the alcohol extract revealed yellow fluorescence under 360 nm UV lamp. Microscope identification of the powder displayed pollen grains, crystal sheath fibers, cellulose, vessels, starch grains, cork cells, and other characteristic fragments. In addition, DNA barcoding electrophoresis results showed that P. capitatum showed a clear and bright single band near 500 bp, and further sequencing results showed that the sequence differences were mainly concentrated in ITS1 and ITS2 region. [Conclusions] Systematic evaluation for the identification of P. capitatum is established, which combines with macroscopic identification, physicochemical identification, powder microscope identification, and DNA molecular identification. Finally, the original medicinal material is identified as P. capitatum Buch.-Ham. ex D. Don. | Bo TU Xu ZHANG Minghui HE Shanggao LIAO Yongqin ZENG Yan LIN | 2023 | Medicinal Plant2023，14，4： | 1 |
| 15 | Preparation and magnetic properties of magnetite nanoparticles by sol–gel method显示文摘 | Jing Xu Haibin Yang Wuyou Fu Kai Du Yongming Sui Jiuju Chen Yi Zeng Minghui Li Guangtian Zou | 2006 | Journal of Magnetism and Magnetic Materials2006，，2： | 1 |
| 16 | Potential use of a dried saliva spot(DSS)in therapeutic drug monitoring and disease diagnosis显示文摘In recent years,scientific researchers have increasingly become interested in noninvasive sampling methods for therapeutic drug monitoring and disease diagnosis.As a result,dried saliva spot(DSS),which is a sampling technique for collecting dried saliva samples,has been widely used as an alternative matrix to serum for the detection of target molecules.Coupling the DSS method with a highly sensitive detection instrument improves the efficiency of the preparation and analysis of biological samples.Furthermore,dried blood spots,dried plasma spots,and dried matrix spots,which are similar to those of the DSS method,are discussed.Compared with alternative biological fluids used in dried spot methods,including serum,tears,urine,and plasma,saliva has the advantage of convenience in terms of sample collection from children or persons with disabilities.This review aims to provide integral strategies and guidelines for dried spot methods to analyze biological samples by illustrating several dried spot methods.Herein,we summarize recent advancements in DSS methods from June 2014 to March 2021 and discuss the advantages and disadvantages of the key aspects of this method,including sample preparation and method validation.Finally,we outline the challenges and prospects of such methods in practical applications. | Yu Han Xi-Ling Li Minghui Zhang Jing Wang Su Zeng Jun Zhe Min | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 1 |
| 17 | Versatile SrFeO_(x) for memristive neurons and synapses显示文摘Spiking neural network(SNN)consisting of memristor-based artificial neurons and synapses has emerged as a compact and energy-efficient hardware solution for spatiotemporal information processing.However,it is challenging to develop memristive neurons and synapses based on the same material system because the required resistive switching(RS)characteristics are different.Here,it is shown that SrFeO_(x)(SFO),an intriguing material system exhibiting topotactic phase transformation between insulating brownmillerite(BM)SrFeO_(2).5 phase and conductive perovskite(PV)SrFeO_(3) phase,can be engineered into both neuronal and synaptic devices.Using a BM-SFO single layer as the RS medium,the Au/BM-SFO/SrRuO_(3)(SRO)memristor exhibits nonvolatile RS behavior originating from the formation/rupture of PV-SFO filaments in the BM-SFO matrix.By contrast,using a PV-SFO(matrix)/BM-SFO(interfacial layer)bilayer as the RS medium,the Au/PV-SFO/BM-SFO/SRO memristor exhibits volatile RS behavior originating from the interfacial BM-PV phase transformation.Synaptic and neuronal characteristics are further demonstrated in the Au/BM-SFO/SRO and Au/PV-SFO/BM-SFO/SRO memristors,respectively.Using the SFO-based synapses and neurons,fully memristive SNNs are constructed by simulation,which show good performance on unsupervised image recognition.Our study suggests that SFO is a versatile material platform on which both neuronal and synaptic devices can be developed for constructing fully memristive SNNs. | Kaihui Chen Zhen Fan Jingjing Rao Wenjie Li Deming Wang Changjian Li Gaokuo Zhong Ruiqiang Tao Guo Tian Minghui Qin Min Zeng Xubing Lu Guofu Zhou Xingsen Gao Jun-Ming Liu | 2022 | Journal of Materiomics2022，8，5： | 0 |
| 18 | Problems and Challenges Associated with Renaming Non-alcoholic Fatty Liver Disease to Metabolic Associated Fatty Liver Disease显示文摘Non-alcoholic fatty liver disease(NAFLD)has become the world’s largest chronic liver disease in the 21st century,affecting 20%-30%of the world’s population.As the epidemiology,etiology,and pathogenesis of NAFLD have been studied in-depth,it has been gradually recognized that most patients with NAFLD have one or more combined metabolic abnormalities known as metabolic syndrome.In 2020,the international expert group changed the name of NAFLD to metabolic-associated fatty liver disease(MAFLD)and proposed new diagnostic criteria for MAFLD and MAFLD-related liver cirrhosis,as well as the conceptual framework of other cause-related fatty liver diseases to avoid diagnosis based on the exclusion of other causes and better reflect its pathogenesis.However,there are still many ambiguities in the term,and changing the name does not address the unmet key needs in the field.The change from NAFLD to MAFLD was not just a change of definition.The problems and challenges are summarized as follows:epidemiology,children,rationality of'metabolism,'diagnostic criteria,double/multiple causes,drug discovery,clinical trials,and awareness raising.Metabolic-associated fatty liver disease has complex disease characteristics,and there are still some problems that need to be solved. | Minghui Zeng Lin Chen Yuqin Li Yuqiang Mi Liang Xu | 2023 | Infectious Diseases & Immunity2023，3，3： | 0 |
| 19 | Experimental search for high-performance ferroelectric tunnel junctions guided by machine learning显示文摘Ferroelectric tunnel junction(FTJ)has attracted considerable attention for its potential applications in nonvolatile memory and neuromorphic computing.However,the experimental exploration of FTJs with high ON/OFF ratios is a challenging task due to the vast search space comprising of ferroelectric and electrode materials,fabrication methods and conditions and so on.Here,machine learning(ML)is demonstrated to be an effective tool to guide the experimental search of FTJs with high ON/OFF ratios.A dataset consisting of 152 FTJ samples with nine features and one target attribute(i.e.,ON/OFF ratio)is established for ML modeling.Among various ML models,the gradient boosting classification model achieves the highest prediction accuracy.Combining the feature importance analysis based on this model with the association rule mining,it is extracted that the utilizations of{graphene/graphite(Gra)(top),LaNiO_(3)(LNO)(bottom)}and{Gra(top),Ca_(0.96)Ce_(0.04)MnO_(3)(CCMO)(bottom)}electrode pairs are likely to result in high ON/OFF ratios in FTJs.Moreover,two previously unexplored FTJs:Gra/BaTiO_(3)(BTO)/LNO and Gra/BTO/CCMO,are predicted to achieve ON/OFF ratios higher than 1000.Guided by the ML predictions,the Gra/BTO/LNO and Gra/BTO/CCMO FTJs are experimentally fabricated,which unsurprisingly exhibit≥1000 ON/OFF ratios(~8540 and~7890,respectively).This study demonstrates a new paradigm of developing high-performance FTJs by using ML. | Jingjing Rao Zhen Fan Qicheng Huang Yongjian Luo Xingmin Zhang Haizhong Guo Xiaobing Yan Guo Tian Deyang Chen Zhipeng Hou Minghui Qin Min Zeng Xubing Lu Guofu Zhou Xingsen Gao Jun-Ming Liu | 2022 | Journal of Advanced Dielectrics2022，12，3： | 0 |
| 20 | Long-term outcomes of intraoperative radiotherapy for early-stage breast cancer in China: amulticenter real-world study显示文摘Dear Editor,Intraoperative radiotherapy(IORT)is an accelerated par-tial breast irradiation(APBI)treatment that is accom-plished intraoperatively.Numerous clinical trials indicate that IORT is safe and effective,non-inferior to standard whole-breast external beam radiotherapy(EBRT)for low-risk patients who receive breast-conserving surgery[1-3].Nevertheless,these studies mainly included non-Asians and thus lack adequate evidence to support the value of IORT in Asian patients with breast cancer. | Xin Wang Kexin Feng Wenyan Wang Xiangzhi Meng Jiaqi Liu Yang Yang Yuting Zhong Jingruo Li Shikai Wu Minghui Li Pan Ma Qinfu Feng Hongmei Zeng Yuanting Gu Xiru Li Zhaoqing Fan Xiang Wang | 2022 | Cancer Communications2022，42，3： | 0 |
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