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| 1 | Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia显示文摘The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)and the inflammationmediating Th17 cells plays an essential role.Previously,we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells(fetal component)participated in the pathogenesis of PE.However,as one of the potential immune regulatory molecules,whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified.Thus,we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers.Here,we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate(placental maternal side)and peripheral blood of patients with PE.In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs,which was dependent on the paracrine signaling of IL-6 in trophocytes,induced by CD81.In a CD81-induced PE rat model,we found a significant shift of T cell differentiation towards Th17 cells,and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells.These results define a vital regulatory cascade involving trophocyte-derived CD81,IL-6,and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE. | Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | Rational Fabrication of Superhydrophobic Nanocone Surface for Dynamic Water Repellency and Anti-icing Potential显示文摘In this work,a simple and economic route was presented to fabricate an anti-icing superhydrophobic surface with nanocone structures,which were constructed only by one-step facile method of hydrothermal treatment with zinc acetate on the aluminum substrate.After modifying with fluoroalkylsilane (FAS-17),the nanocone structures with the appropriate size could induce the high superhydrophobicity with the water contact angle reaching 160.2° ± 0.4° and the sliding angle only being 1 ° ± 0.5°.Under the dynamic environments,the impact droplets could rapidly bounced off the surface with the shorter contact time of^1 0.6 ms,and it was mainly attributing to lower capillary adhesive force (water adhesion force of 4.1 μN) induced by the open system of nanocone structures.Furthermore,the superhydrophobic nanocone surfaces were verified to be a promising anti-icing/icephobic materials,on which the water droplets needed to spend the time of ~517 s to complete the entire freezing process at-10 ℃,displaying the increased ~50 times of icing-delay performance comparing with untreated substrate.Even if ice finally was formed on the superhydrophobic nanocone surfaces,it could be easily removed away with lower ice adhesion of^45 kPa.The repeatable measurement of ice adhesion strength on the same place of the superhydrophobic surface is still far less than the surface ice adhesion of smooth substrate,exhibiting better stability. | Yuehan Xie Haifeng Chen Yizhou Shen Jie Tao Mingming Jin Yu Wu Wenqing Hou | 2019 | Journal of Bionic Engineering2019，16，1： | 7 |
| 3 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 4 | Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17显示文摘雌激素涉及支持肺癌症房间分割和转移。云母和 MICB 为 NKG2D 作为 ligands 工作,在生来的杀手(NK ) 上表示的重要 immunoreceptor 房间。然而,雌激素是否调整 MICA/B 表示并且影响肿瘤免疫者逃跑,仍然保持未知。在这研究,我们测量了非小的房间肺癌症(NSCLC ) 房间线与雌激素对待的云母, MICB 和 ADAM17in 的 mRNA 层次。LTEP-a2 和 A549 上的 MICA/B 的表面表示用流动 cytometry 被检测。我们证明 mRNA 和在肺腺癌房间线的 MICA/B 的能分泌的蛋白质层次是由 estradiol 的 upregulated。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。MICA/B downregulated 的这分泌物 NK92 房间的表面上的 NKG2D 受体并且损害了 NK 房间的细胞毒素的活动。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。而且,在 estradiol 和云母的表示的集中之间的重要关联在 NSCLC 病人的肿瘤纸巾被发现。因此,我们断定雌激素能通过 ADAM17 调整 MICA/B 的表示和分泌物,它帮助肺癌症房间逃离调停 NKG2D 的有免疫力的监视。 | Jing Ren Yunzhong Nie Mingming Lv Sunan Shen Ruijing Tang Yujun Xu Yayi Hou Shuli Zhao Tingting Wang | 2015 | Cellular & Molecular Immunology2015，12，6： | 6 |
| 5 | Dissipation of polycyclic aromatic hydrocarbons and microbial activity in a field soil planted with perennial ryegrass显示文摘 | Dengqiang FU Ying TENG Yuanyuan SHEN Mingming SUN Chen TU Yongming LUO Zhengao LI Peter CHRISTIE | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 6 |
| 6 | Toward dendrite-free and anti-corrosion Zn anodes by regulating a bismuth-based energizer显示文摘Aqueous rechargeable zinc metal batteries display high theoretical capacity along with economical effectiveness,environmental benignity and high safety.However,dendritic growth and chemical corrosion at the Zn anodes limit their widespread applications.Here,we construct a Zn/Bi electrode via in-situ growth of a Bi-based energizer upon Zn metal surface using a replacement reaction.Experimental and theoretical calculations reveal that the Bi-based energizer composed of metallic Bi and ZnBi alloy contributes to Zn plating/stripping due to strong adsorption energy and fast ion transport rates.The resultant Zn/Bi electrode not only circumvents Zn dendrite growth but also improves Zn anode anti-corrosion performance.Specifically,the corrosion current of the Zn/Bi electrode is reduced by 90%compared to bare Zn.Impressively,an ultra-low overpotential of 12mV and stable cycling for 4000h are achieved in a Zn/Bi symmetric cell.A Zn–Cu/Bi asymmetric cell displays a cycle life of 1000 cycles,with an average Coulombic efficiency as high as 99.6%.In addition,an assembled Zn/Bi-activated carbon hybrid capacitor exhibits a stable life of more than 50,000 cycles,an energy density of 64Wh kg−1,and a power density of 7kWkg−1.The capacity retention rate of a Zn/Bi–MnO_(2)full cell is improved by over 150%compared to a Zn–MnO_(2)cell without the Bi-based energizer.Our findings open a new arena for the industrialization of Zn metal batteries for large-scale energy storage applications. | Mingming Wang Yahan Meng Ke Li Touqeer Ahmad Na Chen Yan Xu Jifei Sun Mingyan Chuai Xinhua Zheng Yuan Yuan Chunyue Shen Ziqi Zhang Wei Chen | 2022 | eScience2022，2，5： | 4 |
| 7 | Isolation and cloning of the gene encoding high affinity phosphate transporter in rice显示文摘High affinity phosphate transporterplays an important role in plantadapting to low phosphorus. Isolationof genes coding this kind of proteinhas attracted worldwide scholars toaccomplish. We aimed to isolate thegene and transfer it to target | MING Feng LIANG Bing YE Mingming,and SHEN Daling,Inst of Genetics,Fudan Univ,Shanghai 200433,China | 2002 | Chinese Rice Research Newsletter2002，10，1： | 2 |
| 8 | TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573显示文摘 | Zhengmao Lu Tianhang Luo Mingming Nie Tao Pang Xin Zhang Xiaojun Shen Liye Ma Jianwei Bi Guo Wei Guoen Fang Xuchao Xue | 2015 | FEBS Letters2015，，： | 1 |
| 9 | A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis显示文摘The therapy of bone defects based on advanced biological scaffolds offers the most promising therapeutic strategy for bone reconstruction.It is still challenging to develop scaffolds with the mechanical,osteogenic,angiogenic,and antibacterial properties required for bone defect reconstruction.Here,a novel organic/inorganic composite scaffold(zinc-whitlockite(ZnWH)/G/H)was synthesized using gellan gum(GG),human-like collagen(HLC),and ZnWH nanoparticles.The scaffold had excellent mechanical properties,adjustable swelling ratio,and interconnected pore structure.In addition to its excellent biocompatibility,it could promote osteogenic differentiation by releasing ZnWH nanoparticles to stimulate human bone marrow mesenchymal stem cells(hBMSCs)to upregulate the levels of alkaline phosphatase(ALP),osteocalcin(OCN),and osteopontin(OPN).In addition,this study showed that ZnWH nanoparticles could also promote angiogenesis by upregulating the paracrine secretion of vascular endothelial growth factor(VEGF)in hBMSCs.At the same time,the scaffold could inhibit the proliferation of bacteria.After 12 weeks of treatment in the rabbit femoral defect model,the ZnWH/G/H scaffold significantly accelerated the process of bone reconstruction.Therefore,these results demonstrate that the prepared novel nanocomposite scaffold,ZnWH/G/H,offers a promising candidate for bone regeneration. | Mingming Wang Jiaxin Yao Shihong Shen Chunning Heng Yanyi Zhang Tao Yang Xiaoyan Zheng | 2023 | Nano Research2023，16，1： | 1 |
| 10 | Catalytic Performanceof Silica-Supported Chromium Oxide Catalysts in Ethane Dehy- drogenation with Carbon Dioxide 显示文摘 | Ge Xin Zhu Mingming Shen Jianyi | 2002 | React Kinet Catal Lett2002，77，1： | 1 |
| 11 | Low infrared emitter from Ti3C2Tx MXene towards highly-efficient electric/solar and passive radiative heating显示文摘Realizing all-day and all-weather energy-saving heating is crucial for mitigating the global energy and ecology crisis.Electric/solar heating are two promising heating approaches,yet materials with high elec-trical conductivity,high solar absorptivity,and low infrared emissivity at the same time are rare in na-ture,which are highly anticipated and of great significance for highly efficient electric/solar heating.In this work,we demonstrate that Ti_(3)C_(2)T_(x) MXene with low IR emissivity(14.5%)fills the gap in the absence of the above materials,exhibiting a remarkable electric/solar heating performance.The saturated heating temperature of Ti_(3)C_(2)T_(x) film reaches a record-high value of 201°C at a low driving voltage of 1.5 V,and reaches 84.3°C under practical solar irradiation(750 W/m^(2))with a high solar to the thermal conversion efficiency of 75.3%,which is far superior to other reported materials.Meanwhile,the low IR emissivity endows Ti_(3)C_(2)T_(x) with a remarkable passive radiative heating capability of 7.0°C,ensuring zero-energy heating without electric/solar energy supply.The intrinsic characteristic of high electrical conductivity,high solar absorptivity,and low IR emissivity makes Ti_(3)C_(2)T_(x) unique existence in nature,which is highly promising for all-day and all-weather energy-saving heating. | Mingming Shen Jiahao Ni Yanxia Cao Yanyu Yang Wanjie Wang Jianfeng Wang | 2023 | Journal of Materials Science & Technology2023，，2： | 1 |
| 12 | Gallium-based liquid metal micro/nanoparticles for photothermal cancer therapy显示文摘Gallium-based liquid metals have attracted significant interest in the biomedical field due to their unique properties such as low viscosity,good fluidity,high thermal/electrical conductivity,and good biocompatibility.Meanwhile,photothermal therapy has made great development in the field of antitumor with its advantages of low adverse effects,high specificity,and repeatable treatment.The photothermal capability possessed by gallium-based liquid metals makes them show unparalleled advantages in photothermal therapy.Liquid metal-based photothermal therapy has progressed in recent years and can perform a vital role in accurate and noninvasive antitumor therapy.Herein,a review of the major preparation methods of liquid metal micro/nanoparticles,the mechanism of liquid metal photothermal conversion,and discussions on the factors affecting the photothermal properties of liquid metals are presented.The biological applications of liquid metal photothermal therapy in synergy with other therapies are discussed,as well as the current challenges and opportunities for the clinical translation of liquid metals in biomedical applications. | Mingming Fu Yifeng Shen Hao Zhou Xiaojia Liu Wenjun Chen Xing Ma | 2023 | Journal of Materials Science & Technology2023，，11： | 1 |
| 13 | Numerical Modelling and Simulation of Seepage in Tight Sandstone Based on Parallel Lattice Boltzmann Method显示文摘1 Introduction Lattice Boltzmann Method(LBM)have a remarkable ability to simulate single,multiphase and multicomponent fluids(Michael&Daniel,2007).Ludwig Boltzmann’s work is based on a simple idea that a gas is composed of interacting particles which could be analysed by Newton’s laws.So the flowing property of gas could be give out | TANG Mingming LU Shuangfang LIANG Hongru YAN Bihui MA Huifang SHEN Shan | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 14 | Fine Geological Modeling of the Tight Oil Reservoir显示文摘1 Introduction The study area of Northern Honggang is located in the Daan-Honggang terrace in the central depression of the southern Songliao basin,covering an area of 110km2.The oil field is categorized as an ultra-low permeability reservoir and the target horizon is the Fuyu oil layer.The reservoir is characterized as poor physical property。 | LIANG Hongru LU Shuangfang TANG Mingming YAN Bihui SHEN Shan | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
| 15 | Method on Pore Structure of Tight Reservoir显示文摘1 Introduction The physical properties of tight reservoir depends largely on its micro and super-micro pore structures,which mainly includes the size of pores and throats and their distribution,the collection form of pores and throats space,the connectivity among pores and throats and so on.The size | SHEN Shan LU Shuangfang TANG Mingming Liang Hongru YAN Bihui | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
| 16 | FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction:evidence from an Asian population显示文摘The association among plasma trimethylamine-N-oxide(TMAO),FMO3 polymorphisms,and chronic heart failure(CHF)remains to be elucidated.TMAO is a microbiota-dependent metabolite from dietary choline and carnitine.A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction,with the longest follow-up of 7 years.The concentrations of plasma TMAO and its precursors,namely,choline and carnitine,were determined by liquid chromatography-mass spectrometry,and the FMO3 E158K polymorphisms(rs2266782)were genotyped.The top tertile of plasma TMAO was associated with a significant increment in hazard ratio(HR)for the composite outcome of cardiovascular death or heart transplantation(HR=1.47,95%CI=1.13-1.91,P=0.004)compared with the lowest tertile.After adjustments of the potential confounders,higher TMAO could still be used to predict the risk of the primary endpoint(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).This result was also obtained after further adjustment for carnitine(adjusted HR=1.33,95%CI=1.01-1.74,P=0.039).The FM03 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort,and lower TMAO levels were found in the AA-genotype.Thus,higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders,and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels. | Haoran Wei Mingming Zhao Man Huang Chenze Li Jianing Gao Ting Yu Qi Zhang Xiaoqing Shen Liang Ji Li Ni Chunxia Zhao Zeneng Wang Erdan Dong Lemin Zheng Dao Wen Wang | 2022 | Frontiers of Medicine2022，16，2： | 0 |
| 17 | Study on the Fracturing Parameters and Productivity of Horizontal Wells显示文摘1 Introduction Hydraulic fracturing refers to the parting of geomaterials due to excessively high fluid pressure.The most common application of hydraulic fracturing is enhanced oil recovery,in which increase in functional permeability of the ground is achived by the formation of | TANG Mingming LU Shuangfang LIANG Hongru YAN Bihui SHEN Shan | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
| 18 | Geological Modeling on the Reservoir of Oil Sand in Estuary显示文摘1 Introduction Athabasca oil sands are large deposits of heavy crude oil,located in northeastern Alberta Basin,Canada.Those oil sands,hosted primarily in upper and middle of McM urray Formation,is in 18m in thickness and 160m-180m in buried depth.The average liquid saturation | YAN Bihui LU Shuangfang TANG Mingming LIANG Hongru SHEN Shan | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
| 19 | Nonequilibrium hot-electron-induced wavelength-tunable incandescent-type light sources显示文摘The collective oscillation of electrons located in the conduction band of metal nanostructures being still energized,with the energy up to the bulk plasmon frequency,are called nonequilibrium hot electrons.It can lead to the state-filling effect in the energy band of the neighboring semiconductor.Here,we report on the incandescent-type light source composed of Au nano rods decorated with single Ga-doped ZnO microwire(AuNRs@ZnO:Ga MW).Benefiting from Au nanorods with controlled aspect ratio,wavelength-tunable incandescent-type lighting was achieved,with the dominating emission peaks tuning from visible to near-infrared spectral regions.The intrinsic mechanism was found that tunable nonequilibrium distribution of hot electrons in ZnO:Ga MW,injected from Au nanorods,can be responsible for the tuning emission features.Apart from the modification over the composition,bandgap engineering,doping level,etc.,the realization of electrically driving the generation and injection of nonequilibrium hot electrons from single ZnO:Ga MW with Au nanostructure coating may provide a promising platform to construct electronics and optoelectronics devices,such as electric spasers and hot-carrier-induced tunneling diodes. | ZHIPENG SUN MINGMING JIANG WANGQI MAO CAIXIA KAN CHONGXIN SHAN DEZHEN SHEN | 2020 | Photonics Research2020，8，1： | 0 |
| 20 | Biodegradable interference distraction implant:a promising replacement for conventional implant in patients with insufficient alveolar bone height显示文摘Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented to simplify the treatment procedure,but the shortcomings of Dl have limited its clinical use.We introduced biodegradable polyester to a novel Dl,called biodegradable interference distraction implant(BIDI).The purpose of this study was to assess the radiological,histological,and biomechanical properties of BIDI in animal models.Methods BIDIs were manufactured and inserted into the atrophied mandibles of 6 dogs. | Yongfeng Li Tao Li Bo Shao Yingying Sun Yuan Gao Yongqiang Zhang Qi Gao Shuning Shen Qiang Niu Mingming Shen Liang Kong | 2013 | 医用生物力学2013，28，S1： | 0 |
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