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| 1 | The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;3显示文摘增加的庄稼收益被要求支持世界范围的快速的人口生长。谷物重量是米饭产量的一个关键部件,但是控制它的内在的分子的机制留下逃犯。这里,我们报导为米饭谷物长度,重量和产量的控制克隆和一个新量的特点地点(QTL ) 的描述。这个地点, GL3.1,编码蛋白质磷酸酶 kelch (PPKL ) 家庭 —Ser/Thr 磷酸酶。GL3.1 是大谷物 WY3 变化的一个成员,它比小谷物 FAZ1 变化与更弱的 dephosphorylation 活动被联系。GL3.1-WY3 在小穗状花小穗影响蛋白质 phosphorylation 加速房间分割,从而导致更长的谷物和更高的收益。进一步的研究直接显示出那 GL3.1 dephosphorylates 它的底层, Cyclin-T1; 3,它很少仅仅在植物被学习了。Cyclin-T1 的 downregulation; 3 在更短的谷物导致了米饭,它在房间周期规定为 Cyclin-T 显示新奇功能。我们的调查结果为通过影响 Cyclin-T1 的 phosphorylation 的新奇调停磷酸酶的进程被驾驶的谷物尺寸和产量的规定建议新机制; 3 在房间周期前进期间,并且这样提供新卓见进位于庄稼种子开发下面的机制。我们引起了包含表明了增加的谷物产量的自然 GL3.1 等位基因的一个新变化,它显示 GL3.1 是为引起产量很高的庄稼的一个强大的工具。 | Peng Qi You-Shun Lin Xian-Jun Song Jin-Bo Shen Wei Huang Jun-Xiang Shan Mei-Zhen Zhu Liwen Jiang Ji-Ping Gao Hong-Xuan Lin | 2012 | Cell Research2012，22，12： | 132 |
| 2 | The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer显示文摘China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western countries.Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients.The Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad.By referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes.This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer. | Feng-Hua Wang Lin Shen Jin Li Zhi-Wei Zhou Han Liang Xiao-Tian Zhang Lei Tang Yan Xin Jing Jin Yu-Jing Zhang Xiang-Lin Yuan Tian-Shu Liu Guo-Xin Li Qi Wu Hui-Mian Xu Jia-Fu Ji Yuan-Fang Li Xin Wang Shan Yu Hao Liu Wen-Long Guan Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 127 |
| 3 | Chemotherapy and target therapy for hepatocellular carcinoma:New advances and challenges显示文摘Primary liver cancer is one of the commonest causes of death.Hepatocellular carcinoma(HCC) accounts for 90% of primary liver cancers.For patients with unresectable or metastatic HCC,conventional chemotherapy is of limited or no benefit.Sorafenib is the only systemic treatment to demonstrate a statistically significant but modest overall survival benefit,leading to an era of targeted agents.Many clinical trials of targeted drugs have been carried out with many more in progress.Some drugs like PTK787 showed potential benefits in the treatment of HCC.Despite these promising breakthroughs,patients with HCC still have a dismal prognosis.Recently,both a phase Ⅲ trial of everolimus and a phase Ⅱ clinical trial of trebananib failed to demonstrate effective antitumor activity in advanced HCC.Sorafenib still plays a pivotal role in advanced HCC,leading to further explorations to exert its maximum efficacy.Combinations targeted with chemotherapy or transarterial chemoembolization is now being tested and might bring about advances.New targeted agents such as mammalian target of rapamycin inhibitors are under investigation,as well as further exploration of the mechanism of hepatocarcinogenesis. | Gan-Lu Deng Shan Zeng Hong Shen | 2015 | World Journal of Hepatology2015，7，5： | 30 |
| 4 | Principles,structures,and implementation of reconfigurable ternary optical processors显示文摘This paper discusses the principles,structures,and implementation procedures for reconfiguring a ternary optical processor (TOP).Typical structures,classifications,and naming of the TOP and basic operation units (BOUs) are described in this paper.The circuit implementations,commands,and processes for the reconfiguration are also discussed in detail.A simple analysis of the high performance and low power consumption of ternary optical computers is presented.Finally,an experiment is performed on reconfiguring a 1-bit BOU,which shows that the principles of reconfigurable TOPs are valid,and that the implementations and commands for the reconfiguration are effective. | JIN Yi WANG HongJian OUYANG shan ZHOU Yu SHEN YunPu PENG JunJie LIU XueMin | 2011 | Science China(Information Sciences)2011，54，11： | 23 |
| 5 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 6 | Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice显示文摘Salvianolic acid B is isolated from Salvia miltiorrhiza,the root of which is widely used as a traditional Chinese medicine to treat stroke.However,little is known about how salvianolic acid B influences growth characteristics of neural stem cells (NSCs).The purpose of the present study was to evaluate the effects of salvianolic acid B on proliferation,neurite outgrowth and differentiation of NSCs derived from the cerebral cortex of embryonic mice using MTT,flow cytometry,immunofluorescence and RT-PCR.It was found that 20 μg mL·1 and 40 μg mL·1 salvianolic acid B had similar effects on proliferation of NSCs,and a suitable concentration of salvianolic acid B increased the number of NSCs and their derivative neurospheres.The growth-promoting activity of salvianolic acid B was dependent on and associated with an accumulation in the G2/S-phase cell population.Salvianolic acid B also promoted the neurite outgrowth of NSCs and their differentiation into neurons.The mRNA for tau,GFAP and nestin were present in differentiating neurospheres induced by salvianolic acid B.However,high-level expression of tau mRNA and low-level expression of GFAP mRNA was detected in differentiated cells,in contrast to the control conditions.This collective evidence indicates that exogenous salvianolic acid B is capable of promoting proliferation of neurospheres and differentiation towards the neuronal lineage in vitro and may act in the proliferation of NSCs and may promote NSC differentiation into neuronal cells. | GUO GuoQing1,LI Bin1,WANG YuanYuan1,SHAN AiJing1,SHEN WeiZai1,YUAN Lin2 & ZHONG ShiZhen2 1Department of Anatomy,Medical College of Jinan University,Guangzhou 510630,China 2Institute of Clinical Anatomy,Key Laboratory of Tissue Construction and Detection of Guangdong Province,Southern Medical University,Guangzhou 510150,China | 2010 | Science China(Life Sciences)2010，53，6： | 21 |
| 7 | Inhibitory effects of tanshinone Ⅱ-A on invasion and metastasis of human colon carcinoma cells显示文摘 | Yun-feng SHAN Xian SHEN Yuan-kang XIE Ji-cai CHEN Hong-qi SHI Zheng-ping YU Qi-tong SONG Men-tao ZHOU Qi-yu ZHANG | 2009 | Acta Pharmacologica Sinica2009，30，11： | 18 |
| 8 | Adsorption behavior of phosphate on Lanthanum(Ⅲ) doped mesoporous silicates material显示文摘A series of lanthanum doped meosoporous MCM-41(LaxM41,x is Si/La molar ratio) was prepared by sol-gel method.The surface structure of the materials was investigated with X-ray diffraction and N2 adsorption/desorption technique.The content of La in the materials was determined by ICP.It was found that the La content of La25M41,La50M41 and La100M41 was 7.53%,3.89% and 2.32%,respectively.The phosphate adsorption capacities increased with increasing amount of La incorporation.With 0.40 g La25M41 99.7% phosphate could be removed.The effects of Si/La molar ratio,LaxM41 dose,pH,initial concentration of phosphate solution,co-ions on phosphate adsorption were also evaluated.The phosphate adsorption kinetics of LaxM41 could be well-described by the pseudo second-order model,and Langmuir isotherm fit equilibrium data much better than the Freundlich isotherm. | Jianda Zhang Zhemin Shen Wenpo Shan Ziyan Chen Zhijian Mei Yangming Lei Wenhua Wang | 2010 | Journal of Environmental Sciences2010，22，4： | 18 |
| 9 | Impact of multidisciplinary team working on the management of colorectal cancer显示文摘背景被用于诊断和治疗的技术的不断、快速的发展使 colorectal 癌症的管理更困难取决于单个 discipline.Colorectal 癌症工作的多学科的队( MDT )模型被英国和另外的国家推荐,但是几乎在这研究的 China.The 目的研究 colorectal 癌症的管理的 MDT 的影响上没有很少信息是在 MDT.Meth 的开始以后在 colorectal | Ye Ying-jiang Shen Zhan-long Sun Xian-tao Wang Zhi-feng Shen Dan-hua Liu Hui-jun Zhang Wan-lei Chen Ya-lin Zhou Jing Poston, G. J. Wang Shan | 2012 | Chinese Medical Journal2012，，2： | 17 |
| 10 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 11 | Liver targeting and the delayed drug release of the nanoparticles of adriamycin polybutylcyanoacrylate in mice显示文摘指向药交货系统的背景肝能改进药品效果并且减轻在带治疗学的药的肝 diseases.Nanoparticles 的治疗的药当前在有大临床的意义的热调查下面的化疗的 cytotoxicity。这研究被瞄准经由侧面的尾巴静脉在注射以后在老鼠身体调查 theadriamycin polybutylcyanoacrylate nanoparticle (ADM-PBCA-NP ) 的不同组织分发,并且学习在正常老鼠肝上在不同直径指向 ADM-PBCA-NP 的效果的肝。180 只 Kunming 老鼠随机在各个带着 30 只老鼠被划分成 6groups 的方法组织(在不同直径范围的 ADM-PBCA-NP 的 5 个处理组,非结合的免费 adriamycin 注射作为控制组被采用) 。结合的任何一个或免费 adriamycin 的单个剂量等于身体重量的 2 mg/kg 经由尾巴静脉被交付。在每条小道的五个鼠标在 5 点被牺牲, 15, 30 分钟, 1, 5 和 12 小时帖子注射分别地。adriamycin 集中在分别地镇定肝,肾,怒气,心,肺和血浆与荧光察觉者用高效液体层析被表明。结果与控制组,相比, adriamycin 几乎没在处理组的心肌肉被检测(P <
0.05 ) 。结合 nanoparticle 的 adriamycin 从肾织物快速被清理。在试验性的组的鼠标肝和怒气的 adriamycin 集中在控制组比那显著地高,除了有 nanoparticles 直径的组(22.3 ± 6.2 ) nm (P <
0.05 ) 。ADM-PBCA-NP 在(101.0 ± 20.3 ) nm 直径有最高的肝分发,并且在肝的第二最高的 adriamycindistribution 是组(143.0 ± 2 3.5 ) nm 直径(P <
0.05 ) 。而且,在试验性的组在察觉时期期间在肝慢慢地释放的 adriamycinwas。ADM-PBCA-NPin (22.3 ± 6 .2 ) nm 直径没在肝,肾,心,怒气,和肺的织物被散布。在 100-150 nm 直径范围的结论 ADM-PBCA-NP 有最好的肝与慢药版本的一个特征指向。它也减少在心,肾和肺的药分发。在肝癌症的治疗, polybutylcyanoacrylate nanoparticles 系统有一个好肝指向能力,它增加反癌症活动并且显著地减少 adriamycin 的毒性。 | SHEN Liang-fang ZHANG Yang-de SHEN Hai-ju ZENG Shan WANG Xin WANG Cheng LE Yuan SHEN Hong | 2006 | Chinese Medical Journal2006，，15： | 15 |
| 12 | Prevalence, clinical characteristics and outcome in patients with chronic heart failure and diabetes显示文摘背景长期的心失败( CHF )和糖尿病 mellitus 高预示因为互连的 pathophysiologic process.This ,大队学习试图分析流行的病态和死亡, clinicaI 特征和有 CHF 和有 NYHA functionaI 班的 1119 个病人的 diabetes.Methods A totaI 的病人的长期的结果-并且左室的喷射部分( LVEF )<45%在1995年1月和2009年5月之间是 recruited.Clinical 变量,生物化学并且 echocardiographic | SHI Chuan WANG Ling-jie HU Dan-feng LI Jin-ping ZHU Tian-qi SHAN Ying ZHAO Jian-rong ZHANG Feng-ru SHEN Wei-feng | 2010 | Chinese Medical Journal2010，，6： | 14 |
| 13 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 14 | Experimental investigation of shale imbibition capacity and the factors influencing loss of hydraulic fracturing fluids显示文摘Spontaneous imbibition of water-based fracturing fluids into the shale matrix is considered to be the main mechanism responsible for the high volume of water loss during the flowback period. Understanding the matrix imbibition capacity and rate helps to determine the fracturing fluid volume, optimize the flowback design, and to analyze the influences on the production of shale gas.Imbibition experiments were conducted on shale samples from the Sichuan Basin, and some tight sandstone samples from the Ordos Basin. Tight volcanic samples from the Songliao Basin were also investigated for comparison. The effects of porosity, clay minerals, surfactants, and KCl solutions on the matrix imbibition capacity and rate were systematically investigated. The results show that the imbibition characteristic of tight rocks can be characterized by the imbibition curve shape, the imbibition capacity, the imbibition rate, and the diffusion rate. The driving forces of water imbibition are the capillary pressure and the clay absorption force. For the tight rocks with low clay contents,the imbibition capacity and rate are positively correlated with the porosity. For tight rocks with high clay content,the type and content of clay minerals are the most important factors affecting the imbibition capacity. The imbibed water volume normalized by the porosity increases with an increasing total clay content. Smectite and illite/smectite tend to greatly enhance the water imbibition capacity.Furthermore, clay-rich tight rocks can imbibe a volume ofwater greater than their measured pore volume. The average ratio of the imbibed water volume to the pore volume is approximately 1.1 in the Niutitang shale, 1.9 in the Lujiaping shale, 2.8 in the Longmaxi shale, and 4.0 in the Yingcheng volcanic rock, and this ratio can be regarded as a parameter that indicates the influence of clay. In addition,surfactants can change the imbibition capacity due to alteration of the capillary pressure and wettability. A 10wt% KCl solution can inhibit clay absorption to reduce the imbibition capacity. | Hong-Kui Ge Liu Yang Ying-Hao Shen Kai Ren Fan-Bao Meng Wen-Ming Ji Shan Wu | 2015 | Petroleum Science2015，12，4： | 13 |
| 15 | Effect of Two Administration Routes of Shenmai Injection(参麦注射液)on Pulmonary Gas Exchange Function after Tourniquet-Induced Ischemia-Reperfusion显示文摘Objective:To compare the effect between nebulized and intravenous administration of Shenmai Injection(参麦注射液) on pulmonary gas exchange function of patients following tourniquet-induced lower limb ischemia-reperfusion.Methods:Thirty-eight patients scheduled for lower extremity surgery were randomized into three groups using the closed envelop method:Shenmai Injection was administered 30 min before tourniquet inflation by nebulization[0.6 mL/kg in 10 mL normal saline(NS)]in the nebulization group or by intravenous drip(0.6 mL/kg dissolved in 250 mL of 10%glucose) in the intravenous drip group,and equal volume of NS was given intravenously in the NS group;15 in each group.Arterial blood gases were analyzed,serum levels of malonaldehyde(MDA) and interleukine-6(IL-6) and interleukine-8(IL-8) were determined using the method of thiobarbituric acid reaction and enzyme-linked immuno sorbent assay respectively just before tourniquet inflation(TO),and at 0.5 h(T1),2 h(T2),6 h(T3) after tourniquet deflation.Results:Compared with baselines at TO,MDA levels significantly increased at T2,T3 in the NS group and at T3 in the nebulization group,and IL-6 and IL-8 levels were significantly increased at T2,T3 in NS,the intravenous drip and the nebulization groups(P<0.05).Arterial pressure of oxygen(PaO_2) at T3 was decreased,while alveolararterial oxygen tension showed difference(PA-aDO_2) at T3 in the NS group;RI at T3 in both intravenous drip and the nebulization groups were enhanced(P<0.05).Compared with the NS group,MDA and IL-8levels at T2,T3,IL-6 at T3 in the intravenous drip group,and IL-8 at T3 in the nebulization group were all remarkably increased(P<0.05).Additionally,MDA level at T3 in the nebulization group was higher than that in the intravenous drip group(P<0.05).Conclusions:Intravenous administration of Shenmai Injection provided a better protective effect than nebulization in mitigating pulmonary gas exchange dysfunction in patients following tourniquet-induced limb ischemia-reperfusion. | JIN Jian-guo SHEN Hai-jian SHAN Yuan-lu CHEN Lei ZHAO Xi-yue WANG Liang-rong LIN Li-na | 2017 | Chinese Journal of Integrative Medicine2017，23，1： | 13 |
| 16 | Effects of operational factors on soluble microbial products in a carrier anaerobic baffled reactor treating dilute wastewater显示文摘The effects of feed strength, hydraulic residence time (HRT), and operational temperatures on soluble microbial product (SMP) production were investigated, to gain insights into the production mechanism. A carrier anaerobic baffled reactor (CABR) treating dilute wastewater was operated under a wide range of operational conditions, namely, feed strengths of 300–600 mg/L, HRTs of 9– 18 h, and temperatures of 10–28°C. Generally, SMP production increased with increasing feed strength and decreasing temperature. At high temperature (28°C), SMP production increased with decreasing HRT. As the temperature was decreased to 18 and 10°C, the SMP production was at its peak for 12 h HRT. Therefore, temperature could be an important determinant of SMP production along with HRT. A higher SMP to soluble chemical oxygen demand (SCOD) ratio was found at high temperature and long HRT because of complete volatile fatty acid degradation. SMP accounted for 50%–75% of the SCOD in the last chamber of the CABR. As a secondary metabolite, some SMP could be consumed at lower feed strength. | FENG Huajun HU Lifang SHAN Dan FANG Chengran HE Yonghua SHEN Dongsheng | 2008 | Journal of Environmental Sciences2008，20，6： | 12 |
| 17 | Adoptive therapy with CAR redirected T cells for hematological malignancies显示文摘The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells engineered with chimeric antigen receptor(CAR) were reported to show unprecedented responses in a range of hematological malignancies. The persistence of the CAR-T cell can last for years and tends toward long-term antitumor memory by which relapses can be effectively prevented. The primary side effects that appear in most clinical trials are cytokine release syndrome and neurotoxicity. However, these symptoms can be treated and reversed. In this review, we describe CAR structure and function and summarize recent advances in CAR-T cell therapy in hematological malignancies. | Shiqi Li Zhi Yang Junjie Shen Juanjuan Shan Cheng Qian | 2016 | Science China(Life Sciences)2016，59，4： | 11 |
| 18 | Hangzhou criteria as downstaging criteria in hepatocellular ca显示文摘Background:The downstaging of hepatocellular carcinoma(HCC)has been confirmed to benefit liver transplantation(LT)patients whose tumors are beyond the transplantation criteria.Milan criteria(MC),a tumor size and number-based assessment,is currently used as the endpoint in these patients.However,many studies believe that tumor biological behavior should be added to the evaluation criteria for downstaging efficacy.Hence,this study aimed to explore the feasibility of Hangzhou criteria(HC),which introduced tumor grading and alpha-fetoprotein in addition to tumor size and number,as an endpoint of downstaging.Methods:We performed a multicenter and retrospective study of 206 patients accepted locoregional therapy(LRT)as downstaging/bridge treatment prior to LT in three centers of China.Results:Recipients were divided into four groups:failed downstaging to the HC(group A,n=46),successful downstaging to the HC(group B,n=30),remained within the HC all the time(group C,n=113),and tumor progressed(group D,n=17).The 3-year HCC recurrence probabilities of groups B and C were not significantly different(10.3%vs.11.6%,P=0.87).The HCC recurrent rate was significantly higher in group A(52.3%)compared with that in group B/C(P<0.05).Seven patients(7/76,9.2%)whose tumor exceeded the the HC were successfully downstaged to the MC,and 39.5%(30/76)to the the HC.In group B,23 patients remained beyond the MC and their survivals were as well as those of patients within the MC.Conclusions:Compared to the MC,HC downstaging criteria can give more HCC patients access to LT and furthermore,the outcome of these patients is the same as those matching MC downstaging criteria.Hangzhou downstaging criteria therefore is applicable in clinical practice. | Qi-Fan Zhan Sun-Bin Ling Yi-Nan Deng Qiao-Nan Shan Qian-Wei Ye Sheng-Jun Xu Guang-Jiang Jiang Di Lu Xu-Yong Wei Li Zhuang Wu Zhang Tian Shen Bei-Ni Cen Hai-Yang Xie Ji-Min Liu Jian Wu Shu-Sen Zheng Yang Yang Xiao Xu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 11 |
| 19 | Nitrogen cycle in the hyporheic zone of natural wetlands显示文摘Nitrogen(N)is one of the most important components and ecological factors for natural wetland ecosystems.It is mainly derived from runoff input,atmospheric deposition,and biological N fixation.The transport and transformation of N in natural wetlands primarily occur in the hyporheic zone(HZ),a buffer area of intensified biogeochemical activity that is often regarded as the sink,source,and converter of N in wetlands.The main ways of N attenuation in the HZ are denitrification,anaerobic ammonia oxidation(anammox),and wetland plant adsorption.The effects of internal and human factors on the N cycle are illustrated in this article.The results indicate that N sources are influenced by human factors such as agricultural activities and fossil combustion,while N attenuation is affected by internal factors,including oxygen concentration,carbon and phosphorus availability,pH and Eh changes,and microorganism actions.Finally,some research trends are provided to get a better understanding of the N cycle in the HZ of natural wetlands.This study may provide a clear perspective of N cycle in the HZ and their interactions between various factors. | Nianqing Zhou Shan Zhao Xinping Shen | 2014 | Chinese Science Bulletin2014，59，24： | 10 |
| 20 | An improved analytical model of cutting temperature in orthogonal cutting of Ti6Al4V显示文摘Cutting heat has significant effects on the machined surface integrity of titanium alloys in the aerospace field. Many unwanted problems such as surface burning, work hardening, and tool wear can be induced by high cutting temperatures. Therefore, it is necessary to accurately predict the cutting temperature of titanium alloys. In this paper, an improved analytical model of the cutting temperature in orthogonal cutting of titanium alloys is proposed based on the Komanduri-Hou model and the Huang-Liang model. The temperatures at points in a cutting tool, chip, and workpiece are calculated by using the moving heat source method. The tool relief angle is introduced into the proposed model, and imaginary mirrored heat sources of the shear plane heat source and the frictional heat source are applied to calculate the temperature rise in a semi-infinite medium. The heat partition ratio along the tool-chip interface is determined by the discretization method. For validation purpose, orthogonal cutting of titanium alloy Ti6Al4V is performed on a lathe by using a sharp tool. Experimental results show to be consistent well with those of the proposed model,yielding a relative difference of predicted temperature from 0.49% to 9.00%. The model demonstrates its ability of predicting cutting temperature in orthogonal cutting of Ti6Al4V. | Chenwei SHAN Xu ZHANG Bin SHEN Dinghua ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，3： | 10 |
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