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| 1 | A recombinant receptor-binding domain in trimeric form generates protective immunity against SARSCoV-2 infection in nonhuman primates显示文摘A safe and effective vaccine is critical to combat the COVID-19 pandemic.Here,we developed a trimeric SARS-CoV-2 receptor-binding domain(RBD)subunit vaccine candidate that simulates the natural structure of the spike(S)trimer glycoprotein.Immunization with the RBD trimer-induced robust humoral and cellular immune responses,and a high level of neutralizing antibodies was maintained for at least 4.5 months.Moreover,the antibodies that were produced in response to the vaccine effectively cross-neutralized the SARS-CoV-2501Y.V2 variant(B.1.351).Of note,when the vaccine-induced antibodies dropped to a sufficiently low level,only one boost quickly activated the anamnestic immune response,conferring full protection against a SARSCoV-2 challenge in rhesus macaques without typical histopathological changes in the lung tissues.These results demonstrated that the SARS-CoV-2 RBD trimer vaccine candidate is highly immunogenic and safe,providing long-lasting,broad,and significant immunity protection in nonhuman primates,thereby offering an optimal vaccination strategy against COVID-19. | Limin Yang Deyu Tian Jian-bao Han Wenhui Fan Yuan Zhang Yunlong Li Wenqiang Sun Yanqiu Wei Xiaodong Tian Dan-dan Yu Xiao-li Feng Gong Cheng Yuhai Bi Yong-tang Zheng Wenjun Liu | 2021 | The Innovation2021，2，3： | 3 |
| 2 | Towards Practical Application of Li-S Battery with High Sulfur Loading and Lean Electrolyte:Will Carbon-Based Hosts Win This Race?显示文摘As the need for high-energy–density batteries continues to grow, lithium-sulfur(Li–S) batteries have become a highly promising next-generation energy solution due to their low cost and exceptional energy density compared to commercially available Li-ion batteries. Research into carbon-based sulfur hosts for Li–S batteries has been ongoing for over two decades, leading to a significant number of publications and patents.However, the commercialization of Li–S batteries has yet to be realized. This can be attributed, in part, to the instability of the Li metal anode. However, even when considering just the cathode side, there is still no consensus on whether carbon-based hosts will prove to be the best sulfur hosts for the industrialization of Li–S batteries. Recently, there has been controversy surrounding the use of carbon-based materials as the ideal sulfur hosts for practical applications of Li–S batteries under high sulfur loading and lean electrolyte conditions. To address this question, it is important to review the results of research into carbon-based hosts, assess their strengths and weaknesses, and provide a clear perspective. This review systematically evaluates the merits and mechanisms of various strategies for developing carbon-based host materials for high sulfur loading and lean electrolyte conditions. The review covers structural design and functional optimization strategies in detail, providing a comprehensive understanding of the development of sulfur hosts. The review also describes the use of efficient machine learning methods for investigating Li–S batteries. Finally, the outlook section lists and discusses current trends, challenges, and uncertainties surrounding carbon-based hosts, and concludes by presenting our standpoint and perspective on the subject. | Yi Gong Jing Li Kai Yang Shaoyin Li Ming Xu Guangpeng Zhang Yan Shi Qiong Cai Huanxin Li Yunlong Zhao | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 3 | Gravitational wave astronomy: the current status显示文摘In the centenary year of Einstein's General Theory of Relativity, this paper reviews the current status of gravitational wave astronomy across a spectrum which stretches from attohertz to kilohertz frequencies. Sect. 1 of this paper reviews the historical development of gravitational wave astronomy from Einstein's first prediction to our current understanding the spectrum. It is shown that detection of signals in the audio frequency spectrum can be expected very soon, and that a north-south pair of next generation detectors would provide large scientific benefits. Sect. 2 reviews the theory of gravitational waves and the principles of detection using laser interferometry. The state of the art Advanced LIGO detectors are then described. These detectors have a high chance of detecting the first events in the near future. Sect. 3 reviews the KAGRA detector currently under development in Japan,which will be the first laser interferometer detector to use cryogenic test masses. Sect. 4 of this paper reviews gravitational wave detection in the nanohertz frequency band using the technique of pulsar timing. Sect. 5 reviews the status of gravitational wave detection in the attohertz frequency band, detectable in the polarisation of the cosmic microwave background, and discusses the prospects for detection of primordial waves from the big bang. The techniques described in sects. 1–5 have already placed significant limits on the strength of gravitational wave sources. Sects. 6 and 7 review ambitious plans for future space based gravitational wave detectors in the millihertz frequency band. Sect. 6 presents a roadmap for development of space based gravitational wave detectors by China while sect. 7 discusses a key enabling technology for space interferometry known as time delay interferometry. | BLAIR David JU Li ZHAO ChunNong WEN LinQing CHU Qi FANG Qi CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong REITZE David H. ARAI Koji ZHANG Fan FLAMINIO Raffaele ZHU XingJiang HOBBS George MANCHESTER Richard N. SHANNON Ryan M. BACCIGALUPI Carlo GAO Wei XU Peng BIAN Xing CAO ZhouJian CHANG ZiJing DONG Peng GONG XueFei HUANG ShuangLin JU Peng LUO ZiRen QIANG Li'E TANG WenLin WAN XiaoYun WANG Yue XU ShengNian ZANG YunLong ZHANG HaiPeng LAU Yun-Kau NI Wei-Tou | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 1 |
| 4 | 1+1>2: Learning from the interfacial modulation on single-atom electrocatalysts to design dual-atom electrocatalysts for dinitrogen reduction显示文摘Developing efficient electrocatalysts for converting dinitrogen to ammonia through electrocatalysis is of significance to the decentralized ammonia production. Here, through high-throughput density functional theory calculations, we demonstrated that the interfacial modulation of hexagonal boron nitride/graphene(hBN-graphene) could sufficiently improve the catalytic activity of the single transition metal atom catalysts for nitrogen reduction reaction(NRR). It was revealed that Re@hBN-graphene and Os@hBN-graphene possessed remarkable NRR catalytic activity with low limiting potentials of 0.29 V and 0.33 V, respectively. Furthermore, the mechanism of the enhanced catalytic activity was investigated based on various descriptors of the adsorption energies of intermediates, where the synergistic effect of hBN and graphene in the hybrid substrate was found to play a key role. Motivated by the synergistic effect of hybrid substrate in single-atom catalysts, a novel strategy was proposed to efficiently design dual-atom catalysts by integrating the merits of both metal components. The as-designed dual-atom catalyst Fe-Mo@hBN exhibited more excellent NRR catalytic performance with a limiting potential of 0.17 V, manifesting the solidity of the design strategy. Our findings open new avenues for the search of heterostructure substrates for single-atom catalysts and the efficient design of dualatom catalysts for NRR. | Qiang Zhou Feng Gong Yunlong Xie Rui Xiao | 2023 | Green Energy & Environment2023，8，6： | 0 |
| 5 | Control of large linear magnetoelectricity in Co_(3)NiNb_(2)O_(9)显示文摘Magnetoelectric(ME)materials have caught worldwide attentions owing to their potential technological applications in ME switching devices or high-density data storage.However,realizing a sufficiently strong ME effect in one single material is always the key issue.Herein,we systematically investigate the Co_(3)NiNb_(2)O_(9),including the characterization of its crystalline structure,magnetism,specific heat,and pyroelectric properties.It is revealed that Co_(3)NiNb_(2)O_(9) exhibits a remarkable ME response below the magnetic phase transition temperature of TN-32 K.On one hand,the magnetic field-induced electric polarization is observed below TN while it is non-ferroelectric at no magnetic field.The evaluated ME coefficient is as large as 21.2 ps/m.On the other hand,the magnetization is significantly modulated by the applied electric field,with the inverse ME coefficient being 14.1 ps/m.The observed ME responses suggest a stable ME mutual control by the magnetic or electric field in Co_(3)NiNb_(2)O_(9). | Xiang Li Yu Wang Meifeng Liu Yunlong Xie Jiahua Min Xiyu Chen Jingwen Gong Leiyu Li Min Zeng Yiming Xu Yiru Wang Biwen Li Xiuzhang Wang Jun-Ming Liu | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 6 | Porcine enteric alphacoronavirus infection increases lipid droplet accumulation to facilitate the virus replication显示文摘Coronaviruses are widely transmissible between humans and animals, causing diseases of varying severity. Porcine enteric alphacoronavirus(PEAV) is a newly-discovered pathogenic porcine enteric coronavirus in recent years, which causes watery diarrhea in newborn piglets. The host inflammatory responses to PEAV and its metabolic regulation mechanisms remain unclear, and no antiviral studies have been reported. Therefore, we investigated the pathogenic mechanism and antiviral drugs of PEAV. The transcriptomic analysis of PEAV-infected host cells revealed that PEAV could upregulate lipid metabolism pathways. In lipid metabolism, steady-state energy processes, which can be mediated by lipid droplets(LDs), are the main functions of organelles. LDs are also important in viral infection and inflammation. In infected cells, PEAV increased LD accumulation, upregulated NF-κB signaling, promoted the production of the inflammatory cytokines IL-1β and IL-8, and induced cell death. Inhibiting LD accumulation with a DGAT-1 inhibitor significantly inhibited PEAV replication, downregulated the NF-κB signaling pathway, reduced the production of IL-1β and IL-8, and inhibited cell death. The NF-κB signaling pathway inhibitor BAY11-7082 significantly inhibited LD accumulation and PEAV replication. Metformin hydrochloride also exerted anti-PEAV effects and significantly inhibited LD accumulation, downregulated the NF-κB signaling pathway, reduced the production of IL-1β and IL-8, and inhibited cell death. LD accumulation in the lipid metabolism pathway therefore plays an important role in the replication and pathogenesis of PEAV, and metformin hydrochloride inhibits LD accumulation and the inflammatory response to exert anti-PEAV activity and reducing pathological injury. These findings contribute new targets for developing treatments for PEAV infections. | Qi Gao Yongzhi Feng Ting Gong Dongdong Wu Xiaoyu Zheng Yizhuo Luo Yunlong Yang Zebu Song Lang Gong Guihong Zhang | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 7 | Does Minimizing Ventricular Pacing Reduce the Incidence of Atrial Fibrillation ? A Systematic Review and Meta-analysis of Randomized Controlled Trials显示文摘Background:Right ventricular pacing disrupts atrioventricular synchrony and increases the risk of atrial fi brillation(AF).However,whether algorithms for minimizing ventricular pacing reduce the incidence of AF remains controversial.Therefore,we conducted a systematic review and meta-analysis to compare the incidence of AF between minimizing ventricular pacing and conventional pacing protocols in patients with pacemakers implanted.Methods:The PubMed,Embase,and Cochrane Library databases were searched up to August 1,2017,for randomized controlled trials that reported the incidence of AF in patients with and without the use of algorithms for minimizing ventricular pacing.Results:Eleven studies comprising 5705 participants(61%males,mean age 71 years[standard deviation 11 years])were fi nally included in the analysis.The mean follow-up duration was 24 months.Use of algorithms for minimizing ventricular pacing signifi cantly reduced the incidence of AF,with an odds ratio of 0.74(95%confi dence interval 0.55–1.00;P<0.05).There was moderate heterogeneity among studies(I 2=63%).Conclusions:The incidence of AF was reduced by 26%with use of algorithms for minimizing ventricular pacing.The incorporation of such algorithms in routine clinical practice should in theory lead to a decrease in AF-related morbidity and mortality. | Ishan Lakhani Mengqi Gong Cheuk Wai Wong George Bazoukis Konstantinos PLetsas Guangping Li Khalid bin Wahleed Yunlong Xia Adrian Baranchuk Gary Tse Keith Sai Kit Leung Tong Liu Dong Chang | 2020 | Cardiovascular Innovations and Applications2020，，3： | 0 |
| 8 | Advances in thermal-related analysis techniques for solid-state lithium batteries显示文摘Solid-state lithium batteries(SSLBs)have been broadly accepted as a promising candidate for the next generation lithium-ion batteries(LIBs)with high energy density,long duration,and high safety.The intrinsic non-flammable nature and electrochemical/thermal/mechanical stability of solid electrolytes are expected to fundamentally solve the safety problems of conventional LIBs.However,thermal degradation and thermal runaway could also happen in SSLBs.For example,the large interfacial resistance between solid electrolytes and electrodes could aggravate the joule heat generation;the anisotropic thermal diffusion could trigger the uneven temperature distribution and formation of hotspots further leading to lithium dendrite growth.Considerable research efforts have been devoted to exploring solid electrolytes with outstanding performance and harmonizing interfacial incompatibility in the past decades.There have been fewer comprehensive reports investigating the thermal reaction process,thermal degradation,and thermal runaway of SSLBs.This review seeks to highlight advanced thermal-related analysis techniques for SSLBs,by focusing particularly on multiscale and multidimensional thermal-related characterization,thermal monitoring techniques such as sensors,thermal experimental techniques imitating the abuse operating condition,and thermalrelated advanced simulations.Insightful perspectives are proposed to bridge fundamental studies to technological relevance for better understanding and performance optimization of SSLBs. | Jianan Wang Kai Yang Shiyi Sun Qianyue Ma Gong Yi Xin Chen Ze Wang Wei Yan Xinhua Liu Qiong Cai Yunlong Zhao | 2023 | InfoMat2023，5，4： | 0 |
| 9 | Continual driver behaviour learning for connected vehicles and intelligent transportation systems: Framework, survey and challenges显示文摘Modelling,predicting and analysing driver behaviours are essential to advanced driver assistance systems(ADAS)and the comprehensive understanding of complex driving scenarios.Recently,with the development of deep learning(DL),numerous driver behaviour learning(DBL)methods have been proposed and applied in connected vehicles(CV)and intelligent transportation systems(ITS).This study provides a review of DBL,which mainly focuses on typical applications in CV and ITS.First,a comprehensive review of the state-of-the-art DBL is presented.Next,Given the constantly changing nature of real driving scenarios,most existing learning-based models may suffer from the so-called“catastrophic forgetting,”which refers to their inability to perform well in previously learned scenarios after acquiring new ones.As a solution to the aforementioned issue,this paper presents a framework for continual driver behaviour learning(CDBL)by leveraging continual learning technology.The proposed CDBL framework is demonstrated to outperform existing methods in behaviour prediction through a case study.Finally,future works,potential challenges and emerging trends in this area are highlighted. | Zirui Li Cheng Gong Yunlong Lin Guopeng Li Xinwei Wang Chao Lu Miao Wang Shanzhi Chen Jianwei Gong | 2023 | Green Energy and Intelligent Transportation2023，2，4： | 0 |
| 10 | Driving mechanism and boundary control of urban sprawl显示文摘自从改革和洞起来,瓷器经济完成了显著开发那么做都市化。然而,在之间有一个不可避免的矛盾城市散漫并且可耕地和环境的保护。由重新定义城市散漫边界,这份报纸是在瓷器都市化上下文上为上面的冲突提供一个答案。理想的边界,中等边界和限制边界被定义为城市在空间散漫。作为一个盒子拿南京城市,三城市散漫边界基于农业陆地资源的计算在这份报纸被估计在南京的价值。结果显示出那 1 ) 综合价值农业(栽培) 在南京的陆地资源是 1. | Dongmei JIANG Xiaoshun LI Futian QU Mingyan LI Shaoliang ZHANG Yunlong GONG Xiaoping SHI Xin CHEN | 2015 | Frontiers of Environmental Science & Engineering2015，9，2： | 0 |
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