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| 1 | Preliminary Results of In-situ Stress Measurements along the Longmenshan Fault Zone after the Wenchuan M_s 8.0 Earthquake显示文摘Four months after the Wenchuan M_s 8 earthquake in western Sichuan,China,in situ stress measurements were carried out along the Longmenshan fault zone with the purpose of obtaining stress parameters for earthquake hazard assessment.In-situ stresses were measured in three new boreholes by using overcoring with the piezomagnetic stress gauges for shallow depths and hydraulic fracturing for lower depths.The maximum horizontal stress in shallow depths(~20 m) is about 4.3 MPa,oriented N19°E,in the epicenter area at Yingxiu Town,about 9.7 MPa,oriented N51°W,at Baoxing County in the southwestern Longmenshan range,and about 2.6 MPa,oriented N39°E,near Kangding in the southernmost zone of the Longmenshan range.Hydraulic fracturing at borehole depths from 100 to 400 m shows a tendency towards increasing stress with depth.A comparison with the results measured before the Wenchuan earthquake along the Longmenshan zone and in the Tibetan Plateau demonstrates that the stress level remains relatively high in the southwestern segment of the Longmenshan range,and is still moderate in the epicenter zone.These results provide a key appraisal for future assessment of earthquake hazards of the Longmenshan fault zone and the aftershock occurrences of the Wenchuan earthquake. | WU Manlu ZHANG Yueqiao LIAO Chunting CHEN Qunce MA Yinsheng WU Jinsheng YAN Junfeng OU Mingyi | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 31 |
| 2 | A Novel Mitogen-Activated Protein Kinase Gene in Maize (Zea mays),ZmMPK3,is Involved in Response to Diverse Environmental Cues显示文摘In search for components of mitogen-activated protein kinase (MAPK) cascades in maize (Zea mays) involved in response to abscisic acid (ABA) stimulus,a novel MAPK gene,ZmMPK3,from ABA-treated maize leaves cDNA was isolated and characterized.The full length of the ZmMPK3 gene is 1 520 bp and encodes a 376 amino acid protein with a predicted molecular mass of 43.5 kD and a pI of 5.83.ZmMPK3 contains all 11 MAPK conserved subdomains and the phosphorylation motif TEY.Amino acid sequence alignment revealed that ZmMPK3 shared high identity with group-A MAPK in plants.A time course (30–360 min) experiment using a variety of signal molecules and stresses revealed that the transcripts level of ZmMPK3 accumulated markedly and rapidly when maize seedlings were subjected to exogenous signaling molecules: ABA,H2O2,jasmonic acid and salicylic acid,various abiotic stimuli such as cold,drought,ultraviolet light,salinity,heavy metal and mechanical wounding.Its transcription was also found to be tissue-specific regulated.Here,we show that ABA and H2O2 induced a significant increase in the ZmMPK3 activity using immunoprecipitation and in-gel kinase assay.Furthermore,the results showed that the ZmMPK3 protein is localized mainly to the nucleus.These results suggest that the ZmMPK3 may play an important role in response to environmental stresses. | Jinxiang Wang Haidong Ding Aying Zhang Fangfang Ma Jianmei Cao Mingyi Jiang | 2010 | Journal of Integrative Plant Biology2010，52，5： | 16 |
| 3 | Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer显示文摘胰腺的癌症是有导致世界范围的高死亡率的一个高变形的潜力的好攻击的恶意。尽管巨噬细胞有潜力杀死肿瘤房间并且对肿瘤得到有免疫力的回答,有证据,联系肿瘤的巨噬细胞(TAM ) 支持肿瘤前进并且压制 T 房间回答。CC-chemokine ligand 20 (CCL20 ) 并且它的唯一的受体 CC-chemokine 受体(CCR6 ) 6 被癌症房间为移植和转移利用并且在癌症的发展和前进起重要作用。最近的研究证明了 CCL20 的表示是在胰腺的癌症的 upregulated;然而, CCL20 的行动的机制尚待充分被阐明。在这研究,包括变形胰腺的癌症织物,在胰腺的癌症织物的 TAM 的 CCL20 的异常表示被检测。CCL20 表示比在胰腺的癌症房间排队的在巨噬细胞是更加更高的,特别地在 interleukin-4-treated (M2 ) 巨噬细胞。用胰腺的癌症房间的 Boyden 房间试金,我们发现 M2 巨噬细胞分泌的 CCL20 支持了胰腺的癌症房间的迁居,上皮间充质的转变,和侵略。RNA 干扰结果证明 CCR6 是为在胰腺的癌症房间的 CCL20 的受体,调停这些房间的增加的侵略性质由 CCL20 支持了。用一个老鼠模型,我们在在 vivo 支持胰腺的癌症生长和肝转移证实了 CCR6/CCL20 的角色。我们的调查结果在胰腺的癌症提供卓见进藏匿巨噬细胞的 CCL20 的重要角色并且含有 CCR6/CCL20 同样潜在的治疗学的目标。 | Bingyan Liu Yiping Jia Jun Ma Shaoqiu Wu Haosheng Jiang Yan Cao Xianjun Sun Xiang Yin Shuo Yan Mingyi Shang Aiwu Mao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 13 |
| 4 | MiR-181a enhances drug sensitivity in mitoxantone-resistant breast cancer cells by targeting breast cancer resistance protein (BCRP/ABCG2)显示文摘 | Xuyang Jiao Lin Zhao Mengtao Ma Xuefeng Bai Miao He Yuanyuan Yan Yan Wang Qiuchen Chen Xinnan Zhao Mingyi Zhou Zeshi Cui Zhihong Zheng Enhua Wang Minjie Wei | 2013 | Breast Cancer Research and Treatment2013，，3： | 1 |
| 5 | Experiment investigation on influence of boundary conditions on cooling effect and mechanism of crushed-rock layers显示文摘 | Lai Yuanming Ma Weidong Zhang Mingyi | 2006 | Cold Regions Science and Technology2006，45，2： | 1 |
| 6 | Stomatin plays a suppressor role in non-small cell lung cancer metastasis显示文摘Objective:Metastasis is one of the key causes of high mortality in lung cancer.Aberrant DNA methylation is a common event in metastatic lung cancer.We aimed to identify new epigenetic regulation of metastasis-associated genes and characterize their effects on lung cancer progression.Methods:We screened genes associated with non-small cell lung cancer(NSCLC)metastasis by integrating datasets from the Gene Expression Omnibus(GEO)database.We obtained epigenetic-regulated candidate genes by analyzing the expression profile of demethylation genes.By overlapping analysis,epigenetically modulated metastasis-associated genes were obtained.Kaplan-Meier plotter(KM plotter)was utilized to assess the overall survival(OS)of stomatin in lung cancer.Immunohistochemistry(IHC)was conducted to determine the association between stomatin and metastasis-associated clinical indicators.Both in vitro and in vivo assays were performed to investigate the potential role of stomatin in metastasis.The regulation mechanisms of transforming growth factorβ1(TGFβ1)on stomatin were determined by Sequenom MassARRAY quantitative methylation and western blot assays.Results:A series of bioinformatic analyses revealed stomatin as the metastasis-associated gene regulated by DNA methylation.The KM plotter analysis showed a positive association between stomatin and the OS of lung cancer.IHC analysis indicated that the decreased stomatin expression is linked with advanced TNM stage.Loss-and gainof-function experiments displayed that stomatin could inhibit the migration and invasion of NSCLC cells.Furthermore,TGFβ1 repressed stomatin expression during epithelial-to-mesenchymal transition(EMT).The negative correlation between stomatin and TGFβ1 was also validated in advanced stage III lung tumor samples.The underlying mechanism by which TGFβ1 inhibits stomatin is due in part to DNA methylation.Conclusions:Our results suggest that stomatin may be a target for epigenetic regulation and can be used to prevent metastatic diseases. | Huaying An Xiao Ma Mingyi Liu Xiaotong Wang Xundong Wei Wei Yuan Jie Ma | 2019 | Chinese Journal of Cancer Research2019，31，6： | 1 |
| 7 | Inhibitory Effect of Tanshinones on TNF-α-induced Inflammation in Human Aortic Endothelial Cells显示文摘[Objectives] To study the anti-inflammatory activity and mechanism of tanshinone I,cryptotanshinone and 15,16-dihydrotanshinone I on HAECs induced by TNF-α. [Methods]Vitamin E was used as a positive control and TNF-α-induced human aortic endothelial cells( HAECs) were selected as the inflammation model cells. The m RNA levels of IL-6,ICAM-1,VCAM-1,and NF-κB were analyzed by quantitative RT-PCR. The protein expression of NF-κB,ICAM-1,VCAM-1 and phosphorylation of ERK1/2 were determined by Western blot. The adhesion of U937 to HAECs was assessed by BCECF/AM labeling assay. [Results] TNF-α-induced over-expression of IL-6,NF-κB,ICAM-1,and VCAM-1 in HAECs were down-regulated by tanshinone I( TAN),cryptotanshinone( CPT) and 15,16-dihydrotanshinone I( DHT) both in m RNA and protein levels,respectively. Meanwhile 15,16-dihydrotanshinone I and cryptotanshinone could inhibit phosphorylation of ERK1/2 and tanshinone I inhibited U937 adhesion to HAECs significantly. [Conclusions] Tanshinones could inhibit TNF-α induced inflammatory responses on HAECs and the mechanism might be related to inhibition of phosphorylation of ERK1/2 and blocking NF-κB signaling pathway. | Ziru ZHANG Mingyi MA Longru SUN | 2018 | Medicinal Plant2018，9，3： | 1 |
| 8 | Effect of the Intro- duction of Polydimethylsiloxane on the Foaming Behavior of Block-Copolymerized Polypropylene 显示文摘 | Wang Mingyi Ma Jun Chu R | 2012 | J Appl Polym Sci2012，123，5： | 1 |
| 9 | Evidence for a predisposing background for CAG expansion leading to HTY mutation in a Chinese population 显示文摘 | Ma Mingyi Yang Yuan Shang Huifang | 2010 | J Neurol Sci2010，298，12： | 1 |
| 10 | Experimental investigation on influence of boundary conditions on cooling effect and mechanism of crushed-rock layers 显示文摘 | Yuanming Lai Weidong Ma Mingyi Zhang | 2006 | Cold Regions Science and Technology2006，45，2： | 1 |
| 11 | Human cytomegalovirus RNA2.7 inhibits RNA polymeraseⅡ(PolⅡ)Serine-2 phosphorylation by reducing the interaction between PolⅡand phosphorylated cyclin-dependent kinase 9(pCDK9)显示文摘Human cytomegalovirus(HCMV)is a ubiquitous pathogen belongs to betaherpesvirus subfamily.RNA2.7 is a highly conserved long non-coding RNA accounting for more than 20%of total viral transcripts.In our study,functions of HCMV RNA2.7 were investigated by comparison of host cellular transcriptomes between cells infected with HCMV clinical strain and RNA2.7 deleted mutant.It was demonstrated that RNA polymeraseⅡ(PolⅡ)-dependent host gene transcriptions were significantly activated when RNA2.7 was removed during infection.A145 nt-in-length motif within RNA2.7 was identified to inhibit the phosphorylation of PolⅡSerine-2(PolⅡS2)by reducing the interaction between PolⅡand phosphorylated cyclin-dependent kinase 9(pCDK9).Due to the loss of PolⅡS2 phosphorylation,cellular DNA pre-replication complex(pre-RC)factors,including Cdt1 and Cdc6,were significantly decreased,which prevented more cells from entering into S phase and facilitated viral DNA replication.Our results provide new insights of HCMV RNA2.7 functions in regulation of host cellular transcription. | Yujing Huang Xin Guo Jing Zhang Jianming Li Mingyi Xu Qing Wang Zhongyang Liu Yanping Ma Ying Qi Qiang Ruan | 2022 | Virologica Sinica2022，37，3： | 0 |
| 12 | Label-free breast cancer detection and classification by convolutional neural network-based on exosomes surface-enhanced raman scattering显示文摘Because the breast cancer is an important factor that threatens women's lives and health,early diagnosis is helpful for disease screening and a good prognosis.Exosomes are nanovesicles,secreted from cells and other body fluids,which can reflect the genetic and phenotypic status of parental cells.Compared with other methods for early diagnosis of cancer(such as circulating tumor cells(CTCs)and circulating tumor DNA),exosomes have a richer number and stronger biological stability,and have great potential in early diagnosis.Thus,it has been proposed as promising biomarkers for diagnosis of early-stage cancer.However,distinguishing different exosomes remain is a major biomedical challenge.In this paper,we used predictive Convolutional Neural model to detect and analyze exosomes of normal and cancer cells with surface-enhanced Raman scattering(SERS).As a result,it can be seen from the SERS spectra that the exosomes of MCF-7,MDA-MB-231 and MCF-10A cells have similar peaks(939,1145 and 1380 cm^(-1)).Based on this dataset,the predictive model can achieve 95%accuracy.Compared with principal component analysis(PCA),the trained CNN can classify exosomes from different breast cancer cells with a superior performance.The results indicate that using the sensitivity of Raman detection and exosomes stable presence in the incubation period of cancer cells,SERS detection combined with CNN screening may be used for the early diagnosis of breast cancer in the future. | Xiao Ma Honglian Xiong Jinhao Guo Zhiming Liu Yaru Han Mingdi Liu Yanxian Guo Mingyi Wang Huiqing Zhong Zhouyi Guo | 2023 | Journal of Innovative Optical Health Sciences2023，16，2： | 0 |
| 13 | Direct incorporation of paraffin wax as phase change material into mass concrete for temperature control: mechanical and thermal properties显示文摘Taking advantage of heat absorbing and releasing capability of phase change material(PCM),Paraffin wax-based concrete was prepared to assess its automatic temperature control performance.The mechanical properties of PCM concrete with eight different Paraffin wax contents were tested by the cube compression test and four-point bending test.The more Paraffin wax incorporated,the greater loss of the compressive strength and bending strength.Based on the mechanical results,four contents of Paraffin wax were chosen for studying PCM concrete's thermal properties,including thermal conductivity,thermal diffusivity,specific heat capacity,thermal expansion coefficient and adiabatic temperature rise.When the Paraffin wax content increases from 10%to 20%,the thermal conductivity and the thermal diffusivity decrease from 7.31 kJ/(m·h·°C)to 7.10 kJ/(m·h·°C)and from 3.03×10−3 m2/h to 2.44×10−3 m2/h,respectively.Meanwhile the specific heat capacity and thermal expansion coefficient rise from 5.38×10−1 kJ/(kg·°C)to 5.76×10−1 kJ/(kg·°C)and from 9.63×10−6/°C to 14.02×10−6/°C,respectively.The adiabatic temperature rise is found to decrease with an increasing Paraffin wax content.Considering both the mechanical and thermal properties,15%of Paraffin wax was elected for the mass concrete model test,and the model test results confirm the effect of Paraffin wax in automatic mass concrete temperature control. | Tao Luo JuanJuan Ma Fang Liu MingYi Zhang ChaoWei Sun YanJun Ji XiaoSa Yuan | 2021 | Research in Cold and Arid Regions2021，13，1： | 0 |
| 14 | Plasmonic polydopamine-modified TiO_(2)nanotube substrates for surface-assisted laser desorption/ionization mass spectrometry imaging显示文摘Mass spectrometry imaging(MSI)has made the spatio-chemical characterization of a broad range of small-molecule metabolites within biological tissues possible.However,available matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)suffers from severe background interferences in low-mass ranges and inhomogeneous matrix deposition.Thus,surface-assisted LDI-MS(SALDI-MS)has been an attractive alternative for high-sensitivity detection and imaging of small biomolecules.In this study,we construct a new composite substrate,hydrophobic polydopamine(hPDA)-modified TiO_(2)nanotube(TDNT)coated with plasmonic gold nanoparticle(AuNP-hPDA-TDNT),as a dual-polarity SALDI substrate using an easy and cost-effective fabrication approach.Benefitting from the synergistic effects of TDNT semiconductor and plasmonic PDA modification,this SALDI substrate exhibits superior performance for dual-polarity detection of a vast diversity of small molecules.Highly reduced background interferences,lower detection limits,and spot-to-spot repeatability can be achieved using AuNP-hPDA-TDNT substrates.Due to its unique imprinting performance,various metabolites and lipids can be visualized within jatropha integerrima petals,ginkgo leaves,strawberry fruits,and latent fingerprints.More valuably,the universality of this matrix-free substrate is demonstrated for mapping spatial distribution of lipids within mouse brain tissue sections.Considered together,this AuNP-hPDA-TDNT material is expected to be a promising SALDI substrate in various fields,especially in nanomaterial development and life sciences. | Dong Chen Mingyi Du Yudi Huang Yizhu Xu Yingying Chen Lianlian Ma Qingrong Xie Xinhai Zhu Zilong Chen Hanhong Xu Xinzhou Wu Zhibin Yin | 2023 | Nano Research2023，16，2： | 0 |
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