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| 1 | Electroacupuncture at Dazhui(GV14) and Mingmen(GV4) protects against spinal cord injury:the role of the Wnt/β-catenin signaling pathway显示文摘Electroacupuncture at Dazhui(GV14) and Mingmen(GV4) on the Governor Vessel has been shown to exhibit curative effects on spinal cord injury; however, the underlying mechanism remains poorly understood. In this study, we established rat models of spinal cord injury using a modified Allen's weight-drop method. Ninety-nine male Sprague-Dawley rats were randomly divided into three equal groups: sham(only laminectomy), SCI(induction of spinal cord injury at T10), and EA(induction of spinal cord injury at T10 and electroacupuncture intervention at GV14 and GV4 for 20 minutes once a day). Rats in the SCI and EA groups were further randomly divided into the following subgroups: 1-day(n = 11), 7-day(n = 11), and 14-day(n = 11). At 1, 7, and 14 days after electroacupuncture treatment, the Basso, Beattie and Bresnahan locomotor rating scale showed obvious improvement in rat hind limb locomotor function, hematoxylin-eosin staining showed that the histological change of injured spinal cord tissue was obviously alleviated, and immunohistochemistry and western blot analysis showed that Wnt1, Wnt3 a, β-catenin immunoreactivity and protein expression in the injured spinal cord tissue were greatly increased compared with the sham and SCI groups. These findings suggest that electroacupuncture at GV14 and GV4 upregulates Wnt1, Wnt3 a, and β-catenin expression in the Wnt/β-catenin signaling pathway, exhibiting neuroprotective effects against spinal cord injury. | Xin Wang Su-hua Shi Hai-jiang Yao Quan-kai Jing Yu-ping Mo Wei Lv Liang-yu Song Xiao-chen Yuan Zhi-gang Li Li-na Qin | 2016 | Neural Regeneration Research2016，11，12： | 13 |
| 2 | Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation. | GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 3 | Petroleum Geology in Deepwater Settings in a Passive Continental Margin of a Marginal Sea:A Case Study from the South China Sea显示文摘Deepwater oil and gas exploration has become a global hotspot in recent years and the study of the deep waters of marginal seas is an important frontier research area.The South China Sea(SCS)is a typical marginal sea that includes Paleo SCS and New SCS tectonic cycles.The latter includes continental marginal rifting,intercontinental oceanic expansion and oceanic shrinking,which controlled the evolution of basins,and the generation,migration and accumulation of hydrocarbons in the deepwater basins on the continental margin of the northern SCS.In the Paleogene,the basins rifted along the margin of the continent and were filled mainly with sediments in marine-continental transitional environments.In the Neogene–Quaternary,due to thermal subsidence,neritic-abyssal facies sediments from the passive continental margin of the SCS mainly filled the basins.The source rocks include mainly Oligocene coal-bearing deltaic and marine mudstones,which were heated by multiple events with high geothermal temperature and terrestrial heat flow,resulting in the generation of gas and oil.The faults,diapirs and sandstones controlled the migration of hydrocarbons that accumulated principally in a large canyon channel,a continental deepwater fan,and a shelf-margin delta. | ZHANG Gongcheng FENG Congjun YAO Xingzong JI Mo YANG Haizhang QU Hongjun ZENG Qingbo ZHAO Zhao SUN Rui | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 6 |
| 4 | Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).SARS-Co V-2 infection was first detected in Wuhan,China in late December 2019.The virus was spreading rapidly to other cities of China and accumulating cases had been reported(Li et al.2020). | Xiaoping Chen Qunqun Jiang Zhiyong Ma Jiaxin Ling Wenjia Hu Qian Cao Pingzheng Mo Lei Yao Rongrong Yang Shicheng Gao Xien Gui Wei Hou Yong Xiong Jinlin Li Yongxi Zhang | 2020 | Virologica Sinica2020，35，6： | 6 |
| 5 | THE SINGULARLY PERTURBED BOUNDARY VALUE PROBLEMS FOR SEMILINEAR ELLIPTIC EQUATION显示文摘The singularly perturbed boundary value problems for the semilinear elliptic equation are considered. Under suitable conditions and by using the fixed point theorem, the existence, uniqueness and asymptotic behavior of solution for the boundary value problems are studied. | Mo Jiaqi Yao Jingsun | 2001 | Analysis in Theory and Applications2001，17，4： | 5 |
| 6 | Synthesis, Microstructure and Optical Absorption of Coatings with Doping of Nano-TiO_2 for Protection Against UltravioletIrradiation显示文摘The synthesis of dispersions of MMA (methylmethacrylate) with different concentrations of oleic acid coated nano-TiO2 particles was performed by hydrolysis of TiCI4 in the mixture solutions of MMA, oleic acid and H2O with various concentrations. When MMA: oleic acid: H2O : TiCi4 =1.00: 0.064 : 0.01: 0.032 (by mol fraction), the dispersion of MMA with oleic acid coated nano-TiO2 particles was very stable. Optical absorption result showed that the absorption band was located in the ultraviolet range from 200 to 400 nm. This dispersion was added to a kind of automobile surface lustering agent (type II), and then this lustering agent with nano-TiO2 was coated on the surface of automobile surface paint. When the doping amount of the dispersion in the lustering agent=10 vol. pct, the state of paint (color and glossiness) did not present any change after irradiation of an ultraviolet lamp with the power of 1000 watt for two days. The sample with surface paint and lustering agent doped by 10 percent dispersion after suffering from irradiation of the sunlight for half a year (from May to November) kept the original state. However, for the samples with automobile paint and lustering agent without doping of nano- TiO2, the color and glossiness lost easily after irradiation of an ultraviolet lamp. These results prove that nano-TiO2 is a kind of high-efficient additive of paint for protection against ultraviolet irradiation. | Ye ZHANG and Lide ZHANG (Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China) Chimei MO, Yuanhong LI, Lianzeng YAO and Weili CAI (Department of Materials Science and Engineering, University of Science and Technology of China | 2000 | Journal of Materials Science & Technology2000，16，3： | 5 |
| 7 | GENERALIZED SOLUTION OF SINGULARLY PERTURBED PROBLEMS FOR REACTION DIFFUSION EQUATIONS显示文摘The singularly perturbed initial boundary value problem for reaction diffusion equation is considered. Under suitable conditions the existence, uniqueness and asymptotic behavior of the generalized solution for the problems are studied. | Yao Jingsun Mo Jiaqi | 2006 | Annals of Differential Equations2006，22，1： | 4 |
| 8 | Diagonal-symmetrical and Midline-symmetrical Unit Cells with Same Porosity for Bone Implant: Mechanical Properties Evaluation显示文摘In this study, mechanical properties of bionic porous structures with diagonal-symmetrical and midline-symmetrical unit cells were studied when the porosities were same. Three typical unit cells (Diamond (DO), Rhombic Dodecahedron (RD), and Octet Truss (OT)) were selected, in which DO has diagonal-symmetrical shape, while RD and OT share midline-symmetrical structure. Based on the same porosity, corresponding models were designed, and Ti6Al4V samples were manufactured by electron beam melting. Then, using Mechanical Properties Testing (MPT) and Finite Element Analysis (FEA) methodologies, mechanical properties and transmissions of different porous structures were evaluated. Besides, composition and details before and after printing were analyzed with Energy Dispersive Spectrometer (EDS), X-ray diffraction (XRD) and Scanning Electron Microscope (SEM). MPT results showed that midline-symmetrical shape would have superior compressive performance than diagonal-symmetrical shape, but opposite trend for the torsion performance, which were in line with FEA prediction. Furthermore, effective modulus of DO, RD and OT were 2.59 GPa, 4.89 GPa, and 1.77 GPa, approximating the mechanical properties of human bones. Additionally, manufacturing defects and discrepancies between FEA and MPT were found. This study would provide great helps for unit cell selection and initial mechanical properties matching for optimum bone implants. | Jian Li Diansheng Chen Yingying Zhang Yan Yao Zhongjun Mo Lizhen Wang Yubo Fan | 2019 | Journal of Bionic Engineering2019，16，3： | 4 |
| 9 | THE NONLINEAR NONLOCAL SINGULARLY PERTURBED PROBLEMS FOR REACTION DIFFUSION EQUATIONS WITH A BOUNDARY PERTURBATION显示文摘The nonlinear nonlocal singularly perturbed initial boundary value problems for reaction diffusion equations with a boundary perturbation is considered. Under suitable conditions, the outer solution of the original problem is obtained. Using the stretched variable, the composing expansion method and the expanding theory of power series the initial layer is constructed. And then using the theory of differential inequalities the asymptotic behavior of solution for the initial boundary value problems is studied. Finally the existence and uniqueness of solution for the original problem and the uniformly valid asymptotic estimation are discussed. | Jingsun Yao Jiaqi Mo | 2005 | Analysis in Theory and Applications2005，21，3： | 4 |
| 10 | Structural design and parameter determination for fluted-roller fertilizer applicator显示文摘The instability of the motion layer of fertilizer particle influences the precision and the accuracy of the amount of fertilizer application in the working process of fluted-roller fertilizer applicator.The characteristics of the motion layer were investigated,and a systematic scheme was proposed for designing the structures of fertilizer-filling cavity,fertilizer-filling surface and fertilizer-delivery cavity.The key parameters of the structure were studied by discrete element method.It was figured out that to ensure the smooth operation of fertilizer applicator,the fertilizer-filling angle was 105°,fertilizer-contact angle should be large than 100°,and the fertilizer-resistance angle should be smaller than 35°.Moreover,the stability of fertilizer motion morphology was investigated to verify the design.The results showed that when the roll rotational speed was larger than 120 deg/s,compared with the conventional design the CV of the amount of fertilizer application was reduced from 1.5%-3.5%to 0.5%-1.0%,and the accuracy of the fertilizer discharge was improved with the square of the correlation coefficient between the amount of fertilizer application and the roll rotational speed was larger than 0.999.It was deduced from the results that the precision and accuracy of the amount of fertilizer application are improved via eliminating the driving layer and enhancing the stable filling and conveying of the forced layer. | Shan Zeng Yipeng Tan Yu Wang Xiwen Luo Lamei Yao Dengpan Huang Zewen Mo | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 4 |
| 11 | B7-H4 expression is elevated in human U251 glioma stem-like cells and is inducible in monocytes cultured with U251 stem-like cell conditioned medium显示文摘Previous studies indicated that B7-H4,the youngest B7 family,negatively regulates T cell-mediated immunity and is significantly overexpressed in many human tumors.Tumor stem cells are purported to play a role in tumor renewal and resistance to radiation and chemotherapy.However,the link between B7-H4and tumor stem cells is unclear.In this study,we investigated B7-H4 expression in the medium of human glioma U251 cell cultures.Immunofluorescence results showed that U251 cells cultured in serum-free medium(supplemented with 2%B27,20 ng/mL epidermal growth factor,20 ng/mL basic fibroblast growth factor)maintained stem-like cell characteristics,including expression of stem cell marker CD133 and the neural progenitor cell markers nestin and SOX2.In contrast,U251 cells cultured in serum-containing medium highly expressed differentiation marker glial fibrillary acidic protein.Flow cytometry analysis showed serum-free medium-cultured U251 cells expressed higher intracellular B7-H4 than serumcontaining medium-cultured U251 cells(24%-35%vs.8%-11%,P<0.001).Immunofluorescence in purified monocytes from normal human peripheral blood mononuclear cells revealed moderate expression of B7-H4 after stimulation with conditioned medium from U251 cells cultured in serum-containing medium.Moreover,conditioned medium from U251 stem-like cells had a significant stimulation effect on B7-H4expression compared with serum-containing conditioned medium(P<0.01).Negative costimulatory molecule B7-H4 was preferentially expressed in U251 stem-like cells,and conditioned medium from these cells more effectively induced monocytes to express B7-H4 than conditioned medium from U251 cells cultured in the presence of serum.Our results show that U251 stem-like cells may play a more crucial role in tumor immunoloregulation with high expression of B7-H4. | Lian-Jie Mo Hong-Xing Ye Ying Mao Yu Yao Jian-Min Zhang | 2013 | Chinese Journal of Cancer2013，32，12： | 3 |
| 12 | Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation显示文摘Resveratrol(RES),a non-flavonoid polyphenol extracted from a wide variety of plants,exhibits neuroprotective activities against Parkinson’s disease(PD).However,undesirable water solubility of RES reduces its oral bioavailability and demonstrates lowefficacy in blood and brain,thus limiting its application.In present study,a nanocrystal formulation of RES(RES-NCs)was developed to enhance its oral bioavailability and delivery into brain for PD treatment.RES-NCs were fabricated with hydroxypropyl methylcellulose(HPMC)stabilizer via antisolvent precipitation approach.The obtained RES-NCs displayed the particle size of 222.54±1.66 nm,the PDI of 0.125±0.035,the zeta potential of−9.41±0.37mV,and a rapid in vitro dissolution rate.Molecular dynamics simulation of RES and HPMC revealed an interaction energy of−68.09 kJ/mol and a binding energy of−30.98±0.388 kJ/mol,indicating that the spontaneous binding between the two molecules is through van der Waals forces.RES-NCs conferred enhanced cellular uptake as well as improved permeability relative to pure RES.In addition,RES-NCs were able to protect neurons against cytotoxicity induced by MPP+.Meanwhile,RES-NCs exerted no significant toxic effects on zebrafish embryos and larvae,and did not influence their survival and hatching rates.When orally administered to rats,RES-NCs exhibited more favorable pharmacokinetics than pure RES,with higher plasma and brain concentrations.More importantly,MPTP-induced PD mice showed notable improvements in behavior,attenuated dopamine deficiency,and elevated levels of dopamine and its metabolites after the treatment with RES-NCs.Furthermore,immunoblot analysis revealed that the neuroprotective role of RES-NCsmay be at least partially mediated by Akt/Gsk3βsignaling pathway.Taken altogether,RES-NCs can serve as a potential treatment modality for PD,offering means of improving RES oral bioavailability and brain accumulation. | Sha Xiong Wei Liu Yile Zhou Yousheng Mo Yao Liu Xiaojia Chen Huafeng Pan Dongsheng Yuan QiWang Tongkai Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，4： | 3 |
| 13 | THE SOLVABILITY FOR NONLINEAR SINGULARLY PERTURBED DIFFERENTIAL SYSTEM显示文摘The solvability for the nonlinear singularly perturbed boundary value pro- blem of differential system is considered.Using the boundary layer corrective method the formal asymptotic solution is constructed.And using the theory of differential inequality proves the uniform validity of the asymptotic expansion for the solution. | Yao Jingsun Chen Lihua Mo Jiaqi | 2007 | Annals of Differential Equations2007，23，3： | 2 |
| 14 | Evolutionary biogeography on Ophiocordyceps sinensis:An indicator of molecular phylogeny to geochronological and ecological exchanges显示文摘The fungus Ophiocordyceps sinensis is endemic to the vast region of the Qinghai-Tibetan plateau(QTP).The unique and complex geographical environmental conditions have led to the 'sky island' distribution structure of O.sinensis.Due to limited and unbalanced sample collections,the previous data on O.sinensis regarding its genetic diversity and spatial structure have been deemed insufficient.In this study,we analyzed the diversity and phylogeographic structures of O.sinensis using internally transcribed spacer region(ITS) and 5-locus datasets by a large-scale sampling.A total of 111 haplotypes of ITS sequences were identified from 948 samples data of the fungus O.sinensis,with representing high genetic diversity,and 8 phylogenetic clades were recognized in O.sinensis.Both the southeastern Tibet and the northwestern Yunnan were the centers of genetic diversity and genetic differentiation of the fungus,and they were inferred as the glacial refugia in the Quaternary.Three distribution patterns were identified to correspond to the 8 clades,including but not limited to the coexistence of widely and specific local distributive structures.It also revealed that the differentiation pattern of O.sinensis did not fit for the isolation-by-distance model.The differentiation into the 8 clades occurred between 1.56 Myr and6.62 Myr.The ancestor of O.sinensis most likely originated in the late Miocene(6.62 Myr) in the northwestern Yunnan,and the Scene A-C of the Qinghai-Tibetan movements may have played an important role in the differentiation of O.sinensis during the late Miocene-Pliocene periods.Our current results provide a much clearer and detailed understanding of the genetic diversity and geographical spatial distribution of the endemic alpine fungus O.sinensis.It also revealed that the geochronology resulting from paleogeology could be cross-examined with biomolecular clock at a finer scale. | Yongdong Dai Changkui Wu Feng Yuan Yuanbing Wang Luodong Huang Zihong Chen Wenbo Zeng Yao Wang Zhuliang Yang Pusheng Zeng Paul Lemetti Xuanxue Mo Hong Yu | 2020 | Geoscience Frontiers2020，11，3： | 2 |
| 15 | Effects of Application of Cassava Alcohol Anaerobic Fermentation Liquid and Mulching of Film on Overwintering and Next Year's Growth and Yield of Banana显示文摘The effects of application of cassava alcohol anaerobic fermentation liquid and mulching of film on overwintering and next year's growth and yield of banana were investigated in this study.The results showed that the application of cassava alcohol anaerobic fermentation liquid with COD concentration of 1 200-2 000 mg/L(900 m^3/hm^2) and mulching of film significantly increased the soil organic matter and available potassium contents in banana orchard,improved the cold resistance of banana seedlings,increased the pseudostem height,pseudostem circumference,green leaf number and chlorophyll content of next year's banana seedlings,brought the flower bud emergence period and harvest period forward,and significantly increased the yield per plant. | Yunchuan MO Yingyi DENG Xu ZHENG Yixin YE Ganhui MO Minzheng WEI Weiliu LI Feng LI Jiechun PAN Chanchan QIN Meiling SU Yao FU | 2016 | Agricultural Science & Technology2016，17，7： | 2 |
| 16 | Shock Solution for a Class of Nonlinear Elliptic Equation显示文摘The boundary value problem for the nonlinear elliptic equation is considered. The outer solution for the original problem is obtained. The boundary and interior layer correction terms are constructed by introducing stretched variables and setting local coordinate systems near the boundary and interior discontinuous point of outer solution. Under suitable conditions, using the differential inequalities and the mean value theorem, the existence of the shock solution for boundary value problem is proved and the asymptotic behavior of the solution is studied. | CHEN Lihua YAO Jingsun MO Jiaqi | 2011 | Wuhan University Journal of Natural Sciences2011，16，4： | 2 |
| 17 | Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy显示文摘Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors;however,its efficacy towards solid cancer remains challenging.We therefore focused on developing nanobody-based CAR-T cells that treat the solid tumor.CD105 expression is upregulated on neoangiogenic endothelial and cancer cells.CD105 has been developed as a drug target.Here we show the generation of a CD105-specific nanobody,an anti-human CD105 CAR-T cells,by inserting the sequences for anti-CD105 nanobody-linked standard cassette genes into AAVS1 site using CRISPR/Cas9 technology.Co-culture with CD105+target cells led to the activation of anti-CD105 CAR-T cells that displayed the typically activated cytotoxic T-cell characters,ability to proliferate,the production of pro-inflammatory cytokines,and the specific killing efficacy against CD105+target cells in vitro.The in vivo treatment with anti-CD105 CAR-T cells significantly inhibited the growth of implanted CD105+tumors,reduced tumor weight,and prolonged the survival time of tumor-bearing NOD/SCID mice.Nanobody-based CAR-T cells can therefore function as an antitumor agent in human tumor xenograft models.Our findings determined that the strategy of nanobody-based CAR-T cells engineered by CRISPR/Cas9 system has a certain potential to treat solid tumor through targeting CD105 antigen. | Fengzhen Mo Siliang Duan Xiaobing Jiang Xiaomei Yang Xiaoqiong Hou Wei Shi Cueva Jumbo Juan Carlos Aiqun Liu Shihua Yin Wu Wang Hua Yao Zihang Yu Zhuoran Tang Shenxia Xie Ziqiang Ding Xinyue Zhao Bruce D.Hammock Xiaoling Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 18 | MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages显示文摘 | Min Zhang Jian-Feng Wu Wu-Jun Chen Shi-Lin Tang Zhong-Cheng Mo Yan-Yan Tang Yuan Li Jia-Lin Wang Xiang-Yu Liu Juan Peng Kong Chen Ping-Ping He Yun-Cheng Lv Xin-Ping Ouyang Feng Yao Deng-Pei Tang Francisco S. Cayabyab Da-Wei Zhang Xi-Long Zheng Guo-Ping Ti | 2014 | Atherosclerosis2014，，1： | 2 |
| 19 | A Tumorigenic Factor Interactome Connected through Tumor Suppressor MicroRNA-198 in Human Pancreatic Cancer显示文摘 | Christian Marin-Muller Dali Li Uddalak Bharadwaj Min Li Changyi Chen Sally E. Hodges William E. Fisher Qianxing Mo Mien-Chie Hung Qizhi Yao | 2013 | Clinical Cancer Research2013，，21： | 2 |
| 20 | Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration显示文摘Osteochondral defects(OCD)cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and inflammation.Conventional strategies,such as the control of implant microstructure or the introduction of growth factors,have limited functions failing to manage these complex environments.Here we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes(CuTA@SF)to provide a suitable microenvironment for enhanced OCD regeneration.The incorporation of CuTA nanozymes endowed the SF hydrogel with a uniform microstructure and elevated hydrophilicity.In vitro cultivation of mesenchymal stem cells(MSCs)and chondrocytes showed that CuTA@SF hydrogel accelerated cell proliferation and enhanced cell viability,as well as had antioxidant and antibacterial properties.Under the inflammatory environment with the stimulation of IL-1β,CuTA@SF hydrogel still possessed the potential to promote MSC osteogenesis and deposition of cartilage-specific extracellular matrix(ECM).The proteomics analysis further confirmed that CuTA@SF hydrogel promoted cell proliferation and ECM synthesis.In the full-thickness OCD model of rabbit,CuTA@SF hydrogel displayed successfully in situ OCD regeneration,as evidenced by micro-CT,histology(HE,S/O,and toluidine blue staining)and immunohistochemistry(Col I and aggrecan immunostaining).Therefore,CuTA@SF hydrogel is a promising biomaterial targeted at the regeneration of OCD. | Zhicheng Cao Hongmei Wang Jialin Chen Yanan Zhang Qingyun Mo Po Zhang Mingyue Wang Haoyang Liu Xueyang Bao Yuzhi Sun Wei Zhang Qingqiang Yao | 2023 | Bioactive Materials2023，，2： | 2 |
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