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| 1 | Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure显示文摘SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart.Here we show that the early postnatal hearts expressed the highest level of SIRT1deacetylase activity compared to adult and aged hearts.We generated transgenic mice with cardiac-specific expression of a dominant-negative form of the human SIRT1(SIRT1H363Y),which represses endogenous SIRT1 activity.The transgenic mice displayed dilated atrial and ventricular chambers,and died early in the postnatal period.Pathological,echocardiographic and molecular phenotype confirmed the presence of dilated cardiomyopathy.Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis revealed a greater abundance of apoptotic nuclei in the hearts of transgenic mice.Furthermore,we show that cardiomyocyte apoptosis caused by suppression of SIRT1 activity is,at least in part,due to increased p53acetylation and upregulated Bax expression.These results indicate that dominant negative form of SIRT1(SIRT1H363Y)overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure,suggesting a critical role of SIRT1 in preserving normal cardiac development during the early postnatal period. | MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei | 2014 | Science China(Life Sciences)2014，57，9： | 12 |
| 2 | Structural basis of Zika virus helicase in recognizing its substrates显示文摘Zika 的最近的爆炸爆发病毒(ZIKV ) 感染在南方和中美洲和加勒比海被报导了。与 ZIKV 感染联系的新生的头小畸型已经引起了国际担心的一种公共健康紧急情况。没有特定的疫苗或药当前是可得到的治疗 ZIKV 感染。ZIKV helicase,在病毒的 RNA 复制起一个枢轴的作用,是为治疗的一个吸引人的目标。我们决定了 ZIKV helicase-ATP-Mn 2+ 和 ZIKV helicase-RNA 的水晶结构。这是到 ATP 的任何 flavivirus helicase 界限的第一结构。有相关 flavivirus helicases 的比较证明了尽管在活跃地点的批评 P 环在不同种类之中有可变符合构造,认出 ATP/Mn 2+ 采用一个相同模式。ZIKV helicase-RNA 的结构表明了在 RNA 绑定之上,马达领域的旋转能引起重要 conformational 变化。惊人地,尽管 ZIKV 和登革热病毒(DENV ) apo-helicases 份额为 RNA 绑定保存了残余,他们在为 RNA 识别的不同单个模式的马达域旋转结果的不同礼貌。它建议 flavivirus helicases 能发展了一台保存引擎为 RNA 放松,而是不同马达领域旋转从 nucleoside triphosphate 把化学能变换成机械精力在可变 RNA 识别的结果适应单个病毒的复制的模式。 | Hongliang Tian Xiaoyun Ji Xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang Cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao | 2016 | Protein & Cell2016，7，8： | 3 |
| 3 | Obser- vations and Mechanistic Insights on Unusual Stability of Neu- tral Nickel Complexes with a Sterically Crowded Metal Center 显示文摘 | Song Dongpo Wang Yongxia Mu Hongliang | 2011 | Organometallics2011，30，5： | 1 |
| 4 | Highly active single-component neutral nickel ethylene polymerization catalysts: The influence of electronic effects and spectator ligands显示文摘 | Mu Hongliang Ye Weiping Song Dongpo | 2010 | Organometallics2010，29，： | 1 |
| 5 | Effect of topography on the changes of Urumqi Glacier No.1 in the Chinese Tianshan Mountains显示文摘Topography plays an important role in determining the glacier changes.However,topography has often been oversimplified in the studies of the glacier changes.No systematic studies have been conducted to evaluate the relationship between the glacier changes and topographic features.The present study provided a detailed insight into the changes in the two branches(east branch and west branch)of Urumqi Glacier No.1 in the Chinese Tianshan Mountains since 1993 and systematically discussed the effect of topography on the glacier parameters.This study analyzed comprehensive recently observed data(from 1992/1993 to 2018/2019),including mass balance,ice thickness,surface elevation,ice velocity,terminus,and area,and then determined the differences in the changes of the two branches and explored the effect of topography on the glacier changes.We also applied a topographic solar radiation model to analyze the influence of topography on the incoming shortwave radiation(SW_(in))across the entire glacier,focusing on the difference in the SW_(in) between the two branches.The glacier mass balance of the east branch was more negative than that of the west branch from 1992/1993 to 2018/2019,and this was mainly attributed to the lower average altitude of the east branch.Compared with the west branch,the decrease rate of the ice velocity was lower in the east branch owing to its relatively increased slope.The narrow shape of the west branch and its southeast aspect in the earlier period resulted in a larger glacier terminus retreat of the west branch.The spatial variability of the SW_(in) across the glacier surface became much larger as altitude increased.The SW_(in) received by the east branch was slightly larger than that received by the west branch,and the northern aspect could receive more SW_(in),leading to glacier melting.In the future,the difference of the glacier changes between the two branches will continue to exist due to their topographic differences.This work is fundamental to understanding how topographic features affect the glacier changes,and provides information for building different types of relationship between the glacier area and ice volume to promote further studies on the basin-scale glacier classification. | LI Hongliang WANG Puyu LI Zhongqin JIN Shuang XU Chunhai MU Jianxin HE Jie YU Fengchen | 2022 | Journal of Arid Land2022，14，7： | 0 |
| 6 | Synergistic Effect of Platinum Single Atoms and Nanoclusters Boosting Electrocatalytic Hydrogen Evolution显示文摘Maximizing atomic utilization of precious metalbased catalysts is of great significance in heterogeneous catalysis,also becoming a useful strategy to develop efficient electrocatalysts for hydrogen evolution reaction(HER).Although the dispersion of platinum(Pt)as single atoms(SAs)has increasingly been used in the design of HER electrocatalysts,it is still controversial if the SAs possess higher reactivity relative to the nanoparticles with identical atom loading. | Yihui Zhu Pengfei Tian Hongliang Jiang Jingren Mu Lu Meng Xiaozhi Su Yu Wang Yunxiang Lin Yihua Zhu Li Song Chunzhong Li | 2021 | CCS Chemistry2021，3，10： | 0 |
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