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| 1 | Immunological effect of local ablation combined with immunotherapy on solid malignancies显示文摘Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to treatment.Furthermore,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical practice.To enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to emerge.Local ablations have considerable advantages as an alternative therapeutic option,especially its minimal invasiveness.In addition,local ablations have shown immune-regulatory effect in preclinical and clinical studies.Although the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid malignancies.This article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused ultrasound.We also discuss the value of local ablations combined with immunotherapy.Local ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated. | Yusuke Takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara Masafumi Kawamura | 2017 | Chinese Journal of Cancer2017，36，6： | 6 |
| 2 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 3 | Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm显示文摘 | Teruhiko Ito Hirofumi Yasue Michihiro Yoshimura Shota Nakamura Masafumi Nakayama Yukio Shimasaki Eisaku Harada Yuji Mizuno Hiroaki Kawano Hisao Ogawa | 2002 | Human Genetics2002，，1： | 1 |
| 4 | Molecular-pathological prognostic factors of gastric cancer: a review显示文摘 | Wataru Yasui Naohide Oue Phyu Phyu Aung Shunji Matsumura Mariko Shutoh Hirofumi Nakayama | 2005 | Gastric Cancer2005，，2： | 1 |
| 5 | Effect of blood pressure and diabetes on stroke in progression显示文摘 | Henrik Stig Jorgensen Hirofumi Nakayama | 1994 | Lan- cet1994，344，： | 1 |
| 6 | Outcome and time course of recovery in stroke. Part I: Outcome. The Copenhagen stroke study显示文摘 | Henrik S. J?rgensen Hirofumi Nakayama Hans O. Raaschou J?rgen Vive-Larsen Mogens St?ier Tom S. Olsen | 1995 | Archives of Physical Medicine and Rehabilitation1995，，5： | 1 |
| 7 | Plasma Level of B-Type Natriuretic Peptide as a Prognostic Marker After Acute Myocardial Infarction: A Long-Term Follow-Up Analysis显示文摘 | Satoru Suzuki Michihiro Yoshimura Masafumi Nakayama Yuji Mizuno Eisaku Harada Teruhiko Ito Shota Nakamura Koji Abe Megumi Yamamuro Tomohiro Sakamoto Yoshihiko Saito Kazuwa Nakao Hirofumi Yasue Hisao Ogawa | 2004 | Circulation2004，，11： | 1 |
| 8 | A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer显示文摘 | Shunji Matsumura Naohide Oue Hirofumi Nakayama Yasuhiko Kitadai Kazuhiro Yoshida Yoshiyuki Yamaguchi Kazue Imai Kei Nakachi Keisuke Matsusaki Kazuaki Chayama Wataru Yasui | 2005 | Journal of Cancer Research and Clinical Oncology2005，，1： | 1 |
| 9 | Treatment and Rehabilitation on a Stroke Unit Improves 5-Year Survival: A Community-Based Study显示文摘 | Henrik Stig Jorgensen Lars Peter Kammersgaard Hirofumi Nakayama Hans Otto Raaschou Kim Larsen Per Hubbe Tom Skyhoj Olsen | 1999 | Stroke: A Journal of Cerebral Circulation1999，，5： | 1 |
| 10 | A single nucleotide polymorphism in the MMP -9 promoter affects tumor progression and invasive phenotype of gastric cancer 显示文摘 | Shunji Matsumura Naohide Oue Hirofumi Nakayama | 2005 | Cancer Res Clin Oncol2005，131，： | 1 |
| 11 | 局部消融术联合免疫治疗对实体恶性肿瘤的免疫效应显示文摘最近的综合研究表明肿瘤细胞周围的免疫微环境与肿瘤的进展、转移和对治疗的反应密切相关。而且,一些免疫治疗试验已取得了成功的结果,用于临床实践的免疫治疗药物也可以获得。为了增强其已证实的疗效,免疫治疗和消融术的联合使用已开始出现。局部消融作为一种替代治疗方案具有相当大的优势,尤其是其微侵袭特性。此外,局部消融在临床前和临床研究中也显示出免疫调节作用。虽然相应的机制尚不清楚,但局部消融结合免疫治疗已被建议用于治疗几种实体恶性肿瘤。本文对局部消融的免疫调节效应方面发表的文献进行了综述,包括立体定向放射治疗、冷冻消融、射频消融和高强度聚焦超声。我们还讨论了局部消融与免疫治疗联合使用的价值。局部消融有改善未来患者预后的潜力,但局部消融与免疫治疗联合使用的有效性和安全性有待进一步研究。 | Yusuke Takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara Masafumi Kawamura | 2018 | 癌症2018，37，10： | 1 |
| 12 | Effect of blood pressure and diabetes on stroke in progression显示文摘 | Henrik Stig Jorgensen Hirofumi Nakayama | 1994 | Lancet1994，344，： | 1 |
| 13 | Seizures in Acute Stroke: Predictors and Prognostic Significance: The Copenhagen Stroke Study显示文摘 | Jakob Reith Henrik Stig Jorgensen Hirofumi Nakayama Hans Otto Raaschou Tom Skyhoj Olsen | 1997 | Stroke A Journal of Cerebral Circulation1997，，8： | 1 |
| 14 | Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma显示文摘 | Jie Zhang Reiko Ito Naohide Oue Xudong Zhu Yasuhiko Kitadai Kazuhiro Yoshida Hirofumi Nakayama Wataru Yasui | 2003 | Virchows Archiv2003，，6： | 1 |
| 15 | Forecasting of future coal demand and transportation in China显示文摘 | NAKAYAMA HIROFUMI IMURA HIDEFUMI | 1997 | Environmental Systems Research1997，25，： | 1 |
| 16 | Expression of UDP-GalNAc: polypeptide Nacetylgalactosaminyltransferase isozymes T1 and T2 in human colorectal cancer显示文摘 | Isao Nishimori Hirofumi Nakayama | 2000 | J Gartroenterol2000，35，： | 1 |
| 17 | A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive pheno- type of gastric cancer 显示文摘 | Shunji Matsumura Naohide Oue Hirofumi Nakayama e- tal | 2005 | Cancer Res Clin 0ncol2005，，131： | 1 |
| 18 | Novel therapeutic option for refractory heart failure in elderly patients with chronic kidney disease by incremental peritoneal dialysis显示文摘 | Masaru Nakayama Hirofumi Nakano Masaaki Nakayama | 2009 | Journal of Cardiology2009，，1： | 1 |
| 19 | A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer显示文摘 | Shunji Matsumura Naohide Oue Hirofumi Nakayama Yasuhiko Kitadai Kazuhiro Yoshida Yoshiyuki Yamaguchi Kazue Imai Kei Nakachi Keisuke Matsusaki Kazuaki Chayama Wataru Yasui | 2005 | Journal of Cancer Research and Clinical Oncology2005，，1： | 1 |
| 20 | Molecular-pathological prognostic factors of gastric cancer: a review显示文摘 | Wataru Yasui Naohide Oue Phyu Phyu Aung Shunji Matsumura Mariko Shutoh Hirofumi Nakayama | 2005 | Gastric Cancer2005，，2： | 1 |
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