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| 1 | Nuclear factor-kappaB activation on the reactive oxygen species in acute necrotizing pancreatitic rats显示文摘AIM: To investigate the potential role of nuclear factor kappa-B (NF-κB) activation on the reactive oxygen species in rat acute necrotizing pancreatitis (ANP) and to assess the effect of pyrrolidine dithiocarbamate (PDTC, an inhibitor of NF-κB).METHODS: Rat ANP model was established by retrograde injection of 5% sodium taurocholate into biliopancreatic duct. Rats were randomly assigned to three groups (10rats each): Control group, ANP group and PDTC group. At the 6th h of the model, the changes of the serum amylase,nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD) and pancreatic morphological damage were observed. The expressions of inducible nitric oxide (iNOS) were observed by SP immunohistochemistry. And the expressions of NF-κB p65 subunit mRNA were observed by hybridization in situ.RESULTS: Serum amylase and NO level decreased significantly in ANP group as compared with PDTC administrated group [(7 170.40±1 308.63) U/L vs(4 074.10±1 719.78) U/L,P<0.05], [(76.95±9.04) μmol/L vs (65.18±9.02) μmol/L,P<0.05] respectively. MDA in both ANP and PDTC group rose significantly over that in control group [(9.88±1.52)nmol/L, (8.60±1.41) nmol/L, vs (6.04±1.78) nmol/L,P<0.05], while there was no significant difference between them. SOD levels in both ANP and PDTC group underwent a significant decrease as compared with that in control [(3 214.59±297.74) NU/mL, (3 260.62±229.44) NU/mL,vs (3 977.80±309.09) NU/mL, P<0.05], but there was no significant difference between them. Though they were still higher than those in Control group, pancreas destruction was slighter in PDTC group, iNOS expression and NF-κB p65 subunit mRNA expression were lower in PDTC group as compared with ANP group.CONCLUSION: We conclude that correlation among NF-κB activation, serum amylase, reactive oxygen species level and tissue damage suggests a key role of NF-κB in the pathogenesis of ANP. Inhibition of NF-κB activation may reverse the pancreatic damage of rat ANP and the production of reactive oxygen species. | Jin Long Na Song Xi-Ping Liu Ke-Jian Guo Ren-Xuan Guo | 2005 | World Journal of Gastroenterology2005，11，27： | 18 |
| 2 | Selenium Supplementation Alleviates Autoimmune Thyroiditis by Regulating Expression of Th1/Th2 Cytokines显示文摘Selenium (Se) is an essential trace element.Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens.However,the effects of Se on the cytokines in AITD are still unclear.So we researched the role of Selenium (Se) and Th1/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).The data shown that high Se intake reduced the autoantibody titers and alleviated the | TAN Long SANG Zhong Na SHEN Jun WU Yun Tang YAO Zhai Xiao ZHANG Jin Xiang ZHAO Na ZHANG Wan Qi | 2013 | Biomedical and Environmental Sciences2013，26，11： | 10 |
| 3 | Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis显示文摘 | Na Cui Hao Wang Long-Xiang Su Jia-Hui Zhang Yun Long Da-Wei Liu | 2017 | Chinese Medical Journal2017，，10： | 10 |
| 4 | Stepwise-Nanocavity-Assisted Transmissive Color Filter Array Microprints显示文摘Visible-light color flters using patterned nanostructures have attracted much interest due to their various advantages such as compactness,enhanced stability,and environmental friendliness compared with traditional pigment or dye-based optical flters.While most existing studies are based on planar nanostructures with lateral variation in size,shape,and arrangement,the vertical dimension of structures is a long-ignored degree of freedom for the structural colors.Herein,we demonstrate a synthetic platform for transmissive color flter array by coordinated manipulations between height-varying nanocavities and their lateral flling fractions.Te thickness variation of those nanocavities has been fully deployed as an alternative degree of freedom,yielding vivid colors with wide gamut and excellent saturation.Experimental results show that the color-rendering capability of the pixelated nanocavities can be still retained as pixels are miniaturized to 500 nm.Crosstalk between closely spaced pixels of a Bayer color flter arrangement was calculated,showing minimal crosstalk for 1μm2 square subpixels.Our work provides an approach to designing and fabricating ultracompact color flter arrays for various potential applications including stained-glass microprints,microspectrometers,and high-resolution image sensing systems. | Yasi Wang Mengjie Zheng Qifeng Ruan Yanming Zhou Yiqin Chen Peng Dai Zhengmei Yang Zihao Lin Yuxiang Long Ying Li Na Liu Cheng-Wei Qiu Joel K.W.Yang Huigao Duan | 2018 | Research2018，，1： | 8 |
| 5 | Diacylglycerol Compounds from Barks of Betula platyphylla with Inhibitory Activity against Acyltransferase显示文摘Objective To identify the active compounds from the barks of Betula platyphylla for inhibitory on diacylglycerol acyltransferase(DGAT1).Methods Bioassay-guided fractionation resulted in the isolation of DGAT1 inhibitory activity of lupane triterpenes.Results Ten compounds were identified as lupenone(1),lupeol(2),betulinic acid(3),betulinaldehyde(4),betulin(5),3-deoxybetulonic acid(6),glochidonol(7),lup-20/29-ene-1β/3β-diol(8),3α-hydroxy-lup-20(29)-en-23,28-dioic acid(9),and 3α,11α-dihydroxy-23-oxo-lup-20(29)-en-28-oic acid(10).Compounds 3-6,9,and 10 inhibited DGAT1 with IC50 values ranging from(11.2±0.3)to(38.6±1.2)μmol/L.Conclusion Compounds 6,9,and 10 are first isolated from the barks of B.platyphylla.,and compounds 3-6,9,and 10 from the barks of B.platyphylla are responsible for the inhibition on DGAT1. | Nan Zhang Na Li Ya-nan Sun Jia-lin Li Shan-shan Xing Zhen-dong Tuo Long Cui | 2014 | Chinese Herbal Medicines2014，6，2： | 8 |
| 6 | Two new lignans from Dipteronia dyeriana显示文摘新 sesquilignan, 7 鈥 ? 8 鈥 ? didehydroherpetotriol (1 ) ,和新 lignan glycoside,(+)-isolariciresinol-9 鈥 ?O- 伪 -l-rhamnopyranosyl-(1 鈫 ? 6 )- 尾 -d-glucopyranoside (2 ) ,从 Dipteronia dyeriana 的分支被孤立。他们的结构被分光镜的方法和化学证据阐明。与 39 渭 m ol/L 的 IC50 价值对人的白血球过多症 K562 房间加重 1 项拥有的禁止的活动。 | Rong Guo Min Luo Chun Lin Long Ma Lin Li Zhi Qin Ouyang Yi Ping Zhou Yue Hu Wang Xing Yu Li Ya Na Shi | 2008 | Chinese Chemical Letters2008，19，10： | 7 |
| 7 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 8 | Effect of lit-moxa stimulation of Guanyuan(CV 4) acupoint on levels of lactic acid and super-oxide dismutase in skeletal muscle of rats显示文摘OBJECTIVE:To observe the effect of lit-moxa stimulating acupoint Guanyuan(CV 4) on lactic acid and super-oxide dismutase(SOD) in skeletal muscle after exercise exhaustion.METHODS:Twenty-eight adult male Sprague-Dawley rats were randomly divided into normal control group,exhausted control group,exercise group and moxibustion group using exercise training and mild heating with lit-moxa stick as treatment methods.The exhausted control group,moxibustion group and exercise group received an exhaustive swimming after 20 days of intervention.Swimming exhausted times were recorded.Lactic acid and SOD concentration in soleus muscle were detected and compared between every two groups.RESULTS:The swimming exhausted times of the moxibustion group and the exercise group were significantly increased compare to the exhausted control group(P < 0.05).The lactic acid of the exhausted control group was significantly increased comparing with the normal control group(P <0.05),and the lactic acid of the moxibustion group and the exercise group were significantly lower than that of the exhausted control group(P < 0.05).The SOD level of the exhausted control group was significantly decreased comparing with the normal control group(P < 0.05),and the SOD level of the moxibustion group and the exercise group were significantly higher than that of the exhausted control group(both,P < 0.05).There was no statistical difference between the moxibustion group and the exercise group.CONCLUSION:With lit moxa stick,heat stimulating acupoint of Guanyuan(CV 4) decreased the levels of lactic acid and SOD in rat's skeletal muscle. | Mo Jie Wu Lili Sun Zhifang Wang Hongbin Ding Na He Long Zhang Lufen Liu Tonghua Li Xiaohong | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 6 |
| 9 | Recovery of rare earths and aluminum from FCC waste slag by acid leaching and selective precipitation显示文摘This paper investigated the recovery of rare earth elements(REEs) and aluminum(AI) from the waste slag discharged by FCC catalyst factory(FCC waste slag) via acid leaching and selective precipitation.Analysis methods such as ICP-AES, XRF and XRD were applied to obtain experiment data. The maximum leaching efficiency of REEs and Al was achieved at pH value of 1 and with liquid to solid ratio of 4:1,Under such conditions, 91.01%, 92.24% and 94.77% of La, Ce and Al were extracted at 20 ℃ for 2 h from the FCC waste slag, respectively. The SiO_2 content in the leaching residue was 88.3%, which can be used as an available silicon resource. The REEs can be precipitated in the form of REEs and sodium double sulfate(NaRE(SO_4)_2·xH_2 O) by adding Na_2 SO_4 to the leaching solution, while Al remained in the solution. Afterwards, the pH value of the filtrate was adjusted to 4.5, and Al was precipitated as AI(OH)_3. Finally,NaRE(SO_4)_2·xH_2 O and Al(OH)_3 were converted into RECl_3 and Al_2(SO4)_3 solution,respectively, which were recycled to manufacture zeolite. This process recovered REEs and Al from the FCC waste slag and reduced the emissions of waste slag simultaneously, which has an important economic and environment significance. | Jinyu wang Xiaowei Huang Dali Cui Liangshi Wang Zongyu Feng Bin Hu Zhiqi Long Na Zhao | 2017 | Journal of Rare Earths2017，35，11： | 4 |
| 10 | Translation and validation of the Tibetan confusion assessment method for the intensive care unit显示文摘Background: At present, there is no available delirium translated assessment method for 3.3 million Tibetans. This study ai provide a method for delirium assessment for Tibetan patients speaking this language by validating a translation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Methods: The study was conducted between July 2018 and November 2018. Patients were screened for delirium by a neurologist using the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV). Patients were subsequently screened by two nurses using Tibetan translations of the CAM-ICU. With DSM-IV criterion as the reference standard, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to assess the validity of the CAM-ICU criterion. Interrater reliability was determined by comparing the CAM-ICU ratings of nurse 1 vs. nurse 2 using the k coefficient. Results: Ninety-six patients were assessed independently by two nurses and one neurologist. According to DSM-IV standard, 42 out of 96 (43.8%) patients developed delirium. The sensitivities of Tibetan CAM-ICU were 90.5% for nurse 1 and 92.9% for nurse 2, respectively. Their specificities were 85.2% and 90.7%, respectively. The PPV were 82.6% for nurse 1 and 88.6% for nurse 2. Their NPV were 92.0% and 94.2%, respectively. The Tibetan CAM-ICU was done with good interrater reliability between nurse 1 and nurse 2 (k=0.91, P<0.001). Conclusion: The Tibetan CAM-ICU shows good validity and might be incorporated into clinical practice in Tibetan Intensive Care Units. | Qu-Zhen Danzeng Na Cui Hao Wang Wen-Jun Pan Yun Long Yang-Zong Deji Cheng Ze Zeng Ren | 2019 | Chinese Medical Journal2019，，10： | 4 |
| 11 | Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice显示文摘Objective Interferon-induced transmembrane protein 3(IFITM3)is an important member of the IFITM family.However,the molecular mechanisms underlying its antiviral action have not been completely elucidated.Recent studies on IFITM3,particularly those focused on innate antiviral defense mechanisms,have shown that IFITM3 affects the body’s adaptive immune response.The aim of this study was to determine the contribution of IFITM3 proteins to immune control of influenza infection in vivo.Methods We performed proteomics,flow cytometry,and immunohistochemistry analysis and used bioinformatics tools to systematically compare and analyze the differences in natural killer(NK)cell numbers,their activation,and their immune function in the lungs of Ifitm3-/-and wild-type mice.Results Ifitm3-/-mice developed more severe inflammation and apoptotic responses compared to wild-type mice.Moreover,the NK cell activation was higher in the lungs of Ifitm3-/-mice during acute influenza infection.Conclusions Based on our results,we speculate that the NK cells are more readily activated in the absence of IFITM3,increasing mortality in Ifitm3-/-mice. | SUN Qiang LEI Na LU Jian GAO Rong Bao LI Zi LIU Li Qi SUN Ying GUO Jun Feng WANG Da Yan SHU Yue Long | 2020 | Biomedical and Environmental Sciences2020，33，5： | 4 |
| 12 | Polyelectrolyte gelatin-chitosan hydrogel optimized for 3D bioprinting in skin tissue engineering显示文摘Bioprinting is a promising automated platform that enables the simultaneous deposition of multiple types of cells and biomaterials to fabricate complex three-dimensional(3D)tissue constructs.Collagen-based biomaterial used in most of the previous works on skin bioprinting has poor printability and long crosslinking time.This posed an immense challenge to create 3D constructs with pre-determined shape and configuration at high throughput.Recently,the use of chitosan for wound healing applications has attracted huge attention due to its attractive traits such as its antimicrobial properties and ability to trigger hemostasis.In this paper,we optimized polyelectrolyte gelatin-chitosan hydrogel for 3D bioprinting.Modification to the chitosan was carried out via the oppositely charged functional groups from chitosan and gelatin at a specific pH of^pH 6.5 to form polyelectrolyte complexes.The polyelectrolyte hydrogels were evaluated in terms of physical interactions within polymer blend,rheological properties(viscosities,storage and loss modulus),printing resolution at varying pressures and feed rates and biocompatibility.The polyelectrolyte gelatin-chitosan hydrogels formulated in this work was optimized for 3D bioprinting at room temperature to achieve high shape fidelity of the printed 3D constructs and good biocompatibility with fibroblast skin cells. | Wei Long Ng Wai Yee Yeong May Win Naing | 2016 | International Journal of Bioprinting2016，2，1： | 4 |
| 13 | Effect of Rheum palmatum L.on NF-κ B signaling pathway of mice with acute liver failure显示文摘Objective:To explore the regulation effect of Rheum palmatum(R.palmatum) L.on NF-κ.B signaling pathway of ALF mice.Methods:The intraperitoneal injection of D-GalN/LPS was employed for the model building.Mice in the treatment group and positive control group were given the R,palmatum L.and bifendate before the model building.Mice in the normal group were given the intraperitoneal injection of equivalent normal saline for continuously 3d.After 16 h of model building,the blood was collected from eyeballs of mice and then mice were executed.The measurement was performed on the content of ALT,AST,NO and 11-1βin the serum of mice in eaeh group,as well as the activity of Caspase 3 and Caspase 8 in the liver tissue.HE staining was employed to detect the pathological morphology of liver;and the western blot was used to detect the expression of iNOS,COX-2,Bax,Bcl-2,PCNA,NF-κ B p65 and I κ.B.Results:The content of ALT,AST,NO and I1-1β in the serum and the activity of Caspase 3 and Caspase 8 in the liver tissue were increased in the mice of ALF model group.Besides,the expression of iNOS,COX-2 and Bax was increased,the expression of Bcl-2 and PCNA was decreased,the phosphorylation of NF-κ B p65 and 1κ B was significant and the treatment group of R.palmatum L.could inhibit such change.Conclusions:Through NF-κB signaling pathway,the R.palmatum L.could reduce the content of enzyme of liver function and inflammation factor in the serum of ALF mice,regulate the expression of cell apoptosisrelated protein and improve the symptoms of ALF mice. | Rong-Zhen Zhang Hua Qiu Na Wang Fu-Li Long De-Wen Mao | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 4 |
| 14 | Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene显示文摘The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases(TALENs) technology to generate Leptin receptor(Lepr) knockout rats on the Sprague Dawley(SD) genetic background. Through direct injection of in vitro transcribed m RNA of TALEN pairs into SD rat zygotes, somatic mutations were induced in two of three resulting pups. One of the founders carrying bi-allelic mutation exhibited early onset of obesity and infertility. The other founder carried a chimeric mutation which was efficiently transmitted to the progenies. Through phenotyping of the resulting three lines of rats bearing distinct mutations in the Lepr locus, we found that the strains with a frame-shifted or premature stop codon mutation led to obesity and metabolic disorders. However, no obvious defect was observed in a strain with an in-frame 57 bp deletion in the extracellular domain of Lepr. This suggests the deleted amino acids do not significantly affect Lepr structure and function. This is the first report of generating the Lepr mutant obese rat model in SD strain through a reverse genetic approach. This suggests that TALEN is an efficient and powerful gene editing technology for the generation of disease models. | Yuting Chen Wenqing Lu Na Gao Yi Long Yanjiao Shao Meizhen Liu Huaqing Chen Shixin Ye Xueyun Ma Mingyao Liu Dali Li | 2017 | Science China(Life Sciences)2017，60，2： | 4 |
| 15 | Accelerated Autophagy of Cecal Ligation and Puncture-Induced Myocardial Dysfunction and Its Correlation with Mammalian Target of Rapamycin Pathway in Rats显示文摘 | Hao Wang Na Cui Wen Han Long-Xiang Su Yun Long Da-Wei Liu | 2018 | Chinese Medical Journal2018，，10： | 4 |
| 16 | An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s显示文摘瞄准:底层鸡尾酒经常被用来评估细胞色素 P450 (CYP ) 在探查底层之中的调停酶的药相互作用和潜在的相互作用。这里,我们重新优化增加为候选人屏蔽的可靠性和精确性的底层鸡尾酒方法加重并且从直接 CYP 抑制试金扩展了方法到时间依赖者抑制(TDI ) assay.Methods:在包含人的肝微体(0.1 mg/mL ) 的反应混合物,两个都,底层鸡尾酒(为 1A2,为 2A6 的香豆素,为 2B6 的 bupropion,为 2C9 的 diclofenac,为 2D6 的 dextromethorphan,和为 3A4 的睾丸激素的非那西汀) 和孵化时间的集中被优化。底层探针的代谢物被(MRM ) 使用平淡的 LC/MS/MS 的多重反应的监视同时分析。直接 CYP 抑制用 7 个禁止者被验证(α -naphthoflavone, tranylcypromine, ticlopidine, fluconazole,奎尼定, ketoconazole 和 1-ABT ) 。时间依赖者抑制部分与 5 个禁止者(ketoconazole, verapamil,奎尼定, paroxetine 和 1-ABT ) 被验证 .Results:当单个底层和底层鸡尾酒被测试时,抑制曲线侧面和 7 个 CYP 禁止者的 IC 50 价值是近似的,并且与以前报导的价值一致。当单个底层和底层鸡尾酒在 TDI assay.Conclusion 被测试时,类似的结果在 5 个禁止者的 IC 50 移动被获得:6-in-1 底层鸡尾酒(为 1A2, 2A6, 2B6, 2C9, 2D6 和 3A ) 为估计 CYP 抑制和药候选人的时间依赖者抑制是可靠的。 | Zhong-hua CHEN Su-xing ZHANG Na LONG Li-shan LIN Tao CHEN Fei-peng ZHANG Xue-qin LV Pei-zhen YE Ning LI Ke-zhi ZHANG | 2016 | Acta Pharmacologica Sinica2016，37，5： | 4 |
| 17 | Commercialized non-Camellia tea:traditional function and molecular identification显示文摘Non-Camellia tea is a part of the colorful Chinese tea culture,and is also widely used as beverage and medicine in folk for disease prevention and treatment.In this study,37 samples were collected,including 33 kinds of non-Camellia teas and 4 kinds of teas(Camellia).Traditional functions of non-Camellia teas were investigated.Furthermore,non-Camellia teas of original plants were characterized and identified by molecular methods.Four candidate regions(rbcL,matK,ITS2,psbA-trnH)were amplified by polymerase chain reaction.In addition,DNA barcodes were used for the first time to discriminate the commercial non-Camellia tea and their adulterants,and to evaluate their safety.This study showed that BLASTN and the relevant phylogenetic tree are efficient tools for identification of the commercial non-Camellia tea and their adulterants.However,some sequences from original plants have not been found and there is a limitation of sequence number of original plants in GenBank.Submitting more original plant sequences to the GenBank will be helpful for evaluating the safety of non-Camellia teas. | Ping Long Zhanhu Cui Yingli Wang Chunhong Zhang Na Zhang Minhui Li Peigen Xiao | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 3 |
| 18 | Altered CD8+ T-cell counts as an early predictor of prognosis in critically ill immunocompromised patients with invasive pulmonary aspergillosis显示文摘 | Cui Na Wang Hao Long Yun Liu Dawei | 2014 | Chinese Medical Journal2014，，1： | 3 |
| 19 | Concurrent optimization of structural topology and infill properties with a CBF-based level set method显示文摘In this paper,a parametric level-set-based topology optimization framework is proposed to concurrently optimize the structural topology at the macroscale and the effective infill properties at the micro/meso scale.The concurrent optimization is achieved by a computational framework combining a new parametric level set approach with mathematical programming.Within the proposed framework,both the structural boundary evolution and the effective infill property optimization can be driven by mathematical programming,which is more advantageous compared with the conventional partial differential equatiodriven level set approach.Moreover,the proposed approach will be more efficient in handling nonlinear problems with multiple constraints.Instead of using radial basis functions(RBF),in this paper,we propose to construct a new type of cardinal basis functions(CBF)for the level set function parameterization.The proposed CBF parameterization ensures an explicit impose of the lower and upper bounds of the design variables.This overcomes the intrinsic disadvantage of the conventional RBF-based parametric level set method,where the lower and upper bounds of the design variables oftentimes have to be set by trial and error;A variational distance regularization method is utilized in this research to regularize the level set function to be a desired distanceregularized shape.With the distance information embedded in the level set model,the wrapping boundary layer and the interior infill region can be naturally defined.The isotropic infill achieved via the mesoscale topology optimization is conformally fit into the wrapping boundary layer using the shape-preserving conformal mapping method,which leads to a hierarchical physical structure with optimized overall topology and effective infill properties.The proposed method is expected to provide a timely solution to the increasing demand for multiscale and multifunctional structure design. | Long JIANG Yang GUO Shikui CHEN Peng WEI Na LEI Xianfeng David GU | 2019 | Frontiers of Mechanical Engineering2019，14，2： | 3 |
| 20 | Association between Coronary Atherosclerotic Plaque Composition and Cardiovascular Disease Risk显示文摘Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional analysis in 549 subjects without previous diagnosis or clinical symptoms of CVD in a community cohort of middle-aged Chinese adults. The participants underwent coronary computed tomography(CT) angiography for the evaluation of the presence and composition of coronary plaques. CVD risk was evaluated by the Framingham risk score(FRS) and the 10-year atherosclerotic cardiovascular disease(ASCVD) risk score. Results Among the 549 participants, 267(48.6%) had no coronary plaques, 201(36.6%) had noncalcified coronary plaques, and 81(14.8%) had calcified or mixed coronary plaques. The measures of CVD risk including FRS and ASCVD risk score and the likelihood of having elevated FRS significantly increased across the groups of participants without coronary plaques, with noncalcified coronary plaques, and with calcified or mixed coronary plaques. However, only calcified or mixed coronary plaques were significantly associated with an elevated ASCVD risk score [odds ratio(OR) 2.41; 95% confidence interval(CI) 1.09-5.32] compared with no coronary plaques, whereas no significant association was found for noncalcified coronary plaques and elevated ASCVD risk score(OR 1.25; 95% CI 0.71-2.21) after multivariable adjustment. Conclusion Calcified or mixed coronary plaques might be more associated with an elevated likelihood of having CVD than noncalcified coronary plaques. | LI Lin WANG Long LIU Shan Shan ZHAO Zhi Yun LI Mian WANG Tian Ge XU Min LU Jie Li CHEN Yu Hong WANG Shuang Yuan DAI Meng HOU Ya Nan WU Xue Yan MA Li Na WANG Wei Qing XU Yu BI Yu Fang | 2019 | Biomedical and Environmental Sciences2019，32，2： | 3 |
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