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| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | Inhibition of smoothened decreases proliferation of Synoviocytes in rheumatoid arthritis显示文摘像成纤维细胞的 synoviocytes (FLS ) 在风湿性关节炎(RA ) 贡献 synovial 增生。Smoothened (Smo ) 是发信号的声音的刺猬(嘘) 的一个关键部件并且贡献肿瘤房间增长。这研究的目的是在 RA synoviocyte 增长调查 Smo 的角色。FLS 从 RA synovium 被孤立。发信号的嘘用一个 Smo 对手(GDC-0449 ) 和在 FLS 指向 Smo 基因的小介入 RNA (siRNA ) 被学习。房间增长被使用 kit-8 试金和房间周期分发确定, apoptosis 被流动 cytometry 评估。房间周期相关的基因和蛋白质被即时 PCR 和西方的污点检测。与 GDC-0449 或 Smo-siRNA 对待的 FLS 与控制相比显示出显著地减少的增长(P < 0.05 ) 。有 GDC-0449 的孵化或有 Smo-siRNA 的 transfection 与控制相比导致了 G 1 阶段房间的重要增加(P < 0.05 ) 。房间周期拘捕被 cyclin D1 和 E1 mRNA 表示的重要增加验证,在在 Smo-siRNA transfected 房间的 cyclin 依赖的 kinase p21 mRNA 表示的减少(P < 0.05 ) 。cyclin D1 的蛋白质表示也是在 Smo 基因以后的 downregulated 击倒(P < 0.05 ) 。结果建议发信号的嘘以一种 Smo 依赖的方式在 RA-FLSs 增长起一个重要作用并且可以贡献 synovial 增生。指向嘘发信号可以帮助与 RA 在病人控制联合损坏。 | Shang-ling Zhu Jian-lin Huang Wei-xiang Peng Dan-chun Wu Min-qi Luo Qiu-xia Li Zhao-xia Li Xiao-xue Feng Fang Liu Ming-xia Wang Wei-qian Chen Nancy Olsen Song Guo Zheng | 2017 | Cellular & Molecular Immunology2017，14，2： | 9 |
| 3 | uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis显示文摘Urokinase-type plasminogen activator receptor(uPAR),is a multifunctional receptor on cell surface,widely present in endothelial cells,fibroblasts,and a variety of malignant cells.Current studies have suggested that uPAR overexpressed on synovial tissues or in synovial fluid or plasma in patients with rheumatoid arthritis(RA).However,there are limited researches regarding the role of uPAR on fibroblast-like synoviocytes of rheumatoid arthritis(RA-FLSs)and its underlying mechanisms.Here,our studies show that the expression of uPAR protein was significantly higher in fibroblast-like synoviocytes(FLSs)from RA than those from osteoarthritis or traumatic injury patients.uPAR gene silencing significantly inhibited RA-FLSs cell proliferation,restrained cell transformation from the G0/G1 phase to S phase,aggravated cell apoptosis,interfered with RA-FLSs cell migration and invasion,and reduced activation of the PI3K/Akt signaling pathway,which may be associated withβ1-integrin.Cell supernatants from uPAR gene-silenced RA-FLSs markedly inhibited the migration and tubule formation ability of the HUVECs(a human endothelial cell line).Therefore,we demonstrate that uPAR changes the biological characteristics of RA-FLSs,and affects neoangiogenesis of synovial tissues in patients with RA.All of these may be associated with theβ1-integrin/PI3K/Akt signaling pathway.These results imply that targeting uPAR and its downstream signal pathway may provide therapeutic effects in RA. | Yan Liu Yun Feng Pan You-qiu Xue Lin-kai Fang Xing-hua Guo Xin Guo Meng Liu Bi-yao Mo Meng-ru Yang Fang Liu Yun-ting Wu Nancy Olsen Song Guo Zheng | 2018 | Cellular & Molecular Immunology2018，15，2： | 9 |
| 4 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 5 | Development and cross-sectional validation of the Childhood Asthma Control Test显示文摘 | Andrew H. Liu Robert Zeiger Christine Sorkness Todd Mahr Nancy Ostrom Somali Burgess Jacqueline Carranza Rosenzweig Ranjani Manjunath | 2007 | The Journal of Allergy and Clinical Immunology2007，，4： | 2 |
| 6 | High-resolution two-photon transcranial imaging of brain using direct wavefront sensing显示文摘Imaging of the brain in its native state at high spatial resolution poses major challenges to visualization techniques.Two-photon microscopy integrated with the thinned-skull or optical clearing skull technique provides a minimally invasive tool for in vivo imaging of the cortex of mice without activating immune response and inducing brain injury.However,the imaging contrast and spatial resolution are severely compromised by the optical heterogeneity of the skull,limiting the imaging depth to the superficial layer.In this work,an optimized configuration of an adaptive optics two-photon microscope system and an improved wavefront sensing algorithm are proposed for accurate correction for the aberrations induced by the skull window and brain tissue.Using this system,we achieved subcellular resolution transcranial imaging of layer 5 pyramidal neurons up to 700μm below pia in living mice.In addition,we investigated microglia–plaque interaction in living brain of Alzheimer’s disease and demonstrated high-precision laser dendrotomy and single-spine ablation. | CONGPING CHEN ZHONGYA QIN SICONG HE SHAOJUN LIU SHUN-FAT LAU WANJIE WU DAN ZHU NANCY Y.IP JIANAN Y.QU | 2021 | Photonics Research2021，9，6： | 2 |
| 7 | US Renal Data System 2011 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Blanche Chavers David Gilbertson Charles Herzog Kirsten Johansen Bertram Kasiske Nancy Kutner Jiannong Liu Wendy St. Peter Haifeng Guo Sally Gustafson Brooke Heubner Kenneth Lamb Shuling Li Suying Li Yi Peng Yang Qiu Trici | 2011 | American Journal of Kidney Diseases2011，，1： | 1 |
| 8 | High glucose impairs voltage-gated K^+ channel current in rat small coronary arteries显示文摘 | Liu YP Terata K Nancy J | 2001 | Circulation Research2001，89，2： | 1 |
| 9 | Effects of Resuscitation Fluid on Neurologic Physiology After Cerebral Trauma and Hemorrhage显示文摘 | Andrew J. Baker Eugene Park Greg M. T. Hare Elaine Liu Nancy Sikich David C. Mazer | 2008 | The Journal of Trauma: Injury Infection and Critical Care2008，，2： | 1 |
| 10 | Development of a portable hyperspectral imaging system for monitoring the efficacy of sanitation procedures in food processing facilities显示文摘 | Alan M Lefcourt Michael S Wiederoder Nancy Liu | 2013 | Journal of Food Engineering2013，117，1： | 1 |
| 11 | Intratympanic Steroid Injection for Treatment of Idiopathic Sudden Hearing Loss显示文摘 | William H. Slattery Laurel M. Fisher Zarina Iqbal Rick A. Friedman Nancy Liu | 2005 | Otolaryngology - Head and Neck Surgery2005，，2： | 1 |
| 12 | TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation显示文摘 | Xiping Cheng Jie Jin Lily Hu Dongbiao Shen Xian-ping Dong Mohammad A. Samie Jayne Knoff Brian Eisinger Mei-ling Liu Susan M. Huang Michael J. Caterina Peter Dempsey Lowell Evan Michael Andrzej A. Dlugosz Nancy C. Andrews David E. Clapham Haoxing Xu | 2010 | Cell2010，，2： | 1 |
| 13 | Strength Training in Older Adults: The Benefits for Osteoarthritis显示文摘 | Nancy Latham Chiung-ju Liu | 2010 | Clinics in Geriatric Medicine2010，，3： | 1 |
| 14 | US Renal Data System 2011 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Blanche Chavers David Gilbertson Charles Herzog Kirsten Johansen Bertram Kasiske Nancy Kutner Jiannong Liu Wendy St. Peter Haifeng Guo Sally Gustafson Brooke Heubner Kenneth Lamb Shuling Li Suying Li Yi Peng Yang Qiu Trici | 2011 | American Journal of Kidney Diseases2011，，1： | 1 |
| 15 | Effect of Short - term Cyclic Stretch on Sodium Pump Activity in Aortic Smooth Cells显示文摘 | EMEL SONGU - MIZE NANCY SEVIEUX XIANG LIU | 2001 | Am J Physiol Heart Cire Physiol2001，281，： | 1 |
| 16 | MicroRNA Pathways Modulate Polyglutamine-Induced Neurodegeneration显示文摘 | Julide Bilen Nan Liu Barrington G. Burnett Randall N. Pittman Nancy M. Bonini | 2006 | Molecular Cell2006，，1： | 1 |
| 17 | Oral steroid regimens for idiopathic sudden sensorineural hearing loss显示文摘 | William H. Slattery Laurel M. Fisher Zarina Iqbal Nancy Liu | 2005 | Otolaryngology - Head and Neck Surgery2005，，1： | 1 |
| 18 | Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus显示文摘AIM: To determine the safety profile of new hepatitis C virus(HCV) treatments in liver transplant(LT) recipients with recurrent HCV infection.METHODS: Forty-two patients were identified with recurrent HCV infection that underwent LT at least 12 mo prior to initiating treatment with a Sofosbuvir-based regimen during December 2013-June 2014. Cases were patients who experienced hepatic decompensation and/or serious adverse events(SAE) during or within one month of completing treatment. Controls had no evidence of hepatic decompensation and/or SAE. HIVinfected patients were excluded. Cumulative incidence of decompensation/SAE was calculated using the Kaplan Meier method. Exact logistic regression analysis was used to identify factors associated with the composite outcome. RESULTS: Median age of the 42 patients was 60 years [Interquartile Range(IQR): 56-65 years], 33%(14/42) were female, 21%(9/42) were Hispanic, and 9%(4/42) were Black. The median time from transplant to treatment initiation was 5.4 years(IQR: 2.1-8.8 years). Thirteen patients experienced one or more episodes of hepatic decompensation and/or SAE. Anemia requiring transfusion, the most common event, occurred in 62%(8/13) patients, while 54%(7/13) decompensated. The cumulative incidence of hepatic decompensation/SAE was 31%(95%CI: 16%-41%). Risk factors for decompensation/SAE included lower pre-treatment hemoglobin(OR = 0.61 per g/d L, 95%CI: 0.40-0.88, P < 0.01), estimated glomerular filtration rate(OR = 0.95 per m L/min per 1.73 m^2, 95%CI: 0.90-0.99, P = 0.01), and higher baseline serum total bilirubin(OR = 2.43 per mg/d L, 95%CI: 1.17-8.65, P < 0.01). The sustained virological response rate for the cohort of 42 patients was 45%, while it was 31% for cases.CONCLUSION: Sofosbuvir/ribavirin will continue to be used in the post-transplant population, including those with HCV genotypes 2 and 3. Management of anemia remains an important clinical challenge. | Neal Patel Kian Bichoupan Lawrence Ku Rachana Yalamanchili Alyson Harty Donald Gardenier Michel Ng David Motamed Viktoriya Khaitova Nancy Bach Charissa Chang Priya Grewal Meena Bansal Ritu Agarwal Lawrence Liu Gene Im Jennifer Leong Leona Kim-Schluger Joseph Odin Jawad Ahmad Scott Friedman Douglas Dieterich Thomas Schiano Ponni Perumalswami Andrea Branch | 2016 | World Journal of Gastroenterology2016，22，9： | 1 |
| 19 | Hypoglycemia is More Common Among Type 2 Diabetes Patients with Limited Health Literacy: The Diabetes Study of Northern California (DISTANCE)显示文摘 | Urmimala Sarkar Andrew J. Karter Jennifer Y. Liu Howard H. Moffet Nancy E. Adler Dean Schillinger | 2010 | Journal of General Internal Medicine2010，，9： | 1 |
| 20 | G protein β3 subunit variant and essential hypertension in Taiwan — a case–control study显示文摘 | Cheng-Ho Tsai Hung-I Yeh Yusan Chou Hsin-Fu Liu Tzu-Yao Yang Jyh-Chwan Wang Nancy M. Wang Jan-Gowth Chang | 2000 | International Journal of Cardiology2000，，2： | 1 |
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