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| 1 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 2 | Factors associated with the overall survival of elderly patients with hepatocellular carcinoma显示文摘AIM:To identify the factors associated with overall survival of elderly patients with hepatocellular carcinoma(HCC).METHODS:A total of 286 patients with HCC(male/female:178/108,age:46-100 years),who were diagnosed and treated by appropriate therapeutic procedures between January 2000 and December 2010,were enrolled in this study.Patients were stratified into two groups on the basis of age:Elderly(≥ 75 years old) and non-elderly(< 75 years old).Baseline clinical characteristics as well as cumulative survival rates were then compared between the two groups.Univariate and multivariate analyses were used to identify the factors associated with prolonged overall survival of patients in each group.Cumulative survival rates in the two groups were calculated separately for each modified Japan Integrated Stage score(mJIS score) category by the Kaplan-Meier method.In addition,we compared the cumulative survival rates of elderly and non-elderly patients with good hepatic reserve capacity(≤ 2 points as per mJIS).RESULTS:In the elderly group,the proportion of female patients,patients with absence of hepatitis B or hepatitis C viral infection,and patients with coexisting extrahepatic comorbid illness was higher(56.8% vs 31.1%,P < 0.001;27.0% vs 16.0%,P = 0.038;33.8% vs 22.2%,P = 0.047;respectively) than that in the nonelderly group.In the non-elderly group,the proportion of hepatitis B virus(HBV)-infected patients was higher than that in the elderly group(9.4% vs 0%,P = 0.006).The cumulative survival rates in the elderly group were 53.7% at 3 years and 32.9% at 5 years,which were equivalent to those in the non-elderly group(55.9% and 39.4%,respectively),as shown by a log-rank test(P = 0.601).In multivariate analysis,prolonged survival was significantly associated with the extent of liver damage and stage(P < 0.001 and P < 0.001,respectively),but was not associated with patient age.However,on individual evaluation of factors in both groups,stage was significantly(P < 0.001) associated with prolonged survival.Regarding mJIS scores of ≤ 2,the rate of female patients with this score was higher in the elderly group when compared to that in the non-elderly group(P = 0.012) and patients ≥ 80 years of age tended to demonstrate shortened survival.CONCLUSION:Survival of elderly HCC patients was associated with liver damage and stage,but not age,except for patients ≥ 80 years with mJIS score ≤ 2. | Hideki Fujii Yoshito Itoh Naoki Ohnishi Masafumi Sakamoto Tohru Ohkawara Yoshihiko Sawa Koichi Nishida Yasuo Ohkawara Kanji Yamaguchi Masahito Minami Takeshi Okanoue | 2012 | World Journal of Gastroenterology2012，18，16： | 4 |
| 3 | Case of autoimmune hepatitis with markedly enlarged hepatoduodenal ligament lymph nodes显示文摘Autoimmune hepatitis(AIH) is a necroinflammatory liver disease of unknown etiology.The disease is characterized histologically by interface hepatitis,biochemically by increased aspartate aminotransferase and alanine aminotransferase levels,and serologically by increased autoantibodies and immunoglobulin G levels.Here we discuss AIH in a previously healthy 37-year-old male with highly elevated serum levels of soluble interleukin-2 receptor and markedly enlarged hepatoduodenal ligament lymph nodes(HLLNs,diameter,50 mm).Based on these observations,the differential diagnoses were AIH,lymphoma,or Castleman's disease.Liver biopsy revealed the features of interface hepatitis without bridging fibrosis along with plasma cell infiltration which is the typical characteristics of acute AIH.Lymph node biopsy revealed lymphoid follicles with inflammatory lymphocytic infiltration;immunohistochemical examination excluded the presence of lymphoma cells.Thereafter,he was administered corticosteroid therapy:after 2 mo,the enlarged liver reached an almost normal size and the enlarged HLLNs reduced in size.We could not find AIH cases with such enlarged lymph nodes(diameter,50 mm) in our literature review.Hence,we speculate that markedly enlarged lymph nodes observed in our patient may be caused by a highly activated,humoral immune response in AIH. | Hideki Fujii Naoki Ohnishi Kazuho Shimura Masafumi Sakamoto Tohru Ohkawara Yoshihiko Sawa Koichi Nishida Yasuo Ohkawara Tatsuro Kobata Kanji Yamaguchi Yoshito Itoh | 2013 | World Journal of Gastroenterology2013，19，11： | 3 |
| 4 | Prognostic Index for Patients with Hepatocellular Carcinoma Combined with Tumor Thrombosis in the Major Portal Vein显示文摘 | Iwao Ikai Etsuro Hatano Suguru Hasegawa Hideaki Fujii Kojiro Taura Naoki Uyama Yasuyuki Shimahara | 2006 | Journal of the American College of Surgeons2006，，3： | 2 |
| 5 | Function and diagnostic value of Anosmin‐1 in gastric cancer progression显示文摘 | Mitsuro Kanda Dai Shimizu Tsutomu Fujii Satoshi Sueoka Yuri Tanaka Kazuhiro Ezaka Hideki Takami Haruyoshi Tanaka Ryoji Hashimoto Naoki Iwata Daisuke Kobayashi Chie Tanaka Suguru Yamada Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasu | 2016 | Int. J. Cancer2016，，3： | 1 |
| 6 | Interferometric Determination of the Diameter of a Silicon Sphere Using a Direct Optical Frequency Tuning System显示文摘 | Kuramoto Naoki Fujii Kenichi | 2003 | IEEE Transactions on Instrumentation and Measurement2003，52，2： | 1 |
| 7 | Nitrogen removal performance and microbial community analysis of an anaerobic up-flow granular bed anammox reactor显示文摘 | Cho Sunja Yoshitaka Takahashi Naoki Fujii | 2010 | Chemosphere2010，，78： | 1 |
| 8 | Volume Determination of a Silicon Sphere Using an Improved Interferometer with Optical Frequency Tuning显示文摘 | Kuramoto Naoki Fujii Kenichi | 2005 | IEEE Transactions on Instrumentation and Measurement2005，54，2： | 1 |
| 9 | Translational implication of Kallmann syndrome-1 gene expression inhepatocellular carcinoma显示文摘 | Yuri Tanaka Mitsuro Kanda Hiroyuki Sugimoto Dai Shimizu Satoshi Sueoka Hideki Takami Kazuhiro Ezaka Ryoji Hashimoto Yukiyasu Okamura Naoki Iwata Chie Tanaka Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro | 2015 | International Journal of Oncology2015，，6： | 1 |
| 10 | Density Determination of Silicon Spheres Using an Interferometer with Optical Frequency Tuning显示文摘 | Kuramoto Naoki Fujii Kenichi Yasushi Azuma | 2007 | IEEE Transactions on Instrumentation and Measurement2007，56，2： | 1 |
| 11 | Enhanced transformation of diphenylarsinic acid in soil under sulfate-reducing conditions显示文摘 | Ling Guan Shihoko Hisatomi Kunihiko Fujii Masanori Nonaka Naoki Harada | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 12 | Monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics显示文摘Backgrounds ATP is the major energy source for myotube contraction,and is quickly produced to compensate ATP consumption and to maintain sufficient ATP level.ATP is consumed mainly in cytoplasm and produced in mitochondria during myotube contraction.To understand the mechanism of ATP homeostasis during myotube contraction,it is essential to monitor mitochondrial ATP at single-cell level,and examine how ATP is produced and consumed in mitochondria.Methods:We established C2C12 cell line stably expressing fluorescent probe of mitochondrial ATP,and induced differentiation into myotubes・We gave electric pulse stimulation to the differentiated myotubes,and measured mitochondrial ATP.We constructed mathematical model of mitochondrial ATP at single-cell level,and analyzed kinetic parameters of ATP production and consumption.Results:We performed hierarchical clustering analysis of time course of mitochondrial ATP,which resulted in two clusters.Cluster 1 showed strong transient increase,whereas cluster 2 showed weak transient increase.Mathematical modeling at single-cell level revealed that the ATP production rate of cluster 1 was larger than that of cluster 2,and that both regulatory pathways of ATP production and consumption of cluster 1 were faster than those of cluster 2.Cluster 1 showed larger mitochondrial mass than cluster 2,suggesting that cluster 1 shows the similar property of slow muscle fibers,and cluster 2 shows the similar property of fast muscle fibers.Conclusions Cluster 1 showed the stronger mitochondrial ATP increase by larger ATP production rate,but not smaller consumption.Cluster 1 might reflect the larger oxidative capacity of slow muscle fiber. | Naoki Matsuda Ken-ichi Hironaka Masashi Fujii Takumi Wada Katsuyuki Kunida Haruki Inoue Miki Eto Daisuke Hoshino Yasuro Furuichi Yasuko Manabe Nobuharu LFujii Hiroyuki Noji Hiromi Imamura Shinya Kuroda | 2020 | Quantitative Biology2020，8，3： | 1 |
| 13 | Interferometric determination of the diameter of a silicon sphere using a direct optical frequency tuning system 显示文摘 | Kuramoto Naoki Fujii Kenichi | 2003 | IEEE Transactions on Instrumentation and Measurement(S0018-9456)2003，52，2： | 1 |
| 14 | Biodegradation of diphenylarsinic acid to arsenic acid by novel soil bacteria isolated from contaminated soil显示文摘 | Naoki Harada Kazuhiro Takagi Koji Baba Kunihiko Fujii Akio Iwasaki | 2010 | Biodegradation2010，，3： | 1 |
| 15 | Present State of the Avogadro Constant Determination from Silicon Crystals with Natural Isotopic Compositions 显示文摘 | Fujii Kenichi Waseda Atsushi Kuramoto Naoki | 2005 | IEEE Trans on IM2005，54，2： | 1 |
| 16 | Stromal cell derived factor 1 (SDF 1 ) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells ( CFU-MK ) 显示文摘 | Keiko Hodohara Nobutaka Fujii Naoki Yamamoto | 2000 | Blood2000，95，3： | 1 |
| 17 | Density determination of silicon spheres using an interferometer with optical frequency tuning显示文摘 | Naoki Kuramoto Kenichi Fujii Yasushi Azuma | 2007 | IEEE Transactions on Instrumentation and Measurement2007，56，2： | 1 |
| 18 | Dose-escalating and pharmacokinetic study of a weekly combination of pa- clitaxel and carboplatin for inoperable non-small cell lung cancer: JCOG 9910-DI显示文摘 | Naoki K Kunikane H Fujii T | 2009 | Japanese Journal of Clinical Oncology2009，39，9： | 1 |
| 19 | Corrosion of reduced activation ferritic martensitic steel JLF-1 in purified Flinak at static and flowing conditions显示文摘 | Masatoshi Kondo Takuya Nagasaka Valentyn Tsisar Akio Sagara Takeo Muroga Takashi Watanabe Tomoko Oshima Yukihiro Yokoyama Hiroshi Miyamoto Eiji Nakamura Naoki Fujii | 2010 | Fusion Engineering and Design2010，，7： | 1 |
| 20 | Corrosion characteristics of reduced activation ferritic steel, JLF-1 (8.92Cr–2W) in molten salts Flibe and Flinak显示文摘 | Masatoshi Kondo Takuya Nagasaka Qi Xu Takeo Muroga Akio Sagara Nobuaki Noda Daisuke Ninomiya Masaru Nagura Akihiro Suzuki Takayuki Terai Naoki Fujii | 2009 | Fusion Engineering and Design2009，，7： | 1 |
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