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    题名 作者 年代 出处 被引量
1Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AM PK显示文摘Feng ZOU Xian-qing MAO Nian WANG Jian LIU Jing-ping OU-YANG 2009Acta Pharmacologica Sinica2009,30,12:38
2Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients显示文摘The novel contagious primary atypical pneumonia epidemic,which broke out in Wuhan,China,in December 2019,is now formally called Coronavirus Disease 2019(COVID-19),with the causative virus named as Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).1,2 Recent studies have shown that in addition to dyspnea,hypoxemia,and acute respiratory distress,lymphopenia,and cytokine release syndrome are also important clinical features in patients with severe SARS-CoV-2 infection.3 This suggests that homeostasis of the immune system plays an important role in the development of COVID-19 pneumonia.Hong-Yi Zheng Mi Zhang Cui-Xian Yang Nian Zhang Xi-Cheng Wang Xin-Ping Yang Xing-Qi Dong Yong-Tang Zheng 2020Cellular & Molecular Immunology2020,17,5:38
3Impact of land use change on water resource allocation in the middle reaches of the Heihe River Basin in northwestern China显示文摘In recent decades, China has been experiencing rapid economic development, population growth and urbanization. These processes have stressed the shortages of water resources in China, especially in the arid re- gions of northwestern China. In order to sustain the expanding cropland, people increased groundwater exploitation in these regions. The purpose of this study was to quantitatively analyze the changes in land use and water re- sources, and their relationship in the middle reaches of the Heihe River Basin, a typical inland river basin in northwest China. The data of land use change were interpreted using aerial photographs(1965) and Landsat TM images(1986 and 2007). The data of irrigation water volume in the irrigation districts were spatialized in the middle reaches of the Heihe River Basin. The spatial variation of the groundwater depth was interpolated using the geo- statistical method. The results showed that the cultivated cropland area along oasis fringe increased by 15.38% and 43.60% during the periods 1965–1986 and 1986–2007, respectively. Surface water amount for irrigation had almost doubled from 1956 to 2010. The decrease of grassland area mainly occurred at the alluvial fan in front of the Qilian Mountains, with 36.47% during 1965–1986 and 38.56% during 1986–2007, respectively. The groundwater depth in front of the mountain constantly increased from 1986 to 2007. We found that the overuse of surface water and overexploitation of groundwater had direct consequences on the natural environments. We suggests that the efficiency of surface water resources use among different irrigation districts needs to be improved, which will sig- nificantly ease the conflicts between increasing water demand for irrigation and a shortage of water resources in the middle reaches of the Heihe River Basin.YanYun NIAN Xin LI Jian ZHOU XiaoLi HU 2014Journal of Arid Land2014,6,3:32
4Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBCID4 phosphorylation显示文摘Jian LIU Jing-fang ZHANG Jin-zhi LU De-ling ZHANG Ke LI Ke SU Jing WANG Ye-min ZHANG Nian WANG Si-tu YANG Lang BU Jing-ping OU-YANG 2013Acta Pharmacologica Sinica2013,34,1:26
5Pyroptosis: mechanisms and diseases显示文摘Currently,pyroptosis has received more and more attention because of its association with innate immunity and disease.The research scope of pyroptosis has expanded with the discovery of the gasdermin family.A great deal of evidence shows that pyroptosis can affect the development of tumors.The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds.In this review,we provide basic knowledge of pyroptosis,explain the relationship between pyroptosis and tumors,and focus on the significance of pyroptosis in tumor treatment.In addition,we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis.In brief,pyroptosis is a double-edged sword for tumors.The rational use of this dual effect will help us further explore the formation and development of tumors,and provide ideas for patients to develop new drugs based on pyroptosis.Pian Yu Xu Zhang Nian Liu Ling Tang Cong Peng Xiang Chen 2021Signal Transduction and Targeted Therapy2021,6,4:26
6Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats显示文摘瞄准:为了从知母属调查 steroidal saponins 的保护的效果,卵巢切除术(OVX ) 上的 asphodeloides (ATS ) 导致了骨头损失。方法:Sprague-Dawley 老鼠被划分成假冒并且 OVX 组。OVX 老鼠与车辆, nylestriol 或 steroidal saponins 摘录被对待 12 个星期。浆液钙,磷,雌二醇(E (2 )) , osteocalcin 集中和浆液硷性磷酸酯酶活动被测量。骨头密度是由双精力的 X 光检查 absorptiometry 的 assayed。波形钙化纵近似胫骨先验(PTM ) 节为 histomorphometric 被切并且染色骨头的分析。结果:在 OVX 老鼠,在浆液的硷性磷酸酯酶活动显著地被增加, osteocalcin 的集中被 ATS 处理减少,它没在体重上有影响。同时,子宫的萎缩和骨头矿物质密度(BMD ) 的降下被处理与 ATS 一起压制。另外, ATS 们完全改正了减少在浆液的钙和 E (2 ) 的集中在 OVX 观察了老鼠。组织学的结果证明 ATS 们在在近似胫骨干骺端(PTM ) 的小梁的分离的小梁的厚度和 OVX 老鼠的增加阻止了减少。然而,它没在 OVX 老鼠改变骨破折数字。而且, ATS (300 mg/kg ) 在在 OVX 老鼠支持骨头形成行动上有显著效果。Nylestriol 处理减少了骨头形成率和矿物质并置率。结论:知母属 asphodeloides 的 steroidal saponins 的足够的供应通过骨头形成的提升然而并非骨吸收的抑制在老鼠阻止了导致 OVX 的骨头损失。Hua NIAN Lu-ping QIN Wan-sheng CHEN Qiao-yan ZHANG Han-chen ZHENG Yin WANG 2006Acta Pharmacologica Sinica2006,27,6:20
7A Single Nucleotide Deletion in J Encoding GmELF3 Confers Long Juvenility and Is Associated with Adaption of Tropic Soybean显示文摘Yanlei Yue Nianxi Liu Bingjun Jiang Mu Li Haijie Wang Ze Jiang Huanting Pan Qiuju Xia Qibin Ma Tianfu Han Hai Nian 2017Molecular Plant2017,10,4:20
8Enhanced control of DFIG-used back-to-back PWM VSC under unbalanced grid voltage conditions显示文摘This paper presents a unified positive-and negative-sequence dual-dq dynamic model of wind-turbine driven doubly-fed induction generator(DFIG) under unbalanced grid voltage conditions. Strategies for enhanced control and operation of a DFIG-used back-to-back(BTB) PWM voltage source converter(VSC) are proposed. The modified control design for the grid-side converter in the stationary αβ frames diminishes the amplitude of DC-link voltage ripples of twice the grid frequency,and the two proposed control targets for the rotor-side converter are alternatively achieved,which,as a result,improve the fault-ride through(FRT) capability of the DFIG based wind power generation systems during unbalanced network supply. A complete unbalanced control scheme with both grid-and rotor-side converters included is designed. Finally,simulation was carried out on a 1.5 MW wind-turbine driven DFIG system and the validity of the developed unified model and the feasibility of the proposed control strategies are all confirmed by the simulated results.HU Jia-bing HE Yi-kang NIAN Heng 2007Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007,8,8:20
9Extension of Isometries Between the Unit Spheres of Normed Space E and C(Ω)显示文摘在这份报纸,我们学习在 normed 空间 E 和 C 的联合起来的范围之间的 isometries 的延期(惟) 。我们获得那在 normed 空间 E 和 C 的联合起来的范围之间的任何 surjective isometry (惟) 能被扩大是整个空间 E 上的线性 isometry 并且把一个肯定答案给相应 Tingley 鈥檚 问题(在哪儿惟是一个紧缩的度量标准空间) 。关键词等轴的印射 - 等轴的扩展 - Tingley 鈥檚 问题先生(2000 ) 题目分类 46B04 - 46B20 - 47A67 -Xi Nian FANG Jian Hua WANG 2006Acta Mathematica Sinica,English Series2006,22,6:18
10Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases:An update显示文摘Long-chain acyl-Co A synthetase(ACSL) family members include five different ACSL isoforms, each encoded by a separate gene and have multiple spliced variants. ACSLs on endoplasmic reticulum and mitochondrial outer membrance catalyze fatty acids with chain lengths from 12 to 20 carbon atoms to form acyl-Co As, which are lipid metabolic intermediates and involved in fatty acid metabolism, membrane modifications and various physiological processes. Gain- or lossof-function studies have shown that the expression of individual ACSL isoforms can alter the distribution and amount of intracellular fatty acids. Changes in the types and amounts of fatty acids, in turn, can alter the expression of intracellular ACSLs. ACSL family members affect not only the proliferation of normal cells, but the proliferation of malignant tumor cells. They also regulate cell apoptosis through different signaling pathways and molecular mechanisms. ACSL members have individual functions in fatty acid metabolism in different types of cells depending on substrate preferences, subcellular location and tissue specificity, thus contributing to liver diseases and metabolic diseases, such as fatty liver disease, obesity, atherosclerosis and diabetes. They are also linked to neurological disorders and other diseases. However, the mechanisms are unclear. This review addresses new findings in the classification and properties of ACSLs and the fatty acid metabolismassociated effects of ACSLs in diseases.Sheng Yan Xue-Feng Yang Hao-Lei Liu Nian Fu Yan Ouyang Kai Qing 2015World Journal of Gastroenterology2015,21,12:18
11Transurethral seminal vesiculoscopy for recurrent hemospermia: experience from 419 cases显示文摘Rui Chen Lei Wang Xia Sheng Shu-Guang Piao Xin-Wen Nian Xin Cheng Tie Zhou Hui-Zhen Li Ya-Wei Liu Guang-Hua Chen Chun-Lei Zhang De-Pei Kong Guang-An Xiao Xin Lu Zhen-Yu Jia Zhi-Yong Liu Ying-Hao Sun 2018Asian Journal of Andrology2018,20,5:18
12Follow-up study of hepatitis C virus infection in uremic patients on maintenance hemodialysis for 30 months显示文摘INTRODUCTIONA high prevalence of antibodies to hepatitis C virus(HCV)(range from 3.3%-80%)has beenreported in hemodialysis(HD)patients,andworrisome as it often becomes chronic and induceschronic liver disease,therefore thenephrologists face a major challenge of how toprevent it.The main route of HCV transmissionNian Song Wang Lu Tan Liao Yan Juan Zhu Wei Pan Fang Fang 2000World Journal of Gastroenterology2000,6,6:17
13Vector meson spin alignment by the strong force field显示文摘Observation of unexpectedly large global spin alignment of φ vector mesons in non-central heavy-ion collisions by STAR experiment may reveal the non-perturbative nature of quark interaction in hot matter through fluctuating strong force field with short correlation length.Xin‑Nian Wang 2023Nuclear Science and Techniques2023,34,1:15
14Rice Ferredoxin-Dependent Glutamate Synthase Regulates Nitrogen-Carbon Metabolomes and Is Genetically Differentiated between japonica and indica Subspecies显示文摘当通过夫酸安 synthetase/glutamine:2-oxoglutarate amidotransferase (GS/GOGAT ) 的 Gln 和 Glu 骑车,植物吸收从土壤吸收进器官的形式的无机的氮。而 GS 从 Glu 和氨催化 Gln 的形成, GOGAT 从 Gln 催化一个酰胺组的转移到 2-oxoglutarate 生产 Glu 的二个分子。然而,处于碳氮平衡的 GS/GOGAT 周期的规章的角色很好没被理解。这里,我们报导米饭的功能的描述反常细胞激动素反应 1 (ABC1 ) 编码一个铁氧化还原蛋白依赖者(Fd ) 的基因 -GOGAT。弱变异的等位基因 abc1-1 异种显示出典型氮缺乏的症候群,而 T-DNA insertional 异种 abc1-2 是幼苗致命。Metabolomics 分析在 abc1-1 在 tricarboxylic 酸周期与高 N/C 比率(Gln 和 Asn ) 和几中介揭示了氨基酸的过多的数量的累积,建议 ABC1 起在氮吸收和碳氮平衡的一个关键作用。五非同义的单个核苷酸的多型性在编码区域的 ABC1 被识别并且作为三不同 haplotypes 描绘了,它高度并且明确地在装饰用的梨树和 indica 亚种之间被区分了。一起,这些结果建议 ABC1/OsFd-GOGAT 由 modulating 氮吸收和碳氮平衡为植物生长和开发是必要的。Xiaolu Yang Jinqiang Nian Qincliun xie Jian Feng Fengxia Zhang Hongwei Jing Jian Zhang Guojun Dong Yan Liang Juli Peng GuodongWang Qian Qian Jianru Zuo 2016Molecular Plant2016,9,11:14
15Associations of blood pressure and arterial compliance with occupational noise exposure in female workers of textile mill显示文摘在那里的背景是噪音暴露的动脉的依从上的很少研究。学习是理解在听见损失,血压和在噪音在工作地点铺平的纺织品 mill.Methods 暴露了到职业噪音的女工人的动脉的依从之间的关系的这的目的与一 HS6288 健全水平米被测量。堆积噪音暴露(CNE ) 根据噪音紧张和暴露时期被计算。听说能力和动脉的依从在 618 噪音被测量暴露了工人。数据库与 EpiData 被建立,统计分析与噪音铺平的 SAS 软件 9.1.3 .Results 被执行是到 113.5dB (A) ,在监视地点的 92.5% 噪音的层次在国家标准上是的 80.1dB (A) 。高频率听觉损失(HFHL ) 的发生是 24.43% ,语言频率听觉缺陷(LFHI ) 是 0.81% 。高血压的发生是 7.93% 。收缩血压(SBP ) 和在高频率听觉损失组的心脏舒张的血压(DBP ) 比在正常听觉组(P0.05 ) 的那些显著地高,当 C1 (大动脉依从) 和 C2 (小动脉依从) 显著地更低时(P0.05 ) 。高血压组的高频率听觉阀值(HFHT ) 比在正常血压组(P0.05 ) 显著地高,当 C1 和 C2 显著地更低时(P0.05 ) 。 C1 和 C2 与 HFHT 有否定关联, SBP , DBP ,动脉的压力(地图)的平均数,脉搏压力( PP )和多重回归分析的 .The 显示出的脉搏率( PR )( P0.05 )血压和 PR 是 C1 和 C2.LFHT 上的主要影响因素,这是对 C2 的影响, C1.Conclusions 纺织品工厂噪音污染上的 HFHT 是很严肃的并且在工人的家上有明显的影响听觉的功能。有 Iow 动脉依从或与高血压的女工人可能正在受不了听觉损失;那些与噪音导致了听说如果她常常暴露于大声工业的噪音,损失可能正在患高血压。NI Chun-hui CHEN Zhi-yong ZHOU Yin ZHOU Jian-wei Pan Jing-jing LIU Nian WANG Jun LIANG Chen-ke ZHANG Zhi-zhong ZHANG Yu-jun 2007Chinese Medical Journal2007,,15:12
16CAS FGOALS-f3-L Model Datasets for CMIP6 Historical Atmospheric Model Intercomparison Project Simulation显示文摘The outputs of the Chinese Academy of Sciences(CAS) Flexible Global Ocean–Atmosphere–Land System(FGOALS-f3-L) model for the baseline experiment of the Atmospheric Model Intercomparison Project simulation in the Diagnostic,Evaluation and Characterization of Klima common experiments of phase 6 of the Coupled Model Intercomparison Project(CMIP6) are described in this paper. The CAS FGOALS-f3-L model, experiment settings, and outputs are all given. In total,there are three ensemble experiments over the period 1979–2014, which are performed with different initial states. The model outputs contain a total of 37 variables and include the required three-hourly mean, six-hourly transient, daily and monthly mean datasets. The baseline performances of the model are validated at different time scales. The preliminary evaluation suggests that the CAS FGOALS-f3-L model can capture the basic patterns of atmospheric circulation and precipitation well, including the propagation of the Madden–Julian Oscillation, activities of tropical cyclones, and the characterization of extreme precipitation. These datasets contribute to the benchmark of current model behaviors for the desired continuity of CMIP.Bian HE Qing BAO Xiaocong WANG Linjiong ZHOU Xiaofei WU Yimin LIU Guoxiong WU Kangjun CHEN Sicheng HE Wenting HU Jiandong LI Jinxiao LI Guokui NIAN Lei WANG Jing YANG Minghua ZHANG Xiaoqi ZHANG 2019Advances in Atmospheric Sciences2019,36,8:12
17The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment.ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart 2019Science China(Physics,Mechanics & Astronomy)2019,62,2:11
18Mitosin/CENP-F is a conserved kinetochore protein subjected to cyto plasmic dynein-mediated poleward transport显示文摘Mitosin/CENP-F is a human nuclear protein transiently associated with the outer kinetochore plate in M phase and is involved in M phase progression. LEK1 and CMF1, which are its murine and chicken orthologs, however, are implicated in muscle differentiation and reportedly not distributed at kinetochores.We therefore conducted several assays to clarify this issue. The typical centromere staining patterns were observed in mitotic cells from both human primary culture and murine, canine, and mink cell lines. A C-terminal portion of LEK1 also conferred centromere localization. Our analysis further suggests conserved kinetochore localization of mammalian mitosin orthologs. Moreover, mitosin was associated preferentially with kinetochores of unaligned chromosomes. It was also constantly transported from kinetochores to spindle poles by cytoplasmic dynein. These properties resemble those of other kinetochore proteins important for the spindle checkpoint, thus implying a role of mitosin in this checkpoint. Therefore, mitosin family may serve as multifunctional proteins involved in both mitosis and differentiation.ZHEN YE YANG, JING GUO, NING LI, MIN QIAN, SHENG NIAN WANG, XUE LIANG ZHULaboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China 2003Cell Research2003,13,4:11
19The Citrus Huanglongbing Crisis and Potential Solutions显示文摘Citrus is one of the top three fruit crops worldwide.Citrus production is facing an unprecedented crisis due to Huanglongbing(HLB,also known as citrus greening),which is the most devastating disease of citrus.HLB was first reported in Asia a century ago.HLB is associated with Candidatus Liberibacter asiaticus(Las),Ca.L.americanus(Lam),and Ca.L.africanus(Bove,2006),which belong to the gramegative a-proteobacteria.Among them,Las is the most widely spread.Las and Lam are vectored by Diaphorina citri Kuwayama(ACP),whereas Laf is transmitted by Trioza erytreae.Nian Wang 2019Molecular Plant2019,12,5:10
20The Ghd7 transcription factor represses ARE1 expression to enhance nitrogen utilization and grain yield in rice显示文摘The genetic improvement of nitrogen use efficiency(NUE)of crops is vital for grain productivity and sustainable agriculture.However,the regulatory mechanism of NUE remains largely elusive.Here,we report that the rice Grain number,plant height,and heading date7(Ghd7)gene genetically acts upstream of ABC1 REPRESSOR1(ARE1),a negative regulator of NUE,to positively regulate nitrogen utilization.As a transcriptional repressor,Ghd7 directly binds to two Evening Element-like motifs in the promoter and intron 1 of ARE1,likely in a cooperative manner,to repress its expression.Ghd7 and ARE1 display diurnal expression patterns in an inverse oscillation manner,mirroring a regulatory scheme based on these two loci.Analysis of a panel of 2656 rice varieties suggests that the elite alleles of Ghd7 and ARE1 have undergone diversifying selection during breeding.Moreover,the allelic distribution of Ghd7 and ARE1 is associated with the soil nitrogen deposition rate in East Asia and South Asia.Remarkably,the combination of the Ghd7 and ARE1 elite alleles substantially improves NUE and yield performance under nitrogen-limiting conditions.Collectively,these results define a Ghd7–ARE1-based regulatory mechanism of nitrogen utilization,providing useful targets for genetic improvement of rice NUE.Qing Wang Qingmei Su Jinqiang Nian Jian Zhang Meng Guo Guojun Dong Jiang Hu Rongsheng Wang Changshuo Wei Guanwen Li Wan Wang Hui-Shan Guo Shaoyang Lin Wenfeng Qian XianzhiXie Qian Qian Fan Chen Jianru Zuo 2021Molecular Plant2021,14,6:10
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