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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | The Ghd7 transcription factor represses ARE1 expression to enhance nitrogen utilization and grain yield in rice显示文摘The genetic improvement of nitrogen use efficiency(NUE)of crops is vital for grain productivity and sustainable agriculture.However,the regulatory mechanism of NUE remains largely elusive.Here,we report that the rice Grain number,plant height,and heading date7(Ghd7)gene genetically acts upstream of ABC1 REPRESSOR1(ARE1),a negative regulator of NUE,to positively regulate nitrogen utilization.As a transcriptional repressor,Ghd7 directly binds to two Evening Element-like motifs in the promoter and intron 1 of ARE1,likely in a cooperative manner,to repress its expression.Ghd7 and ARE1 display diurnal expression patterns in an inverse oscillation manner,mirroring a regulatory scheme based on these two loci.Analysis of a panel of 2656 rice varieties suggests that the elite alleles of Ghd7 and ARE1 have undergone diversifying selection during breeding.Moreover,the allelic distribution of Ghd7 and ARE1 is associated with the soil nitrogen deposition rate in East Asia and South Asia.Remarkably,the combination of the Ghd7 and ARE1 elite alleles substantially improves NUE and yield performance under nitrogen-limiting conditions.Collectively,these results define a Ghd7–ARE1-based regulatory mechanism of nitrogen utilization,providing useful targets for genetic improvement of rice NUE. | Qing Wang Qingmei Su Jinqiang Nian Jian Zhang Meng Guo Guojun Dong Jiang Hu Rongsheng Wang Changshuo Wei Guanwen Li Wan Wang Hui-Shan Guo Shaoyang Lin Wenfeng Qian XianzhiXie Qian Qian Fan Chen Jianru Zuo | 2021 | Molecular Plant2021，14，6： | 10 |
| 3 | Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells显示文摘各种各样的干细胞类型在对待光敏电阻器为他们的潜在的申请被测试了退化疾病,例如视网膜炎 pigmentosa (RP ) 和年龄相关的有斑点的退化(AMD ) 。仅仅胚胎的干细胞(转换字符) 到目前为止被显示了产生恢复光敏电阻器缺乏的老鼠的轻反应的功能的光敏电阻器房间,但是仍然有肿瘤形成的一些担心。在这研究,我们有成功地有教养的 Nestin + Sox2 + Pax6 + multipotent 从成年老鼠视网膜的网膜的干细胞(RSC ) ,它能够生产恢复跟随移植的光敏电阻器缺乏的 rd1 异种老鼠的轻反应的功能的光敏电阻器房间。在他们面对 FGF 和 EGF 为超过 35 个段落被扩展了以后,有教养的 RSC 仍然维持稳定的增长和区别潜力。在合适的区别条件下面,他们能区分进在成年视网膜发现的所有主要网膜的房间类型。更重要地,他们能高效地在优化区别条件下面区分进光敏电阻器房间。直到慢慢地堕落的 rd7 异种的 subretinal 空间的后面的移植看,导出 RSC 的光敏电阻器房间与居民一起集成到视网膜,词法上类似于的内长的光敏电阻器和形成的 synapases 网膜的神经原。当移植了进光敏电阻器缺乏的 rd1 异种老鼠的眼睛时,一个 RP 模型,导出 RSC 的光敏电阻器能部分恢复轻反应,显示那些导出 RSC 的光敏电阻器是功能的。最后,为在移植光敏电阻器的眼睛的肿瘤形成没有证据。因此,这研究证明了从成年视网膜孤立的 RSC 有生产能潜在地恢复光敏电阻器房间的损失在 RP 和 AMD 引起的失去的视觉的功能的光敏电阻器房间的潜力。 | Tianqing Li Michelle Lewallen Shuyi Chen Wei Yu Nian Zhang Ting Xie | 2013 | Cell Research2013，23，6： | 7 |
| 4 | Multi-objective Optimal Generation Dispatch With Consideration of Operation Risk显示文摘 | QIU Wei ZHANG Jianhua LIU Nian ZHU Xingyang LIU Lihua | 2012 | 中国电机工程学报2012，32，22： | 4 |
| 5 | Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues显示文摘九外消旋的 homocamptothecin 衍生物被综合,在 vitro antitumor,活动被标准 MTT 方法评估。结果比 iritecan 显示出复合有的更高的 antitumor 活动的那一些。 | Liang You Wan Nian Zhang Zhen Yuan Miao Wei Guo Xiao Ying Che Wen Ya Wang Chun Quan Sheng Jiang Zhong Yao Ting Zhou | 2008 | Chinese Chemical Letters2008，19，7： | 3 |
| 6 | Novel Phenomenon on Valence Unvariation of Doping Ion in Yb:YAG Transparent Ceramics Using MgO Additives显示文摘Yb:YAG nanopowders were synthesized by the alcohol-water co-precipitation method adding MgO as sintering additives. Appropriate amount of MgO adding can restrict the agglomeration and reduce the particle size of Yb:YAG powders. When the MgO content was 0.04wt%, well-dispersed Yb:YAG powders with ellipsoidal particles of less than 100 nm diameter were obtained. The experimental results showed the valence variation of doping ion Yb3+ would not appear when adding MgO as sintering additives, so ceramics showed colorless transparent instead of green due to Yb2+ color center using traditional SiO2 as additives. The transmission of the sintered Yb:YAG ceramics can reach 80.6% even without annealing. Ceramic morphology showed that the grains had uniform-distribution with the size of 10 μm or so, and no impurity and pore existed in the grain boundary and crystalline while using optimal sintering conditions. | 卢忠文 卢铁城 WEI Nian MA Benyuan ZHANG Wei LI Feng GUAN Yongbing | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，2： | 2 |
| 7 | Dimension of Maximal Attractors for the m-dimensional Cahn Hilliard System显示文摘根据在产品空格的 m-dimensionalCahn-Hilliard 系统的最大的引起注意的人的存在(L^2 (Ω))~ m 并且(H^2 (Ω))~ m 在这篇论文,它的 Hausdorffdimension 被计算系统的线性变化操作符的直角的设计估计。 | Wei Nian ZHANG(Weinian Zhang) | 2005 | Acta Mathematica Sinica,English Series2005，21，6： | 2 |
| 8 | Real time bipolar time-of-flight mass spectrometer for analyzing single aerosol particles显示文摘 | Lei Li Zhengxu Huang Junguo Dong Mei Li Wei Gao Huiqing Nian Zhong Fu Guohua Zhang Xinhui Bi Ping Cheng Zhen Zhou | 2011 | International Journal of Mass Spectrometry2011，，2： | 2 |
| 9 | Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase显示文摘 | Hong Nian Wei Zhang Hexin Shi Qingzhen Zhao Qi Xie Shangying Liao Yan Zhang Zhuqiang Zhang Chen Wang Chunsheng Han | 2008 | Cell Research2008，18，7： | 2 |
| 10 | Analysis of QTLs for erucic acid and oil content in seeds on A8 chromosome and the linkage drag between the alleles for the two traits in Brassica napus显示文摘The history of canola breeding began with the discovery of germplasm with low erucic acid content in seeds of spring forage cultivar in the 1950's.FAE1 mutations led to a dramatic decrease of the seed erucic acid content in Arabidopsis thaliana.The products of the two FAE1 loci,BnA8.FAE1 and BnC3.FAE1,showed additive effects to the level of erucic acid content in oilseed rape.Previous research believed that the pleiotropy of FAE1 was responsible for the decrease in seed oil content along with the reduction of seed erucic acid content in the modern cultivars.TN DH population was developed from a canola cultivar Tapidor and a Chinese traditional cultivar Ningyou7.The population had been tested in 10 and 11 environments to map QTLs for the erucic acid content and oil content in seeds.As the map resolution increased,a novel QTL for seed erucic acid content was revealed,after Meta-analysis,7 cM away from the most significant seed erucic acid content QTL where BnA8.FAE1 is located.Seven independent QTLs for seed oil content(qOC) were detected around the two seed erucic acid content QTLs(qEA) across 39.20 cM on linkage group A8.Two of the qOCs co-localized with the two qEAs,respectively,and were detected in a single environment.The other five qOCs were detected in 10 of 11 environments independent of qEAs.Alleles from Tapidor in all the QTLs at the 0-39.20 cM region contributed negative effects to either erucic acid content or oil content in seeds.Parallel,geno-typing showed that on 5 of the 7 QTLs regions,Tapidor alleles had the same genotypes with that in 'Liho',the original low seed erucic acid content source.Through rounds of crossbreeding with oil-cropped cultivars and intensive selection for multi generations,Tapidor still had the inferior alleles for low seed oil content from 'Liho',the forage rape.This showed a strong linkage drag of low seed oil content,which was controlled by the five qEA-independent qOCs,with low seed erucic acid content.Ninety cultivars of B.napus from 8 countries were used to analyze the genetic drag with 9 molecular markers located in the QTL confidence intervals(24.04 cM) on linkage group A8.It was noticed that more than 46% of the cultivars with low seed erucic acid content trait remained the genotype of low seed oil content at least in one locus.Backcross and marker-assisted selection could break the genetic drag between the low oil content and erucic acid in seeds in the process for breeding modern high seed oil content canola cultivars. | Zhengying Cao Fang Tian Nian Wang Congcong Jiang Bing Lin Wei Xia Jiaqin Shi Yah Long Chunyu Zhang Jinling Meng | 2010 | Journal of Genetics and Genomics2010，37，4： | 2 |
| 11 | Extension of VIKOR method for decision making problem based on hesitant fuzzy set显示文摘 | Nian Zhang Guiwu Wei | 2013 | Applied Mathematical Modelling2013，37，7： | 1 |
| 12 | Discussion on the differential solutions of the iterated equation ∑i=1^nλif^i(x)=F(x) 显示文摘 | ZHANG Wei nian | 1990 | Nonlinear a nalysis Theory Methods and Applications1990，36，： | 1 |
| 13 | Time-resolved strain mapping measurements of individual Portevin-Le Chatelier deformation bands显示文摘 | Tong Wei Tao Hong Zhang Nian | 2005 | Scripta Materialia2005，53，： | 1 |
| 14 | Increasing Prevalence of Type 2 Diabetes in Chinese Adults in Shanghai显示文摘 | Li Rui Lu Wei Jiang Qing Wu Li Yan Yun Zhao Gen Ming Shi Liang Yang Qu Di Ruan Ye Jiang Junyi Zhang Sheng Nian Xu Wang Hong Zhong Wei Jian | 2012 | EN2012，，5： | 1 |
| 15 | Real time bipolar time-of-flight mass spectrometer for analyzing single aerosol particles显示文摘 | Lei Li Zhengxu Huang Junguo Dong Mei Li Wei Gao Huiqing Nian Zhong Fu Guohua Zhang Xinhui Bi Ping Cheng Zhen Zhou | 2011 | International Journal of Mass Spectrometry2011，，2： | 1 |
| 16 | Generalization of A Retarded Gronwall-Like Inequality and Its Applications显示文摘 | AGARWAL R P DENG Sheng fu ZHANG Wei nian | 2005 | ApplMathComput2005，165，： | 1 |
| 17 | Extension of VIKOR method for decision making problem based on hesitant fuzzy set显示文摘 | Nian Zhang Guiwu Wei | 2012 | Applied Mathematical Modelling2012，，： | 1 |
| 18 | MicroRNA‐125b attenuates epithelial‐mesenchymal transitions and targets stem‐like liver cancer cells through small mothers against decapentaplegic 2 and 4显示文摘 | Jun‐Nian Zhou Quan Zeng Hai‐Yang Wang Biao Zhang Si‐Ting Li Xue Nan Ning Cao Chun‐Jiang Fu Xin‐Long Yan Ya‐Li Jia Jing‐Xue Wang Ai‐Hua Zhao Zhi‐Wei Li Yan‐Hua Li Xiao‐Yan Xie Xiao‐Mei Zhang Yan Dong Ying‐Chen Xu Li‐Juan He Wen Yue Xue‐Tao Pei | 2015 | Hepatology2015，，3： | 1 |
| 19 | Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz显示文摘Sixteen diterpenoid alkaloids(DAs),including six aconitine-type alkaloids(5 and 9−13),seven 7,17-seco-aconitine-type alkaloids(1−4,6−8),two napelline-type alkaloids(14 and 15)as well as one veatchine-type alkaloid(16),were isolated from the aerial parts of Aconitum flavum Hand.-Mazz.In which,flavumolines A−D(1−4)were four new ones,and flavu-moline E(5)was reported as natural compound for the first time.Their chemical structures were elucidated by the analysis of extensive spectroscopic data.The inhibitory activities of these isolates on Cav3.1 low voltage-gated Ca^(2+)channel,NO production in LPS-activated RAW264.7cells,five human tumor cell lines,as well as acetylcholinesterase(AChE)were tested. | Na Zhang Fan Xia Song-Yu Li Yin Nian Li-Xin Wei Gang Xu | 2021 | Natural Products and Bioprospecting2021，11，4： | 1 |
| 20 | Public Health in China:The Shanghai CDC Perspective显示文摘 | Jing Peng Sheng Nian Zhang Wei Lu | 2003 | Am J Public Health2003，93，12： | 1 |
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