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| 1 | Non-alcoholic fatty liver disease-a chronic disease of the 21^(st) century显示文摘Non-alcoholic fatty liver disease(NAFLD) comprises a spectrum of metabolic states ranging from simple steatosis to inflammation with associated fibrosis to cirrhosis. Though accumulation of hepatic fat is not associated with a significant increase in mortality rates, hepatic inflammation is, as this augments the risk of terminal liver disease, i.e.,cirrhosis, hepatic decompensation(liver failure) and/or hepatocellular carcinoma. Disease progression is usually slow, over a decade or more and, for the most part, remains asymptomatic. Recent estimates suggest that the global prevalence of NAFLD is high, about one in four. In most cases, NAFLD overlaps with overweight, obesity,cardiovascular disease and the metabolic syndrome with numerous contributing parameters including a dysregulation of adipose tissue, insulin resistance, type 2 diabetes, changes in the gut microbiome, neuronal and hormonal dysregulation and metabolic stress. NAFLD is diagnosed incidentally, despite its high prevalence. Non-invasive imaging techniques have emerged, making it possible to determine degree of steatosis as well asfibrosis. Despite this,the benefit of routine diagnostics remains uncertain. A better understanding of the(molecular) pathogenesis of NAFLD is needed combined with long-term studies where benefits of treatment can be assessed to determine costbenefit ratios. This review summarizes the current state of knowledge and possible areas of treatment. | Peter Metrakos Tommy Nilsson | 2018 | The Journal of Biomedical Research2018，32，5： | 4 |
| 2 | One stop shop:backbones trees for important phytopathogenic genera:Ⅰ(2014)显示文摘Many fungi are pathogenic on plants and cause significant damage in agriculture and forestry.They are also part of the natural ecosystem and may play a role in regulating plant numbers/density.Morphological identification and analysis of plant pathogenic fungi,while important,is often hampered by the scarcity of discriminatory taxonomic characters and the endophytic or inconspicuous nature of these fungi.Molecular(DNA sequence)data for plant pathogenic fungi have emerged as key information for diagnostic and classification studies,although hampered in part by non-standard laboratory practices and analytical methods.To facilitate current and future research,this study provides phylogenetic synopses for 25 groups of plant pathogenic fungi in the Ascomycota,Basidiomycota,Mucormycotina(Fungi),and Oomycota,using recent molecular data,up-to-date names,and the latest taxonomic insights.Lineagespecific laboratory protocols together with advice on their application,as well as general observations,are also provided.We hope to maintain updated backbone trees of these fungal lineages over time and to publish them jointly as new data emerge.Researchers of plant pathogenic fungi not covered by the present study are invited to join this future effort.Bipolaris,Botryosphaeriaceae,Botryosphaeria,Botrytis,Choanephora,Colletotrichum,Curvularia,Diaporthe,Diplodia,Dothiorella,Fusarium,Gilbertella,Lasiodiplodia,Mucor,Neofusicoccum,Pestalotiopsis,Phyllosticta,Phytophthora,Puccinia,Pyrenophora,Pythium,Rhizopus,Stagonosporopsis,Ustilago and Verticillium are dealt with in this paper. | Kevin D.Hyde R.Henrik Nilsson S.Aisyah Alias Hiran A.Ariyawansa Jaime E.Blair Lei Cai Arthur W.A.M.de Cock Asha J.Dissanayake Sally L.Glockling Ishani D.Goonasekara Michal Gorczak Matthias Hahn Ruvishika S.Jayawardena Jan A.L.van Kan Matthew H.Laurence C.AndréLévesque Xinghong Li Jian-Kui Liu Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda Frank N.Martin Eric H.C.McKenzie Alistair R.McTaggart Peter E.Mortimer Prakash V.R.Nair Julia Pawlowska Tara L.Rintoul Roger G.Shivas Christoffel F.J.Spies Brett A.Summerell Paul W.J.Taylor Razak B.Terhem Dhanushka Udayanga Niloofar Vaghefi Grit Walther Mateusz Wilk Marta Wrzosek Jian-Chu Xu JiYe Yan Nan Zhou | 2014 | Fungal Diversity2014，，4： | 3 |
| 3 | Vildagliptin Enhances Islet Responsiveness to Both Hyper- and Hypoglycemia in Patients with Type 2 Diabetes显示文摘 | Bo Ahrén Anja Schweizer Sylvie Dejager Beth E. Dunning Peter M. Nilsson Margaretha Persson James E. Foley | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，4： | 3 |
| 4 | Increased risk of cirrhosis and hepatocellular cancer during long-term follow-up of patients with biopsy-proven NAFLD显示文摘 | Kristina ? nnerhag Peter M Nilsson Stefan Lindgren | 2014 | Scandinavian Journal of Gastroenterology2014，，9： | 2 |
| 5 | Active matrix display based on all-organic electrochemical smart pixels printed on paper显示文摘 | Andersson Peter Nilsson David Svensson Per-Olof | 2002 | Advanced Materials2002，14，20： | 2 |
| 6 | Priori strain discrimination using luminescent conjugated polymers显示文摘 | Christina J Sigurdson K Peter R Nilsson Simone Hornemann | 2007 | Nature Metheds2007，1，12： | 1 |
| 7 | Microbial carbon mineralisation in an acid surface peat: Effects of environmental factors in laboratory incubations显示文摘 | Bergman I Peter Lundberg Mats Nilsson | 1999 | Soil Biology and Biochemistry1999，31，13： | 1 |
| 8 | Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study显示文摘 | Sten Nilsson Lars Franzén Christopher Parker Christopher Tyrrell René Blom Jan Tennvall Bo Lennern?s Ulf Petersson Dag C Johannessen Michael Sokal Katharine Pigott Jeffrey Yachnin Michael Garkavij Peter Strang Johan Harmenberg Bj?rg Bolstad ?yvind S Brula | 2007 | Lancet Oncology2007，，7： | 1 |
| 9 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
| 10 | Arylboronic acids as versatile coupling partners in fast microwave promoted oxidative Heck chemistry 显示文摘 | Murugaiah M S Andappan Peter Nilsson Mats Larhed | 2003 | Molecular Diversity2003，7，： | 1 |
| 11 | Reduced complexity Schnorr-Eu- chner decoding algorithms for MIMO systems 显示文摘 | Guo Zhan Peter Nilsson | 2004 | IEEE Communications Letters2004，8，5： | 1 |
| 12 | Consequences of orthostatic blood pressure variability in middle-aged men (The Malm? Preventive Project)显示文摘 | Artur Fedorowski Lars Stavenow Bo Hedblad G?ran Berglund Peter M Nilsson Olle Melander | 2010 | Journal of Hypertension2010，，3： | 1 |
| 13 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
| 14 | Serine/threonine kinase 39 is a candidate gene for primary hypertension especially in women: results from two cohort studies in Swedes显示文摘 | Cristiano Fava Elisa Danese Martina Montagnana Marketa Sj?gren Peter Almgren Gunnar Engstr?m Peter Nilsson Bo Hedblad Gian C Guidi Pietro Minuz Olle Melander | 2011 | Journal of Hypertension2011，，3： | 1 |
| 15 | A valve-less diffuser micropump for microfluidic analytical systems显示文摘 | Wouter Van der Wijingaart Peter Nilsson | 2001 | Sensors and Actuators B2001，72，： | 1 |
| 16 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
| 17 | Seasonal Changes of Leachate Production and quality from Test Cells显示文摘 | Matthias A Kasson Peter Nilsson | 1997 | Journal of Environmental Engineering1997，，9： | 1 |
| 18 | A Formal Basis for the Heuristic Determination of Minimum Cost Paths显示文摘 | Peter Hart Nils Nilsson Bertram Raphael | 1968 | IEEE Transactions on Systems Science and Cybernetics1968，4，2： | 1 |
| 19 | Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers显示文摘Background The clinical presentations of frontotemporal dementia(FTD)are diverse and overlap with other neurological disorders.There are,as of today,no biomarkers in clinical practice for diagnosing the disorders.Here,we aimed to find protein markers in cerebrospinal fluid(CSF)from patients with FTD,presymptomatic mutation carriers and non-carriers.Methods Antibody suspension bead arrays were used to analyse 328 proteins in CSF from patients with behavioural variant FTD(bvFTD,n=16)and progressive primary aphasia(PPA,n=13),as well as presymptomatic mutation carriers(PMC,n=16)and non-carriers(NC,n=8).A total of 492 antibodies were used to measure protein levels by direct labelling of the CSF samples.The findings were further examined in an independent cohort including 13 FTD patients,79 patients with Alzheimer’s disease and 18 healthy controls.Results We found significantly altered protein levels in CSF from FTD patients compared to unaffected individuals(PMC and NC)for 26 proteins.The analysis show patterns of separation between unaffected individuals and FTD patients,especially for those with a clinical diagnosis of bvFTD.The most statistically significant differences in protein levels were found for VGF,TN-R,NPTXR,TMEM132D,PDYN and NF-M.Patients with FTD were found to have higher levels of TN-R and NF-M,and lower levels of VGF,NPTXR,TMEM132D and PDYN,compared to unaffected individuals.The main findings were reproduced in the independent cohort.Conclusion In this pilot study,we show a separation of FTD patients from unaffected individuals based on protein levels in CSF.Further investigation is required to explore the CSF profiles in larger cohorts,but the results presented here has the potential to enable future clinical utilization of these potential biomarkers within FTD. | Julia Remnestål Linn Oijerstedt Abbe Ullgren Jennie Olofsson Sofia Bergström Kim Kultima Martin Ingelsson Lena Kilander Mathias Uhlén Anna Månberg Caroline Graff Peter Nilsson | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 20 | A valve-less diffuser micropump for microfluidic analytical systems显示文摘 | Andersson Helene Wijngaart Wouter van der Nilsson Peter | 2001 | Sens Actuat2001，72，3： | 1 |
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