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| 1 | Optimal time to use low molecular weight heparin on prethrombotic state of rat chronic obstructive pulmonary disease model显示文摘 | Wang Yanqing Sun Nina Cheng Zhaozhong Tong Li | 2014 | Chinese Medical Journal2014，，3： | 19 |
| 2 | Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection显示文摘Missense mutations in Leucine-Rich Repeat Kinase 2(LRRK2)cause the majority of familial and some sporadic forms of Parkinson’s disease(PD).The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity,promoting the development of LRRK2 kinase inhibitors as therapeutics.Many potent and specific small-molecule LRRK2 inhibitors have been reported with promise.However,nearly all inhibitors are ATP competitive—some with unwanted side effects and unclear clinical outcome—alternative types of LRRK2 inhibitors are lacking.Herein we identify 5′-deoxyadenosylcobalamin(AdoCbl),a physiological form of the essential micronutrient vitamin B12 as a mixed-type allosteric inhibitor of LRRK2 kinase activity.Multiple assays show that AdoCbl directly binds LRRK2,leading to the alterations of protein conformation and ATP binding in LRRK2.STD-NMR analysis of a LRRK2 homologous kinase reveals the contact sites in AdoCbl that interface with the kinase domain.Furthermore,we provide evidence that AdoCbl modulates LRRK2 activity through disrupting LRRK2 dimerization.Treatment with AdoCbl inhibits LRRK2 kinase activity in cultured cells and brain tissue,and prevents neurotoxicity in cultured primary rodent neurons as well as in transgenic C.elegans and D.melanogaster expressing LRRK2 disease variants.Finally,AdoCbl alleviates deficits in dopamine release sustainability caused by LRRK2 disease variants in mouse models.Our study uncovers vitamin B12 as a novel class of LRRK2 kinase modulator with a distinct mechanism,which can be harnessed to develop new LRRK2-based PD therapeutics in the future. | Adam Schaffner Xianting Li Yacob Gomez-Llorente Emmanouela Leandrou Anna Memou Nicolina Clemente Chen Yao Farinaz Afsari Lianteng Zhi Nina Pan Keita Morohashi Xiaoluan Hua Ming-Ming Zhou Chunyu Wang Hui Zhang Shu G.Chen Christopher J.Elliott Hardy Rideout Iban Ubarretxena-Belandia Zhenyu Yue | 2019 | Cell Research2019，29，4： | 7 |
| 3 | Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction显示文摘The individual difference and non-repeatability in acupuncture have not only restricted the development of acupuncture,but have also affected the specificity of acupoints.The present study used instruments to control needle depth,lifting and thrusting frequency,and the duration of acupuncture.Effects of the quantified acupuncture were observed at Neiguan(PC6)with different stimulation parameters.A frequency of 1,2,or 3 Hz and duration of 5,60,or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery.Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60seconds significantly increased cerebral blood flow and decreased the ratio of infarct volume.Interactions between frequency and duration play a critical role in quantified acupuncture therapy. | Yanan Zhang Sha Yang Xiaonong Fan Shu Wang Nina He Lingxin Li Ding Luo Xuemin Shi | 2013 | Neural Regeneration Research2013，8，28： | 7 |
| 4 | Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis显示文摘The achievement of functional nanomodules for subcellular label-free measurement has long been pursued in order to fully understand cellular functions.Here,a compact label-free nanosensor based on a fiber taper and zinc oxide nanogratings is designed and applied for the early monitoring of apoptosis in individual living cells.Because of its nanoscale dimensions,mechanical flexibility,and minimal cytotoxicity to cells,the sensing module can be loaded in cells for long term in situ tracking with high sensitivity.A gradual increase in the nuclear refractive index during the apoptosis process is observed,revealing the increase in molecular density and the decrease in cell volume.The strategy used in our study not only contributes to the understanding of internal environmental variations during cellular apoptosis but also provides a new platform for nonfluorescent fiber devices for investigation of cellular events and understanding fundamental cell biochemical engineering. | Danran Li Nina Wang Tianyang Zhang Guangxing Wu Yifeng Xiong Qianqian Du Yunfei Tian Weiwei Zhao Jiandong Ye Shulin Gu Yanqing Lu Dechen Jiang Fei Xu | 2022 | Advanced Photonics2022，4，1： | 5 |
| 5 | Efficient perovskite solar cells based on novel three-dimensional TiO2 network architectures显示文摘典型地,使用 TiO 2 nanoparticle 为电子运输小径和 perovskite 免职作为脚手架拍摄的 Mesoscopic 铅卤化物 perovskite 太阳能电池。这里,我们证明胀大导致 mesoporous 块共聚物能是为由联合原子层免职技术生产三维的 TiO 2 网络的模板。厚度可调节的 TiO 2 网络是为有效 perovskite 太阳能电池的优秀其他的支架材料。我们用这的最好表现的房间一 270 ? 厚模板完成了的 nm 12.5 的高效率 ? 有是的太古的 poly-3-hexylthiophene 的 % 洞运输材料。高效在接口被归因于直接运输小径和脚手架,小漏水流和大部分减少的再结合率的高吸收。结果证明 TiO 2 网络建筑学是为 mesoscopic perovskite 太阳能电池的有希望的脚手架。 | Hao Lu Kaimo Deng Nina Yan Yulong Ma Bangkai Gu Yong Wang Liang Li | 2016 | Science Bulletin2016，61，10： | 4 |
| 6 | Effects of atmospheric circulation on summertime precipitation variability and glacier mass balance over the Tuyuksu Glacier in Tianshan Mountains, Kazakhstan显示文摘The amount and the form of precipitation have significant effects on glacier mass balances in high altitude mountain areas by controlling the accumulation, the ablation and the energy balance of a glacier through impact on the surface albedo. The liquid precipitation has negative effects on glacier accumulation and may increase the ablation of surface ice through the heat input for melting. The timing and the forms of precipitation over glacierized regions depend on the weather processes both locally and regionally. Early studies showed that regional to large-scale atmospheric circulation processes play a key role in affecting the precipitation events over glaciers. This paper analyzed the relationship between the inter-annual variability of the summertime precipitation over the Tuyuksu Glacier and the atmospheric circulation types, which related to various atmospheric circulation types in the Northern Hemisphere. Results indicated that the decrease in the duration of zonal processes and the increase in the meridional northern processes were observed in the last decade. The total summer precipitation associated with these processes also increased along with an increase of summertime solid precipitation. Although the decadal fluctuation of glaciological parameters were found in dependent of the above large-scale atmospheric circulation processes, global warming was a dominant factor leading to the mass loss in the recent decades under the background of the increase in precipitation over the Tuyuksu Glacier. | Nina K KONONOVA Nina V PIMANKINA Lyudmila A YERISKOVSKAYA LI Jing BAO Weijia LIU Shiyin | 2015 | Journal of Arid Land2015，7，5： | 4 |
| 7 | Characterization and of Ralstonia TAL-Like DNA-Binding Specificities Effectors显示文摘从 Xanthomonas sp 的抄写像使活跃之物的受动器(故事) 。为染色体工程应用被用作可定制的 DNA 有约束力的模块。Ralstonia solanacearum 像故事的蛋白质(RTL ) 展出类似的结构的特征到故事,包括一个中央 DNA 有约束力的领域填写了 of35 氨基的酸长的重复。这里,我们描绘他们作为 transcriptional 使活跃之物在植物房间原子核, mediateDNA 绑定,和力量功能本地化的 RTL 和表演。RTL 有唯一的 DNA 有约束力的体系结构并且是 enrichedin 重复变量 di 残余(RVD ) ,它决定重复 DNA 有约束力的特性。我们决定了 DNA 有约束力的 specificitiesfor RVD 序列 ND, HN, NP,和 NT。RVD ND 调停和 C 核苷酸的高度特定的相互作用, HN interactsspecifically 与 A 和 G 核苷酸,和 NP 绑在 C, A,和 G 核苷酸。而且,我们发展了一高度为设计 RTL 受动器的 efficientrepeat 集会途径。一起拿,我们的数据证明 RTL 是是要定制为指向的 genomic 和 epigenomicmodifications 绑在选择用户的 DNA 序列的优秀选择的唯一的 DNA-targetingmodules。这些调查结果将在 pathogenicityof Ralstonia spp.Key 词有关 RTL 分子的生物学和 RTL 角色便于研究: | Lixin Li Ahmed Atef Agnieszka Piatek Zahir Ali Marek Piatek Mustapha Aouida Altanbadralt Sharakuu Ali Mahjoub Guangchao Wang Suhail Khan Nina V. Fedoroff Jian-Kang Zhu Magdy M. Mahfouz | 2013 | Molecular Plant2013，6，4： | 3 |
| 8 | Obtaining More Information about Precipitation Biases over East Asia from Hourly-Scale Evaluation of Model Simulation显示文摘The hourly summer precipitation simulations over East Asia by the Chinese Academy of Meteorological Science Climate System Model(CAMS-CSM)high-resolution Atmospheric Model Intercomparison Project(AMIP)runs(T255,~50 km)were evaluated based on the merged hourly precipitation product released by the China Meteorological Administration(CMA).The results show that the simulation biases are closely related to the topography,with the precipitation amount and frequency overestimated(underestimated),and duration of precipitation events being longer(shorter),over the western high-altitude(eastern plain)regions of China.Six regions with large discrepancies were further analyzed.In terms of the frequency-intensity structure,the overestimation of precipitation frequency is mainly due to the excessive simulated weak precipitation over the four regions with positive biases:the southern edge of the Tibetan Plateau(STP),the northeastern edge of the Tibetan Plateau(NETP),the eastern periphery of the Tibetan Plateau(EPTP),and the mountainous area of North China(NCM);while the underestimation of frequency is mainly due to the insufficient precipitation with moderate intensity over the two regions with negative biases:lower reaches of the Yangtze River(LYR)and the South China coast(SCC).Based on the duration-diurnal structure analysis,two kinds of precipitation events with different natures can be distinguished.The long-duration night to early morning precipitation events have a significant contribution to the precipitation amount biases for all the six key regions,and this kind of precipitation mainly affects the precipitation diurnal variation over the mountainous areas or steep terrain.Although the short-duration afternoon precipitation events only have a greater contribution to the precipitation amount biases over the SCC region,this kind of precipitation affects the diurnal variation over the NCM region and the two key regions with negative biases.Such a detailed hourly-scale evaluation is helpful for enriching the understanding of simulation biases and to further improve model performance. | Nina LI Jian LI Xinyao RONG Haoming CHEN Yufei XIN Jingzhi SU | 2020 | Journal of Meteorological Research2020，34，3： | 3 |
| 9 | Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity显示文摘Memory CD8 T cells can provide long-term protection against tumors,which depends on their enhanced proliferative capacity,self-renewal and unique metabolic rewiring to sustain cellular fitness.Specifically,memory CD8 T cells engage oxidative phosphorylation and fatty acid oxidation to fulfill their metabolic demands.In contrast,tumor-infiltrating lymphocytes(TILs)display severe metabolic defects,which may underlie their functional decline.Here,we show that overexpression of proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),the master regulator of mitochondrial biogenesis(MB),favors CD8 T cell central memory formation rather than resident memory generation.PGC-1α-overexpressing CD8 T cells persist and mediate more robust recall responses to bacterial infection or peptide vaccination.Importantly,CD8 T cells with enhanced PGC-1αexpression provide stronger antitumor immunity in a mouse melanoma model.Moreover,TILs overexpressing PGC-1αmaintain higher mitochondrial activity and improved expansion when rechallenged in a tumor-free host.Altogether,our findings indicate that enforcing mitochondrial biogenesis promotes CD8 T cell memory formation,metabolic fitness,and antitumor immunity in vivo. | Nina Dumauthioz Benjamin Tschumi Mathias Wenes Bastien Marti Haiping Wang Fabien Franco Wenhui Li Isabel CLopez-Mejia Lluis Fajas Ping-Chih Ho Alena Donda Pedro Romero Lianjun Zhang | 2021 | Cellular & Molecular Immunology2021，18，7： | 3 |
| 10 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 11 | Differences in the Rainfall Characteristics between Mount Tai and Its Surrounding Areas显示文摘As a typical small-scale, isolated topography, Mount Tai exhibits great differences in precipitation characteristics from the surrounding areas. It was found that the amount of rainfall occurring over Mount Tai is significantly larger than what is observed in the surrounding areas. Based on hourly rain gauge records for the warm season(May to September) of 1996–2015, differences between Mount Tai and its surrounding areas were further revealed in terms of rainfall diurnal variation, spatial scale, and evolution process. The diurnal variation of the enhancement on rainfall amount exhibit 'dual peaks' occurring in the early morning and afternoon, and the dual peaks are mainly attributable to rainfall frequency. The diurnal phase of the rainfall amount in the surrounding areas lags 1 h behind that over Mount Tai. Regarding differences in rainfall spatial scale, compared to those of surrounding areas, precipitation over Mount Tai is characterized by a smaller coverage, especially in the early morning. Mount Tai also tends to have a kind of unique, small-scale rainfall in the afternoon and at night. Based on statistical analysis of precipitation events,differences in rainfall evolution process were identified as well. Rainfall over Mount Tai often starts earlier in the afternoon and ends later at night than it does in the surrounding areas. Furthermore, nocturnal rainfall events over Mount Tai are prone to peaking over a shorter period and enduring for a longer period after reaching their maximum intensity, compared with nocturnal rainfall events occurring in the surrounding areas. Rainfall events over Mount Tai always last longer, especially those occurring in the early morning. In general, Mount Tai has a large enhancement effect on rainfall. | Yuting GAN Nina LI Jian LI | 2019 | Journal of Meteorological Research2019，33，5： | 3 |
| 12 | Requirement of a Homolog of Glucosidase Ⅱ β-Subunit for EFR-Mediated Defense Signaling in Arabidopsis thaliana显示文摘 | Nina von Numers Mantas Survila Markku Aalto Martine Batoux Pekka Heino E. Tapio Palva Jing Li | 2010 | Molecular Plant2010，3，4： | 2 |
| 13 | Analysis of the HNF4A isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis显示文摘Objective:Hepatocyte nuclear factor 4α(HNF4 A)has been demonstrated to be an oncogene in gastric cancer(GC).However,the roles of different HNF4 A isoforms derived from the 2 different promoters(P1 and P2)and the underlying mechanisms remain obscure.Methods:The expression and prognostic values of P1-and P2-HNF4 A were evaluated in The Cancer Genome Atlas(TCGA)databases and GC tissues.Then,functional assays of P1-and P2-HNF4 A were conducted both in vivo and in vitro.High-throughput RNA-seq was employed to profile downstream pathways in P1-and P2-HNF4 A-overexpressing GC cells.The expression and gene regulation network of the candidate target genes identified by RNA-seq were characterized based on data mining and functional assays.Results:HNF4 A amplification was a key characteristic of GC in TCGA databases,especially for the intestinal type and early stage.Moreover,P1-HNF4 A expression was significantly higher in tumor tissues than in adjacent non-tumor tissues(P<0.05),but no significant differences were found in P2-HNF4 A expression(P>0.05).High P1-HNF4 A expression indicated poor prognoses in GC patients(P<0.01).Furthermore,P1-HNF4 A overexpression significantly promoted SGC7901 and BGC823 cell proliferation,invasion and migration in vitro(P<0.01).Murine xenograft experiments showed that P1-HNF4 A overexpression promoted tumor growth(P<0.05).Mechanistically,RNA-seq showed that the cytokine-cytokine receptor interactions pathway was mostly enriched in P1-HNF4 A-overexpressing GC cells.Finally,chemokine(C-C motif)ligand 15 was identified as a direct target of P1-HNF4 A in GC tissues.Conclusions:P1-HNF4 A was the main oncogene during GC progression.The cytokine-cytokine receptor interaction pathway played a pivotal role and may be a promising therapeutic target. | Zhen Ni Wenquan Lu Qi Li Chuan Han Ting Yuan Nina Sun Yongquan Shi | 2021 | Cancer Biology & Medicine2021，18，2： | 2 |
| 14 | Study on Anti-infection Effect of Polysaccharide from Agaricus blazei Murrill on Mice显示文摘In order to study the anti-infection effect of phoshporylated Agaricus blazei polysaccharide on mice,mice were drenched phoshporylated A. blazei polysaccharide for 14 d,and an A. blazei polysaccharide control group and a blank control group were also set. The mice in all the three groups were infected with Escherichia coli on the 15^(th)day and the 29^(th)day of the experiment,the body weight of the mice in each group was recorded,as well as the spleen index on the 29^(th)day of infection and the 36^(th)day of the experiment,and the anti-E. coli titer in serum was also detected. The results showed that phoshporylated A. blazei polysaccharide could promote and maintain the development of spleen,and improve the immune response of organisms,thereby resisting bacterial infection. Furthermore,phoshporylated A. blazei polysaccharide has better immunoregulation and anti-infection effects than A. blazei polysaccharide,and could play an important role in veterinary clinical treatment and prevention and control of diseases as a immunologic adjuvant or immunopotentiator. | Chao REN Yuqing ZHOU Shuifeng XIAN Jie LI Deliang WEI Yao LU Nina JIA Shunzi YUAN | 2018 | Agricultural Biotechnology2018，7，4： | 2 |
| 15 | Bistable Stochastic Resonance Enhanced 4-ary PAM Signal Detection under Low SNR显示文摘To boost the performance of 4-ary pulse amplitude modulated(PAM) at low signal-to-noise ratio(SNR), bistable stochastic resonance(BSR) system is introduced into digital communications system and get a reliable signal detection scheme. In this paper, we first analyse BSR system for different amplitudes of 4-ary PAM signals. The steadystate of the bistable system will be statistically distinct, and the feasibility of the proposed detection scheme is confirmed. On this basis, we present a detailed study on steady-state transitions of the BSR system, and an explicit expression of the bistable system parameters is derived. By setting the bistable system parameters, bistable system, 4-ary PAM signal, and noise reach the resonance state, and the BSR-based detection scheme is implemented. Moreover, we derive an analytical expression to calculate the symbol error rate(SER) of 4-ary PAM signals with the BSR-based detection under additive white Gaussian noise(AWGN). Finally, the simulation results validate that BSR-based detection scheme can improve the detection performance while efficiently reducing the symbol error rate. | Linlin Liang Nina Zhang Haiyan Huang Zan Li | 2019 | China Communications2019，16，4： | 2 |
| 16 | Comparison of gastric vas cular anatomy by monochromatic and polychromatic dual-energy spectral computed tomography imaging显示文摘 | Yamin Wan Zhizhen Li Nina i | 2014 | J International Medi cal Research2014，42，1： | 1 |
| 17 | PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients显示文摘 | Yoichi Nagata Keng-Hsueh Lan Xiaoyan Zhou Ming Tan Francisco J. Esteva Aysegul A. Sahin Kristine S. Klos Ping Li Brett P. Monia Nina T. Nguyen Gabriel N. Hortobagyi Mien-Chie Hung Dihua Yu | 2004 | Cancer Cell2004，，2： | 1 |
| 18 | (Metal yolk)/(porous ceria shell)nanostructures for high-performance plasmonic photocatalysis under visible light显示文摘We describe a route to the preparation of(metal yolk)/(porous ceria shell)nanostructures through the heterogeneous growth of ceria on porous metal nanoparticles followed by the calcination-induced shrinkage of the nanoparticles.The approach allows for the control of the ceria shell thickness,the metal yolk composition and size,which is difficult to realize through common templating approaches.The yolk/shell nanostructures with monometallic Pt and bimetallic PtAg yolks featuring plasmon-induced broadband light absorption in the visible region are rationally designed and constructed.The superior photocatalytic activities of the obtained nanostructures are demonstrated by the selective oxidation of benzyl alcohol under visible light.The excellent activities are ascribed to the synergistic effects of the metal yolk and the ceria shell on the light absorption,electron-hole separation and efficient mass transfer.Our synthesis of the(metal yolk)/(porous ceria shell)nanostructures points out a way to the creation of sophisticated heteronanostructures for high-performance photocatalysis. | Nina Jiang Danyang Li Lili Liang Qing Xu Lei Shao Shi-Bin Wang Aizheng Chen Jianfang Wang | 2020 | Nano Research2020，13，5： | 1 |
| 19 | Preparation and electrochemical properties of RuO 2 /polyaniline electrodes for supercapacitors显示文摘 | Xiang Li Weiping Gan Feng Zheng Lulu Li Nina Zhu Xiaoqing Huang | 2012 | Synthetic Metals (-)2012，，11： | 1 |
| 20 | Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation显示文摘Desmoplastic small round cell tumor(DSRCT) is a rare,aggressive malignant neoplasm of unknown origin, and is comprised of small round cells with a characteristic desmoplastic stroma. DSRCT typically expresses epithelial, mesenchymal and neural markers simultaneously. We describe a case of DSRCT with an atypical immunohistochemical profile and rhabdoid-like tumor cells on electron microscopy. In the present case, the neoplastic cells were positive only for vimentin, desmin(cytoplasmic membranous pattern) and CD56,and negative for smooth muscle actin, synaptophysin,CD117, CD45, myogenin, CAM5.2, pancytokeratin,WT1, EMA, CD99, neurofilament, CD34 and p53. Ki67 showed a low proliferative activity. Electron microscopy showed focal rhabdoid differentiation. However, INI-1(SNF-5/BAF47) demonstrated preservation of nuclear positivity in the neoplastic cells. Cytogenetic studies showed translocation t(11;22)(p13;q12) confirming an EWSR1-WT1 translocation characteristic for DSRCT, and t(1;15)(q11;p11.2) of unknown significance. This case is a diagnostic challenge because of atypical immunohistochemical profile and cytogenetic study is crucial in rendering the correct diagnosis. | Li Liang Nina Tatevian Meenakshi Bhattacharjee Kuojen Tsao John Hicks | 2014 | World Journal of Clinical Cases2014，2，8： | 1 |
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