|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Electroacupuncture in the repair of spinal cord injury:inhibiting the Notch signaling pathway and promoting neural stem cell proliferation显示文摘Electroacupuncture for the treatment of spinal cord injury has a good clinical curative effect, but the underlying mechanism is unclear. In our experiments, the spinal cord of adult Sprague-Dawley rats was clamped for 60 seconds. Dazhui(GV14) and Mingmen(GV4) acupoints of rats were subjected to electroacupuncture. Enzyme-linked immunosorbent assay revealed that the expression of serum inflammatory factors was apparently downregulated in rat models of spinal cord injury after electroacupuncture. Hematoxylin-eosin staining and immunohistochemistry results demonstrated that electroacupuncture contributed to the proliferation of neural stem cells in rat injured spinal cord, and suppressed their differentiation into astrocytes. Real-time quantitative PCR and western blot assays showed that electroacupuncture inhibited activation of the Notch signaling pathway induced by spinal cord injury. These findings indicate that electroacupuncture repaired the injured spinal cord by suppressing the Notch signaling pathway and promoting the proliferation of endogenous neural stem cells. | Xin Geng Tao Sun Jing-hui Li Ning Zhao Yong Wang Hua-lin Yu | 2015 | Neural Regeneration Research2015，10，3： | 33 |
| 2 | Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection显示文摘 | DAI Ning LI De-zhi CHEN Ji-chao CHEN Yu-sheng GENG Rong HU Ying-hui YANG Jing-ping DU Juan HU Cheng-ping ZHANG Wei LI Jia-shu YU Qin WAN Huan-ying MU Lan ZHONG Xiao-ning WEI Li-ping MA Jian-jun WANG Qiu-yue HU Ke TIAN Gui-zhen CAI Shao-xi WANG Rui-qin HE Bei WANG Si-qin WANG Zhan-wei ZHAO Su-rui GAO Zhan-cheng | 2010 | Chinese Medical Journal2010，，18： | 13 |
| 3 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 4 | Exploratory clinical study of chidamide,an oral subtype-selective histone deacetylase inhibitor,in combination with exemestane in hormone receptor-positive advanced breast cancer显示文摘Objective: The recurrence or progression under endocrine therapy in hormone receptor-positive(HR+)advanced breast cancer(ABC) remained a critical clinical challenge.Chidamide is an oral subtype-selective histone deacetylase(HDAC) inhibitor with multiple functions in tumor growth inhibition and microenvironment modulation via epigenetic reprogramming.The purpose of this study was to evaluate the safety,pharmacokinetics(PK),and preliminary efficacy of chidamide in combination with exemestane in HR+ ABC patients.Methods: Eligible patients were postmenopausal women with HR+ ABC recurrent or progressed to at least one endocrine therapy.Blood samples were obtained in the run-in period and the first day of combination treatment for PK analysis.In combination treatment,patients were given exemestane 25mg daily and chidamide 30mg twice a week(BIW) until progression of disease or intolerable toxicities.A treatment cycle was defined as 4 weeks.Safety,PK parameters,and preliminary efficacy were evaluated.Results: A total of 20 patients were enrolled between July and December,2015.The median number of treatments cycle was 5.2(20.8 weeks) with 2 patients still on treatment at the data cut-off date of October,2017.The treatment-related adverse events(AE) ≥ grade 3 in more than 2 patients were neutropenia(35%),thrombocytopenia(30%),and leucopenia(20%).The plasma exposure of exemestane was consistent in the presence or absence of chidamide.A slight increase in chidamide exposure was noted in the presence of exemestane,probably due to the inter-and intra-patient variations.The best response in 16 evaluable patients was assessed by Response Evaluation Criteria in Solid Tumors(RECIST),including 4 patients with partial response,10 patients with stable disease.The median progression-free survival(PFS) was 7.6 months.Conclusions: The combination of chidamide with exemestane was generally well tolerated with promising preliminary efficacy in HR+ ABC patients.The overall results from this study encourage further pivotal trial in this patient population. | Qingyuan Zhang Tao Wang Cuizhi Geng Yue Zhang Jinwen Zhang Zhiqiang Ning Zefei Jiang | 2018 | Chinese Journal of Cancer Research2018，30，6： | 11 |
| 5 | Space-Air-Ground Integrated Network (SAGIN) for 6G: Requirements, Architecture and Challenges显示文摘As the fifth-generation(5G)mobile communication network may not meet the requirements of emerging technologies and applications,including ubiquitous coverage,industrial internet of things(IIoT),ubiquitous artificial intelligence(AI),digital twins(DT),etc.,this paper aims to explore a novel space-air-ground integrated network(SAGIN)architecture to support these new requirements for the sixth-generation(6G)mobile communication network in a flexible,low-latency and efficient manner.Specifically,we first review the evolution of the mobile communication network,followed by the application and technology requirements of 6G.Then the current 5G non-terrestrial network(NTN)architecture in supporting the new requirements is deeply analyzed.After that,we proposes a new flexible,low-latency and flat SAGIN architecture,and presents corresponding use cases.Finally,the future research directions are discussed. | Huanxi Cui Jun Zhang Yuhui Geng Zhenyu Xiao Tao Sun Ning Zhang Jiajia Liu Qihui Wu Xianbin Cao | 2022 | China Communications2022，19，2： | 11 |
| 6 | Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3显示文摘Modiled citrus pectin (MCP) is a carbohydrate enriched complex, which has been implicated in cancer treatment and prevention. However, the effects of MCP on urinary bladder cancer (UBC) are unknown. In this study, MCP was first tested in T24 and J82 human UBC cells and showed the inhibition of cell viability by the sulforhodamine B (SRB) assay. The MCP-treated UBC cells exhibited G2/M phase arrest with the decrease of Cyclin B1 and phosphorylated Cdc2. Caspase-3 was also activated, leading to the cleavage of Caspase-3 and PARP. We further explored the possible molecular mechanisms upon MCP treatment in UBC cells. Reduction of galectin-3 was observed and followed with the inactivation of Akt signaling pathway. Of note, galectin-3 knockdown by RNA interference recapitulated the MCP-mediated anti-proliferation, cell cycle arrest and apoptosis. Moreover, oral administration of MCP to the T24 xenograft-bearing nude mice inhibited the tumor growth significantly (P<0.05). Quantification analysis of immunohistochemistry staining for Ki67 and cleaved Caspase-3 confirmed the decrease of proliferation index (P<0.05) and the increase of apoptosis index (P<0.01) in 700 mg/kg MCP-fed UBC xenografts. Using the information from TCGA database, we revealed that the overexpression of galectin-3 was associated with high tumor grade with lymph node metastasis, poor overall survival in UBC patients. Considering the remarkable inhibitory effects of MCP on UBC cell proliferation and survival in vitro and in vivo mainly through galectin-3, which is upregulated in UBCs, MCP may become an attractive agent, as a natural dietary fiber, for prevention and therapy of UBCs. | Tian Fang Dan-dan Liu He-ming Ning Dan Liu Jing-ya Sun Xiao-jing Huang Yu Dong Mei-yu Geng Shi-feng Yun Jun Yan Rui-min Huang | 2018 | Acta Pharmacologica Sinica2018，39，12： | 10 |
| 7 | Unpalatable Weed Stellera chamaejasme L. Provides Biotic Refuge for Neighboring Species and Conserves Plant Diversity in Overgrazing Alpine Meadows on the Tibetan Plateau in China显示文摘Steller chamaejasme L.(S. chamaejasme for short) is one of the most noxious unpalatable weeds in China, which has been frequently reported its negative interaction(i.e. competition and allelopathy) with other herbaceous species in grasslands. This study compared species diversity, biomass and sexual reproduction of herbaceous plants in meadows with S. chamaejasme and in open meadows without S. chamaejasme in overgrazing meadows on the Tibetan Plateau in China to determine whether positive facilitation exist between S. chamaejasme and other herbaceous species under livestock's overgrazing. The results showed that there are more herbaceous species in meadows with S. chamaejasme than those in open meadows(35s and30s, respectively). Diversity index and above-ground biomass were also significantly higher in meadows with S. chamaejasme. There were 39%(11/28) of all species with sexual reproduction found in meadows with S. chamaejasme, which was 7 times more than those in open meadows. Our study showed that S. chamaejasme could provide biotic refuge for neighboring plants and preserve plant diversity from livestock's overgrazing in alpine meadows on the Tibetan Plateau. It also suggested that inter-specific facilitation between S. chamaejasme and other herbaceous species may play a key role in overgrazing alpine meadows. | CHENG Wei SUN Geng DU Lin-fang WU Yan ZHENG Qun-ying ZHANG Hong-xuan LIU Lin WU Ning | 2014 | Journal of Mountain Science2014，11，3： | 7 |
| 8 | Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China显示文摘背景基因机制贡献血压规定。这研究调查了谷胱甘肽 peroxidase (GPx-3 ) 标签单身者核苷酸多型性(SNP ) 是否在 Fuxin 县,辽宁省,参与的 China.Methods 土生土长的韩福新人, 523 无关的 hypertensives 和 547 控制的农村区域与高血压被联系被招募。GPx-3 基因的所有标签 SNP 被选择。我们在 Bonferroni 修正前与 pyrosequencing.Results 在 DNA 水池估计了 SNP 等位基因频率,为 rs8177417 的 C 等位基因频率比在控制的那些在 hypertensives 是显著地更高的(23.4% 对 19.3% , P=0.014 ) ;为 rs3828599 的 T 等位基因频率比在控制的那些在 hypertensives 是显著地更低的(35.6% 对 40.8% , P=0.009 ) 。然而,当为多重测试的 Bonferroni 修正被使用时, GPx-3 基因的仅仅多型性 rs3828599 与高血压被联系(P=0.045,或:0.833, 95%CI:0.695-0.998 ).Conclusion GPx-3 基因的 rs3828599 的多型性可能从 Fuxin 用农村汉汉语与高血压被联系,辽宁。 | HAO Ying WU Bao-gang SHI Jin CHEN Yan-li SUN Zhao-qing ZHENG Li-qiang ZHANG Xin-gang GENG Ning LI Tie-jun LI Hong SUN Ying-xian | 2011 | Chinese Medical Journal2011，，14： | 7 |
| 9 | PNPLA3 I148M variant in nonalcoholic fatty liver disease:Demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis显示文摘Patatin-like phospholipase domain-containing 3(PNPLA3 or adiponutrin) displays anabolic and catabolic activities in lipid metabolism,and has been reported to be significantly associated with liver fat content.Variousstudies have established a strong link between the 148 isoleucine to methionine protein variant(I148M) of PNPLA3 and liver diseases,including nonalcoholic fatty liver disease(NAFLD).However,detailed demographic and ethnic characteristics of the I148 M variant and its role in the development of nonalcoholic fatty liver fibrosis have not been fully elucidated.The present review summarizes the current knowledge on the association between the PNPLA3 I148 M variant and NAFLD,and especially its role in the development of nonalcoholic fatty liver fibrosis.First,we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148 M variant and the presence of metabolic syndrome on the association between PNPLA3 I148 M and NAFLD.Then,we explore the role of the PNPLA3 I148 M in the development of nonalcoholic fatty liver fibrosis,and hypothesize the underlying mechanisms by speculating a pro-fibrogenic network.Finally,we briefly highlight future research that may elucidate the specific mechanisms of the PNPLA3 I148 M variant in fibrogenesis,which,in turn,provides a theoretical foundation and valuable experimental data for the clinical management of nonalcoholic fatty liver fibrosis. | Li-Zhen Chen Yong-Ning Xin Ning Geng Man Jiang Ding-Ding Zhang Shi-Ying Xuan | 2015 | World Journal of Gastroenterology2015，21，3： | 6 |
| 10 | Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway显示文摘Periprosthetic osteolysis(PPO)remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles.Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and loosening prostheses.Additionally,the NLRP3 inflammasome is activated by prosthetic particles.Sirtuin3,an NAD+-dependent deacetylase of mitochondria,regulates the function of mitochondria in diverse activities.However,whether SIRT3 can mitigate wear debris-induced osteolysis by inhibiting the NLRP3 inflammasome and enhancing osteogenesis has not been previously reported.Therefore,we investigated the role of SIRT3 during the process of titanium(Ti)particle-induced osteolysis.We revealed that upregulated SIRT3 dramatically attenuated Ti particle-induced osteogenic inhibition through suppression of the NLRP3 inflammasome and improvement of osteogenesis in vivo and in vitro.Moreover,we found that SIRT3 interference in the process of Ti particle-induced osteolysis relied on the GSK-3β/β-catenin signalling pathway.Collectively,these findings indicated that SIRT3 may serve as a rational new treatment against debris-induced PPO by deacetylase-dependent inflammasome attenuation. | Kai Zheng Jiaxiang Bai Ning Li Meng Li Houyi Sun Weicheng Zhang Gaoran Ge Xiaolong Liang Huaqiang Tao Yi Xue Yuefeng Hao Chen Zhu Yaozeng Xu Dechun Geng | 2021 | Bioactive Materials2021，6，10： | 5 |
| 11 | Effects of Waxy Maize Relay Intercropping and Residue Retention on Rhizosphere Microbial Communities and Vegetable Yield in a Continuous Cropping System显示文摘Intercropping and residue retention contribute to high yield and quality of crops. However, their coupled effects on rhizospheric microbial communities under a continuous vegetable cropping system have not been adequately addressed. The objective of the present study was to assess the effects on soil microbial community and yields of waxy maize(Zea mays L.) intercropped with or without residue retention in a continuous broccoli(Brassica oleracea L.) cropping system, i.e., relay intercropping of broccoli and waxy maize(B/M-B), relay intercropping of broccoli and waxy maize with residue retention(B/MR-B), and broccoli monoculture(B-B). The biomass yields of spring and autumn vegetables in B/MR-B were 16.3%–32.5% and 30.1%–46.1% higher than those of B-B,respectively. Autumn vegetable economic yields of B/MR-B were 28.2%–40.3% higher than B-B. The average well color development followed the order: B/MR-B > B/M-B > B-B. The Shannon index, Simpson index, and Mc Intosh index were higher in B/MR-B than under monoculture. A principal component analysis showed that microbial communities of B/MR-B soils differed from those of B/M-B and B-B soils. Carbon(C) sources utilized by the rhizosphere microorganisms were mainly carbohydrates, carboxylic acids, amino acids, and polymers; however, the C sources for the soil microbial community differed between intercropping and monoculture. The communities from B/MR-B preferred amino acids and polymers. Available nitrogen(N), potassium(K), and phosphorus(P) had an obvious impact on soil microbial community. Additionally, the C source utilization by microorganisms was significantly affected by p H and available K and P. Cropping system diversification through relay intercropping and residue retention effectively improved the functional diversity of the soil microbial communities and increased the yields of vegetables. | ZHANG Xuepeng NING Tangyuan HAN Huifang SUN Tao LI Geng LI Zengjia Rattan LAL | 2018 | Pedosphere2018，28，1： | 5 |
| 12 | Sustained high level transgene expression in mammalian cells mediated by the optimized piggyBac transposon system显示文摘Sustained,high level transgene expression in mammalian cells is desired in many cases for studying gene functions.Traditionally,stable transgene expression has been accomplished by using retroviral or lentiviral vectors.However,such viral vector-mediated transgene expression is often at low levels and can be reduced over time due to low copy numbers and/or chromatin remodeling repression.The piggyBac transposon has emerged as a promising nonviral vector system for efficient gene transfer into mammalian cells.Despite its inherent advantages over lentiviral and retroviral systems,piggyBac system has not been widely used,at least in part due to their limited manipulation flexibilities.Here,we seek to optimize piggyBac-mediated transgene expression and generate a more efficient,user-friendly piggyBac system.By engineering a panel of versatile piggyBac vectors and constructing recombinant adenoviruses expressing piggyBac transposase(PBase),we demonstrate that adenovirusmediated PBase expression significantly enhances the integration efficiency and expression level of transgenes in mesenchymal stem cells and osteosarcoma cells,compared to that obtained from co-transfection of the CMV-PBase plasmid.We further determine the drug selection timeline to achieve optimal stable transgene expression.Moreover,we demonstrate that the transgene copy number of piggyBac-mediated integration is approximately 10 times higher than that mediated by retroviral vectors.Using the engineered tandem expression vector,we show that three transgenes can be simultaneously expressed in a single vector with high efficiency.Thus,these results strongly suggest that the optimized piggyBac system is a valuable tool for making stable cell lines with sustained,high transgene expression. | Xiang Chen Jing Cui Zhengjian Yan Hongmei Zhang Xian Chen Ning Wang Palak Shah Fang Deng Chen Zhao Nisha Geng Melissa Li Sahitya K.Denduluri Rex C.Haydon Hue H.Luu Russell R.Reid Tong-Chuan He | 2015 | Genes & Diseases2015，2，1： | 5 |
| 13 | Genetic Diversity, Antimicrobial Resistance, and Virulence Genes of Aeromonas Isolates from Clinical Patients, Tap Water Systems, and Food显示文摘Objective This study aimed to evaluate the genetic diversity,virulence,and antimicrobial resistance of Aeromonas isolates from clinical patients,tap water systems,and food.Methods Ninety Aeromonas isolates were obtained from Ma’anshan,Anhui province,China,and subjected to multi-locus sequence typing(MLST)with six housekeeping genes.Their taxonomy was investigated using concatenated gyr B-cpn60 sequences,while their resistance to 12 antibiotics was evaluated.Ten putative virulence factors and several resistance genes were identified by PCR and sequencing.Results The 90 Aeromonas isolates were divided into 84 sequence types,80 of which were novel,indicating high genetic diversity.The Aeromonas isolates were classified into eight different species.PCR assays identified virulence genes in the isolates,with the enterotoxin and hemolysin genes act,aer A,alt,and ast found in 47(52.2%),13(14.4%),22(24.4%),and 12(13.3%)of the isolates,respectively.The majority of the isolates(≥90%)were susceptible to aztreonam,imipenem,cefepime,chloramphenicol,gentamicin,tetracycline,and ciprofloxacin.However,several resistance genes were detected in the isolates,as well as a new mcr-3 variant.Conclusions Sequence type,virulence properties,and antibiotic resistance vary in Aeromonas isolates from clinical patients,tap water systems,and food. | MENG Shuang WANG Yong Lu LIU Chen Geng YANG Jing YUAN Min BAI Xiang Ning JIN Dong LIANG Jun Rong CUI Zhi Gang LI Juan | 2020 | Biomedical and Environmental Sciences2020，33，6： | 5 |
| 14 | Threshold effects of tourism agglomeration on the green innovation efficiency of China's tourism industry显示文摘Industrial agglomeration is an essential and effective way to integrate resources and elements. Its impact on the green innovation efficiency of the tourism industry is a process of continuous development and dynamic change. This paper, based on the provincial panel data from 2006 to 2015, uses super SBM model to measure the green innovation efficiency of China's tourism industry.The threshold regression model is employed to conduct empirical tests of the nonlinear threshold effect of agglomeration on the green innovation efficiency of tourism industry. The inter-provincial differences of various threshold effects and their possible causes are analyzed. Results indicate that the green innovation efficiency of China's tourism industry is generally growing, while regional disparity is significant with a gradient decrease along the eastern-central-western regions. There is an obvious positive nonlinear relationship between tourism agglomeration and green innovation efficiency. It is also found that with the increase of agglomeration, its influence is at a high level. As the level of agglomeration crosses the first threshold, its impact is at a low level, and when it crosses the second threshold, the impact of tourism agglomeration is at an intermediate level. Finally, this paper proposes the basic path and some policy recommendations to promote the green innovation efficiency of the tourism industry in China. | Jia Liu Qiuyue Song Ning Liu Christina Gengging Chi | 2018 | Chinese Journal of Population,Resources and Environment2018，16，3： | 4 |
| 15 | Agricultural Land Suitability of Production Space in the Taihang Mountains, China显示文摘The contradiction between the shortage of land for agriculture due to rapid expansion of industrialization and urbanization and increasing population pressure is projected to impose great threats to future food security.Agricultural land suitability evaluation is an effective approach to improve the utilization of land resources for crop production and thus enhance the capacity of food provision.In this study, we evaluated the land suitability for agriculture of the production space in the Taihang Mountains by three steps: establishing indicator system, determining weights for indicators, and constructing a fuzzy matter-element model to assess the grades of suitability.Results showed that the land suitability had a significant linear correlation with potential crop yields, indicating our evaluation was effective to predict crop production.The spatial pattern of land suitability for crop production demonstrated that land with higher suitability was generally located in piedmont plains and basins, while land with lower suitability was mostly situated in mountainous areas.The area of highly, moderately, marginally suitable and unsuitable land for agriculture was 32.13%, 28.58%, 37.49% and 1.80% of the production space, respectively.However, the correlation degree analysis indicated that the requirements of these four suitability grades were currently not satisfied but could be potentially fulfilled.In terms of indicator weights, soil properties were much more important than topography and location conditions to influence the grades of suitability.Among all indicators, slope, soil organic matter, soil texture and soil depth were the most influential factors, so slope farming prevention and organic fertilization were most likely to improve land suitability for agriculture.Compared the outputs of our land suitability evaluation model with the distribution of the existing croplands, we found that about 66.52% of marginally suitable and 54.55% of unsuitable land for agriculture were currently used for croplands.Therefore, de-farming policy should be implemented in areas of these two suitability grades.In contrast, cropland expansion was encouraged in the land that was highly or moderately suitable for agriculture.Our evaluation of agricultural land suitability is beneficial for future land use planning and decision-making in the Taihang Mountains. | GENG Shoubao SHI Peili ZONG Ning ZHU Wanrui | 2019 | Chinese Geographical Science2019，29，6： | 4 |
| 16 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 17 | Discovery of a high-altitude ecotype and ancient lineage of Arabidopsis thaliana from Tibet显示文摘Arabidopsis thaliana(A.thaliana)has long been a model species for dicotyledon study,and was the first flowering plant to get its genome completed sequenced[1].Although most wild A.thaliana are collected in Europe,several studies have found a rapid A.thaliana west-east expansion from Central Asia[2].The Qinghai-Tibet Plateau(QTP)is close to Central Asia and known for its high alti- | Liyan Zeng Zhuoya Gu Min Xu Ning Zhao Weidong Zhu Takahiro Yonezawa Tianmeng Liu Lha Qiong Tashi Tersing Lingli Xu Yang Zhang Rongyan Xu Ningyu Sun Yanyan Huang Jiankun Lei Liang Zhang Feng Xie Fang Zhang Hongya Gu Yupeng Geng Masami Hasegawa Ziheng Yang M. James C. Crabbe Fan Chen Yang Zhong | 2017 | Science Bulletin2017，62，24： | 3 |
| 18 | Numerical simulation of flow focusing pattern and morphological changes in two-phase flow inside nozzle显示文摘The flow focusing nozzle is a new type of nozzle that performs effective atomization of the discrete phase by means of high-speed motion of the continuous phase.The flow pattern and its morphological changes have a significant effect on the atomization, but the influence of different parameters on the morphological change of the flow pattern remains unclear.The flow focusing pattern and morphological changes in the two-phase flow inside the nozzle were simulated numerically, based on the volume of fluid method.The results demonstrate that the ratio of the nozzle-to-capillary distance and capillary diameter, the gas–liquid velocity ratio, and capillary diameter have significant effects on the flow pattern.When the ratio of the nozzle-to-capillary distance H and capillary diameter D increases, or the capillary diameter D increases, the flow pattern tends to transform into a laminar form; however, when the gas–liquid velocity ratio V increases, the flow pattern tends to transform into a turbulence form.Furthermore, we define the cone-shaped expansion rate, cone-shaped focusing rate,and cone angle in order to study the morphological changes in the cone shape inside the nozzle.The results indicate that the morphological change of the cone shape and flow pattern transformation is interrelated.When the cone shape tends to be unstable, the flow pattern changes towards flow blurring, whereas, a stable cone indicates that the flow tends to exhibit a droplet pattern. | Jin Zhao Zhi Ning Ming Lü Geng Wang | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 2 |
| 19 | Temperature dependence of densities of Sb and Bi melts显示文摘The densities of Sb and Bi melts were investigated by an improved Archimedean method. The results show that the density of the Sb melt decreases linearly with increasing temperature,but the density of the Bi melt firstly increases and then decreases as the temperature increases. There is a maximum density value of 10.002 g/cm3 at 310 ℃ ,about 39℃ above the melting point. The temperature depend-ence of the Sb melt is well fitted with the expression ρ =6.8590-5.8105×10-4T,and that of the Bi melt is fitted with ρ =10.3312-1.18×10-3T. The results were discussed from a microstructure viewpoint. | GENG HaoRan SUN ChunJing WANG Rui QI XiaoGang ZHANG Ning | 2007 | Chinese Science Bulletin2007，52，15： | 2 |
| 20 | Highly chemoselective lipase from Candida sp.99-125 catalyzed ring-opening polymerization for direct synthesis of thiol-terminated poly(e-caprolactone)显示文摘Lipase from Candida sp.99-125 catalyzed ring-opening polymerization of e-caprolactone in the presence of 6-mercapto-1-hexanol was presented as a new metal-free approach for direct synthesis of welldefined thiol-terminated poly(e-caprolactone).Remarkably,high chemoselectivity of lipase from Candida sp.99-125 toward hydroxyl and thiol was exhibited and quantitative thiol fidelity over 90% was achieved.The tedious protecting/deprotecting steps for thiol and metal residue were avoided.The polymerizations with around 70% monomer conversion were conducted in bulk and toluene at relative low temperature of 40 8C.Number–average molecular weight of resulted polymers ranged from 3000 to4700 Da by changing the feed ratio between monomer and initiator.The structures of obtained thiolterminated poly(e-caprolactone) were demonstrated by combining NMR and SEC analyses. | Ning Zhu Zi-Long Zhang Wei He Xiao-Cheng Geng Zheng Fang Xin Li Zhen-Jiang Li Kai Guo | 2015 | Chinese Chemical Letters2015，26，3： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员