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| 1 | Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation显示文摘ABSTRACTHuman placenta-derived mononuclear cells (MNC) were isolated by a Percoll density gradient and cultured in mesen-chymal stem cell (MSC) maintenance medium. The homogenous layer of adherent cells exhibited a typical fibroblast-like morphology, a large expansive potential, and cell cycle characteristics including a subset of quiescent cells. In vitrodifferentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic, osteogenic andchondrogenic lineages. Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was ahomogeneous cell population devoid of hematopoietic cells, which uniformly expressed CD29, CD44, CD73, CD105,CD166, laminin, fibronectin and vimentin while being negative for expression of CD31, CD34, CD45 and α-smoothmuscle actin. Most importantly, immuno-phenotypic analyses demonstrated that these cells expressed class I majorhistocompatibility complex (MHC-I), but they did not express MHC-II molecules. Additionally these cells could sup-press umbilical cord blood (UCB) lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli. Thisstrongly implies that they may have potential application in allograft transplantation. Since placenta and UCB arehomogeneous, the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells(HSC) from UCB to reduce the potential graft -versus-host disease (GVHD) in recipients. | Chang Dong LI Wei Yuan ZHANG He Lian LI Xiao Xia JIANG Yi ZHANG Pei Hsien TANG Ning MAO | 2005 | Cell Research2005，15，7： | 36 |
| 2 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 3 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 4 | Treatment of coking wastewater by a novel electric assisted micro-electrolysis filter显示文摘A newly designed electric assisted micro-electrolysis filter(E-ME) was developed to investigate its degradation efficiency for coking wastewater and correlated characteristics. The performance of the E-ME system was compared with separate electrolysis(SE) and micro-electrolysis(ME) systems. The results showed a prominent synergistic effect on COD removal in E-ME systems. Gas chromatography/mass spectrometry(GC–MS) analysis confirmed that the applied electric field enhanced the degradation of phenolic compounds.Meanwhile, more biodegradable oxygen-bearing compounds were detected. SEM images of granular activated carbon(GAC) showed that inactivation and blocking were inhibited during the E-ME process. The effects of applied voltage and initial p H in E-ME systems were also studied. The best voltage value was 1 V, but synergistic effects existed even with lower applied voltage. E-ME systems exhibited some p H buffering capacity and attained the best efficiency in neutral media, which means that there is no need to adjust p H prior to or during the treatment process. Therefore, E-ME systems were confirmed as a promising technology for treatment of coking wastewater and other refractory wastewater. | Ruosong Xie Miaomiao Wu Guangfei Qu Ping Ning Yingying Cai Pei Lv | 2018 | Journal of Environmental Sciences2018，30，4： | 12 |
| 5 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 6 | A low-noise fully-differential CMOS preamplifier for neural recording applications显示文摘A fully-differential bandpass CMOS preamplifier for extracellular neural recording is presented in this paper.The capacitive-coupled and capacitive-feedback topology is adopted.We describe the main noise sources of the proposed preamplifier and discuss the methods for achieving the lowest input-referred noise.The preamplifier has a midband gain of 43 dB and a DC gain of 0.The-3 dB upper cut-off frequency of the preamplifier is 6.8 kHz.The lower cut-off frequency can be adjusted for amplifying the field or action potentials located in different bands.It has an input-referred noise of 3.36 μVrms integrated from 1 Hz to 6.8 kHz for recording the local field potentials(LFPs)and the mixed neural spikes with a power dissipation of 24.75 μW from 3.3 V supply.When the passband is configured as 100 Hz-6.8 kHz for only recording spikes,the noise is measured to be 3.01 μVrms.The 0.115 mm2 prototype chip is designed and fabricated in 0.35-μm N-well CMOS(complementary metal oxide semiconductor)2P4M process. | ZHANG Xu PEI WeiHua HUANG BeiJu GUAN Ning CHEN HongDa | 2012 | Science China(Information Sciences)2012，55，2： | 11 |
| 7 | Effect of a Traditional Chinese Medicine combined therapy on adolescent idiopathic scoliosis:a randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness of a combined Traditional Chinese Medicine(TCM) therapy versus conventional treatment on adolescent idiopathic scoliosis.METHODS:One hundred twenty outpatients with mild and moderate adolescent idiopathic scoliosis were randomly divided into a TCM group(TCMG)and a brace group(CG).TCMG patients underwent Daoyin,Tuina,and acupotomology therapies.CG patients were treated with a Milwaukee brace.Each patient's Cobb angle was measured after 12 and 24 months of treatment,and pulmonary function was determined after 12 months of treatment.Average electromyogram(AEMG) ratio of the surface electromyogram was measured after 6 and 12 months of treatment and followed-up after 18 and 24 months.RESULTS:The Cobb angle significantly decreased in both groups after 12 months of treatment compared with before treatment(P< 0.05).The percentages of original Cobb angle in TCMG and CG were51.4%and 47.8%(P > 0.05) after 12 months and62.5%and 34.7%(P < 0.05) after 24 months,respectively.Pulmonary function significantly improved after 12 months in TCMG(P < 0.05) but significantly decreased in CG(P < 0.05).The AEMG ratio was significantly lower(P < 0.01) and tended to remain at1 after stopping treatment in TCMG,but increased in CG(P<0.05).CONCLUSION:TCM combined therapy can prevent the progression of scoliosis.The AEMG ratio is a promising index that could replace radiography in the evaluation of treatment effect and progression in scoliosis. | Wei Hui Xu Jinyuan Jiang Zhong Ye Shuliang Song Hongquan Ning Xitao Huang Huanmin Chen Wei Pei Jianwei Jiang Nengyi Chen Shao Du Honggen | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 9 |
| 8 | Mechanism of pulse magneto-oscillation grain refinement on pure Al显示文摘Pulse magneto-oscillation (PMO) was developed as a novel technique to refine the solidification structure of pure aluminium.Its grain refining mechanism was proposed.The PMO refinement mechanism is that the nucleus falls off from the mould wall and drifts into the melt under the action of PMO.The solidification structure of Al melt depends on the linear electric current density,and also the discharge and oscillation frequencies.The radial pressure of PMO sound wave is the major factor that contributes to the migration of nucleus into the melt. | Pei Ning Gong Yongyong Li Renxing Xia Zanqi Zhai Qijie | 2011 | China Foundry2011，8，1： | 8 |
| 9 | Preliminary study on the living environment of hominids at the Donggutuo site,Nihewan Basin显示文摘The Donggutuo site, situated in the east margin of Nihewan basin, is one of the most important Paleolithic sites in China, characterized by the longest excavation seasons and the most abundant cultural remains recovered in the region. Based on well-constructed sporopollen, sediment grain size analysis, magnetic susceptibility, and iron oxide analysis of the 2000―2001 excavated section, four stages of environmental change in the Nihewan Beds are identified by the authors. The results indicate four major stages of environment and climate change from 1) warm and humid forest grass to 2) temperate and humid forest grass to 3) temperate and dry forest grass to 4) warm and humid forest, which is suitable for hominid occupation. The changes correspond to the stages of lake transgression and regression. The environment after the lake died out away has been cold and dry boschveld. The hominid activities at the site took place in the Early Pleistocene (1.10 Ma), which corresponds to the early three environmental stages. Therefore, it can be inferred that the early hominids adapted to the relatively low lake level episodes through activities involving sporadic stone tool making, procuring of raw materials for tools, concentrating stone artifacts, and hunting and butchering. In conclusion, the results will be of great significance to research regarding the relationship between hominid occupation and environmental changes as well as the adaptive behaviors of early humans at the Donggutuo site. | PEI ShuWen LI XiaoLi LIU DeCheng MA Ning PENG Fei | 2009 | Chinese Science Bulletin2009，54，21： | 7 |
| 10 | Influence of electromagnetic parameters on solidification structure of pure AI in the case of identical power显示文摘 | Yong-yong Gong Shu-min Cheng Yu-yi Zhong Xiang Wang Yun-hu Zhang Qi-jie Zhai Hong-gang Zhong Zhi-shuai Xu Rong Yue Ning Pei | 2018 | Journal of Iron and Steel Research(International)2018，25，8： | 6 |
| 11 | The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats显示文摘Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs [1] . However, few studies | BAI Ya Na MA Li WANG Qiu Ying PU Hong Quan ZHANG Xiao Pei WU Xi Jiang XUAN Xiao Qiang CHENG Ning | 2013 | Biomedical and Environmental Sciences2013，26，7： | 5 |
| 12 | Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex显示文摘The orbitofrontal cortex(OFC)is involved in diverse brain functions via its extensive projections to multiple target regions.There is a growing understanding of the overall outputs of the OFC at the population level,but reports of the projection patterns of individual OFC neurons across different cortical layers remain rare.Here,by combining neuronal sparse and bright labeling with a whole-brain florescence imaging system(fMOST),we obtained an uninterrupted three-dimensional whole-brain dataset and achieved the full morphological reconstruction of 25 OFC pyramidal neurons.We compared the wholebrain projection targets of these individual OFC neurons in different cortical layers as well as in the same cortical layer.We found cortical layer-dependent projections characterized by divergent patterns for information delivery.Our study not only provides a structural basis for understanding the principles of laminar organizations in the OFC,but also provides clues for future functional and behavioral studies on OFC pyramidal neurons. | Junjun Wang Pei Sun Xiaohua Lv Sen Jin Anan Li Jianxia Kuang Ning Li Yadong Gang Rui Guo Shaoqun Zeng Fuqiang Xu Yu-Hui Zhang | 2021 | Neuroscience Bulletin2021，37，4： | 5 |
| 13 | Efficient synthesis of hydroxyl functioned polyesters from natural polyols and sebacic acid显示文摘Amphiphilic 氢氧根工作了聚酯(HFP ) 能为淀粉和树脂的混合被用作 compatibilizers。我们为 HFP 的有效准备开发了一个合成方法。水被高流动率 N2 而非高真空面对 dehydrative 冷凝作用催化剂与木糖醇,山梨糖醇,或甘露糖醇在癸二酸酸的 polycondensation 期间移开,产品与[] 27.2 mL/g, 1903 的 Mn, 167,693 的 Mw, 30.5 的 Tg ? 牵橹湡捩湩吗? | Zhuo Yuan Ning Qing Shan Zhang Qin Pei Wu Yun Zheng Li Dong Xia Ma Jia Zhe Chen | 2011 | Chinese Chemical Letters2011，22，6： | 5 |
| 14 | Detection of the Urinary Biomarkers PYD, CTX-Ⅱ, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China显示文摘Kashin-Beck disease(KBD) is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type Ⅱ collagen(CTX-Ⅱ), pyridinoline(PYD), and deoxypyridinoline(DPD) among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-Ⅱ, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805.59 ng/μmol.cre, 546.47 ng/μmol.cre, and 718.15 pml/μmol.cre, respectively. The differences between KBD patients and healthy controls were statistically significant(Z = 4.405, 3.653, and 3.724; P < 0.001). The higher levels of PYD, CTX-Ⅱ, and DPD detected in KBD patients indicate that they could be used as biomarkers of KBD. | ZHAO Zhi Jun PU Guang Lan ZHAN Pei Zhen LI Qiang WU Chun Ning WANG Li Hua | 2017 | Biomedical and Environmental Sciences2017，30，5： | 5 |
| 15 | Phaeocystis globosa Bloom Monitoring: Based on P. globosa Induced Seawater Viscosity Modification Adjacent to a Nuclear Power Plant in Qinzhou Bay, China显示文摘The mucus produced by the outbreak of Phaeocystis globosa in the adjacent waters of the Fangchenggang Nuclear Power Plant(FCGNPP) in China has blocked the entrance of the cooling water filtration system of the FCGNPP, and posed a threat to the safe operation of the FCGNPP. At present, there is no related research on whether the changes in seawater viscosity could be used as a new method for monitoring and providing early warning of P. globosa tide. During a complete red tide cycle, the temporal and spatial changes in the hydrological conditions(temperature, salinity, dissolved oxygen), chlorophyll-a(Chl-a), composition and abundance of phytoplankton, number and size of P. globose colonies, concentration of transparent exopolymer particles(TEP) and the seawater viscosity were measured in this study. The results indicate that there was an extremely significant negative correlation between the physical seawater viscosity η_(T,S) and temperature, and the correlation coefficient reached-0.998. The biological seawater viscosity η_(Bio) was positively correlated with the number of P. globosa colonies, and the correlation coefficients is 0.747. Because the increase in phytoplankton abundance, especially during the outbreak of P. globosa and a large amount of mucus produced by the colonies could significantly increase seawater viscosity, we suggest that biological factors were the main reasons for the increase in seawater viscosity. The η_(Bio) was completely consistent with the occurrence process of P. globosa bloom and could be used as a valuable index for P. globosa bloom monitoring. | KANG Zhenjun YANG Bin LAI Junxiang NING Yi ZHONG Qiuping LU Dongliang LIAO Riquan WANG Pei Solomon Felix Dan SHE Zhicai JIA Zhen LAO Yanling LI Nan | 2020 | Journal of Ocean University of China2020，19，5： | 5 |
| 16 | Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study显示文摘Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1]. | YANG Jing Li HUANG Jun Jun CHENG Ning ZHANG De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao DING Jiao LIU Nian BAO Kai Fang DING Jie CHEN Xiao Liang ZHENG Tong Zhang BAI Ya Na | 2020 | Biomedical and Environmental Sciences2020，33，8： | 4 |
| 17 | Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect显示文摘Acute liver failure(ALF)is a fatal clinical syndrome with no special drug.Recent evidence shows that modulation of macrophage to inhibit inflammation may be a promising strategy for ALF treatment.In this study we investigated the potential therapeutic effects of melittin,a major peptide component of bee venom both in mice model of ALF and in LPS-stimulated macrophages in vitro,and elucidated the underlying mechanisms.ALF was induced in mice by intraperitoneal injection of D-galactosamine/LPS.Then the mice were treated with melittin(2,4,and 8 mg/kg,ip).We showed that melittin treatment markedly improved mortality,attenuated severe symptoms and signs,and alleviated hepatic inflammation in D-galactosamine/LPS-induced ALF mice with the optimal dose being 4 mg/kg.In addition,melittin within the effective doses did not cause significant in vivo toxicity.In LPS-stimulated RAW264.7 macrophages,melittin(0.7μM)exerted anti-oxidation and anti-inflammation effects.We showed that LPS stimulation promoted aerobic glycolysis of macrophages through increasing glycolytic rate,upregulated the levels of Warburg effect-related enzymes and metabolites including lactate,LDHA,LDH,and GLUT-1,and activated Akt/mTOR/PKM2/HIF-1α signaling.Melittin treatment suppressed M2 isoform of pyruvate kinase(PKM2),thus disrupted the Warburg effect to alleviate inflammation.Molecular docking analysis confirmed that melittin targeted PKM2.In LPS-stimulated RAW264.7 macrophages,knockdown of PKM2 caused similar anti-inflammation effects as melittin did.In D-galactosamine/LPS-induced ALF mice,melittin treatment markedly decreased the expression levels of PKM2 and HIF-1α in liver.This work demonstrates that melittin inhibits macrophage activation-mediated inflammation via inhibition of aerobic glycolysis by targeting PKM2,which highlights a novel strategy of using melittin for ALF treatment. | Xue-gong Fan Si-ya Pei Dan Zhou Peng-cheng Zhou Yan Huang Xing-wang Hu Teng Li Yang Wang Ze-bing Huang Ning Li | 2021 | Acta Pharmacologica Sinica2021，42，8： | 4 |
| 18 | Some basic aspects of polymer nanocomposites: A critical review显示文摘Polymer nanocomposites have been investigated for about three decades. To get deep insights into the modifying effects of various nanofillers on mechanical and physical properties of polymer nanocomposites, the three basic aspects of processing, characterization and properties are critically reviewed in this paper. Nanofillers can be classified into three major types of two-dimensional (2D) layered, one-dimensional (1D) fibrous and zerodimensional (0D) spherical ones and this review thus discusses in detail the processing, characterization and properties of the three types of polymer nanocomposites. It starts with an introduction of various nanoscale fillers such as two-dimensional (2D) nano-clay, graphene and MXene, one dimensional (1D) carbon nanofibers and nanotubes, zero dimensional (0D) silica nanoparticles and ZnO quantum dots as well as nanofiller-polymer interfaces. The processing of these polymer nanocomposites using different methods and the characterization of nanofillers and polymer nanocomposites using various techniques are described. Finally, the mechanical and physical properties of these polymer nanocomposites are discussed by considering the effects of nanofiller type, dispersion and contents;also, interface properties show significant effects on the mechanical properties of polymer nanocomposites and are discussed in some details. | Shaoyun Fu Zheng Sun Pei Huang Yuanqing Li Ning Hu | 2019 | Nano Materials Science2019，1，1： | 4 |
| 19 | The Survey of Cronobacter spp.(formerly Enterbacter sakazakii) in Infant and Follow-up Powdered Formula in China in 2012显示文摘Objective To determine Cronobacter spp.contamination in infant and follow-up powdered formula in China.Methods All of 2282 samples were collected from the retail markets in China from January 2012 to December 2012,and analyzed for Cronobacter spp.by the Chinese National Food Safety Standard.Characterization of the isolates was analyzed by pulsed-field gel electrophoresis(PFGE)with XbaI and Spe I restriction enzymes.Results Cronobacter spp.strains were isolated from 25 samples,and the positive rates in infant powdered formulas and follow-up powdered formulas were 0.90%(10/1011)and 1.18%(15/1271),respectively.Analysis of variable data regarding different purchasing store formats,seasonality,and production locations as well as comparison of infant versus follow-up formulas did not reveal statistically significant factors.During the sampling period,one of six surveillance zones did exhibit a statistically significant trend towards higher positive rate.PFGE characterization of Cronobacter spp.to elucidate genetic diversity revealed only three pairs of Cronobacter spp.out of 25 having the same PFGE patterns.Conclusion The current investigation indicated a lower positive rate of Cronobacter spp.in the powdered formula in China.This evidence suggested contamination originating from multiple different sources during the manufacturing process. | PEI Xiao Yan YAN Lin ZHU Jiang Hui LI Ning GUO Yun Chang FU Ping JIA Hua Yun ZHANG Xiu Li YANG Xiao Rong YANG Da Jin | 2016 | Biomedical and Environmental Sciences2016，29，2： | 4 |
| 20 | Implantable CMOS neuro-stimulus chip for visual prosthesis显示文摘A prototype chip with 2×2 pixels for implanting in blind patients affected by outer retinal degeneration is presented in this paper.This visual prosthesis chip imitates the degenerated photoreceptor cells,senses the incident light and stimulates the remaining healthy layers of retina or optic nerve.Each pixel integrates photodiode and stimulus pulse generator,converting the illumination on the eyes into 3-bit resolution bi-phasic current pulses.On-chip charge cancellation modules are used to discharge each electrode site for tissue safety.The prototype chip is designed and fabricated in 0.18-μm N-well CMOS (complementary metal oxide semiconductor) 1P6M Mix-signal process,with a ±2.5 V dual voltage supply.The functionality of the fabricated chip is demonstrated on anesthetized rabbits.Neural responses in visual cortex are successfully evoked by the neuro-stimulus chip through an on-board trigger interface and flexible electrode. | ZHANG Xu PEI WeiHua HUANG BeiJu WANG ShuJing GUAN Ning GUO Kai WANG Yu GUI Qiang CHEN Jin WANG Kai WU HuiJuan LI XiaoXin LI Kai CHEN HongDa | 2011 | Science China(Information Sciences)2011，54，4： | 3 |
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