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| 1 | MicroRNAs in pathogenesis of breast cancer:Implications in diagnosis and treatment显示文摘MicroR NAs(miR NAs) are small non-coding RNAs generated by a two-step complex process and are post transcriptional negative regulators of their target m RNAs. Dysregulation of many of these miR NAs has been associated with tumorigenesis in various cancers including breast cancer. Aberrantly high expression of specific mi RNAs in breast cancer cells is demonstrated to be linked with inhibition of tumor suppressor genes and promote tumorigenesis. They are classified as oncogenic miR NAs. However, the tumor suppressor miR NAs are downregulated in breast cancer cells, since their major targets are oncogenic m RNAs. Understanding mechanism of action of specific miR NAs in breast cancer cells can be utilized to develop newer anti-cancer therapies. Recently, newer techniques are also developed to detect abundance of specific miR NA in the blood plasma samples and can be used in early diagnosis or prognosis in breast cancer. In this review article, we have discussed several mi RNAs dysregulated in breast cancer and their therapeutic potential. | Nirav R Shah Hexin Chen | 2014 | World Journal of Clinical Oncology2014，5，2： | 8 |
| 2 | Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: Efficacy,safety and cost-comparison显示文摘AIM:To compare effectiveness,safety,and cost of photodynamic therapy(PDT)and radiofrequency ablation(RFA)in treatment of Barrett’s dysplasia(BD).METHODS:Consecutive case series of patients undergoing either PDT or RFA treatment at single center by a single investigator were compared.Thirty-three patients with high-grade dysplasia(HGD)had treatment with porfimer sodium photosensitzer and 630 nm laser(130 J/cm),with maximum of 3 treatment sessions.Fifty-three patients with BD(47 with low-grade dysplasia-LGD,6 with HGD)had step-wise circumferential and focal ablation using the HALO system with maximum of 4 treatment sessions.Both groups received proton pump inhibitors twice daily.Endoscopic biopsies were acquired at 2 and 12 mo after enrollment,with 4-quadrant biopsies every 1 cm of the original BE extent.A complete histological resolution response of BD(CR-D)was defined as all biopsies at the last endoscopy session negative for BD.Fisher’s exact test was used to assess differences between the two study groups for primary outcomes.For all outcomes,a two-sided P value of less than 0.05 was considered to indicate statistical significance.RESULTS:Thirty(91%)PDT patients and 39(74%)RFA were men(P=0.05).The mean age was 70.7±12.2 and 65.4±12.7(P=0.10)year and mean length of BE was 5.4±3.2 cm and 5.7±3.2 cm(P=0.53)for PDT and RFA patients,respectively.The CR-D was(18/33)54.5%with PDT vs(47/53)88.7%with RFA(P=0.001).One patient with PDT had an esophageal perforation and was managed with non-surgical measures and no perforation was seen with RFA.PDT was five times more costly than RFA at our institution.The two groups were not randomized and had different BD grading are the limitations of the study.CONCLUSION:In our experience,RFA had higher rate of CR-D without any serious adverse events and was less costly than PDT for endoscopic treatment of BD. | Atilla Ertan Irum Zaheer Arlene M Correa Nirav Thosani Shanda H Blackmon | 2013 | World Journal of Gastroenterology2013，19，41： | 7 |
| 3 | 胃内滞留漂浮给药系统中使用草药根除幽门螺旋杆菌的研究进展(英文)显示文摘Helicoacter pylori are very common patho-genic bacteria colonizing about half of all popula-tions and associated with the development of seti-ous gastroduodenal diseases like gastric lvm-phoma,peptic ulcers and acute chronic gastritis.Current drug regimes are not wholly effective. | Shreeraj H.SHAH Jayvadan K.PATEL Nirav V.PATEL | 2009 | 中西医结合学报2009，7，10： | 5 |
| 4 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis显示文摘 | Nirav Thosani Harvinder Singh Asha Kapadia Nobuo Ochi Jeffrey H. Lee Jaffer Ajani Stephen G. Swisher Wayne L. Hofstetter Sushovan Guha Manoop S. Bhutani | 2012 | Gastrointestinal Endoscopy2012，，2： | 3 |
| 5 | Reduced incidence and mortality from colorectal cancer with flexible-sigmoidoscopy screening: A meta-analysis显示文摘AIM:To conduct a systematic review and meta-analysis of published population-based randomized controlled trials(RCTs).METHODS:RCTs evaluating the difference in mortality and incidence of colorectal cancer(CRC)between a screening flexible sigmoidoscopy(FS)group and control group(not assigned to screening FS)with a minimum 5 years median follow-up were identified by a search of MEDLINE and EMBASE databases and the Cochrane Central Register for Controlled Trials through August 2013.Random effects model was used for meta-analysis.RESULTS:Four RCTs with a total of 165659 patientsin the FS group and 249707 patients in the control group were included in meta-analysis.Intention-totreat analysis showed that there was a 22%risk reduction in total incidence of CRC(RR=0.78,95%CI:0.74-0.83),31%in distal CRC incidence(RR=0.69,95%CI:0.63-0.75),and 9%in proximal CRC incidence(RR=0.91,95%CI:0.83-0.99).Those who underwent screening FS were 18%less likely to be diagnosed with advanced CRC(OR=0.82,95%CI:0.71-0.94).There was a 28%risk reduction in overall CRC mortality(RR=0.72,95%CI:0.65-0.80)and 43%in distal CRC mortality(RR=0.57,95%CI:0.45-0.72).CONCLUSION:This meta-analysis suggests that screening FS can reduce the incidence of proximal and distal CRC and mortality from distal CRC along with reduction in diagnosis of advanced CRC. | Jennifer Shroff Nirav Thosani Sachin Batra Harminder Singh Sushovan Guha | 2014 | World Journal of Gastroenterology2014，20，48： | 3 |
| 6 | Is Entresto good for the brain?显示文摘The main stay pharmacotherapy for heart failure(HF) is targeted towards rennin-angiotensin-aldosterone(RAAS) and neprilysin pathways(NP). Both therapeutic strategies decreases morbidity and mortality but also carry considerable adverse effects. This review of the literature highlights the new generation of HF drug, sacubitril-valsartan(SV), trade name Entresto(researched as LCZ696, Novartis) which simultaneously blocks RAAS and NP. This dual action of angiotensin receptors blocker and neprilysin inhibitor(NPi) has improved HF prognosis and it is an evolution in the management of HF. Although the initial follow-up of patients treated with SV has yielded promising results, there are concerns regarding potential side effects especially an increase in the risk of Alzheimer's disease(AD) and young onset of AD. NPi interferes with the breakdown and clearing of beta-amyloid peptides, the plaques seen in AD, raising concern for AD in SV patients. On the other hand, hypertension and cardiovascular diseases are established risk factors for AD which can be decreased by SV therapy. It is therefore essential that SV treated patients are followed up over an extended period of time to detect any adverse cognitive changes. | Nirav Patel Jason Gluck | 2017 | World Journal of Cardiology2017，9，7： | 2 |
| 7 | Co-evaporated Cu 2 ZnSnSe 4 films and devices显示文摘 | Ingrid Repins Carolyn Beall Nirav Vora Clay DeHart Darius Kuciauskas Pat Dippo Bobby To Jonathan Mann Wan-Ching Hsu Alan Goodrich Rommel Noufi | 2012 | Solar Energy Materials and Solar Cells2012，，： | 2 |
| 8 | 两个热带树种(柚木和印度实竹)叶面积指数估测异速生长方程(英文)显示文摘通过破坏性抽样、相片网格法和落叶采受器法,获得了印度Shoolpaneshwar野生动物禁猎区内生长的柚木和印度实竹叶面积指数。建立了一个异速生长方程来决定两个树种的叶面积指数。结果表明,异速生长方程获得的叶面积指数与破坏性抽样、相片网格法和落叶采受器法评估得到的指数值相近;2种测定方式下,柚木的均方根误差分别是0.90和1.15,印度实竹的均方根误差分别为0.38和0.46。估计的和计算获得的叶面积指数值匹配性较好,说明用建立的方程计算得到的2个树种叶面积指数的准确性较好。总之,冠幅伸展是一个估计树木叶面积较好的且敏感的参数。本文所提出的方程可以用作估计热带柚木和印度实竹叶面积指数。图4表1参22。 | Dhaval Vyas Nirav mehta J.Dina-karan N.S.R.Krishnayya | 2010 | Journal of Forestry Research2010，21，2： | 2 |
| 9 | 查看详情显示文摘 | Ganapati D.Y Nirav S.D | | 0，，： | 1 |
| 10 | Twenty-nine years after carbon monoxide intoxication 显示文摘 | Fereydoon R Roger W K Nirav M | 2001 | Cinical Neurology and Neurosurgery2001，103，： | 1 |
| 11 | Optimization models for assessing the peak capacity utilization of intelligent transportation systems显示文摘 | Nirav Shah Subodha Kumar Farokh Bastani I-Ling Yen | 2012 | European Journal of Operational Research2012，216，1： | 1 |
| 12 | Omeprazole improves the anti‐obesity and antidiabetic effects of exendin‐4 in db/db mice (奥美拉唑改善唾液素‐4 对 db/db 小鼠的减肥与降糖作用)*显示文摘 | Vishal Patel Amit Joharapurkar Tejal Gandhi Kirti Patel Nirav Dhanesha Samadhan Kshirsagar Vipin Dhote Jaysukh Detroja Rajesh Bahekar Mukul Jain | 2013 | Journal of Diabetes2013，，2： | 1 |
| 13 | Catalytic fluidized-bed combustion enhancement of sulfation of calcium oxide by iron oxide 显示文摘 | Nirav J D Yang R T | 1983 | Ind Eng Chem Process Des Dev1983，22，1： | 1 |
| 14 | Doxorubicin mediated cardiotoxicity in rats: Protective role of felodipine on cardiac indices显示文摘 | Hardik Gandhi Vaibhav B. Patel Nirav Mistry Naeem Patni Jatin Nandania Ramachandran Balaraman | 2013 | Environmental Toxicology and Pharmacology2013，，： | 1 |
| 15 | A Patient on Long-Term Proton Pump Inhibitors Develops Sudden Seizures and Encephalopathy: An Unusual Presentation of Hypomagnesaemia显示文摘 | Nirav Y. Gandhi Walid K. Sharif Sumeet Chadha Jayadave Shakher C. T. Shun E. Umegaki | 2012 | Case Reports in Gastrointestinal Medicine2012，，： | 1 |
| 16 | Endocrine Neoplasm Scintigraphy: Added Value of Fusing SPECT/CT Images Compared With Traditional Side-by-Side Analysis显示文摘 | Christian J. Ingui Nirav P. Shah M Elizabeth Oates | 2006 | Clinical Nuclear Medicine2006，，： | 1 |
| 17 | Cardiology’s 10 Greatest Discoverise of the 20th century显示文摘 | Nirav J M Khan M D Facc M D | 2002 | Texas Heart Insti-tude Journal2002，29，3： | 1 |
| 18 | Subarachnoid hemorrhage and inflammation:Bench to beside and baek显示文摘 | J Javier Proveneio Nirav Vora | 2005 | Seminars in Neurology2005，25，4： | 1 |
| 19 | Dis- tinct Cerebellar Contributions to Intrinsic Connectivity显示文摘 | Christophe Habas Nirav Kamdar Daniel Nguyen | 2009 | Net- works2009，29，26： | 1 |
| 20 | Use of endoscopic third ventri- culostomy in hydrocephalus of tubercular origin 显示文摘 | Sanat B Nirav M Suneel S | 2010 | Childs Nerv Syst2010，26，： | 1 |
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