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| 1 | One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients显示文摘The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI. | Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan Zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu Zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang Jianwu Dai | 2016 | Science China(Life Sciences)2016，59，7： | 18 |
| 2 | Screening of aptamers and their potential application in targeted diagnosis and therapy of liver cancer显示文摘Aptamers are a class of single oligonucleotide molecules(DNA or RNA)that are screened from random DNA or RNA oligonucleotide chain libraries by the systemic evolution of ligands by exponential enrichment technology.The selected aptamers are capable of specifically binding to different targeting molecules,which is achieved by the three-dimensional structure of aptamers.Aptamers are similar in function to monoclonal antibodies,and therefore,they are also referred to as'chemical antibodies'.Due to their high affinity and specificity and low immunogenicity,aptamers are topics of intense interest in today's biological targeting research especially in tumor research.They not only have high potential for clinical advances in tumor targeting detection but also are highly promising as targeted tumor drug carriers for use in tumor therapy.Various experimental studies have shown that aptamer-based diagnostic and therapeutic methods for liver cancer have great potential for application.This paper summarizes the structure,characteristics,and screening methods of aptamers and reviews the recent research progress on nucleic acid aptamers in the targeted diagnosis and treatment of liver cancer. | Guo-Qing Zhang Li-Ping Zhong Nuo Yang Yong-Xiang Zhao | 2019 | World Journal of Gastroenterology2019，25，26： | 7 |
| 3 | Ocular Surface Characteristics and Impression Cytology in Patients with Active versus Inactive Thyroid Eye Disease显示文摘Purpose:To compare the clinical findings, tear film function and impression cytology between patients with active and inactive Thyroid Eye Disease (TED). Methods:.A total of 56 patients with TED and 30 controls were recruited in this prospective observational cohort study. TED patients were divided into active TED and inactive TED types according to a seven-point modified formulation of the Clinical Activity Score (CAS). All participants underwent full eye examinations including Ocular Surface Disease Index (OSDI) score, tear film break-up time (TBUT), fluorescein staining and Schirmer I test. Thirty nine patients with thyroid-associated orbitopathy.(TAO) received Nelson's grade with conjunctival impression cytology. Proptosis, palpebral fissure width and lagophthalmos were assessed. Results:.Ocular surface parameters including proptosis, palpebral fissure width and lagophthalmos did not differ between active and inactive TED patients(P>0.05). Both active and inactive TED patients obtained higher fluorescein staining scores, lower TBUT scores and significantly lower Schirmer test scores than those of controls (P<0.001 for all). Additionally, the TBUT score was significantly lower and the OSDI score significantly higher in the active TED group compared with those in the inactive TED group (P<0.001 for both). Impression cytology revealed a higher proportion of grade 2-3 changes in the active TED group compared with the inactive TED group(P<0.001). Conclusion:.Orbital inflammation in TED patients may lead to decreased tear film stability and ocular surface squamous metaplasia. | Nuo Xu Danping Huang Huasheng Yang Zhaoguang Lai Quan Luo | 2012 | Eye Science2012，27，2： | 3 |
| 4 | FoxM1 mediated resistance to gefitinib in non-sma cell lung cancer cells显示文摘 | Nuo XU Xin ZHANG Xun WANG Hai-yan GE Xiao-ying WANG David GARFIELD Ping YANG Yuan-lin SONG Chun-xue BAI | 2012 | Acta Pharmacologica Sinica2012，33，5： | 3 |
| 5 | Environment-friendly surface cleaning using micro-nano bubbles显示文摘Cleaning a surface using a solution containing a large number of micro to nano scale bubbles has significant advantage regarding environmental protection.This review first briefly introduces the cleaning mechanism of micro-nano bubbles(MNBs),including physical and chemical effects.Then the applications of MNBs in cleaning of metal parts,precision parts,cultural relics or food are introduced.After that,coupled cleaning method of ultrasound and bubbles is introduced.Finally,the characterization methods for the cleaning effect are introduced,which mainly focuses on the changes of physico-chemical properties(mass or cleaning area,infiltration,colony number and light scattering intensity)of the cleaned parts or that(like conductivity)of the solvent.It is believed that MNBs technology will be applied in a broader range of surface cleaning applications. | Nuo Jin Fenghua Zhang Yan Cui Le Sun Haoxiang Gao Ziang Pu Weimin Yang | 2022 | Particuology2022，20，7： | 2 |
| 6 | Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression显示文摘Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in y-secretase component genes.We and other researchers showed that nicastrin (NCSTN) is the most frequently mutated gene in familial AI.In this study,we generated a keratin 5-Cre-driven epidermis-specific Ncstn conditional knockout mutant in mice.We determined that this mutant recapitulated the major phenotypes of AI,including hyperkeratosis of hair follicles and inflammation.In Ncstnflox/flox;K5-Cre mice,the IL-36a expression level markedly increased starting from postnatal day 0 (P0),and this increase occurred much earlier than those of TNF-α,IL-23A,IL-1 3,and TLR4.RNA-Seq analysis indicated that Sprr2d,a member of the small proline-rich protein 2 family,in the skin tissues of the Ncstnflox/flox,;K5-Cre mice was also upregulated on P0.Quantitative reverse-transcription polymerase chain reaction showed that other Sprr2 genes had a similar expression pattern.Our findings suggested that IL-36a might be a key inflammatory cytokine in the pathophysiology of AI and implicate malfunction of the skin barrier in the pathogenesis of AI. | Jun Yang Lianqing Wang Yingzhi Huang Keqiang Liu Chaoxia Lu Nuo Si Rongrong Wang Yaping Liu Xue Zhang | 2020 | Frontiers of Medicine2020，14，3： | 2 |
| 7 | Research progress on bulk nanobubbles显示文摘There are still fundamental problems lying in the basic research of bulk nanobubbles.Are the bulk nanobubbles reported in the literature nano scale bubbles or contaminants in fact?At present,there is not yet sufficient experimental evidence to show that the bulk nanoparticles are only gas bubbles but not other nano scale contaminants.If they are indeed nanobubbles,what causes the bulk nanobubbles observed in the literature to be much more stable than being predicted by the Epstein-Plesset theory?This paper firstly discusses the contradiction between the traditional theory prediction and the observed lifetime of the bulk nanobubbles,and then discusses whether the so-called nanobubbles are gas aggregates.We review the existing typical models,and the influence of different conditions on the stability of bulk nanobubbles,for paving the road to a clear understanding of the stability mechanism of bulk nanobubbles.In addition,the representative production methods and characterization methods of bulk nanobubbles are discussed in order to offer some guidance to their wide range of commercial applications. | Le Sun Fenghua Zhang Xiaoming Guo Zhengming Qiao Yi Zhu Nuo Jina Yan Cui Weimin Yang | 2022 | Particuology2022，20，1： | 2 |
| 8 | Optimized Bio-inspired Micro-pillar Dry Adhesive and Its Application for an Unmanned Aerial Vehicle Adhering on and Detaching from a Ceiling显示文摘Various bio-inspired dry adhesive materials have been investigated.In this work,lithography and silicon deep etching method were used to fabricate bio-inspired micro-pillar dry adhesive materials of which the parameters,such as side length,Height to Side length Aspect Ratio(HSAR),and inter-pillar Distance to Side length Aspect Ratio(DSAR)were comprehensively studied to obtain a dry adhesive with high adhesion.An orthogonal array method was designed and a series of fabrication experiments were conducted to identify optimum parameters,which resulted in a high normal adhesion of 2.98 N·cm^-2 and a shear adhesion of 9.59 N·cm^-2.An adhesion and desorption device was further designed on basis of the optimum dry adhesive,which enables an Unmanned Aerial Vehicle(UAV)to successfully adhere on and detach from a ceiling.This would allow an UAV to stay aloft for prolonged time,which could be invaluable to many applications,such as energy conservation and aerial detection. | Qingsong He Xianrui Xu Zhiwei Yu Kai Huo Zhaoyang Wang Nuo Chen Xuean Sun Gui Yin Peile Du Yang Li Zhendong Dai | 2020 | Journal of Bionic Engineering2020，17，1： | 2 |
| 9 | Biodegradable, Super-Strong, and Conductive Cellulose Macrofibers for Fabric-Based Triboelectric Nanogenerator显示文摘Electronic fibers used to fabricate wearable triboelectric nanogenerator(TENG) for harvesting human mechanical energy have been extensively explored. However, little attention is paid to their mutual advantages of environmental friendliness, mechanical properties, and stability. Here, we report a super-strong, biodegradable, and washable cellulose-based conductive macrofibers, which is prepared by wet-stretching and wet-twisting bacterial cellulose hydrogel incorporated with carbon nanotubes and polypyrrole. The cellulose-based conductive macrofibers possess high tensile strength of 449 MPa(able to lift 2 kg weights), good electrical conductivity(~ 5.32 S cm^(-1)), and excellent stability(Tensile strength and conductivity only decrease by 6.7% and 8.1% after immersing in water for 1 day). The degradation experiment demonstrates macrofibers can be degraded within 108 h in the cellulase solution. The designed fabric-based TENG from the cellulose-base conductive macrofibers shows a maximum open-circuit voltage of 170 V, short-circuit current of 0.8 μA, and output power at 352 μW, which is capable of powering the commercial electronics by charging the capacitors. More importantly, the fabric-based TENGs can be attached to the human body and work as self-powered sensors to effectively monitor human motions. This study suggests the potential of biodegradable, super-strong, and washable conductive cellulose-based fiber for designing eco-friendly fabric-based TENG for energy harvesting and biomechanical monitoring. | Sanming Hu Jing Han Zhijun Shi Kun Chen Nuo Xu Yifei Wang Ruizhu Zheng Yongzhen Tao Qijun Sun Zhong Lin Wang Guang Yang | 2022 | Nano-Micro Letters2022，14，7： | 2 |
| 10 | Integrative genomic analysis of phosphatidylinositol 3-kinase family identifies PIK3R3 as a potential therapeutic target in epitbelial ovarian cancer显示文摘 | Lin Zhang Jia Huang Nuo Yang | 2007 | Clin Cancer Res2007，13，18： | 1 |
| 11 | Vector- based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer显示文摘 | Zhang Lin Yang Nuo Mohamed Hadley A | 2007 | Biochem Biophys Res Commun2007，303，4： | 1 |
| 12 | The “bottom-up” synthesis and applications of persistent luminescence nanoparticles显示文摘Persistent luminescence refers to the phenomenon whereby luminescence remains after excitation ceases.In the past few decades,various kinds of persistent luminescent materials have been developed and widely employed in numerous applications,such as security signs,medical diagnostics and photocatalysis.Persistent luminescent materials offer distinctive advantages for biomedical applications,especially for bioimaging,as they can efficiently avoid autofluorescence and tissue-scattered light interference[1]. | Nuo Yu Yang Li Zhanjun Li Gang Han | 2018 | Science China Chemistry2018，61，7： | 1 |
| 13 | Understanding length dependences of effective thermal conductivity of nanowires显示文摘 | Moran Wang Xiaodong Shan Nuo Yang | 2012 | Physics Letters A2012，，46： | 1 |
| 14 | Tumor-derived Vascular Endothelial Growth Factor Up-Regulates Angiopoietin-2 in Host Endothelium and Destabilizes Host Vasclature, Supporting Angiogenesis in Ovarian 显示文摘 | LIN ZHANG NUO YANG JIN-WAN PARK | 2003 | CancerCancer Res2003，63，： | 1 |
| 15 | Vec- tor-based RNAi, a novel tool for isoform - specific knockdown of VEGF and antiangio -genesis gene therapy of cancer显示文摘 | ZHANG LIN YANG NUO ALISHA MOHAMED-HADLEYB | 2003 | Biochem Biophys Res Commun2003，303，4： | 1 |
| 16 | Thermal Rec- tification in Asymmetric Graphene Ribbons 显示文摘 | YANG Nuo ZHANG Gang LI Baowen | 2009 | Applied Physics Letters2009，95，03： | 1 |
| 17 | Changes in the Urban Surface Thermal Environment of a Chinese Coastal City Revealed by Downscaling MODIS LST with Random Forest Algorithm显示文摘Analysis of the formation and evolution of urban surface thermal environment is crucial for urban planning and improving the environment of a settlement.Qingdao was selected in this study as a typical coastal city undergoing rapid urbanization,and the spatiotemporal dynamic characteristics of its urban surface thermal environment from2010 to 2019 were evaluated.The random forest(RF)algorithm was adopted to obtain its land surface temperature(LST)map with 30-m resolution by downscaling the Moderate Resolution Imaging Spectroradiometer(MODIS)LST product;the remote sensing indices emphasizing different land cover types,LST calculated by the radiative transfer equation,and elevation were used as input variables in the algorithm.The heat island intensity(HII),urban heat island(UHI)volume,and UHI grade were used to analyze the spatiotemporal dynamic characteristics of the urban surface thermal environment in Qingdao.The results show an increasing trend in average HII between 1.1 and 2.52°C in the study area over the past 10 years.The northern city appeared to have the highest UHI volume,while change of the UHI volume in Huangdao District of southwestern Qingdao was the most significant.The areas with high HII have gradually expanded during the last 10 years,and the areas with a 10-yr persistently high HII are distributed mainly in old urban areas with high building density and a dense population.Different factors may influence UHI,such as artificial heat sources,surface heat sources,and hybrid heat sources.Finally,adjusting the urban structure,increasing the vegetated area,and changing building colors are proposed to mitigate UHI in the areas with continuously high HII. | Nuo XU Fan DENG Bingqi LIU Caixia LI Hancong FU Huan YANG Jiahua ZHANG | 2021 | Journal of Meteorological Research2021，35，5： | 1 |
| 18 | Effects of Leptocybe invasa Damage on Chemical Components of Eucalyptus显示文摘[Objective] The aim was to illustrate the relation between Leptocybe invasa and eucalyptus, so as to provide the basis for scientific control of L. invasa. [Method] The chemical components of eucalyptus were extracted by solid phase micro-extraction (SPME) technique and ethanol extraction method, and detected by gas chromatograph-mass spectrometer. The relative contents of various components were determined by area normalization. [Result] When eucalyptus was damaged by L. invasa, not only some substances disappeared, but also new substances were induced. Among 4 induced volatiles, the content of terpinolene was the highest of 37.66%. Eight new chemical substances were also detected from the ethanol extract of damaged leaves, and the content of 3-phenyl-2-propenyl phenpropionate was the highest of 30.95%.[Conclusion] The damage caused by L. invasa had obvious effect on composition and contents of chemical components of eucalyptus. | LV Wen-ling LI Nuo YANG Zhen-de YU Shu-zhong XU Li ZHAO Yan-yan | 2012 | Plant Diseases and Pests2012，3，1： | 1 |
| 19 | Thermal rectifica tion in asymmetric graphene ribbons 显示文摘 | YANG Nuo ZHANG Gang LI Bao wen | 2009 | Applied Physics Let ters2009，95，03： | 1 |
| 20 | Carbon nanocone: A promising thermal rectifier 显示文摘 | YANG Nuo ZHANG Gang LI Bao wen | 2008 | Applied Physics Letters2008，93，24： | 1 |
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