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| 1 | NUMERICAL ANALYSIS OF THE INFLUENCE OF THE TIP CLEARANCE FLOWS ON THE UNSTEADY CAVITATING FLOWS IN A THREE- D IMENSIONAL INDUCER显示文摘To clarify the influences of the tip clearance flows on the unsteady cavitating flow, the three-dimensional unsteady cavitating flows through both the two-dimensional cascades and the three-dimensional inducer with and without tip clearance are performed numerically. The governing equations for the compressible fluid flow with the DES turbulence model are employed with the assumption of the isentropic process of liquid phase. The evolution of cavities is represented as the source/sink of vapor phase. The basic equations in the curve linear coordinate are solved by the finite difference method. As the results of the three-dimensional cavitating flows through the two-dimensional cascades, the tip clearance flows from the pressure side to the suction side of the blade produces the tip vortex cavitation, which affects the sheet cavitation on the leading edge of the next blade and enhances the blockage effect near the casing than the flows without tip clearance. On the other hand, in the case of the three-dimensional inducer, the large backflow cavitation is observed around the inlet of the inducer, where the cavities are developed on the casing by the tip clearance flows. The large pressure gradient between the non-cavitating pressure side and the cavitating suction side enhances the tip clearance flows. The calculation considering the tip clearance reproduces the developed cavitation region similar to that of experimental visualizations. Additionally, the backflow cavitation rotates with the speed slower than the rotation speed of the inducer. Then, the rotation of backflow cavitation causes the periodic fluctuation of the outlet pressure greater than that of the inlet pressure. | OKITA K. UGAJIN H. MATSUMOTO Y. | 2009 | Journal of Hydrodynamics2009，21，1： | 30 |
| 2 | Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients显示文摘AIM:To clarify the utility of using des-γ-carboxy prothrombin(DCP)andα-fetoprotein(AFP)levels to predict the prognosis of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)and the hepatitis C virus(HCV)infections.METHODS:A total of 205 patients with HCC(105patients with HBV infection 100 patients with HCV infection)who underwent primary hepatectomy between January 2004 and May 2012 were enrolled retrospectively.Preoperative AFP and DCP levels were used to create interactive dot diagrams to predict recurrence within 2 years after hepatectomy,and cutoff levels were calculated.Patients in the HBV and HCV groups were classified into three groups:a group with low AFP and DCP levels(LL group),a group in which one of the two parameters was high and the other was low(HL group),and a group with high AFP and DCP levels(HH group).Liver function parameters,the postoperative recurrence-free survival rate,and postoperative overall survival were compared between groups.The survival curves were compared by logrank test using the Kaplan-Meier method.Multivariate analysis using a Cox forward stepwise logistic regression model was conducted for a prognosis.RESULTS:The preoperative AFP cutoff levels for recurrence within 2 years after hepatectomy in the HBV and HCV groups were 529.8 ng/m L and 60 m AU/m L,respectively;for preoperative DCP levels,the cutoff levels were 21.0 ng/m L in the HBV group and 67 m AU/m L in the HCV group.The HBV group was significantly different from the other groups in terms of vascular invasion,major hepatectomy,volume of intraoperative blood loss,and surgical duration.Significant differences were found between the LL group,the HL group,and the HH group in terms of both mean disease-free survival time(MDFST)and mean overall survival time(MOST):64.81±7.47 vs 36.63±7.62 vs 18.98±6.17mo(P=0.001)and 85.30±6.55 vs 59.44±7.87 vs46.57±11.20 mo(P=0.018).In contrast,the HCV group exhibited a significant difference in tumor size,vascular invasion,volume of intraoperative blood loss,and surgical duration;however,no significant difference was observed between the three groups in liver function parameters except for albumin levels.In the LL group,the HL group,and the HH group,the MDFST was 50.09±5.90,31.01±7.21,and 14.81±3.08 mo(log-rank test,P<0.001),respectively,and the MOST was 79.45±8.30,58.82±7.56,and 32.87±6.31 mo(log-rank test,P<0.001),respectively.CONCLUSION:In the HBV group,the prognosis was poor when either AFP or DCP levels were high.In the HCV group,the prognosis was good when either or both levels were low;however,the prognosis was poor when both levels were high.High levels of both AFP and DCP were an independent risk factor associated with tumor recurrence in the HBV and HCV groups.The relationship between tumor marker levels and prognosis was characteristic to the type of viral hepatitis. | Makoto Meguro Toru Mizuguchi Toshihiko Nishidate Kenji Okita Masayuki Ishii Shigenori Ota Tomomi Ueki Emi Akizuki Koichi Hirata | 2015 | World Journal of Gastroenterology2015，21，16： | 16 |
| 3 | Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma显示文摘AIM:To compare the prognoses of hepatocellular carcinoma(HCC)patients that underwent anatomic liver resection(AR)or non-anatomic liver resection(NAR)using propensity score-matched populations.METHODS:Between January 2002 and December2010,268 consecutive HCC patients,including 110 and158 patients that underwent AR and NAR,respectively,were retrospectively enrolled in this study.Forty-four patients from each group were selected and matched using logistic multivariate analysis followed by propensity score analysis.RESULTS:In the whole analysis set,the histological background of the liver,liver function,and tumor marker levels differed significantly among the groups.Although the overall survival(OS)and recurrence-free survival rates of the two groups did not differ significantly in the whole analysis set,the OS of the AR group was significantly longer than that of the NAR group after propensity matching(76.2±6.3 mo vs 58.9±6.3mo;P=0.0039).Although AR(HR=0.456,P=0.039)was found to be a prognostic factor in the univariate analysis,only vascular invasion(HR=0.228,P=0.002)and the hepatocyte growth factor level(HR=52.366,P=0.035)were subsequently found to be independent prognostic factors.CONCLUSION:AR conveys a survival advantage over NAR in specific subpopulations of HCC patients with tumors of less than 5 cm in diameter,single tumor,and good liver function. | Masayuki Ishii Toru Mizuguchi Masaki Kawamoto Makoto Meguro Shigenori Ota Toshihiko Nishidate Kenji Okita Yasutohsi Kimura Thomas T Hui Koichi Hirata | 2014 | World Journal of Gastroenterology2014，20，12： | 12 |
| 4 | Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer显示文摘AIM:To characterize the implications of vascular endothelial growth factor(VEGF)-A in stromal cells and colorectal cancer and the expression of VEGF-A splice variants.METHODS:VEGF-A expression in tumor and stromal cells from 165 consecutive patients with colorectal cancer was examined by immunohistochemistry.The association between VEGF-A expression status and clinicopathological factors was investigated.Twenty freshfrozen samples were obtained for laser capture microdissection to analyze the splice variants of VEGF-A.RESULTS:VEGF-A was expressed in 53.9% and 42.4% of tumor and stromal cells,respectively.VEGF-A expression in tumor cells(t-VEGF-A) was associated with advanced clinical stage(stage 0,1/9;stage 1,2/16;stage 2,32/55;stage 3,38/66;stage 4,16/19,P < 0.0001).VEGF-A expression in stromal cells(s-VEGF-A) increased in the earlier clinical stage(stage 0,7/9;stage 1,6/16;stage 2,33/55;stage 3,22/66;stage 4,5/19;P = 0.004).Multivariate analyses for risk factors of recurrence showed that only s-VEGF-A expression was an independent risk factor for recurrence(relative risk 0.309,95% confidence interval 0.141-0.676,P = 0.0033).The five-year disease-free survival(DFS) rates of t-VEGF-A-positive and-negative cases were 51.4% and 62.9%,respectively.There was no significant difference in t-VEGF-A expression status.The five-year DFS rates of s-VEGF-A-positive and-negative cases were 73.8% and 39.9%,respectively.s-VEGFA-positive cases had significantly better survival than s-VEGF-A-negative cases(P = 0.0005).Splice variant analysis revealed that t-VEGF-A was mainly composed of VEGF165 and that s-VEGF-A included both VEGF165 and VEGF165b.In cases with no venous invasion(v0),the level of VEGF165b mRNA was significantly higher(v0 204.5 ± 122.7,v1 32.5 ± 36.7,v2 2.1 ± 1.7,P = 0.03).The microvessel density tended to be lower in cases with higher VEGF165b mRNA levels.CONCLUSION:s-VEGF-A appears be a good prognostic factor for colorectal cancer and includes VEGF165 and VEGF165b. | Makoto Tayama Tomohisa Furuhata Yoshiko Inafuku Kenji Okita Toshihiko Nishidate Toru Mizuguchi Yasutoshi Kimura Koichi Hirata | 2011 | World Journal of Gastroenterology2011，17，44： | 10 |
| 5 | Prospective Cohort Study of Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma in 8510 Patients显示文摘 | Kenichi Takayasu Shigeki Arii Iwao Ikai Masao Omata Kiwamu Okita Takafumi Ichida Yutaka Matsuyama Yasuni Nakanuma Masamichi Kojiro Masatoshi Makuuchi Yoshio Yamaoka | 2006 | Gastroenterology2006，，2： | 5 |
| 6 | Comprehensive review of post-liver resection surgical complications and a new universal classification and grading system显示文摘Liver resection is the gold standard treatment for certain liver tumors such as hepatocellular carcinoma and metastatic liver tumors. Some patients with such tumors already have reduced liver function due to chronic hepatitis, liver cirrhosis, or chemotherapy-associated steatohepatitis before surgery. Therefore, complications due to poor liver function are inevitable after liver resection. Although the mortality rate of liver resection has been reduced to a few percent in recent case series, its overall morbidity rate is reported to range from 4.1% to 47.7%. The large degree of variation in the post-liver resection morbidity rates reported in previous studies might be due to the lack of consen-sus regarding the definitions and classification of postliver resection complications. The Clavien-Dindo(CD) classification of post-operative complications is widely accepted internationally. However, it is hard to apply to some major post-liver resection complications because the consensus definitions and grading systems for posthepatectomy liver failure and bile leakage established by the International Study Group of Liver Surgery are incompatible with the CD classification. Therefore, a unified classification of post-liver resection complications has to be established to allow comparisons between academic reports. | Masayuki Ishii Toru Mizuguchi Kohei Harada Shigenori Ota Makoto Meguro Tomomi Ueki Toshihiko Nishidate Kenji Okita Koichi Hirata | 2014 | World Journal of Hepatology2014，6，10： | 3 |
| 7 | Anal cushion lifting method is a novel radical management strategy for hemorrhoids that does not involve excision or cause postoperative anal complications显示文摘AIM: To describe the anal cushion lifting(ACL) method with preliminary clinical results. METHODS: Between January to September 2007, 127 patients who received ACL method for hemorrhoid was investigated with informed consent. In this study, three surgeons who specialized in anorectal surgery performed the procedures. Patients with grade two or more severe hemorrhoids according to Goligher's classification were considered to be indicated for surgery. The patients were given the choice to undergo either the ACL method or theligation and excision method. ACL method is an original technique for managing hemorrhoids without excision. After dissecting the anal cushion from the internal sphincter muscle, the anal cushion was lifted to oral side and ligated at the proper position. Clinical characteristics and outcomes of patients were recorded including complications after surgery. RESULTS: A total of 127 patients were enrolled. Their median age was 42(19-84) years, and 74.8% were female. In addition, more than 99% of the patients had grade 3 or worse hemorrhoids. The median followup period was 26(0-88) mo, and the median operative time was 15(4-30) min. After surgery, analgesics were used for a median period of three days(0-21). Pain control was achieved using extra-oral analgesic drugs, although some patients required intravenous injections of analgesic drugs. The median duration of the patients' postoperative hospital stay was 7(2-13) d. A total of 10 complications(7.9%) occurred. Bleeding was observed in one patient and was successfully controlled with manual compression. Urinary retention occurred in 6 patients, but it disappeared spontaneously in all cases. Recurrent hemorrhoids developed in 3 patients after 36, 47, and 61 mo, respectively. No anal stenosis or persistent anal pain occurred. CONCLUSION: We consider that the ACL method might be better than all other current methods for managing hemorrhoids. | Gentaro Ishiyama Toshihiko Nishidate Yuji Ishiyama Akihiko Nishio Ken Tarumi Maiko Kawamura Kenji Okita Toru Mizuguchi Mineko Fujimiya Koichi Hirata | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 3 |
| 8 | A fundamental study of normal layer structure of the gastrointestinal wall visualized by endscopic ultrasonograpphy显示文摘 | Aibe T Fuji K Okita K | 1986 | Scand J Gastroenterol1986，21，123： | 2 |
| 9 | Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness显示文摘 | Takayuki Kondo Masashi Asai Kayoko Tsukita Yumiko Kutoku Yutaka Ohsawa Yoshihide Sunada Keiko Imamura Naohiro Egawa Naoki Yahata Keisuke Okita Kazutoshi Takahashi Isao Asaka Takashi Aoi Akira Watanabe Kaori Watanabe Chie Kadoya Rie Nakano Dai Watanabe Kei | 2013 | Cell Stem Cell2013，，4： | 2 |
| 10 | Increased Rectal Wall Thickness May Predict Relapse in Ulcerative Colitis: A Pilot Follow-Up Study by Ultrasonographic Colonoscopy显示文摘 | S. Higaki H. Nohara Y. Saitoh A. Akazawa H. Yanai T. Yoshida K. Okita | 2002 | Endoscopy2002，，03： | 2 |
| 11 | Report of the 15th follow-up survey of primary liver cancer显示文摘 | Iwao Ikai Yuji Itai Kiwamu Okita Masao Omata Masamichi Kojiro Kenichi Kobayashi Yasuni Nakanuma Shunji Futagawa Masatoshi Makuuchi Yoshio Yamaoka | 2003 | Hepatology Research2003，，1： | 2 |
| 12 | Hepatocellular carcinoma with nonalcoholic steatohepatitis显示文摘 | Sayaka Mori Takahiro Yamasaki Isao Sakaida Taro Takami Eiki Sakaguchi Teruaki Kimura Fumie Kurokawa Shiro Maeyama Kiwamu Okita | 2004 | Journal of Gastroenterology2004，，4： | 2 |
| 13 | Friction welding of cemented carbide alloy to tool steel显示文摘 | Okita K Aritoshi M Mriak P | 1997 | Welding International1997，11，4： | 1 |
| 14 | Left ventricular function after mitral valve replacement with or without chordal preservation显示文摘 | Miki S Ueda Y | 1995 | J Heart Valve Dis1995，，： | 1 |
| 15 | Prospective comparative study of brain protection in total aortic arch replacement:deep hypothermic circulatory arrest with retrograde cerebral perfusion or selective antegrade cerebral perfusion显示文摘 | Minatoya K Tagusari O | 2001 | Ann Thorac Surg2001，72，11： | 1 |
| 16 | Generation of germline-competent induced pluripotent stem cells显示文摘 | Okita K Ichisaka T Yamanaka S | 2007 | Nature2007，448，7151： | 1 |
| 17 | Prospective comparative study of brain protection in total aortic arch replacement: deep hypothermic circulatory arrest with retrograde cerebral perfusion or selective antegrade cerebral perfusion显示文摘 | Okita Y Minatoya K Tagusari O | 2001 | Ann Thorac Surg2001，72，1： | 1 |
| 18 | Characterization of the Relation Among the Mechanical Behavior and the Textures in High Martensitic Dual Phase Steels 显示文摘 | Tomoyoshi Okita Yoshihiro Hosoya Kazuhide Nakaoka | 2005 | ISIJ International2005，45，11： | 1 |
| 19 | Generation of mouse-induced pluripotent stem cells with plasmid vectors显示文摘 | Okita K Hong H Takahashi K | 2010 | Nature Protocol2010，5，： | 1 |
| 20 | Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease显示文摘 | Teiko Kimpara A. Takeda Koichi Watanabe Yasuto Itoyama Shuntaro Ikawa Minro Watanabe Hiroyuki Arai Hidetada Sasaki Susumu Higuchi Naoshi Okita Sadao Takase Hiroshi Saito Kazuhiro Takahashi Shigeki Shibahara | 1997 | Human Genetics1997，，1： | 1 |
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