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| 1 | Clinical impacts of mesothelin expression in gastrointestinal carcinomas显示文摘Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric cancer.The full-length human mesothelin gene encodes the primary product,a 71-k Da precursor protein.The71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the blood.The biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and migration.In pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human cancers.The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.The present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy. | Takahiro Einama Futoshi Kawamata Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Fumihiko Matsuzawa Tatsuzo Mizukami Yuji Konishi Munenori Tahara Toshiya Kamiyama Okio Hino Akinobu Taketomi Satoru Todo | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 4 |
| 2 | Properties of Copper-aluminum Oxide Films Prepared by Solution Methods 显示文摘 | Kazuhiko T Katsuyoshi S Okio N | 2002 | Thin Solid Films2002，411，： | 1 |
| 3 | Properties of copper-aluminum oxide films prepared by solution methods显示文摘 | Kazuhiko Tonooka Katsuyoshi Shimokawa Okio Nishimura | 2002 | Thin Solid Films2002，411，1： | 1 |
| 4 | C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma显示文摘 | Futoshi Kawamata Shigenori Homma Hirofumi Kamachi Takahiro Einama Yasutaka Kato Masumi Tsuda Shinya Tanaka Masahiro Maeda Kazunori Kajino Okio Hino Norihiko Takahashi Toshiya Kamiyama Hiroshi Nishihara Akinobu Taketomi Satoru Todo | 2014 | Journal of Gastroenterology2014，，： | 1 |
| 5 | ERC/mesothelin is expressed in human gastric cancer tissues and celllines显示文摘 | Tomoaki Ito Kazunori Kajino Masaaki Abe Koichi Sato Hiroshi Maekawa Mutsumi Sakurada Hajime Orita Ryo Wada Yoshiaki Kajiyama Okio Hino | 2014 | Oncology Reports2014，，： | 1 |
| 6 | Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin inhuman pancreatic ductal carcinoma显示文摘 | Koichi Inami Kazunori Kajino Masaaki Abe Yoshiaki Hagiwara Masahiro Maeda Masafumi Suyama Sumio Watanabe Okio Hino | 2008 | Oncology Reports2008，，： | 1 |
| 7 | Y-box binding protein-1 expression in diffuse large B-cell lymphoma: an impact on prognosis in the rituximab era显示文摘 | Kyoko Hanzawa Shuji Momose Morihiro Higashi Michihide Tokuhira Reiko Watanabe Kazunori Kajino Okio Hino Shinji Itoyama Masahiro Kizaki Jun-Ichi Tamaru | 2010 | Leukemia & Lymphoma2010，，11： | 1 |
| 8 | Preparation and luminescent properties of sol–gel derived SiO 2 –B 2 O 3 :Tb glass films显示文摘 | Kazuhiko Tonooka Katsuyoshi Shimokawa Okio Nishimura | 2002 | Solid State Ionics2002，，1： | 1 |
| 9 | Molecular tumor markers for asbestos-related mesothelioma: serum diagnostic markers 显示文摘 | Masahiro M Okio H | 2006 | Pathol In2006，56，： | 1 |
| 10 | Hepatoprotective drugs for the treatment of virus-induced chronic hepatitis: from hypercarcinogenic state to hypocarcinogenic state显示文摘 | Toshihiro O Kazunori K Okio H | 2001 | Jpn J Pharmacol2001，87，： | 1 |
| 11 | New porous carbon materials,woodceramics:development and fundamental properties显示文摘 | KAZUNORI K OKIO H | 1996 | Journal of Porous Materials1996，2，： | 1 |
| 12 | Comparison of conventional and novel PET tracers for imaging mesothelioma in nude mice with subcutaneous and intrapleural xenografts显示文摘 | Atsushi B. Tsuji Chizuru Sogawa Aya Sugyo Hitomi Sudo Jun Toyohara Mitsuru Koizumi Masaaki Abe Okio Hino Yoshi-nobu Harada Takako Furukawa Kazutoshi Suzuki Tsuneo Saga | 2009 | Nuclear Medicine and Biology2009，，4： | 1 |
| 13 | Diagnostic biomarker of asbestos- related mesothelioma: example of translational research 显示文摘 | Okio H Kazu S Masahiro M | 2007 | Cancer Sci2007，98，8： | 1 |
| 14 | 南海海槽东部海上生产试采区天然气水合物储层的沉积物矿物成分显示文摘在南海海槽东部生产试采区,对天然气水合物更新世深水浊积岩的沉积物矿物成分进行了测量。我们使用60m钻井岩心样品进行半定量分析天然气水合物储层的矿物和有机质的含量。粉末x射线衍射分析、烧失量测试和场发射电子显微镜显示结果如下:(i)10种主要矿物含量各不相同,其中大多数与中值粒径呈良好的指数相关性;(ii)上层泥质部分主要由富含颗石藻的半深海沉积物组成,然而中部和下层部分的特点是颗石藻相对稀少,富含丰富腐殖质的浊流沉积物;(iii)自生石膏、菱铁矿和莓球状黄铁矿的普遍出现表明早期缺氧和高盐度环境下的成岩作用在一定程度上与天然气水合物的形成有关。这些矿物数据提供了关于热学性质、地质力学特性、有效渗透率、沉积物早期的成岩机制和开发天然气水合物储层的有用信息。 | Kosuke Egawa Okio Nishimura Shoko Izumi 杨振 张莉 万玲 范广慧 | 2016 | 海洋地质2016，0，3： | 0 |
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