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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 3 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 4 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 5 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 6 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 7 | Synthesis of substituted benzoxazoles by the iron(Ⅲ)-catalyzed aerobic oxidation process显示文摘The FeCl3-catalyzed aerobic oxidation process for the synthesis of benzoxazoles,benzothiazole and benzimidazole has been discovered.This method has proved to be effective to a wide range of substrates,and it has been applied for the synthesis of JTP-426467. | CAO Ke,TU YongQiang & ZHANG FuMin P State Key Laboratory of Applied Organic Chemistry and Department of Chemistry,Lanzhou University,Lanzhou 730000,China | 2010 | Science China Chemistry2010，53，1： | 3 |
| 8 | Detection and localization of TNF in human atheroma显示文摘 | Barath P Fishbein MC Cao J | 1990 | Am J Cardiol1990，65，： | 2 |
| 9 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 10 | Field demonstration of in situ immobilization of soil Pb using P amendments显示文摘 | Ming Chen Lena Q Ma Satya P Singh Rocky X Cao Ricardo Melamed | 2002 | Advances in Environmental Research2002，，1： | 2 |
| 11 | Variations of bacterioplankton community composition during Microcystis spp. blooms in a shallow eutrophic lake显示文摘 | Xing P Kong FX Cao HS Zhang M Tan X | 2007 | 中国生物学文摘2007，21，8： | 2 |
| 12 | Effect of Manganese on Grain Refinement of Mg-Al Based Alloys显示文摘 | Cao P Qian M StJohn D H | 2006 | Scripta Materialia2006，54，： | 1 |
| 13 | Expression profile of the channel catfish spleen: analysis of genes involved in immune functions显示文摘 | Kocabas A M Li P Cao D | 2002 | Mar Biotechnol2002，4，： | 1 |
| 14 | Analysis and synthesis of nonlinear time-delay system via fuzzy control approach显示文摘 | Cao Y Y Frank P M | 2000 | IEEE Transaction on Fuzzy Systems2000，8，2： | 1 |
| 15 | Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1 alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression显示文摘 | Karna P Cao Z | 2006 | J Biol Chem2006，281，25： | 1 |
| 16 | Preparation and properties of plasticized starch modified with poly(ε-caprolactone) based waterborne polyurethane显示文摘 | CAO XIAO-DONG CHANG P R HUNEAULT M A | 2008 | Carbohydrate Polymers2008，71，1： | 1 |
| 17 | NAD synthase nmnat acts as a chaperone to protect against neurodegeneration显示文摘 | Zhai R G Zhang F Hiesinger P R Cao Y Haueter C M Bellen H J | 2008 | Nature2008，452，： | 1 |
| 18 | Effect of hot air treatment on post- harvest mould decay in Chinese bayberry fruit and the possible mechanisms显示文摘 | Wang K T Cao S F Jin P | 2010 | International Journal of Food Microbiology2010，141，1： | 1 |
| 19 | Nucleotide sequence and growth hormone regulated expression of salmon insulin-like growth factor I mRNA 显示文摘 | Cao Q P Duguay S J Plisetskaya E | 1989 | Mol Endocrinol1989，3，12： | 1 |
| 20 | Endoleak after en- dovascular aortic repair: classification, diagnosis and management following endovascular thoracic and abdo- minal aortic repair显示文摘 | Cao P De Rango P Verzini F | 2010 | J Cardiovasc Surg (Torino)2010，51，1： | 1 |
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