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| 1 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 2 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 3 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 4 | Posterolateral Transfibular Approach to Tibial Plateau Fractures: Technique, Results, and Rationale显示文摘 | Lucian B Solomon Aaron W Stevenson Robert P V Baird Anthony P Pohl | 2010 | Journal of Orthopaedic Trauma2010，，8： | 2 |
| 5 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 6 | Asymmetrical, water - soluble phthalocyanine dyes for covalent labeling of oligonucleotides显示文摘 | Robert P Hammer Clyde V Owens Seok Hwan Hwang | 2002 | Bioconjugate Chem2002，13，： | 1 |
| 7 | Gene expression analysis of troglitazone reveals its impact on multiple pathways in cell culture:a case for in vitro platforms combined with gene expression analysis for early (idiosyncratic) toxicity screening显示文摘 | Gordon V Patrick P Robert S | 2006 | Inter J Toxicology2006，25，2： | 1 |
| 8 | Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage显示文摘 | Zheng Z Claudiu V C Robert P Stephan | 2003 | EMBO J2003，22，： | 1 |
| 9 | XML-based mobile agents显示文摘 | ROBERT S THARAM D PARTH P YURI V | 2005 | IEEE Computer Society Proceedings of the International Conference on Information Technology:Coding and Computing (ITCC''05)2005，11，： | 1 |
| 10 | Estimating aquifer properties by nonlinear least-squares analysis of pump test response显示文摘 | R A Johns L Senprini P V Roberts | 1992 | Ground water1992，30，1： | 1 |
| 11 | Determination of chlorine dioxide,chlorine,chlorite,and chlorate in water显示文摘 | Aieta E M Roberts P V Hernandez M | 1984 | J AWWA1984，76，1： | 1 |
| 12 | The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment 显示文摘 | Roberts P H Thomas K V | 2006 | Science Total Environment2006，356，13： | 1 |
| 13 | Operative treatment of scapular fractures:a systematic review显示文摘 | Lantry J M Roberts C S Giannoudis P V | | 0，，03： | 1 |
| 14 | Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase- trimethoprim, a drug-receptor system 显示文摘 | DAUBER O P ROBERTS V A OSGUTHORPE D J | 1998 | Proteins: Structure Function and Genetics1998，4，1： | 1 |
| 15 | Class-Based n-gram Models of Natural Language显示文摘 | PETER F B VINCENT J D P PETER V D JENIFER C L ROBERT L M | 1992 | Computational Linguistics1992，，： | 1 |
| 16 | Subzero water permeability parameters of mouse spermatozoa in the presence of extracellular ice and cryoprotective agents 显示文摘 | Devireddy R V Swanlund D J Roberts K P | 1999 | Biol Reprod1999，61，： | 1 |
| 17 | Protein nitration in placenta- functional significance显示文摘 | Webster R P Roberts V H J Myatt L | 2008 | Placenta2008，29，12： | 1 |
| 18 | Pro- ductivity improvements in steelmaking via sensor-based steelmaking process control显示文摘 | Randall P Stone Ray M Figas Jr Robert V Branion | 2006 | Iron & Steel Technology2006，3，1： | 1 |
| 19 | Angiotensin II sustains brain inflammation in mice via TGF-[Beta]显示文摘 | Lanz Tobias V Ding Zhaoqing Ho Peggy P Luo Jian Agrawal Ankur N Srinagesh Hrishikesh Axtell Robert Zhang Hui Platten Michael Wyss-Coray Tony Steinman Lawrence | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
| 20 | Efficient ex- citation energy transfer among multiple dyes in polystyrene micro-spheres显示文摘 | Roberts D V Wittmershaus B P Zhang Y Z | 1998 | J Lumin1998，79，： | 1 |
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