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| 1 | QTG-Seq Accelerates QTL Fine Mapping through QTL Partitioning and Whole-Genome Sequencing of Bulked Segregant Samples显示文摘Deciphering the genetic mechanisms underlying agronomic traits is of great importance for crop improvement. Most of these traits are controlled by multiple quantitative trait loci (QTLs), and identifying the underlying genes by conventional QTL fine-mapping is time-consuming and labor-intensive. Here, we devised a new method, named quantitative trait gene sequencing (QTG-seq), to accelerate QTL fine-mapping. QTGseq combines QTL partitioning to convert a quantitative trait into a near-qualitative trait, sequencing of bulked segregant pools from a large segregating population, and the use of a robust new algorithm for identifying candidate genes. Using QTG-seq, we fine-mapped a plant-height QTL in maize (Zea mays L.), qPH7, to a 300-kb genomic interval and verified that a gene encoding an NF-YC transcription factor was the functional gene. Functional analysis suggested that qPH7-encoding protein might influence plant height by interacting with a CO-like protein and an AP2 domain-containing protein. Selection footprint ana卜 ysis indicated that qPH7 was subject to strong selection during maize improvement. In summary, QTG-seq provides an efficient method for QTL fine-mapping in the era of “big data'. | Hongwei Zhang Xi Wang Qingchun Pan Pei Li Yunjun Liu Xiaoduo Lu Wanshun Zhong Minqi Li Linqian Han Juan Li Pingxi Wang Dongdong Li Yan Liu Qing Li Fang Yang Yuan-Ming Zhang Guoying Wang Lin Li | 2019 | Molecular Plant2019，12，3： | 13 |
| 2 | How does the motor relearning program improve neurological function of brain ischemia monkeys?显示文摘The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia. | Yong Yin Zhen Gu Lei Pan Lu Gan Dongdong Qin Bo Yang Jin Guo Xintian Hu Tinghua Wang Zhongtang Feng | 2013 | Neural Regeneration Research2013，8，16： | 9 |
| 3 | Stability influence factors analysis and construction of a deep beam anchorage structure in roadway roof显示文摘Deep beam anchorage structures based on spatial distribution analysis of the cable prestressed field have been proposed for roadway roof support. Stability and other factors that influence deep beam structures are studied in this paper using mechanical calculations, numerical analysis and field measurements. A mechanical model of deep beam structure subjected to multiple loading is established, including analysis of roof support in the return airway of S1203 working face in the Yuwu coal mine, China. The expression of maximum shear stress in the deep beam structure is deduced according to the stress superposition criterion. It is found that the primary factors affecting deep beam structure stability are deep beam thickness, cable pre-tension and cable spacing. The variation of maximum shear stress distribution and prestressed field diffusion effects according to various factors are analyzed using Matlabòand FLAC3D^(TM) software, and practical support parameters of the S1203 return airway roof are determined.According to the observations of rock pressure, there is no evidence of roof separation, and the maximum values of roof subsidence and convergence of wall rock are 72 and 48 mm, respectively. The results show that the proposed roof support design with a deep beam structure is feasible and achieves effective control of the roadway roof. | Xie Shengrong Gao Mingming Chen Dongdong Sun Yanding Pan Hao Su Hai Lan Shizhong | 2018 | International Journal of Mining Science and Technology2018，28，3： | 7 |
| 4 | Low-temperature Sintering of FeCuCo based Pre-alloyed Powder for Diamond Bits显示文摘We studied the effects of sintering temperature on FeCuCo based pre-alloyed powder for diamond bits.The FeCuCo composite was fabricated by co-precipitation method.With the addition of tungsten carbide(WC),sintering under different temperatures was investigated.Mechanical properties of the FeCuCo based matrix were systematically studied.The structure of the composite was evaluated by X-ray diffraction(XRD) and scanning electron microscope(SEM) was used to analyze the surface of the powder and matrix.The suitable sintering temperature was determined through differential scanning calorimeter(DSC).Micro drilling experiments were performed,and 820 ℃ was identified to be the ideal sintering temperature,at which the matrix shows the best mechanical properties and drilling performance. | 谢德龙 万隆 SONG Dongdong QIN Haiqing PAN Xiaoyi LIN Feng FANG Xiaohu | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 4 |
| 5 | A grouting simulation method for quick-setting slurry in karst conduit:The sequential flow and solidification method显示文摘It is difficult to temporally and spatially track and characterize the slurry viscosity in flowing water during grouting simulation.In this study,a sequential flow and solidification(SFS)method considering the spatial-temporal evolution of slurry viscosity in flowing water in karst conduit is proposed.First,a time-dependent model for the threshold function of slurry viscosity is established.During the grouting process,the spatial-temporal evolution of slurry viscosity is revealed by tracking the diffusion behavior of the slurry injected at different times.This method is capable of describing the gradual solidification process of the slurry during grouting.Furthermore,a physical model of grouting in a karst conduit is developed.Second,the effectiveness of the SFS method in grouting simulation is verified by the experiment of grouting conduit in flowing water.The SFS method enables real-time monitoring of fluid velocity and pressure during grouting in flowing water and provides a feasible calculation method for revealing the grouting plugging mechanism in complex karst conduits at different engineering scales.In addition,it can be used to guide the design of grouting tests in flowing water,improve cost efficiency,and provide theoretical basis for optimizing grouting design and slurry selection. | Zhenhao Xu Dongdong Pan Shucai Li Yichi Zhang Zehua Bu Jie Liu | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 3 |
| 6 | A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information显示文摘The genetic models are greatly important in the analysis of genetic epidemiologic studies and many of the studies are conducted using the trend test under the additive model. However, for many complex diseases and traits, the underlying genetic model for a genetic locus is usually uncertain. So a robust test free of genetic model is appropriate. In this paper, the authors propose a model-embedded trend test by incorporating Hardy-Weinberg equilibrium information and obtain the explicit formula to calculate its statistical significance. Extensive simulation studies show the proposed test is more robust than the existing procedures. Finally, a real application is further analyzed to show the performance of the proposed test. | HU Xiaonan DUAN Xiaogang PAN Dongdong ZHANG Sanguo LI Qizhai | 2017 | Journal of Systems Science & Complexity2017，30，1： | 3 |
| 7 | Control over π-π stacking of heteroheptacene-based nonfullerene acceptors for 16% efficiency polymer solar cells显示文摘Nonfullerene acceptors are being investigated for use in polymer solar cells(PSCs),with their advantages of extending the absorption range,reducing the energy loss and therefore enhancing the power conversion efficiency(PCE).However,to further boost the PCE,mobilities of these nonfullerene acceptors should be improved.For nonfullerene acceptors,the π-π stacking distance between cofacially stacked molecules significantly affects their mobility.Here;we demonstrate a strategy to increase the mobility of heteroheptacene-based nonfullerene acceptors by reducing their n'-7r stacking distances via control over the bulkiness of lateral side chains.Incorporation of 2-butyloctyl substituents into the nonfullerene acceptor(M36)leads to an increased mobility with a reduced π-π stacking distance of 3.45 A.Consequently,M36 affords an enhanced PCE of 16%,which is the highest among all acceptor-donor-acceptor-type nonfullerene acceptors to date.This strategy of control over the bulkiness of side chains on nonfullerene acceptors should aid the development of more efficient PSCs. | Yunlong Ma Dongdong Cai Shuo Wan Pan Yin Pengsong Wang Wenyuan Lin Qingdong Zheng | 2020 | National Science Review2020，7，12： | 2 |
| 8 | FBXL19-AS1 promotes cell proliferation and inhibits cell apoptosis via miR-876-5p/FOXM1 axis in breast cancer显示文摘As the most common cancer and one of the leading causes of cancer-associated mortality,breast cancer continues to need more key molecules to regulate its progression.F-box and leucine-rich repeat protein 19 antisense RNA 1(known as FBXL19-AS1)is a long non-coding RNA(lncRNA)which has been reported as an oncogene in several types of human cancers.However,the specific downstream targets of FBXL19-AS1 remain unknown.In this study,we set out to find more reliable downstream molecules of FBXL19-AS1 in breast cancer.FBXL19-AS1 was expressed at a high level in breast cancer cells.Loss-of-function experiments revealed that silencing FBXL19-AS1 could impair cell proliferation and induce cell apoptosis in breast cancer.In addition,the location of FBXL19-AS1 in the cytoplasm was detected by fluorescent in situ hybridization assay,while FBXL19-AS1 regulated the expression of Forkhead box M1(FOXM1)by directly absorbing miR-876-5p.Through rescue assays,it was observed that FOXM1 overexpression recovered the inhibited tumor growth caused by FBXL19-AS1 downregulation.We affirmed the function of FBXL19-AS1 in breast cancer and described the mechanism of the FBXL19-AS1/miR-876-5p/FOXM1 axis.The current work presents the molecular mechanism which underlies FBXL19-AS1 in breast cancer and suggests a comprehensive,feasible FBXL19-AS1-mediated therapeutic approach for treating breast cancer. | Guolei Dong Teng Pan Dongdong Zhou Chunyan Li Jingjing Liu Jin Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 1 |
| 9 | Overoxidized poly(3,4-ethylenedioxythiophene)-gold nanoparticles-graphene-modified electrode for the simultaneous detection of dopamine and uric acid in the presence of ascorbic acid显示文摘An innovative,ternary nanocomposite composed of overoxidized poly(3,4-ethylenedioxythiophene)(OPEDOT),gold nanoparticles(Au NPs),and electrochemically reduced graphene oxide(ERGO)was prepared on a glassy carbon electrode(GCE)(OPEDOT-Au NPs-ERGO/GCE)through homogeneous chemical reactions and heterogeneous electrochemical methods.The morphology,composition,and structure of this nanocomposite were characterized by transmission electron microscopy,scanning electron microscopy,X-ray diffraction,and X-ray photoelectron spectroscopy.The electrochemical properties of the OPEDOT-Au NPs-ERGO/GCE were investigated by cyclic voltammetry using potassium ferricyanide and hexaammineruthenium(III)chloride redox probe systems.This modified electrode shows excellent electro-catalytic activity for dopamine(DA)and uric acid(UA)under physiological p H conditions,but inhibits the oxidation of ascorbic acid(AA).Linear voltammetric responses were obtained when DA concentrations of approximately 4.0-100μM and UA concentrations of approximately 20-100μM were used.The detection limits(S/N=3)for DA and UA were 1.0 and 5.0μM,respectively,under physiological conditions and in the presence of 1.0 m M of AA.This developed method was applied to the simultaneous detection of DA and UA in human urine,where satisfactory recoveries from 96.7%to 105.0%were observed.This work demonstrates that the developed OPEDOT-Au NPs-ERGO ternary nanocomposite,with its excellent ion-selectivity and electro-catalytic activity,is a promising candidate for the simultaneous detection of DA and UA in the presence of AA in physiological and pathological studies. | Junqiang Pan Mei Liu Dandan Li Haonan Zheng Dongdong Zhang | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 1 |
| 10 | Con- densation Regime Diagram for Supersonic/Sonic Steam Jet in Subcooled Water 显示文摘 | XinZhuang Wu Junjie Yan Dongdong Pan | 2009 | Nuclear Engineering and De- sign2009，239，12： | 1 |
| 11 | An Extrapolation Cascadic MultigridMethod for Elliptic Problems on Reentrant Domains显示文摘This paper proposes an extrapolation cascadic multigrid(EXCMG)method to solve elliptic problems in domains with reentrant corners.On a class ofλ-graded meshes,we derive some new extrapolation formulas to construct a high-order approximation to the finite element solution on the next finer mesh using the numerical solutions on two-level of grids(current and previous grids).Then,this high-order approximation is used as the initial guess to reduce computational cost of the conjugate gradient method.Recursive application of this idea results in the EXCMG method proposed in this paper.Finally,numerical results for a crack problem and an L-shaped problem are presented to verify the efficiency and effectiveness of the proposed EXCMG method. | Kejia Pan Dongdong He Chuanmiao Chen | 2017 | Advances in Applied Mathematics and Mechanics2017，9，6： | 0 |
| 12 | Enhancing the Intermolecular Interactions of Ladder-Type Heteroheptacene-Based Nonfullerene Acceptors for Efficient Polymer Solar Cells by Incorporating Asymmetric Side Chains显示文摘Asymmetric nonfullerene acceptors(NFAs)possess larger dipole moments and stronger intermolecular bonding energy than their symmetric counterparts thereby making them promising candidates for high-performance polymer solar cells(PSCs).Herein,we report twoefficient acceptor–donor–acceptor(A–D–A)type NFAs(M14 and M18)with asymmetric side chains that show enhanced intermolecular interactions compared with their corresponding counterparts(M17 and M19)based on symmetric side chains.Furthermore,M14 and M18 exhibit elevated lowest unoccupiedmolecular orbitals and smallerπ–πstacking distances in comparison with M17 and M19,respectively.In combination with the benchmark polymer donor of PM6,the PM6:M14 blend affords superior charge transport properties,and more importantly,an increased power conversion efficiency(PCE)of 15.49%in comparison with the M17-based counterpart(13.01%PCE).Similarly,the asymmetric M18-based blend also shows a higher PCE of 13.00%than the M19-based blend(11.55%).Through further interface engineering,the bestperforming M14-based device delivers an enhanced PCE of 16.46%,which represents a record value among all asymmetric A–D–A type NFAs.Our results provide new insights into the design of asymmetric NFAs with enhanced intermolecular interactions for highperformance PSCs. | Qisheng Tu Wenjun Zheng Yunlong Ma Ming Zhang Zhijian Li Dongdong Cai Pan Yin Jinyun Wang Shan-Ci Chen Feng Liu Qingdong Zheng | 2023 | CCS Chemistry2023，5，2： | 0 |
| 13 | Investigation of lubricant transfer and distribution at head/disk interface in air-helium gas mixtures显示文摘Lubricant transfer and distribution at the head/disk interface in air-helium gas mixtures is investigated using a developed model that combines an air-bearing model with a molecular dynamics model. The pressure distribution is calculated by the air-bearing model at the head/disk interface with respect to the helium content and the pressure obtained is then input to the molecular dynamics model to understand the lubricant transfer mechanism. Finally, the effects of pressure at the boundary condition and disk velocity on lubricant transfer are discussed in relation to the helium fraction within the air-helium gas mixtures. Results show there is a decrease in the pressure difference with an increase in the helium percentage, which leads to a decrease in the volume of the lubricant transferred. The results also suggest that the lubricant is not easily to transfer in gas mixtures with a high percentage of helium, even when both higher disk velocities and pressure boundary conditions are applied. | Zhengqiang TANG Dongdong ZHOU Tong JIA Deng PAN Chuanwei ZHANG | 2019 | Friction2019，7，6： | 0 |
| 14 | Smartphone-based rapid and visual pathological diagnosis of glioma using perovskite probes显示文摘Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by medical experts.However,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating room.Here,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of glioma.Perovskite quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of glioma.Benefiting from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV lamp.To demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 min.This strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods. | Dongdong Wu Jimei Chi Junzhen Fan Lijun Cheng Xuning Wang Xu Yang Meng Zhang Zewei Lian Zengqi Huang Huadong Wang Hongfei Xie Sisi Chen Qi Pan Zeying Zhang Bingda Chen Guochen Sun Bainan Xu Meng Su Yanlin Song | 2023 | InfoMat2023，5，11： | 0 |
| 15 | Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment显示文摘Odontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of unique clinical features, OMS is difficult to distinguish from other types of rhinosinusitis. Besides, the characteristic infectious pathogeny of OMS makes it is resistant to conventional therapies of rhinosinusitis. Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists and dentists is absolutely urgent to settle these questions and to acquire standardized diagnostic and treatment regimen for OMS. However, this disease has actually received little attention and has been underrepresented by relatively low publication volume and quality. Based on systematically reviewed literature and practical experiences of expert members, our consensus focuses on characteristics, symptoms, classification and diagnosis of OMS, and further put forward multidisciplinary treatment decisions for OMS, as well as the common treatment complications and relative managements. This consensus aims to increase attention to OMS, and optimize the clinical diagnosis and decision-making of OMS, which finally provides evidence-based options for OMS clinical management. | Jiang Lin Chengshuo Wang Xiangdong Wang Faming Chen Wei Zhang Hongchen Sun Fuhua Yan Yaping Pan Dongdong Zhu Qintai Yang Shaohua Ge Yao Sun Kuiji Wang Yuan Zhang Mu Xian Ming Zheng Anchun Mo Xin Xu Hanguo Wang Xuedong Zhou Luo Zhang | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 16 | Grain refinement and strength enhancement in Mg wrought alloys: A review显示文摘Low absolute strength becomes one major obstacle for the wider applications of low/no rare-earth(RE) containing Mg alloys. This review firstly demonstrates the importance of grain refinement in improving strength of Mg alloys by comprehensively comparing with other strategy, e.g., precipitation strengthening. Dynamic recrystallization(DRX) plays a crucial role in refining grain size of Mg wrought alloys.Therefore, secondly, the DRX models, grain nucleation mechanisms and the related grain refinement abilities in Mg alloys are summarized,including phase boundary, twin boundary and general boundary induced recrystallization. Thirdly, the newly developed low-RE containing Mg alloy, e.g., Mg-Ce, Mg-Nd and Mg-Sm based alloys, and the RE-free Mg alloys, e.g., Mg-Al, Mg-Zn, Mg-Sn and Mg-Ca based alloy,are reviewed, with the focus on enhancing the mechanical properties mainly via the grain refinement strategy. At the last section, the perspectives and outstanding issues concerning high-performance Mg wrought alloys are also proposed. This review is meant to promote the deep understanding on the critical role of grain refinement in Mg alloys and provide reference for the development of other high strength and low-cost Mg alloys which are fabricated by the conventional extrusion/rolling processing. | Sen Wang Hucheng Pan Dongsheng Xie Dongdong Zhang Jingren Li Hongbo Xie Yuping Ren Gaowu Qin | 2023 | Journal of Magnesium and Alloys2023，11，11： | 0 |
| 17 | Influence of Natural Fractures on Tight Oil Migration and Production: A Case Study of Permian Lucaogou Formation in Jimsar Sag, Junggar Basin, NW China显示文摘Natural fractures,as the main flow channels and important storage spaces,have significant effects on the migration,distribution,and accumulation of tight oil.According to outcrop,core,formation micro image(FMI),cast-thin-section,and scanning electron microscopy data from the tight reservoir within the Permian Lucaogou Formation of the Junggar Basin,tectonic fractures are prevalent in this formation mainly on micro to large scale.There are two types of fractures worth noticing:diagenetic fractures and overpressure-related fractures,primarily at micro to medium scale.The diagenetic fractures consist of bedding fractures,stylolites,intragranular fractures,grain-boundary fractures,and diagenetic shrinkage fractures.Through FMI interpretation and Monte Carlo method evaluation,the macro-fractures could be considered as migration channels,and the micro-fractures as larger pore throats that function as storage spaces.The bedding fractures formed earlier than all tectonic fractures,while the overpressure-related fractures formed in the Middle and Late Jurassic.The bedding fractures and stylolites function as the primary channels for horizontal migration of tight oil.The tectonic fractures can provide vertical migration channels and reservoir spaces for tight oil,and readjust the tight oil distribution.The overpressure-related fractures are fully filled with calcite,and hence,have little effect on hydrocarbon migration and storage capacity.The data on tight oil production shows that the density and aperture of fractures jointly determine the productivity of a tight reservoir. | Yunzhao Zhang Lianbo Zeng Qun Luo Rukai Zhu Wenya Lyu Dongdong Liu Quanqi Dai Shouxu Pan | 2021 | Journal of Earth Science2021，32，4： | 0 |
| 18 | Genetic dissection of N use efficiency using maize inbred lines and testcrosses显示文摘Although the use of heterosis in maize breeding has increased crop productivity,the genetic causes underlying heterosis for nitrogen(N) use efficiency(NUE) have been insufficiently investigated.In this study,five N-response traits and five low-N-tolerance traits were investigated using two inbred line populations(ILs) consisting of recombinant inbred lines(RIL) and advanced backcross(ABL) populations,derived from crossing Ye478 with Wu312.Both populations were crossed with P178 to construct two testcross populations.IL populations,their testcross populations,and the midparent heterosis(MPH)for NUE were investigated.Kernel weight,kernel number,and kernel number per row were sensitive to N level and ILs showed higher N response than did the testcross populations.Based on a highdensity linkage map,138 quantitative trait loci(QTL) were mapped,each explaining 5.6%–38.8% of genetic variation.There were 52,34 and 52 QTL for IL populations,MPH,and testcross populations,respectively.The finding that 7.6% of QTL were common to the ILs and their testcross populations and that 11.7% were common to the MPH and testcross population indicated that heterosis for NUE traits was regulated by non-additive and non-dominant loci.A QTL on chromosome 5 explained 27% of genetic variation in all of the traits and Gln1-3 was identified as a candidate gene for this QTL.Genome-wide prediction of NUE traits in the testcross populations showed 14%–51% accuracy.Our results may be useful for clarifying the genetic basis of heterosis for NUE traits and the candidate gene may be used for genetic improvement of maize NUE. | Xiaoyang Liu Kunhui He Farhan Ali Dongdong Li Hongguang Cai Hongwei Zhang Lixing Yuan Wenxin Liu Guohua Mi Fanjun Chen Qingchun Pan | 2023 | The Crop Journal2023，11，4： | 0 |
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