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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | The spatio-temporal variation of wintertime subtidal currents in the western Taiwan Strait显示文摘A new data set of observations by six cruises of ship-mounted acoustic doppler current profiler(SADCP) and three 40 d long bottom-mounted ADCPs(BADCPs) is employed to reveal the spatiotemporal variability of tidal and subtidal currents in the western Taiwan Strait(TWS) during winter season. The results confirm the existence of intense cotidal lines for M_2 tidal current, which is located north of 25°N. In this case, no existence of an amphidromic point can be identified. It is also revealed that the counter-wind current(CWC) can extend through the whole western TWS and even occupy the entire water column during winter monsoon relaxation. However,this CWC is observed to be thoroughly overwhelmed by the downwind China coastal current(CCC) during the two big monsoon bloom events in the winter of 2007, and the CCC consequently extends southward throughout the western TWS instead. Most importantly, the variation of the spatial extent for the CWC and the CCC in the western TWS is found to be well explained by the first two modes of the vector empirical orthogonal function(VEOF) analysis, that is, it is mainly controlled by a wind-driven quasi barotropic current as the first mode and slightly modulated by a relatively weak background current with a first-order baroclinic structure as the second mode. | SHEN Junqiang QIU Yun GUO Xiaogang PAN Aijun ZHOU Xiwu | 2017 | Acta Oceanologica Sinica2017，36，11： | 5 |
| 3 | Interface flux reconstruction method based on optimized weight essentially non-oscillatory scheme显示文摘Aimed at the computational aeroacoustics multi-scale problem of complex configurations discretized with multi-size mesh, the flux reconstruction method based on modified Weight Essentially Non-Oscillatory(WENO) scheme is proposed at the interfaces of multi-block grids.With the idea of Dispersion-Relation-Preserving(DRP) scheme, different weight coefficients are obtained by optimization, so that it is in WENO schemes with various characteristics of dispersion and dissipation. On the basis, hybrid flux vector splitting method is utilized to intelligently judge the amplitude of the gap between grid interfaces. After the simulation and analysis of 1D convection equation with different initial conditions, modified WENO scheme is proved to be able to independently distinguish the gap amplitude and generate corresponding dissipation according to the grid resolution. Using the idea of flux reconstruction at grid interfaces, modified WENO scheme with increasing dissipation is applied at grid points, while DRP scheme with low dispersion and dissipation is applied at the inner part of grids. Moreover, Gauss impulse spread and periodic point sound source flow among three cylinders with multi-scale grids are carried out. The results show that the flux reconstruction method at grid interfaces is capable of dealing with Computational Aero Acoustics(CAA) multi-scale problems. | Peixun YU Junqiang BAI Hai YANG Song CHEN Kai PAN | 2018 | Chinese Journal of Aeronautics2018，31，5： | 4 |
| 4 | Site-Specifc Gene Targeting Using Transcription Activator-Like Effector(TALE)-Based Nuclease in Brassica oleracea显示文摘Site-specifc recognition modules with DNA nuclease have tremendous potential as molecular tools for genome targeting.The type III transcription activator-like effectors(TALEs)contain a DNA binding domain consisting of tandem repeats that can be engineered to bind user-defned specifc DNA sequences.We demonstrated that customized TALE-based nucleases(TALENs),constructed using a method called'unit assembly',specifcally target the endogenous FRIGIDA gene in Brassica oleracea L.var.capitata L.The results indicate that the TALENs bound to the target site and cleaved double-strand DNA in vitro and in vivo,whereas the effector binding elements have a 23 bp spacer.The T7 endonuclease I assay and sequencing data show that TALENs made double-strand breaks,which were repaired by a non-homologous end-joining pathway within the target sequence.These data show the feasibility of applying customized TALENs to target and modify the genome with deletions in those organisms that are still in lacking gene target methods to provide germplasms in breeding improvement. | Zijian Sun Nianzu Li Guodong Huang Junqiang Xu Yu Pan Zhimin Wang Qinglin Tang Ming Song Xiaojia Wang | 2013 | Journal of Integrative Plant Biology2013，55，11： | 3 |
| 5 | A GPU-based numerical model coupling hydrodynamical and morphological processes显示文摘Sediment transport simulations are important in practical engineering.In this study,a graphics processing unit(GPU)-based numerical model coupling hydrodynamical and morphological processes was developed to simulate water flow,sediment transport,and morphological changes.Aiming at accurately predicting the sediment transport and sediment scouring processes,the model resolved the realistic features of sediment transport and used a GPU-based parallel computing technique to the accelerate calculation.This model was created in the framework of a Godunov-type finite volume scheme to solve the shallow water equations(SWEs).The SWEs were discretized into algebraic equations by the finite volume method.The fluxes of mass and momentum were computed by the Harten,Lax,and van Leer Contact(HLLC) approximate Riemann solver,and the friction source terms were calculated by the proposed a splitting point-implicit method.These values were evaluated using a novel 2 D edge-based MUSCL scheme.The code was programmed using C++and CUDA,which could run on GPUs to substantially accelerate the computation.The aim of the work was to develop a GPU-based numerical model to simulate hydrodynamical and morphological processes.The novelty is the application of the GPU techniques in the numerical model,making it possible to simulate the sediment transport and bed evolution in a high-resolution but efficient manner.The model was applied to two cases to evaluate bed evolution and the effects of the morphological changes on the flood patterns with high resolution.This indicated that the GPU-based high-resolution hydro-geomorphological model was capable of reproducing morphological processes.The computational times for this test case on the GPU and CPU were298.1 and 4531.2 s,respectively,indicating that the GPU could accelerate the computation 15.2 times.Compared with the traditional CPU high-grid resolution,the proposed GPU-based high-resolution numerical model improved the reconstruction speed more than 2.0-12.83 times for different grid resolutions while remaining computationally efficient. | Jingming Hou Yongde Kang Chunhong Hu Yu Tong Baozhu Pan Junqiang Xia | 2020 | International Journal of Sediment Research2020，35，4： | 3 |
| 6 | Glassy metallic plastics显示文摘This paper reports a class of bulk metallic glass including Ce-, LaCe-, CaLi-, Yb-, and Sr-based metallic glasses, which are regarded as glassy metallic plastics because they combine some unique properties of both plastics and metallic alloys. These glassy metallic plastics have very low glass transition temperature (Tg^25oC to 150oC) and low Young’s modulus (~20 GPa to 35 GPa). Similar to glassy plastics, these metallic plastics show excellent plastic-like deformability on macro-, micro- and even nano-scale in their supercooled liquid range and can be processed, such as elongated, compressed, bent, and imprinted at low temperatures, in hot water for instance. Under ambient conditions, they display such metallic properties as high thermal and electric conductivities and excellent mechanical properties and other unique properties. The metallic plastics have potential applications and are also a model system for studying issues in glass physics. | LI JianFu, WANG JunQiang, LIU XiaoFeng, ZHAO Kun, ZHANG Bo, BAI HaiYang, PAN MingXiang & WANG WeiHua Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 2 |
| 7 | Construction of recombinant plasmid pEGFP-C2-L539fs/47 and its expression in HEK293 cells显示文摘Objective:To reconstruct pEGFP-C2-L539fs/47,a HERG nonsense mutant in eukaryotic expression plasmid,and observe the fusion protein expressed in HEK293 cells(human embryo kidney cells).Methods:After double digestion of pcDNA3-L539fs/47 and pEGFP-C2-HERG with sbf I and Eco91 I,the small product fragment,from pcDNA3-L539fs/47,was subcloned into the big fragment of pEGFP-C2-HERG under T4 ligase.pEGFP-C2-L539fs/47 was identified by agarose gel electrophoresis and sequencing.pcDNA3-L539fs/47 and pEGFP-C2-L539fs/47 were transiently transfected into HEK293 cells by Lipofect,respectively.The expression of fusion protein in HEK293 cells was detected through immunofluorescence,laser confocal imaging scanning in vivo,Western blot and PCR.Results:Mutation region cDNA fragment(about 1 kb) and target vector fragment(about 7.2 kb) were ligated after purification and gel recovery.Agarose gel electrophoresis and sequencing successfully demonstrated eukaryotic expression plasmid pEGFP-C2-L539fs/47,constructed approximately 8.2 kb,sequencing consistent with template gene.The transfection efficiency of recombinant plasmid by fluorescence microscopy was more than60%.Western blot analysis detected pcDNA3-L539fs/47 expression of the protein size 60 KD,the expression of pEGFP-C2 fusion protein size of approximately 90 KD.The L539fs/47 gene expression in HEK293 cells was significant by PCR analysis.Confocal laser imaging showed that pEGFP-C2-L539fs/47 protein was successfully expressed in cytoplasm and cytomembrane of HEK293 cells.Conclusion:pEGFP-C2-L539fs/47 containing the HERG gene mutant was successfully constructed by double digestion method and expressed fusion protein in HEK293 cells,which laid a foundation for the further study on L539fs/47. | Lue Ying Zhang Aifeng Han Wenqi Li Guoliang Zhang Junbo Gao Jie Pan Junqiang Zhang Yong Sun Chaofeng | 2012 | Journal of Medical Colleges of PLA(China)2012，27，3： | 2 |
| 8 | Postoperative Radiotherapy Improved Survival of Poor Prognostic Squamous Cell Carcinoma Esophagus显示文摘 | Junqiang Chen Ji Zhu Jianji Pan Kunshou Zhu Xiongwei Zheng Mingqiang Chen Jiezhong Wang Zhongxing Liao | 2010 | The Annals of Thoracic Surgery2010，，2： | 1 |
| 9 | The pattern and prevalence of lymphatic spread in thoracic oesophageal squamous cell carcinoma显示文摘 | Junqiang Chen Suoyan Liu Jianji Pan Xiongwei Zheng Kunshou Zhu Ji Zhu Jinrong Xiao Mingang Ying | 2009 | European Journal of Cardio-Thoracic Surgery2009，，3： | 1 |
| 10 | Number and Location of Positive Nodes, Postoperative Radiotherapy, and Survival After Esophagectomy With Three-Field Lymph Node Dissection for Thoracic Esophageal Squamous Cell Carcinoma显示文摘 | Junqiang Chen Jianji Pan Xiongwei Zheng Kunshou Zhu Jiancheng Li Mingqiang Chen Jiezhong Wang Zhongxing Liao | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，1： | 1 |
| 11 | Effect of statins use on the prevention of venous thromboembolism: a meta-analysis显示文摘Objective: To estimate the effect of statins use on the prevention of venous thromboembolism (VTE). Methods: We systematically searched MEDLINE (1980-June 2012), EMBASE (1980-June 2012), Google Scholar, Cochrane Library, and ISI Web of Science, manually reviewed references, and contacted experts. Case-control studies and cohort studies that compared any dose of statin with no statin or placebo are included. Data extraction and study quality evaluation were independently conducted in duplicate. Results: 12 studies including four cohort studies and eight case-control studies were identified and eligible for meta-analysis. Upon meta-analysis, statin use was associated with a statistically significant reduction in the odds of developing VTE (OR 0.91, 95% CI 0.86-0.96). Conclusion: This meta-analysis of current and available literature suggests that statins can reduce patient's risk of developing VTE. Due to the limitations of observational study, this conclusion should be considered with caution, and additionally, specifical well-designed trials are needed. | Zhang Zaiwei Tian Hongyan Pan Junqiang Zhao Yaling Wan Zhaofei Zhang Junbo Ma Qiang Tian Hua Han Junli Liu Ya Deng Jizhao | 2012 | Journal of Medical Colleges of PLA(China)2012，27，5： | 1 |
| 12 | Serum carbohydrate antigen-125 is elevated in patients with chronic atrial fibrillation显示文摘Objective: To determine whether CA-125 is elevated in medically stable patients with chronic atrial fibrillation (AF) compared with patients without AF and to examine whether levels of CA-125 are associated with demographic and clinical variables in a sample of patients under study. Methods: 55 patients with chronic AF and 58 control patients in sinus rhythm were included into the study. Patients with acute heart failure (HF), chronic inflammatory or neoplastic disease were excluded from the study. Circulating levels of CA-125 were assessed; all patients underwent clinical examination, assessment and medical records including demographic data, history of comorbid conditions, current use of cardiac medications, and the results of cardiac tests including electrocardiograms. Results: The mean age of the study sample was 53.2±6.5 years and 48% were men. Patients with sinus rhythm were significantly more likely to have lower heart rates, smaller dimensions of left atrium, and to be treated with aspirin. Coumadin, coumadin and digoxin were more often prescribed in patients with chronic AF. The CA-125 levels were significantly higher in patients with chronic AF than in patients in sinus rhythm (48.5±7.65 U/ml and 28.43±5.48 U/ml, P<0.005). An inverse relation was found between CA-125 levels and left ventricular ejection fraction (LVEF) (r=-0.48, P<0.001). CA-125 was significantly related to the left atrium (LA) diameter, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and brain natriuretic peptide (BNP). There was no significant correlation between CA-125 and age. Conclusion: In subjects with chronic AF, CA-125 levels are increased; CA-125 was significantly related to the LA diameter, LVEDD, LVESD and BNP. | Pan Junqiang Zhang Dianxin Zhang Zaiwei Lu Ying Zhou Xin Li Guoliang Sun Chaofeng | 2012 | Journal of Medical Colleges of PLA(China)2012，27，5： | 1 |
| 13 | Overoxidized poly(3,4-ethylenedioxythiophene)-gold nanoparticles-graphene-modified electrode for the simultaneous detection of dopamine and uric acid in the presence of ascorbic acid显示文摘An innovative,ternary nanocomposite composed of overoxidized poly(3,4-ethylenedioxythiophene)(OPEDOT),gold nanoparticles(Au NPs),and electrochemically reduced graphene oxide(ERGO)was prepared on a glassy carbon electrode(GCE)(OPEDOT-Au NPs-ERGO/GCE)through homogeneous chemical reactions and heterogeneous electrochemical methods.The morphology,composition,and structure of this nanocomposite were characterized by transmission electron microscopy,scanning electron microscopy,X-ray diffraction,and X-ray photoelectron spectroscopy.The electrochemical properties of the OPEDOT-Au NPs-ERGO/GCE were investigated by cyclic voltammetry using potassium ferricyanide and hexaammineruthenium(III)chloride redox probe systems.This modified electrode shows excellent electro-catalytic activity for dopamine(DA)and uric acid(UA)under physiological p H conditions,but inhibits the oxidation of ascorbic acid(AA).Linear voltammetric responses were obtained when DA concentrations of approximately 4.0-100μM and UA concentrations of approximately 20-100μM were used.The detection limits(S/N=3)for DA and UA were 1.0 and 5.0μM,respectively,under physiological conditions and in the presence of 1.0 m M of AA.This developed method was applied to the simultaneous detection of DA and UA in human urine,where satisfactory recoveries from 96.7%to 105.0%were observed.This work demonstrates that the developed OPEDOT-Au NPs-ERGO ternary nanocomposite,with its excellent ion-selectivity and electro-catalytic activity,is a promising candidate for the simultaneous detection of DA and UA in the presence of AA in physiological and pathological studies. | Junqiang Pan Mei Liu Dandan Li Haonan Zheng Dongdong Zhang | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 1 |
| 14 | Number and Location of Positive Nodes, Postoperative Radiotherapy, and Survival After Esophagectomy With Three-Field Lymph Node Dissection for Thoracic Esophageal Squamous Cell Carcinoma显示文摘 | Junqiang Chen Jianji Pan Xiongwei Zheng Kunshou Zhu Jiancheng Li Mingqiang Chen Jiezhong Wang Zhongxing Liao | 2012 | International Journal of Radiation Oncology Biology Physics2012，，1： | 1 |
| 15 | Postoperative Radiotherapy Improved Survival of Poor Prognostic Squamous Cell Carcinoma Esophagus显示文摘 | Junqiang Chen Ji Zhu Jianji Pan Kunshou Zhu Xiongwei Zheng Mingqiang Chen Jiezhong Wang Zhongxing Liao | 2010 | The Annals of Thoracic Surgery2010，，2： | 1 |
| 16 | Oxidations of two-dimensional semiconductors:Fundamentals and applications显示文摘Since the discovery of graphene,two-dimensional(2D)semiconductors have been attracted intensive interest due to their unique properties.They have exhibited potential applications in next generation electronic and optoelectronic devices.However,most of the 2D semiconductor are known to suffer from the ambient oxidation which degrade the materials and therefore hinder us from the intrinsic materials’properties and the optimized performance of devices.In this review,we summarize the recent progress on both fundamentals and applications of the oxidations of 2D semiconductors.We begin with the oxidation mechanisms in black phosphorus,transition metal dichalcogenides and transition metal monochalcogenides considering the factors such as oxygen,water,and light.Then we show the commonly employed passivation techniques.In the end,the emerging applications utilizing controlled oxidations will be introduced. | Junqiang Yang Xiaochi Liu Qianli Dong Yaqi Shen Yuchuan Pan Zhongwang Wang Kui Tang Xianfu Dai Rongqi Wu Yuanyuan Jin Wei Zhou Song Liu Jian Sun | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 17 | How Well Do CMIP6 and CMIP5 Models Simulate the Climatological Seasonal Variations in Ocean Salinity?显示文摘This paper includes a comprehensive assessment of 40 models from the Coupled Model Intercomparison Project phase 5(CMIP5)and 33 models from the CMIP phase 6(CMIP6)to determine the climatological and seasonal variation of ocean salinity from the surface to 2000 m.The general pattern of the ocean salinity climatology can be simulated by both the CMIP5 and CMIP6 models from the surface to 2000-m depth.However,this study shows an increased fresh bias in the surface and subsurface salinity in the CMIP6 multimodel mean,with a global average of−0.44 g kg^(−1) for the sea surface salinity(SSS)and−0.26 g kg^(−1) for the 0-1000-m averaged salinity(S1000)compared with the CMIP5 multimodel mean(−0.25 g kg^(−1) for the SSS and−0.07 g kg^(−1) for the S1000).In terms of the seasonal variation,both CMIP6 and CMIP5 models show positive(negative)anomalies in the first(second)half of the year in the global average SSS and S1000.The model-simulated variation in SSS is consistent with the observations,but not for S1000,suggesting a substantial uncertainty in simulating and understanding the seasonal variation in subsurface salinity.The CMIP5 and CMIP6 models overestimate the magnitude of the seasonal variation of the SSS in the tropics in the region 20°S-20°N but underestimate the magnitude of the seasonal change in S1000 in the Atlantic and Indian oceans.These assessments show new features of the model errors in simulating ocean salinity and support further studies of the global hydrological cycle. | Yuanxin LIU Lijing CHENG Yuying PAN Zhetao TAN John ABRAHAM Bin ZHANG Jiang ZHU Junqiang SONG | 2022 | Advances in Atmospheric Sciences2022，39，10： | 0 |
| 18 | Construction of a HERG mutant L539fs/47-*558W pEGFP vector and the expression of the fusion protein in HEK293 cells显示文摘Objective:To construct a human ether-a-go-go-related gene(HERG)nonsense mutant L539fs/47-*558W into the autonomously fluorescent,eukaryotic expression vector pEGFP-C2,and to verify expression of the reconstruct in human embryonic kidney-293(HEK293)cells.Methods:The mutational fragment was subcloned into pEGFP-C2-HERG by double digestion of SbfⅠ,Eco91Ⅰand rejoining of T4 ligase.After verification,the recombinant pEGFP-C2-L539fs/47-*558W and pEGFP-C2-HERG were respectively transfected into HEK293 cells for 48 h by the Lipofect method to observe the expression location of the fusion protein by laser confocal imaging scanning in vivo.pcDNA3-L539fs/47-*558W and pcDNA3-HERG were transfected to observe the expression location of the HERG protein by immunofluoresceoce.The mutant protein size was determined by Western blotting.Results:The about 1 kb-sized mutation region cDNA fragment from pcDNA3-L539fs/47-*558W and the about 7.2 kb-sized target vector fragment from pcDNA3-HERG were ligated after purification and gel recovery.pEGFP-C2-L539fs/47*-558W,approximately 8.2 kb,was demonstrated successfully been constructed under agarose gel electrophoresis and further sequencing.Laser confocal imaging showed that pEGFP-C2-HERG was mainly expressed in the membrane,whereas truncated mutant-type HERG in the pEGFP-C2 vector was partially located in the cytoplasm,the others were transported to the cell membrane in living HEK293 cells.The same as the immunofluoresceoce results after transfection of pcDNA3-HERG and pcDNA3-L539fs/47-558W.Wild-type HERG-GFP fusion protein expressed 160 and 180 kDa bands.The mutant and mutant-GFP fusion proteins were 70 and 100 kDa,respectively.Conclusion:pEGFP-C2-L539fs/47-*558W was successfully constructed by double digestion method GFP had no effect on its protein expression and trafficking in HEK293 cells,which laid a foundation for the further study on L539fs/47-*558W. | ZHANG Junbo Lü Ying ZHANG Aifeng SUN Chaofeng HAN Wenqi LI Guoliang GAO Jie HUO Jianhua PAN Junqiang ZHOU Xin NIU Xiaolin | 2013 | Journal of Medical Colleges of PLA(China)2013，28，4： | 0 |
| 19 | Doctors' faith显示文摘We make some efforts to find some connections between religion and medical science. Medical science can be regarded as sacred and holy as a religion for doctors to believe. The common points between them are the basis to successfully integrate them into doctors' faith. Furthermore, we explain that doctors need a faith to believe so as to meet the demand of humanitarian traits we should have and to do better in the scientific work and win in the battles with the diseases. | ZHANG Junbo Lü Ying ZHANG Aifeng SUN Chaofeng HAN Wenqi LI Guoliang GAO Jie HUO Jianhua PAN Junqiang ZHOU Xin NIU Xiaolin | 2013 | Journal of Medical Colleges of PLA(China)2013，28，1： | 0 |
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