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| 1 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 2 | SOME FEATURES OF CARBON CYCLES IN KARST SYSTEM AND THE IMPLICATION FOR EPIKARSTIFICATION —An Example of Yaji Karst Experimental Site in Guilin,China显示文摘The carbon pools of biomass,littering,and SOC wre studied with regards to carbon cycles in epikarst zone,taking an example of Yaji Karst Experiemnt Site in Guilin.This study was focused on SOC and its lability,SOC decomposition rate,CO 2 regime in the soils. 13 ctracing was used to persua the relation of bicarbonate in karst water to soil carbon.The results indicated sufficient carbon pool in SOC for the driveing CO 2 in the karst system.It was revealed that about 60percent of carbon in epi-karst springs resulted from SOC during spring and summer.Thus,the CO 2,driving the karstification,was not simply due to adsorption of atmospheric CO 2 but due to carbon transfer through the pathway of air-plant-soil-water.The driving force should not be overlooked for the epi-karst formation by soil as an interface of carbon environmental geochemistry. | Pan Genxing Tao Yuxiang Shun Yuhua Teng Yongzhong Han Fushun College of Resource & Environment Science,Nanjing Agricultural Univ.,Nanjing, 210095 People’s Republic of China | 1997 | Journal of Geographical Sciences1997，7，3： | 15 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Insight-HXMT:China's First X-Ray Astronomical Satellite显示文摘The Hard X-ray Modulation Telescope(HXMT) satellite is the first X-ray astronomical satellite in China. Utilizing the 'direct demodulation image reconstruction method', HXMT will perform broad band(1-250 keV) survey of large sky areas in scanning mode, which can result in source detection characterized with high sensitivity and spatial resolution. Point observation is another key working mode of HXMT, and is specified for observations of galactic bright sources like X-Ray Binary(XRB) and others. Additionally, HXMT also has a powerful capability developed for monitoring gamma-ray bursts, which is quite unique in the world due to its energy coverage of 200 keV-3 MeV and largest detection area. The HXMT satellite was launched by a Long March 4 B(LM-4 B) rocket from the Jiuquan Satellite Launch Center on June 15, 2017. The payloads onboard HXMT are a High Energy X-ray Telescope(HE), a Medium Energy X-ray Telescope(ME), a Low Energy X-ray Telescope(LE), and a Space Environment Monitor(SEM).This paper introduces the main technical aspects of the satellite, including scientific objectives, technical features, mission design, and system design. | PAN Teng NI Runli ZHANG Long HONG Bin GU Quanying LU Fangjun XU Yupeng | 2017 | Aerospace China2017，18，4： | 8 |
| 5 | Adrenomedullin up-regulates osteopontin and attenuates vascular calcification via the cAMP/PKA signaling pathway显示文摘 | Yan CAI Xu TENG Chun-shui PAN Xiao-hui DUAN Chao-shu TANG Yong-fen QI | 2010 | Acta Pharmacologica Sinica2010，31，10： | 7 |
| 6 | Confined van der Waals Epitaxial Growth of Two-Dimensional Large Single-Crystal In_(2)Se_(3) for Flexible Broadband Photodetectors显示文摘The controllable growth of two-dimensional(2D)semiconductors with large domain sizes and high quality is much needed in order to reduce the detrimental efect of grain boundaries on device performance but has proven to be challenging.Here,we analyze the precursor concentration on the substrate surface which signifcantly infuences nucleation density in a vapor deposition growth process and design a confned micro-reactor to grow 2D In_(2)Se_(3) with large domain sizes and high quality.Te uniqueness of this confned micro-reactor is that its size is∼102-103 times smaller than that of a conventional reactor.Such a remarkably small reactor causes a very low precursor concentration on the substrate surface,which reduces nucleation density and leads to the growth of 2D In_(2)Se_(3) grains with sizes larger than 200�m.Our experimental results show large domain sizes of the 2D In_(2)Se_(3) with high crystallinity.Te fexible broadband photodetectors based on the as-grown In_(2)Se_(3) show rise and decay times of 140 ms and 25 ms,efcient response(5.6 A/W),excellent detectivity(7×10^(10) Jones),high external quantum efciency(251%),good fexibility,and high stability.Tis study,in principle,provides an efective strategy for the controllable growth of high quality 2D materials with few grain boundaries. | Lei Tang Changjiu Teng Yuting Luo Usman Khan Haiyang Pan Zhengyang Cai Yue Zhao Bilu Liu Hui-Ming Cheng | 2019 | Research2019，，1： | 7 |
| 7 | Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect显示文摘瞄准:为肥沃、不肥沃的人完成 USP26 的全面 haplotype 分析。方法:有严重 oligospermia 或非妨碍的精子缺乏的 200 个不肥沃的人被使遭到为 USP26 基因的全部编码序列定序分析。有证明富饶的 200 个人是由教材延期方法的 genotyped。等位基因 / 遗传型频率,连接不平衡(LD ) 特征和肥沃的人的 haplotypes 与不肥沃的人相比。结果:五单个核苷酸多型性的等位基因频率(370 371insACA, 494T >C, 576G >A, ss6202791C>T, 1737G >A ) 比控制题目在不肥沃的病人是显著地更高的。在不肥沃的人的主要 haplotypes 是 TACCGA (28% 人口) , TGCCGA (15%) , TACCAA (8%) , TGCCAA (6%) , TATCAA (5%) 和 CATCAA (5%) 。为控制题目的主要 haplotypes 是 TACCGA (58% 人口) , CACCGA (7%) , CATCGA (6%) 和 TGCCGA (5%) 。而 haplotypes TACCGA, CACCGA,和 CATCGA 在这些病人是下面播送的, Haplotypes TGCCGA, TATCAA, CATCAA, CATCGC, TACCAA 和 TGCCAA 在有 spermatogenic 缺点的病人是过去播送的。结论:一些 USP26 等位基因和 haplotypes 在台湾在汉国籍与 spermatogenic 缺点被联系,中国。 | I-Wen Lee Long-Ching Kuan Chien-Hung Lin Hsien-An Pan Chao-Chin Hsu Yung-Chieh Tsai Pao-Lin Kuo Yen-Ni Teng | 2008 | Asian Journal of Andrology2008，10，6： | 7 |
| 8 | Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke显示文摘MicroRNAs(miRNAs) regulate protein expression by antagonizing the translation of mRNAs and are effective regulators of normal nervous system development, function, and disease. Micro RNA-29 b(mi R-29 b) plays a broad and critical role in brain homeostasis. In this study, we tested the function of mi R-29 b in animal and cell models by inhibiting mi R-29 b expression. Mouse models of middle cerebral artery occlusion were established using the modified Zea-Longa suture method. Prior to modeling, 50 nmol/kg mi R-29 b antagomir was injected via the tail vein. Mi R-29 b expression was found to be abnormally increased in ischemic brain tissue. The inhibition of mi R-29 b expression decreased the neurological function score and reduced the cerebral infarction volume and cell apoptosis. In addition, the inhibition of mi R-29 b significantly decreased the malondialdehyde level, increased superoxide dismutase activity, and Bcl-2 expression, and inhibited Bax and Caspase3 expression. PC12 cells were treated with glutamate for 12 hours to establish in vitro cell models of ischemic stroke and then treated with the mi R-29 antagomir for 48 hours. The results revealed that mi R-29 b inhibition in PC12 cells increased Bcl-2 expression and inhibited cell apoptosis and oxidative damage. These findings suggest that the inhibition of mi R-29 b inhibits oxidative stress and cell apoptosis in ischemic stroke, producing therapeutic effects in ischemic stroke. This study was approved by the Laboratory Animal Care and Use Committee of the First Affiliated Hospital of Zhengzhou University(approval No. 201709276 S) on September 27, 2017. | Yao-Hua Ma Wen-Jing Deng Zhi-Yi Luo Jing Jing Peng-Wei Pan Yao-Bing Yao Yan-Bo Fang Jun-Fang Teng | 2022 | Neural Regeneration Research2022，17，2： | 6 |
| 9 | Strain hardening behavior of Mg-Y alloys after extrusion process显示文摘The strain hardening is an effective mode of enhancing mechanical properties in alloys.In this work,the strain hardening behaviors of Mg-xY(x=1,2,and 3 wt%)after extrusion process was investigated using uniaxial tensile tests.Results suggest that the Mg-xY alloys are composed ofα-Mg with a little amount of Mg24Y5 phase.The average grain size reduces from 19.8μm to 12.2μm as the Y content adds from 1 wt%to 2 wt%.Nevertheless,when Y content reaches 3 wt%,the grain size reaches to 12.9μm,which is close to that of Mg-2Y.The strain hardening rate decreases from 883 MPa to 798 MPa at(σ-σ0.2)=40 MPa,and Mg-2Y and Mg-3Y have the similar strain hardening response.Moreover,Mg-1Y shows an obvious ascending stage after the steep decreasing stage,which is mainly caused by the activation of twinning.The strain hardening behavior of Mg-xY is explained based on understanding the roles of the deformation mechanisms via deformation microstructure analysis and Visco-Plastic Self Consistent(VPSC)model.The variation of strain hardening characteristics with increasing Y content is related to the effects of grain size and texture. | Chaoyue Zhao Ziyan Li Jiahui Shi Xianhua Chen Teng Tu Zhu Luo Renju Cheng Andrej Atrens Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 6 |
| 10 | Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma显示文摘AIM: To identify clonality and genetic alterations in focal nodular hyperplasia (FNH) and the nodules derived from it. METHODS: Twelve FNH lesions were examined. Twelve hepatocellular adenomas (HCAs) and 22 hepatocellular carcinomas (HCCs) were used as references. Nodules of different types were identified and isolated from FNH by microdissection. An X-chromosome inactivation assay was employed to describe their clonality status. Loss of heterozygosity (LOH) was detected, using 57 markers, for genetic alterations.RESULTS: Nodules of altered hepatocytes (NAH), the putative precursors of HCA and HCC, were found in all the FNH lesions. Polyclonality was revealed in 10 FNH lesions from female patients, and LOH was not detected in any of the six FNH lesions examined, the results apparently showing their polyclonal nature. In contrast, monoclonality was demonstrated in all the eight HCAs and in four of the HCCs from females, and allelic imbalances were found in the HCAs (9/9) and HCCs (15/18), with chromosomal arms 11p, 13q and 17p affected in the former, and 6q, 8p, 11p, 16q and 17p affected in the latter lesions in high frequencies (≥ 30%). Monoclonality was revealed in 21 (40%) of the 52 microdissected NAH, but was not found in any of the f ive ordinary nodules. LOH was found in all of the 13 NAH tested, being highly frequent at six loci on 8p, 11p, 13q and 17p. CONCLUSION: FNH, as a whole, is polyclonal, but some of the NAH lesions derived from it are already neoplastic and harbor similar allelic imbalances as HCAs. | Yi-Ran Cai Li Gong Xiao-Ying Teng Hong-Tu Zhang Cheng-Feng Wang Guo-Lian Wei Lei Guo Fang Ding Zhi-Hua Liu Qin-Jing Pan Qin Su | 2009 | World Journal of Gastroenterology2009，15，37： | 5 |
| 11 | Strain hardening of as-extruded Mg-xZn(x=1, 2, 3 and 4 wt%) alloys显示文摘The influence of Zn on the strain hardening of as-extruded Mg-x Zn(x = 1, 2, 3 and 4 wt%) magnesium alloys was investigated using uniaxial tensile tests at 10^(-3)s^(-1) at room temperature. The strain hardening rate,the strain hardening exponent and the hardening capacity were obtained from true plastic stress-strain curves. There were almost no second phases in the as-extruded Mg-Zn magnesium alloys. Average grain sizes of the four as-extruded alloys were about 17.8 μm. With increasing Zn content from 1 to 4 wt%, the strain hardening rate increased from 2850 MPa to 6810 MPa at(б-б_(0.2)) = 60 MPa, the strain hardening exponent n increased from 0.160 to 0.203, and the hardening capacity, Hc increased from 1.17 to 2.34.The difference in strain hardening response of these Mg-Zn alloys might be mainly caused by weaker basal texture and more solute atoms in the α-Mg matrix with higher Zn content. | Chaoyue Zhao Xianhua Chen Fusheng Pan Jingfeng Wang Shangyu Gao Teng Tu Chunquan Liu Jiahao Yao Andrej Atrens | 2019 | Journal of Materials Science & Technology2019，35，1： | 4 |
| 12 | Signaling pathways and therapeutic interventions in gastric cancer显示文摘Gastric cancer(GC)ranks fifth in global cancer diagnosis and fourth in cancer-related death.Despite tremendous progress in diagnosis and therapeutic strategies and significant improvements in patient survival,the low malignancy stage is relatively asymptomatic and many GC cases are diagnosed at advanced stages,which leads to unsatisfactory prognosis and high recurrence rates.With the recent advances in genome analysis,biomarkers have been identified that have clinical importance for GC diagnosis,treatment,and prognosis.Modern molecular classifications have uncovered the vital roles that signaling pathways,including EGFR/HER2,p53,PI3K,immune checkpoint pathways,and cell adhesion signaling molecules,play in GC tumorigenesis,progression,metastasis,and therapeutic responsiveness.These biomarkers and molecular classifications open the way for more precise diagnoses and treatments for GC patients.Nevertheless,the relative significance,temporal activation,interaction with GC risk factors,and crosstalk between these signaling pathways in GC are not well understood.Here,we review the regulatory roles of signaling pathways in GC potential biomarkers,and therapeutic targets with an emphasis on recent discoveries.Current therapies,including signaling-based and immunotherapies exploited in the past decade,and the development of treatment for GC,particularly the challenges in developing precision medications,are discussed.These advances provide a direction for the integration of clinical,molecular,and genomic profiles to improve GC diagnosis and treatments. | Zi-Ning Lei Qiu-Xu Teng Qin Tian Wei Chen Yuhao Xie Kaiming Wu Qianlin Zeng Leli Zeng Yihang Pan Zhe-Sheng Chen Yulong He | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 4 |
| 13 | Focal nodular hyperplasia of the liver: pathological analysis of 11 cases显示文摘BACKGROUND: Focal nodular hyperplasia (FNH) is a benign tumor-like lesion of the liver, predominantly affect- ing women. Its etiology is obscure and its pathogenesis is poorly understood. FNH should be differentiated from oth- er benign and malignant hepatic lesions. The aim of this study was to explore the pathological characteristics of FNH of the liver. METHODS: Eleven patients with FNH were studied retro- spectively by using hematoxylin and eosin, immunohisto- chemical and histochemical staining. RESULTS: In 8 female and 3 male FNH patients aged 19 to 54 years (mean 32), most of lesions showed central scars macroscopically. Microscopically 8 patients were found of classical type, 2 were of telangiectic type, and 1 was of mixed type. CONCLUSION: FNH is an uncommon benign hyperplastic lesion of the liver. It should be differentiated from hepato- cellular adenoma, alpha-fetoprotein negative hepatocellular carcinoma, and fibrolamellar carcinoma. | Yi Pan, Zhao-Ming Wang, Ling-Jun Mou, Xiao-Dong Teng, Zhou-Jun Zheng and Li-Xiong Ying Hangzhou, ChinaDepartments of Pathology and General Surgery First Affilia- ted Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 3 |
| 14 | Liver disease and Helicobacter显示文摘INTRODUCTIONThehumanuppergastrointestinaltractisofteninfectedwithHelicobacterpylori(H.pylori).Thisureasplitingbacteriumisnowc... | LUO Yu Qin 1, TENG Jin Bo 2, PAN Bo Rong 3 and ZHANG Xue Yong 3 | 1999 | World Journal of Gastroenterology1999，5，4： | 3 |
| 15 | Inducible overexpression of RUNX1b/c in human embryonic stem cells blocks early hematopoiesis from mesoderm显示文摘RUNX1 绝对为 RUNX1b/c 的权威的造血作用,而是功能被要求,人的 RUNX1 的二 isoforms,是不清楚的。我们建立了可诱导的 RUNX1b/c-overexpressing 人的胚胎的干细胞(hESC ) 线,在 RUNX1b/c, overexpression 阻止了 CD34+ 房间的出现早舞台,急速地从而减少造血的干细胞的生产。同时,造血作用相关的因素的表示是 downregulated。然而,如此的阻塞效果从在 hESC/AGM-S3 房间合作文化的白天 6 消失了,证明阻塞发生在 hemogenic endothelial 房间的产生前。这阻塞被 RepSox 部分救,转变生长因素(TGF ) 的一个禁止者 - 发信号的小径,显示在 RUNX1b/c 和 TGF- 小径之间的一种靠近的关系。我们的结果在早造血作用的开发建议 RUNX1b/c 的一个唯一的禁止的函数并且可以在正常和 diseased 模型帮助它的生物函数的进一步的理解。 | Bo Chen Jiawen Teng Hongwei Liu Xu Pan Ya Zhou Shu Huang Mowen Lai Guohui Bian Bin Mao Wencui Sun Qiongxiu Zhou Shengyong Yang Tatsutoshi Nakahata Feng Ma | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 16 | A High-Ductility Mg–Zn–Ca Magnesium Alloy显示文摘A new kind of Mg–2 Zn–0.6 Ca(wt%) alloy was fabricated by casting and hot extrusion as a high-ductility structural material. The extruded alloy exhibits a superior elongation of ~30%, yield strength of 130 MPa and ultimate tensile strength of 280 MPa along the extrusion direction at room temperature. Microstructure, texture and tensile properties of the extruded alloy were investigated in details. The remarkable improvement of ductility is ascribed to the weakened basal texture, refined grains and a small number of second phase in the alloy. | Teng Tu Xian-Hua Chen Jiao Chen Chao-Yue Zhao Fu-Sheng Pan | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，1： | 2 |
| 17 | Perovskite-transition metal dichalcogenides heterostructures: recent advances and future perspectives显示文摘Transition metal dichalcogenides(TMDs)and perovskites are among the most attractive and widely investigated semiconductors in the recent decade.They are promising materials for various applications,such as photodetection,solar energy harvesting,light emission,and many others.Combining these materials to form heterostructures can enrich the already fascinating properties and bring up new phenomena and opportunities.Work in this field is growing rapidly in both fundamental studies and device applications.Here,we review the recent findings in the perovskite-TMD heterostructures and give our perspectives on the future development of this promising field.The fundamental properties of the perovskites,TMDs,and their heterostructures are discussed first,followed by a summary of the synthesis methods of the perovskites and TMDs and the approaches to obtain high-quality interfaces.Particular attention is paid to the TMD-perovskite heterostructures that have been applied in solar cells and photodetectors with notable performance improvement.Finally through our analysis,we propose an outline on further fundamental studies and the promising applications of perovskite-TMD heterostructures. | Ahmed Elbanna Ksenia Chaykun Yulia Lekina Yuanda Liu Benny Febriansyah Shuzhou Li Jisheng Pan Ze Xiang Shen Jinghua Teng | 2022 | Opto-Electronic Science2022，1，8： | 2 |
| 18 | Rotavirus VP7 epitope chimeric proteins elicit cross-immunoreactivity in guinea pigs显示文摘VP7 of group A rotavirus(RVA) contains major neutralizing epitopes. Using the antigenic protein VP6 as the vector, chimeric proteins carrying foreign epitopes have been shown to possess good immunoreactivity and immunogenicity. In the present study, using modified VP6 as the vector,three chimeric proteins carrying epitopes derived from VP7 of RVA were constructed. The results showed that the chimeric proteins reacted with anti-VP6 and with SA11 and Wa virus strains.Antibodies from guinea pigs inoculated with the chimeric proteins recognized VP6 and VP7 of RVA and protected mammalian cells from SA11 and Wa infection in vitro. The neutralizing activities of the antibodies against the chimeric proteins were significantly higher than those against the vector protein VP6 F. Thus, development of chimeric vaccines carrying VP7 epitopes using VP6 as a vector could be a promising alternative to enhance immunization against RVAs. | Bingxin Zhao Xiaoxia Pan Yumei Teng Wenyue Xia Jing Wang Yuling Wen Yuanding Chen | 2015 | Virologica Sinica2015，30，5： | 2 |
| 19 | Application effect of safety hazard self-examination mode in nursing risk management in hepatobiliary surgery显示文摘Objective:To explore the application effect of safety hazard self-examination mode in nursing risk management in hepatobiliary surgery.Methods:Sixty patients underwent hepatobiliary surgery in two tertiary hospitals in Shandong Province from May 2021 to October 2021.According to the different implementation time,they were divided into 30 cases in the observation group and 30 cases in the control group.The control group adopts routine risk assessment,and the observation group adopts the self-examination mode of potential safety hazards on the basis of routine risk assessment to compare the incidence of nursing risk between the two groups.Results:The observation group had a significantly lower incidence of safety hazards in terms of missing surgical instruments,lack of aseptic operation,and postoperative pressure injuries than the control group(P<0.05).Conclusion:The appropriate hazard self-examination mode in the hepatobiliary operation room is of positive significance to improve the safety awareness of operating staff and the comprehensive ability of operating room nurses. | Yong-Chao He Chen Pan Xue Song Xiao Zhang Hong-Xu Ren Teng Sun Xiao-Yu Liu | 2021 | TMR Non-Drug Therapy2021，4，4： | 2 |
| 20 | Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells 显示文摘 | Chou C C Pan S L Teng C M | 2003 | Eur J Pharm Sci2003，19，5： | 2 |
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