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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 3 | Deep water bottom current deposition in the northern South China Sea显示文摘There are some active bottom currents on the northern continental slope of the South China Sea (SCS). Reflection seismic profiles show that the bottom current channels occur in the water depth range of 1000 to 2700 m,extending from the NE to the SW,leading to accumulation of discontinuous drifts with higher sedimentation rates on the eastern side of the channel. The stacking pattern of the layers sug-gests that these drifts propagated southwestward,following the direction of the bottom currents. One sedimentary drift to the southeast of the Dongsha Islands has the highest sedimentation rate of 97cm/ka in the last 12 ka. The sedimentary characteristics of the sediment layers indicate that these bottom currents are most likley caused by the water movement of a branch of the West Pacific Ocean Current,which enters the northern SCS via the Bashi Strait. Once formed,the bottom currents trans-port sediments along the northern slope of SCS southwestward and finally disappear into the central basin of the SCS. Due to the bottom current activity,the deep-sea sedimentary process in the northern SCS is complex. | SHAO Lei LI XueJie GENG JianHua PANG Xiong LEI YongChang QIAO PeiJun WANG LiaoLiang WANG HongBin | 2007 | Science China Earth Sciences2007，50，7： | 43 |
| 4 | Programmed death-1 expression is associated with the disease status in hepatitis B virus infection显示文摘AIM: To define the potential role of programmed death-1/programmed death-ligand (PD-1/PD-L) pathway in different hepatitis B virus (HBV) infection disease status; we examined the expression of PD-1 on antigen specific CD8+ T cells in peripheral blood of patients with chronic hepatitis B (CHB) and acute exacerbation of hepatitis B (AEHB) infection. METHODS: The PD-1 level on CD8+ T lymphocytes and the number of HBV specifi c CD8+ T lymphocytes in patients and healthy controls (HCs) were analyzed by staining with pentameric peptide-human leukocyte antigen2 (HLA2) complexes combined with flow cytometry. Real-time quantitative polymerase chain reaction (PCR) was used to measure the serum HBV-DNA levels. RESULTS: The level of PD-1 expression on total CD8+ T cells in CHB patients (13.86% ± 3.38%) was significantly higher than that in AEHB patients (6.80%± 2.19%, P < 0.01) and healthy individuals (4.63% ± 1.23%, P < 0.01). Compared to AEHB patients (0.81% ± 0.73%), lower frequency of HBV-specific CD8+ T cells was detected in chronic hepatitis B patients (0.37% ± 0.43%, P < 0.05). There was an inverse correlation between the strength of HBV-specific CD8+ T-cell response and the level of PD-1 expression. Besides, there was a significant positive correlation between HBV viral load and the percentage of PD-1 expression on CD8+ T cells in CHB and AEHB subjects (R = 0.541, P < 0.01). However, PD-1 expression was not associated with disease flare-ups as indicated by alanine aminotransferase (ALT) levels (R = 0.066, P > 0.05). CONCLUSION: Our results confirm previous reports that HBV specific CD8+ T-cell response in the peripheral blood is more intense in patients with AEHB than in chronic hepatitis B with persistent viral infection. Moreover, there is a negative correlation between the level of PD-1 and the intensity of virus specific CD8+T cell response. | Plan Ye Zhi-Hong Weng Shu-Ling Zhang Jian-Ao Zhang Lei Zhao Ji-Hua Dong Sheng-Hua Jie Ran Pang Rong-Hua Wei | 2008 | World Journal of Gastroenterology2008，14，28： | 25 |
| 5 | Necking of Q&P Steel during Uniaxial Tensile Test with the Aid of DIC Technique显示文摘A lot of research has been focused on the necking process during the plastic deformation of sheet metals, but the localized necking is rarely distinguished form diffused necking by experiments, due to the limit of measurement equipment and method. Quenching and Partitioning (Q&P) steel is a 3rd generation advanced high strength steel (AHSS). Its good combination of high strength and ductility ensures potential application in automobile industry. Uniaxial tensile tests of QP980 steel sheet at five strain rates are performed to investigate the necking process and the effect of strain rate on necking behavior of Q&P steel. Digital image correlation (DIC) method is applied during tensile tests, and evolutions of major strain, minor strain and normal strain distributions along gauge section of the tensile specimens are obtained. The diffused and localized necking strains are determined according to SWIFT necking theory and HILL necking theory respectively. The test results indicate that with the increasing of strain rate in the investigated range, the diffused necking strain decreases from 0.152 to 0.120 and localized necking strain decreases from 0.245 to 0.137. Meanwhile, the difference of the two strains decreases form 0.096 to 0.017. Thus it can be concluded that strain rate has an influence on both necking strains during the deformation of QP980 steel sheet. Diffused and localized necking strains are determined by uniaxial tensile tests with the aid of DIC technique and the effect of strain rate on necking strains is evaluated. | DING Lei LIN Jianping MIN Junying PANG Zheng YE You | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 11 |
| 6 | First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering显示文摘The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current interest.Elastic scattering is a useful probe for investigating the size and surface diffuseness of exotic nuclei.The development of rare isotope accelerators offers opportunities for such studies.To date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite scarce.In this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb barrier.The angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same energy.This work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei. | Wei Nan Bing Guo Cheng-Jian Lin Lei Yang Dong-Xi Wang Yang-Ping Shen Bing Tang Bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming Jia Yun-Ju Li Chen Chen Li-Hua Chen Qi-Wen Fan Xin-Yue Li Gang Lian Jian-Cheng Liu Tian-Peng Luo Nan-Ru Ma Rui-Gang Ma Xie Ma Ying-Jun Ma Wei-Ke Nan Dan-Yang Pang You-Bao Wang Pei-Wei Wen Feng Yang Yong-Jin Yao Sheng Zeng Hao Zhang Fu-Peng Zhong Shan-Hao Zhong Zhi-Hong Li Tian-Jue Zhang Wei-Ping Liu BRIF Collaboration | 2021 | Nuclear Science and Techniques2021，32，5： | 9 |
| 7 | Preliminary analysis of spatiotemporal pattern of global land surface water显示文摘Land surface water(LSW) is one of the most important resources for human survival and development, and it is also a main component of global water recycling. A full understanding of the spatial distribution of land surface water and a continuous measuring of its dynamics can support to diagnose the global ecosystem and environment. Based on the Global Land 30-water 2000 and Global Land 30-water 2010 products, this research analyzed the spatial distribution pattern and temporal fluctuation of land surface water under scale-levels of global, latitude and longitude, continents, and climate zones. The Global Land 30-water products were corrected the temporal inconsistency of original remotely sensed data using MODIS time-series data, and then calculated the indices such as water area, water ration and coefficient of spatial variation for further analysis. Results show that total water area of land surface is about 3.68 million km2(2010), and occupies 2.73% of land area. The spatial distribution of land surface water is extremely uneven and is gathered mainly in mid- to high-latitude area of the Northern Hemisphere and tropic area. The comparison of water ratio between 2000 and 2010 indicates the overall fluctuation is small but spatially differentiated. The Global Land 30-water products and the statistics provided the fundamental information for analyzing the spatial distribution pattern and temporal fluctuation of land surface water and diagnosing the global ecosystem and environment. | CAO Xin CHEN Jun CHEN LiJun LIAO AnPing SUN FangDi LI Yang LI Lei LIN ZhongHui PANG ZhiGuo CHEN Jin HE ChaoYing PENG Shu | 2014 | Science China Earth Sciences2014，57，10： | 8 |
| 8 | Climate variability recorded by n-alkanes of paleolake sediment in Qaidam Basin on the northeast Tibetan Plateau in late MIS3显示文摘Here we combine n-alkanes preserved in a shell bar section from Qarhan paleolake, Qaidam Basin with the other sedimentary proxies to elucidate the lake evolution process during the period 39.7 to 17.5 14C ka BP (calibrated age ranges from 43.5 to 22.4 cal. ka BP). In different stages, the n-alkane homologues exhibited different distribution modes indicative of variations in the surrounding vegetation and the hydrologic condition of the lake. The n-alkanes proxies (CPIh, ACLh, Paq) have the same trends as the summer solar insolation variation, implying that the summer insolation is the most important climatic factor driving the environmental changes and also indirectly controls lake evolution on the Tibetan Plateau. CPIh and ACLh as well as the total pollen concentration appear to show a trend comparable with methane concentration record from the GRIP ice core that reflected the Dansgaard-Oeschger events. This demonstrates that the paleoclimate variations in Qarhan area generally agree with global climate change and show rapid oscillations in late MIS3. These findings provide the latest molecular fossil evidence from paleolake sediments to confirm that lake evolution on Tibetan Plateau in late MIS3 was closely associated with enhanced summer insolation. | PU Yang ZHANG HuCai LEI GuoLiang CHANG FengQin YANG MingSheng ZHANG WenXiang LEI YanBin YANG LunQing PANG YouZhi | 2010 | Science China Earth Sciences2010，53，6： | 8 |
| 9 | A critical review on the application of biochar in environmental pollution remediation:Role of persistent free radicals(PFRs)显示文摘Biochar as an emerging carbonaceous material has exhibited a great potential in environmental application for its perfect adsorption ability.However,there are abundant persistent free radicals(PFRs)in biochar,so the direct and indirect PFRs-mediated removal of organic and inorganic contaminants by biochar was widely reported.In order to comprehend deeply the formation of PFRs in biochar and their interactions with contaminants,this paper reviews the formation mechanisms of PFRs in biochar and the PFRs-mediated environmental applications of biochar in recent years.Finally,future challenges in this field are also proposed.This review provides a more comprehensive understanding on the emerging applications of biochar from the viewpoint of the catalytic role of PFRs. | Kun Luo Ya Pang Dongbo Wang Xue Li Liping Wang Min Lei Qi Huang Qi Yang | 2021 | Journal of Environmental Sciences2021，33，10： | 8 |
| 10 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 11 | Electro-mechanically controlled assembly of reconfigurable 3D mesostructures and electronic devices based on dielectric elastomer platforms显示文摘The manufacture of 3D mesostructures is receiving rapidly increasing attention,because of the fundamental significance and practical applications across wide-ranging areas.The recently developed approach of buckling-guided assembly allows deterministic formation of complex 3D mesostructures in a broad set of functional materials;with feature sizes spanning nanoscale to centimeter-scale.Previous studies mostly exploited mechanically controlled assembly platforms using elastomer substrates;which limits the capabilities to achieve on-demand local assembly;and to reshape assembled mesostructures into distinct 3D configurations.This work introduces a set of design concepts and assembly strategies to utilize dielectric elastomer actuators as powerful platforms for the electro-mechanically controlled 3D assembly.Capabilities of sequential-local loading with desired strain distributions allow access to precisely tailored 3D mesostructures that can be reshaped into distinct geometries,as demonstrated by experimental and theoretical studies of?30 examples.A reconfigurable inductive-capacitive radio-frequency circuit consisting of morphable 3D capacitors serves as an application example. | Wenbo Pang Xu Cheng Haojie Zhao Xiaogang Guo Ziyao Ji Guorui Li Yiming Liang Zhaoguo Xue Honglie Song Fan Zhang Zheng Xu Lei Sang Wen Huang Tiefeng Li Yihui Zhang | 2020 | National Science Review2020，7，2： | 8 |
| 12 | Control of Facies and Potential on Jurassic Hydrocarbon Accumulation and Prediction of Favorable Targets in the Hinterland Region of the Junggar Basin显示文摘Exploration practices show that the Jurassic System in the hinterland region of the Junggar Basin has a low degree of exploration but huge potential,however the oil/gas accumulation rule is very complicated,and it is difficult to predict hydrocarbon-bearing properties.The research indicates that the oil and gas is controlled by structure facies belt and sedimentary system distribution macroscopically,and hydrocarbon-bearing properties of sand bodies are controlled by lithofacies and petrophysical facies microscopically.Controlled by ancient and current tectonic frameworks,most of the discovered oil and gas are distributed in the delta front sedimentary system of a palaeo-tectonic belt and an ancient slope belt.Subaqueous branch channels and estuary dams mainly with medium and fine sandstone are the main reservoirs and oil production layers,and sand bodies of high porosity and high permeability have good hydrocarbon-bearing properties;the facies controlling effect shows a reservoir controlling geologic model of relatively high porosity and permeability.The hydrocarbon distribution is also controlled by relatively low potential energy at the high points of local structure macroscopically, while most of the successful wells are distributed at the high points of local structure,and the hydrocarbon-bearing property is good at the place of relatively low potential energy;the hydrocarbon distribution is in close connection with faults,and the reservoirs near the fault in the region of relatively low pressure have good oil and gas shows;the distribution of lithologic reservoirs at the depression slope is controlled by the distribution of sand bodies at positions of relatively high porosity and permeability.The formation of the reservoir of the Jurassic in the Junggar Basin shows characteristics of favorable facies and low-potential coupling control,and among the currently discovered reservoirs and industrial hydrocarbon production wells,more than 90%are developed within the scope of faciespotential index FPI>0.5,while the FPI and oil saturation of the discovered reservoir and unascertained traps have relatively good linear correlation.By establishing the relation model between hydrocarbonbearing properties of traps and FPI,totally 43 favorable targets are predicted in four main target series of strata and mainly distributed in the Badaowan Formation and the Sangonghe Formation,and the most favorable targets include the north and east of the Shinan Sag,the middle and south of the Mobei Uplift,Cai-35 well area of the Cainan Oilfield,and North-74 well area of the Zhangbei fault-fold zone. | CHEN Dongxia PANG Xiongqi KUANG Jun KANG Dejiang LEI Lei DENG Yougen | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 7 |
| 13 | Mitochondria-targeted antioxidant peptide SS-31 mediates neuroprotection in a rat experimental glaucoma model显示文摘To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce elevated intraocular pressure (IOP). After 6 weeks, electroretinography (ERG) and flash visual-evoked potentials (F-VEPs) were recorded to assess retinal function. Hematoxylin-eosin staining was performed on retinal cross-sections to measure ganglion cell complex (GCC) thickness. Apoptotic retinal cells were assessed by TUNEL staining. Brn3a-positive retinal ganglion cells (RGCs) were counted in retinal flat mounts via immunofluorescence. The retinal total SOD, SOD2, and MDA expression levels were assessed in retinal tissue homogenates. The cyt c, Baxz and Bcl-2 protein levels in rat retinas were detected by western blot analysis. Bax and Bcl-2 expressions were also evaluated using immunohistochemistry in paraffinized sections. Our results showed that the rats that received microsphere injection developed elevated IOP. SS-31 ameliorated the reductions in the a- and b-wave amplitudes on ERG and the F-VEP amplitude in glaucomatous eyes. GCC thickness was preserved, TUNEL-positive cells were decreased in the retina, and Brn3a-positive RGCs were in creased in the SS-31-treated glaucoma group compared with those in the non-treated glaucoma group. SS-31 significantly reduced MDA levels and increased SOD2 levels after glaucoma induction. Significant suppression of cyt c release, upregulation of Bcl-2, and downregulation of Bax were observed following SS-31 administration. In summary, SS-31 exerts neuroprotective effects in this experimental glaucoma model by inhibiting mitochondrial dysfunction and therefore represents a promising therapeutic agent for glaucoma. | Xiaoqiong Wu Yu Pang Zhilin Zhang Xiabin Li Chao Wang Yingqing Lei Ailing Li Ling Yu Jian Ye | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 7 |
| 14 | Acute pulmonary inflammation is inhibited in CXCR3 knockout mice after short-term cigarette smoke exposure显示文摘瞄准:CXCR3,经由绑定它的特定的 ligand CXCL10,在导致的香烟烟(CS ) 起一个重要作用肺的发炎。CXCR3 优先地在激活的 T 房间被表示(主要 CD8 + T 房间) 。这研究的目的是用 CXCR3 在导致 CS 的肺的损害调查 CXCR3 的角色基因缺乏的(CXCR3−/−) 老鼠。方法:在煽动性的房间和 CD8 + T 房间和在在 mRNA 和蛋白质层次的 bronchoalveolar 洗室年龄液体和肺的煽动性的调停人和 chemokines 的表示的渗入的差别在 CXCR3−/− 之间被比较老鼠并且野类型(WT ) 在在 CS 暴露的 3 d 以后的 2 h 的老鼠。结果:与他们的 WT 对应物相比, CXCR3−/−老鼠显示出减轻的发炎,由更少煽动性的房间证实了特别地细胞毒素的 CD8 + T 房间,在 bronchoalveolar 洗室年龄液体和肺纸巾。在 mRNA 和蛋白质层次,有显著地在 CXCR3−/− 的煽动性、趋化性的 cytokines,包括的 TNF-α , interleukin-8, interferon-γ ,转变生长 factor-β1,和 CXCL10 的底层老鼠。结论:我们 CXCR3 在招募是重要的数据表演煽动性的房间(特别地 CD8 + T 房间) 进航线和肺,以及开始煽动性并且在跟随短期的 CS 侮辱的 2 h 的 fibrotic cytokines 版本。CXCR3 能是为 CS 导致的肺的发炎的处理的一个新奇目标。 | Li NIE Ruo-lan XIANG Yong LIU Wei-xun ZHOU Lei JIANG Bao LU Bao-sen PANG De-yun CHENG Jin-ming GAO | 2008 | Acta Pharmacologica Sinica2008，29，12： | 6 |
| 15 | Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers显示文摘Background: Upon binding luteinizing hormone in the ovary, the luteinizing hormone/choriogonadotropin receptor (LHCGR) is necessary for follicular maturation and ovulation, as well as luteal function. We detected mutations in the LHCGR gene and evaluated their association with superovulation. Methods: Using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing, we examined polymorphisms in LHCGR and the genotypes associated with superovulation traits in 127 Chinese Holstein heifers. Results: A G/T polymorphism (ss52050737) in exon 11 was significantly associated with the total number of ova and the number of transferable embryos. Conclusions: LHCGR may be a new predictor for superovulation in Chinese Holstein heifers. | Yong Yu Yunwei Pang Haichao Zhao Xiaoling Xu Zhonghong Wu Lei An Jianhui Tian | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 6 |
| 16 | Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque (Macaca leonina)显示文摘The northern pig-tailed macaque(Macaca leonina) has been identified as an independent species of Old World monkey, and we previously found that PBMCs from M. leonina were susceptible to human immunodeficiency virus type 1(HIV-1), which may be due to the absence of a TRIM5 protein restricting HIV-1 replication. Here we investigated the infection potentials of six laboratory adapted HIV-1 strains and three primary HIV-1 isolates in PBMCs from M. leonina. The results indicate that these strains are characterized by various but low replication levels, and among which, HIV-1NL4-3 shows the highest replication ability. Based on the abundant evidence of species-specific interactions between restriction factors APOBEC3 and HIV/SIV-derived Vif protein, we subsequently examined the replication potentials of vif-substituted HIV-1(HSIV) in M. leonina PBMCs. Notably, HSIV-vifmac and stHIV-1SV chimeras, two HIV-1NL4-3-derived viruses encoding the viral infectivity factor(Vif) protein from SIVmac239, replicated robustly in cells from M. leonina, which suggests that HSIV could effectively antagonize the antiviral activity of APOBEC3 proteins expressed in cells of M. leonina. Therefore, our data demonstrate that M. leonina has the potential to be developed into a promising animal model for human AIDS. | Ai-Hua LEI Gao-Hong ZHANG Ren-Rong TIAN Jia-Wu ZHU Hong-Yi ZHENG Wei PANG Yong-Tang ZHENG | 2014 | Zoological Research2014，35，3： | 5 |
| 17 | Changes in sea ice kinematics in the Arctic outflow region and their associations with Arctic Northeast Passage accessibility显示文摘Amplification of climate warming in the Arctic is causing a dramatic retreat of sea ice, which means the Arctic sea routes are becoming increasingly accessible. This study used a satellite-derived sea ice motion product to quantify the kinematic features of sea ice in the Arctic outflow region which specially referred to the Fram Strait and to the north of the Northeast Passage(NEP). An observed trend of increased southward sea ice displacement from the central Arctic to the Fram Strait indicated enhancement of the Transpolar Drift Stream(TDS). In the regions to the north of the NEP, the long-term trend of northward sea ice speed in the Kara sector was +0.04 cm/s per year in spring. A significant statistical relationship was found between the NEP open period and the northward speed of the sea ice to the north of the NEP. The offshore advection of sea ice could account for the opening of sea routes by 33% and 15% in the Kara and Laptev sectors, respectively. The difference in sea level pressure across the TDS,i.e., the Central Arctic Index(CAI), presented more significant correlation than for the Arctic atmospheric Dipole Anomaly index with the open period of the NEP, and the CAI could explain the southward displacement of sea ice toward the Fram Strait by more than 45%. The impact from the summer positive CAI reinforces the thinning and mechanical weakening of the sea ice in the NEP region, which improves the navigability of the NEP. | Dawei Gui Xiaoping Pang Ruibo Lei Xi Zhao Jia Wang | 2019 | Acta Oceanologica Sinica2019，38，8： | 5 |
| 18 | Evaluation of Ecosystem Services Value of the Zoigê Wetland Nature Reserve by Multiple Criteria显示文摘Understanding the value of ecosystem services is useful for the decision making and sustainable management of the wetlands. It would be better to integrate ecological, economic and social factors into ecosystem service valuation. The general value of the Zoigê Wetland Nature Reserve in the southwest China by integrating a social welfare weight, which is determined by a three-level analytic hierarchy process, was calculated. Through analyzing the functions, stakeholders and ecosystem services of the Zoigê Wetland Nature Reserve, the six main services, including substance production, flood control, gas regulation, climate regulation, recreation, and biodiversity conservation,were selected; and a three-level hierarchical structure model was established. The top(goal) level of the model refers to the total ecosystem services value of the Zoigê Wetland Nature Reserve, the middle level(stakeholder level) refers to stakeholders at different scales, and the bottom level(service level) refers to individual services provided by the Zoigê Wetland Nature Reserve. The results indicated that the ecosystem services value of the Zoigê Wetland Nature Reserve was 320.38×10~8yuan RMB in 2011. If including the social welfare, the value increased to 2258.68×10~8yuan RMB. The value of biodiversity conservation accounted for the largest proportion, which were 53% without the social welfare and 75% with it. And without the social welfare, flood control, gas regulation, climate regulation of the Zoigê Wetland Nature Reserve accounted for 26%, 11% and 8% of the total value, while the proportion that substance production and recreation values were of the total value were very small. Meanwhile, with the social weight,flood control, gas regulation, climate regulation, recreation of the Zoigê Wetland Nature Reserve accounted for 10%,13%, 1% and 1% of the total value, then the weight of substance production value was also the smallest. | CUI Lijuan SUN Baodi LI Wei PANG Bingliang LEI Yinru MA Muyuan MA Qiongfang | 2016 | 湿地科学2016，14，2： | 5 |
| 19 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 20 | Design and attitude control of a novel robotic jellyfish capable of 3D motion显示文摘Aquatic creatures such as fish,cetaceans,and jellyfish could inspire innovative designs to improve the ways that manmade systems operate in and interact with aquatic environments(1,2)Jellyfish in nature use jet propulsion to move through the water,which have been proven to be one of the most energetically efficient swimmers on the planet(3)Researchers are making an integrated effort to develop smart actuators to fabricate various robotic jellyfish,such as shape memory alloys(SMA)[4],ionic polymer metal composites(IPMC)[5],and dielectric elastomer actuator[6]. | Junzhi YU Xiangbin LI Lei PANG Zhengxing WU | 2019 | Science China(Information Sciences)2019，62，9： | 4 |
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