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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Molecular fossil and paleovegetation records of paleosol S4 and adjacent loess layers in the Luochuan loess section, NW China显示文摘Using gas chromatography-mass spectrometry (GC-MS) technique, a series of biomarkers were identi- fied, including n-alkanes, n-alkane-2-ones, isoprenoid etc. from the loess-paleosol samples collected from the S4 and adjacent L5, L4 of the Luochuan loess section, Northwestern China. Based on these data, especially n-alkanes and high-resolution magnetic susceptibility and grain size data, the pa- leoenvironment and paleovegetation history during S4 was reconstructed. The CPI (Carbon Predomi- nance Index) and correlation between n-alkanes and magnetic susceptibility and grain size data dem- onstrated that the molecular fossils in paleosol and loess layers can reflect the vegetation condition during the loess-paleosol formation, if the allochthonous organic inputs could be excluded reasonably. The ACL (average chain length) index is correlated well with paleomagnetic susceptibility and grain size variations, displaying their good synchrony with warm and humid climate. However, it relatively lagged behind the paleomagnetic susceptibility and the grain size variations when the climate began to deteriorate. During the formation period of paleosol, the n-alkanes was dominated by C31 homologue, indicating that the primary organic input originated from herbs. Our study also demonstrated that the herbs were more flourish than wood plants in Loess Plateau, especially in the Luochuan area during the warm and humid phase, and there was no typical forest vegetation developed in the studied period. | ZHANG HuCai YANG MingSheng ZHANG WenXiang LEI GuoLiang CHANG FengQin PU Yang FAN HongFang | 2008 | Science China Earth Sciences2008，51，3： | 15 |
| 3 | Branched aliphatic alkanes of shell bar section in Qarhan Lake,Qaidam Basin and their paleoclimate significance显示文摘Biomarkers of paleolake deposits from Qarhan Salt Lake in Qaidam Basin,northwest China were sys-tematically analyzed and the A―C series compounds of branched aliphatic alkanes with quaternary substituted carbon atom(BAQCs) were identified. The homologous distinguished three series,A―C,were identified as 5,5-diethylalkanes,6,6-diethylalkanes and 5-butyl,5-ethylalkanes series,and their relative abundance was A > B > C. Series A and C were characterized by odd carbon numbers,whereas series B was characterized by even carbon numbers. The high values of series A corresponded with the high values of series B and C. Therefore,it can be concluded that series A,B and C possess a similar biological origin. The abundance of series A was relatively low in the lower part of the section compared with that in the upper part,implying that these series originated from bacteria and/or algae more prevalent in fresh-mesohaline water,and such kinds of bacteria and/or algae are most likely to be thermophilous species. The A25/nC25 ratio differences in the section show that such branched aliphatic alkanes can be treated as one kind of environmental change proxy for paleolake evolution and may provide important information for the climate reconstruction of the Late Pleistocene. | ZHANG HuCai CHANG FengQin LI Bin LEI GuoLiang CHEN Yue ZHANG WenXiang NIU Jie FAN HongFang YANG MingSheng | 2007 | Chinese Science Bulletin2007，52，9： | 13 |
| 4 | Climatic and environmental implications from n-alkanes in glacially eroded lake sediments in Tibetan Plateau:An example from Ximen Co显示文摘Gas chromatography-mass spectrometry was used to identify a series of n-alkanes in the sediments of a typical glacially eroded lake in the eastern Tibetan Plateau.By comparing the distribution patterns of n-alkanes in lake sediments,surface soils and cow manure,it was shown that n-C 27-n-C 33 alkanes in the soil ecosystem of Ximen Co are derived from vascular plant species and that the distribution pattern of n-C 27-n-C 33 alkanes remains unchanged during the feeding and digestion processes of herbivores.The relative percentage of C 27,C 29 and C 31 n-alkanes decreased from the bottom to the top of the sediment core showing a trend of degradation of higher plants in the Ximen Co lake region during the formation of the 44 cm core.210 Pb dating,combined with pre-existing AMS 14 C dating results showed that the depositional core reflects climatic and environmental variations since about 900 years before present.The n-alkane indexes (ACL 27-33,P aq,P wax) are comparable with regional temperature variation,especially recording the Little Ice Age event (LIA).This study highlights that n-alkanes are valid proxies for paleo-climate and paleo-environment reconstruction,despite the same distribution patterns in n-alkane molecular fossils derived from a typical glacially eroded lake. | PU Yang ZHANG HuCai WANG YongLi LEI GuoLiang NACE Trevor ZHANG ShuPing | 2011 | Chinese Science Bulletin2011，56，14： | 10 |
| 5 | Geochemical fractionation of rare earth elements in lacustrine deposits from Qaidam Basin显示文摘Based on the concentration and distribution pattern analysis of the rare earth elements (REEs) at the Shell Bar section from Qaidam Basin, we studied the geochemical fractionations of REE in paleolake deposits and their paleo-environmental significance. Our results show that the REE concentration in AS (acid soluble) and AR (acid residual) fractions are 20.9 μg/g and 95.4 μg/g (except element Y) individually, showing a strong REE differentiation between AS and AR fractions. However, the two types of fractions (AS & AR) have similar REE distribution patterns, which are slightly rich in light earth rare elements (LREEs), with slightly right-tilting and negative Eu anomaly. The LREE of AR is richer than that of AS. There were no significant correlations between the REE in AS, AR and other proxies. It indicated that the lacustrine deposition had different material sources and experienced varying geochemical procedures. Correlation analysis between the REE and the content of fine grain-size (<4 μm) of the sediments, Rb/Sr ratio and Mn concentration showed high correlation coefficients. Our results demonstrated that the REE in acid soluble and residual fractions bear different environmental significances, which are strongly dependent on local environment. The REE of acid soluble fraction is closely related to the paleoclimatic changes in the lake catchment and the evolutionary processes of lake itself. Our results suggest that δCe and (La/Yb)n could be used as proxies of the reduction-oxidation conditions and furthermore the temperature change and the lake level fluctuations. Using these proxies, we reconstructed the paleoclimate and water level fluctuation history during the high lake level period lasting between 43.5 and 22.4 cal. ka BP. | ZHANG HuCai ZHANG WenXiang CHANG FengQin YANG LunQing LEI GuoLiang YANG MingSheng PU Yang LEI YangBin | 2009 | Science China Earth Sciences2009，52，11： | 9 |
| 6 | Climate variability recorded by n-alkanes of paleolake sediment in Qaidam Basin on the northeast Tibetan Plateau in late MIS3显示文摘Here we combine n-alkanes preserved in a shell bar section from Qarhan paleolake, Qaidam Basin with the other sedimentary proxies to elucidate the lake evolution process during the period 39.7 to 17.5 14C ka BP (calibrated age ranges from 43.5 to 22.4 cal. ka BP). In different stages, the n-alkane homologues exhibited different distribution modes indicative of variations in the surrounding vegetation and the hydrologic condition of the lake. The n-alkanes proxies (CPIh, ACLh, Paq) have the same trends as the summer solar insolation variation, implying that the summer insolation is the most important climatic factor driving the environmental changes and also indirectly controls lake evolution on the Tibetan Plateau. CPIh and ACLh as well as the total pollen concentration appear to show a trend comparable with methane concentration record from the GRIP ice core that reflected the Dansgaard-Oeschger events. This demonstrates that the paleoclimate variations in Qarhan area generally agree with global climate change and show rapid oscillations in late MIS3. These findings provide the latest molecular fossil evidence from paleolake sediments to confirm that lake evolution on Tibetan Plateau in late MIS3 was closely associated with enhanced summer insolation. | PU Yang ZHANG HuCai LEI GuoLiang CHANG FengQin YANG MingSheng ZHANG WenXiang LEI YanBin YANG LunQing PANG YouZhi | 2010 | Science China Earth Sciences2010，53，6： | 8 |
| 7 | ^(10)Be in quartz gravel from the Gobi Desert and evolutionary history of alluvial sedimentation in the Ejina Basin,Inner Mongolia,China显示文摘Reconstructing the evolutionary history of the Gobi deserts developed from alluvial sediments in arid regions has great significance in unraveling changes in both tectonic activity and climate.However,such work is limited by a lack of suitable dating material preserved in the Gobi Desert,but cosmogenic 10Be has great potential to date the Gobi deserts.In the present study,10Be in quartz gravel from the Gobi deserts of the Ejina Basin in Inner Mongolia of China has been measured to assess exposure ages.Results show that the Gobi Desert in the northern margin of the basin developed 420 ka ago,whereas the Gobi Desert that developed from alluvial plains in the Heihe River drainage basin came about during the last 190 ka.The latter developed gradually northward and eastward to modern terminal lakes of the river.These temporal and spatial variations in the Gobi deserts are a consequence of alluvial processes influenced by Tibetan Plateau uplift and tectonic activities within the Ejina Basin.Possible episodes of Gobi Desert development within the last 420 ka indicate that the advance/retreat of alpine glaciers during glacial/interglacial cycles might have been the dominant factor to influencing the alluvial intensity and water volume in the basin.Intense floods and large water volumes would mainly occur during the short deglacial periods. | LU YanWu GU ZhaoYan ALDAHAN Ala ZHANG HuCai POSSNERT Goran LEI GuoLiang | 2010 | Chinese Science Bulletin2010，55，33： | 6 |
| 8 | Development of EST-SSR primers and their practicability test for Laminaria显示文摘Laminaria (Saccharina) is one of the economic important seaweeds.Through sequence analysis of 4 099 ESTs from Laminaria (971 were generated from our own cDNA laboratories and 3 128 were downloaded from updated EST databases) with SSRIT software,two hundred and fifty-four SSRs in 206 ESTs were found.From the 254 SSRs,sixty-three SSR primer-pairs were designed. In order to test their practicability, the 63 primer-pairs were tested in commonly used SSR reaction conditions using 12 Laminara DNA samples as templates. The results show that 23 SSR primer-pairs gave good amplification patterns on most (more than 80%) of the 12 Laminara DNA templates. Genetic diversity study of 12 Laminaria lines,which were widely used in breeding and economic cultivation in China,was performed based on the obtained SSR data. | WANG Guoliang TAN Xiaolong SHEN Junling LI Jian ZHANG Lei SUN Jianwei WANG Bin WENG Manli LIU Tao | 2011 | Acta Oceanologica Sinica2011，30，3： | 3 |
| 9 | Phylogenetic analyses of the genes involved in carotenoid biosynthesis in algae显示文摘Carotenoids play a crucial role in absorbing light energy for photosynthesis,as well as in protecting chlorophyll from photodamage.In contrast to the Streptophyta,few studies have examined carotenoid biosynthetic pathways in algae,owing to a shortage of datasets.As part of the 1000 Plants Project,we sequenced and assembled the transcriptomes of 41 marine macroalgal species,including 22 rhodophytes and 19 phaeophytes,and then combined the datasets with publicly available data from Gen Bank(National Center for Biotechnology Information) and the U.S.Department of Energy Joint Genome Institute.As a result,we identified 68 and 79 fulllength homologs in the Rhodophyta and Phaeophyceae,respectively,of seven inferred carotenoid biosynthetic genes,including the genes for phytoene synthase(PSY),phytoene desaturase(PDS),ζ-carotene desaturase(ZDS),ζ-carotene isomerase(Z-ISO),prolycopene isomerase(crt ISO),lycopene β-cyclase(LCYB),and lycopene ε-cyclase(LCYE).We found that the evolutionary history of the algal carotenoid biosynthetic pathway was more complex than that of the same pathway in the Streptophyta and,more specifically,that the evolutionary history involved endosymbiotic gene transfer,gene duplication,and gene loss.Almost all of the eukaryotic algae that we examined had inherited the seven carotenoid biosynthesis genes via endosymbiotic gene transfer.Moreover,PSY,crt ISO,and the ancestral lycopene cyclase gene(LCY) underwent duplication events that resulted in multiple gene copies,and the duplication and subsequent divergence of LCYB and LCYE specialized and complicated the cyclization of lycopene.Our findings also verify that the loss of LCYE in both the microphytic rhodophytes and phaeophytes explains the differences in their carotenoid patterns,when compared to the macrophytic rhodophytes.These analyses provide a molecular basis for further biochemical and physiological validation in additional algal species and should help elucidate the origin and evolution of carotenoid biosynthetic pathways. | WANG Shanshan ZHANG Lei CHI Shan WANG Guoliang WANG Xumin LIU Tao TANG Xuexi | 2018 | Acta Oceanologica Sinica2018，37，4： | 3 |
| 10 | Simple manganese carbonyl catalyzed hydrogenation of quinolines and imines显示文摘Manganese-catalyzed hydrogenation of unsaturated molecules has made tremendous progresses recently benefiting from non-innocent pincer or bidentate ligands for manganese.Herein,we describe the hydrogenation of quinolines and imines catalyzed by simple manganese carbonyls,Mn2(CO)10 or MnBr(CO)5,thus eliminating the prerequisite pincer-type or bidentate ligands. | Zelong Wang Lei Chen Guoliang Mao Congyang Wang | 2020 | Chinese Chemical Letters2020，31，7： | 2 |
| 11 | On Polynomial Dichotomy of Linear Discrete-Time Systems in Banach Spaces显示文摘This paper deals with two concepts of polynomial dichotomy for linear difference equations which are defined in a Banach space and whose norms can increase not faster than exponentially.Some illustrating examples clarify the relations between these concepts.Our approach is based on the extension of techniques for exponential dichotomy to the case of polynomial dichotomy.The obtained results are generalizations of well-known theorems about the exponential stability and exponential dichotomy. | Tian YUE Guoliang LEI | 2015 | Journal of Mathematical Research with Applications2015，35，5： | 1 |
| 12 | Aerobic SMBR/reverse osmosis system enhanced by Fenton oxidation for advanced treatment of old municipal landfill leachate显示文摘 | ZHANG Guoliang QIN Lei QIN Meng | 2013 | Bioresource Technology2013，142，： | 1 |
| 13 | A novel UV- crosslinked pressure-sensitive adhesive based on photoinitiator-grafted SBS显示文摘 | Guoliang Wu Yue Jiang Lei Ye | 2010 | International Journal of Adhesion & Adhesives2010，30，1： | 1 |
| 14 | Integrating animal manure-based bio-energy production with invasive species control:A case study at Tongren Pig Farm in China显示文摘 | Lu Jianbo Zhu Lei Hu Guoliang | 2010 | Biomass and Bioenergy2010，34，6： | 1 |
| 15 | Integrating animal manure-based bioenergy production with invasive species control: A case study at Tongren Pig Farm in China显示文摘 | Lu Jianbo Zhu Lei Hu Guoliang | 2010 | Biomass and Bioenergy2010，34，6： | 1 |
| 16 | A novel UV - crosslinked pressure - sensitive adhesive based on photoinitiator - grafted SBS 显示文摘 | Wu Guoliang Jiang Yue Ye Lei | 2010 | International Journal Adhesion and adhesives2010，30，1： | 1 |
| 17 | Integrating animal manure-based bioenergy production with invasive species control: A case study at Tongren Pig Farm in China显示文摘 | Jianbo Lu Lei Zhu Guoliang Hu Jianguo Wu | 2010 | Biomass and Bioenergy2010，，6： | 1 |
| 18 | Integrating animal manure-based bioenergy production with invasive species control:A case study at Tongren Pig Farm in China显示文摘 | LU JIANBO ZHU LEI HU GUOLIANG | 2010 | Biomass and Bioenergy2010，34，6： | 1 |
| 19 | SO 4 2? /ZrO 2 –titania nanotubes as efficient solid superacid catalysts for selective mononitration of toluene显示文摘 | Pengfei Chen Mingxing Du He Lei Yan Wang Guoliang Zhang Fengbao Zhang Xiaobin Fan | 2011 | Catalysis Communications2011，，： | 1 |
| 20 | Environmental evolution of Xingkai (Khanka) Lake since 200 ka by OSL dating of sand hills显示文摘Crossing the Sino-Russian boundary, Xingkai Lake is the largest freshwater lake in Northeast Asia. In addition to the lakeshore, there are four sand hills on the north side of the lake that accumulated during a period of sustainable and stable lacustrine trans gression and were preserved after depression. Analysis of well-dated stratigraphic sequences based on 18 OSL datings combined with multiple index analysis of six sites in the sand hills revealed that the north shoreline of Xingkai Lake retreated in a stepwise fashion since the middle Pleistocene, and that at least four transgressions (during 193-183 ka, 136-130 ka, 24-15 ka and since 3 ka) and three depressions occurred during this process. The results of this study confirmed that transgressive stages were concur- rent with epochs of climate cooling, whereas the period of regression corresponded to the climatic optima. Transgressions and regressions were primarily caused by variations in the intensity of alluvial accumulation in the Ussuri River Valley and fluctuations in regional temperature and humidity that were controlled by climatic change. Moreover, one obvious transgressive process that occurred in MIS3 may have been related to enhanced precipitation that was reportedly widespread in the west of China, while shortterm fluctuations in the lake level might well be a direct response to regional precipitation variations on the millennial scale. | ZHU Yun SHEN Ji LEI GuoLiang WANG Yong | 2011 | Chinese Science Bulletin2011，56，24： | 1 |
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