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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 5 | Screening of subclinical hepatic encephalopathy显示文摘 | Michael Groeneweg Wendy Moerland Juan C Quero Wim C.J Hop Paul F Krabbe Solko W Schalm | 2000 | Journal of Hepatology2000，，5： | 2 |
| 6 | Review of position-sensorless operation of brushless permanent-magnet machines显示文摘 | Paul P A John F W | 2006 | IEEE Transactions on Industrial Electronics2006，53，2： | 1 |
| 7 | Esthesioneuroblastoma:Continued Follow-up of a single Institution' s Experience 显示文摘 | Andrew H James F Paul W | 2006 | Arch Otolaryngol Head Neck Surg2006，132，： | 1 |
| 8 | MCM-48-like large meso- porous silicas with tailored pore structure: facile synthesis domain in a ternary triblock copolymer-butanol-bater sys- tem显示文摘 | Kim T W Kleitz F Paul B | 2005 | Journal of the American Chemical Society2005，127，20： | 1 |
| 9 | An expression profile for diagnosis of lymph node metastase from primary heard and neck squamous cell carcinoma显示文摘 | Paul R Lodewyk F W Nienke K | 2005 | Nat Genet2005，37，2： | 1 |
| 10 | Diagnostic accuracy and reliability of muscle strength and endurance measurements in patients with chronic low back pain显示文摘 | Gruther W Wick F Paul B | 2009 | J R ehabil Med2009，41，8： | 1 |
| 11 | Modernizing the Defined Benefit Pension System显示文摘 | Fabozzi F J Pauling W R | 2005 | The Journal of Portfolio Management2005，31，4： | 1 |
| 12 | Development of a vibrating cassava root harvester显示文摘 | Gupta C P Stevens W F Paul S C | 1999 | Agricultural Mechanization in Asia Africa and Latin America1999，30，1： | 1 |
| 13 | Image segmentation based on the integration of colour-texture descriptors-A review显示文摘 | Dana E I Paul F W | 2011 | (44) :2479 -25012011，，44： | 1 |
| 14 | Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study显示文摘 | Ronenn Roubenoff Helen Parise Hélène A Payette Leslie W Abad Ralph D’Agostino Paul F Jacques Peter W.F Wilson Charles A Dinarello Tamara B Harris | 2003 | The American Journal of Medicine2003，，6： | 1 |
| 15 | Standardisafion of HPLC Techniques for the Determination of Naturally-occurring Folates in Food显示文摘 | PAUL M F KARIN W LIISA V | 1999 | Food Chemistry1999，64，： | 1 |
| 16 | Amelioration of marine farming impact on the benthic environment using artificial reefs as biofilters显示文摘 | GAO Q F PAUL K S XU W Z | 2008 | Marine Pollution Bulletin2008，57，： | 1 |
| 17 | Fast phase-based registration of multimodal image data显示文摘 | Alexander W Paul F | 2009 | Signal Processing2009，89，： | 1 |
| 18 | Why modern controllers can go unstable in practice显示文摘 | Nesline F W Paul Z | 1984 | Journal of Guidance1984，7，4： | 1 |
| 19 | Flow cyto-metric analysis and optimisation for measuring phagocytosis in three Australian freshwater fish 显示文摘 | Andrew J H Kathryn O H Paul F A W | 2006 | Fish Shellfish Immunol2006，，20： | 1 |
| 20 | An expression profile for diagnosis of lymph node metastase from primary head and neck squamous cell carcinoma显示文摘 | PAUL R LODEW YK F W NIENKE K | 2005 | Nat Genet2005，37，2： | 1 |
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