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| 1 | Association-Dissociation of Glycolate Oxidase with Catalase in Rice: A Potential Switch to Modulate Intracellular H2O2 Levels显示文摘在氢过氧化物的快速、动态的变化(H 2 O 2) 层次能用作一个重要信号在植物调整各种各样的生物过程。变化被倾斜在它的生产和清除的率,联系膜的 NADPH oxidases 在被知道起一个关键作用之间的平衡认识到。从 NADPH oxidases 独立地工作, glycolate oxidase (GLO ) 最近为 H 2 O 2 生产在在植物的 gene-for-gene 和非主人抵抗期间。在这研究,我们证明 GLO 身体上在米饭叶子与过氧化氢酶(猫) 交往,并且相互作用能是由水杨酸酸(SA ) 的 deregulated。而且,调停 GLO 的 H 2 O 2 累积被 SA synergistically 提高。在酶建筑群基于底层 channeling 的著名机制,导致 SA 的 H 2 O 2 累积多半源于导致 SA 的 GLO 猫分离。在 GLO 猫复杂、调停 GLO 的 H 2 O 2 生产在 photorespiration 期间很高,而为 H 2 O 2( 测量 K m ≈
43 公里) 是非常地低的。这唯一的联合能进一步加强 H 2 O 2 当 GLO 从猫被分裂时。一起拿,我们建议响应环境应力或刺激, GLO 和猫的物理协会分离似乎用作特定的机制调制 H 2 在米饭的 O 2 层次。 | Zhisheng Zhang Yuanyuan Xu Zongwang Xie Xiangyang Li Zheng-Hui He Xin-Xiang Peng | 2016 | Molecular Plant2016，9，5： | 21 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Starch/polyvinyl alcohol blended materials used as solid carbon source for tertiary denitrification of secondary efuent显示文摘Starch/polyvinyl alcohol(PVA) blended materials for using as a solid carbon source(SCS) were prepared by blending PVA and gelatinized starch in an aqueous solution system, in which PVA served as framework material and starch as carbon source. The optimization of starch content and temperature efects were investigated. It was indicated that higher denitrification efciency could be achieved with more starch in the materials. The average specific denitrification rates were 0.93, 0.66, 0.37 and 0.36 mg/(g·day)corresponding to starch content of 70%, 60%, 40% and 30% respectively at 37°C. The denitrification rates increased when operating temperature was raised from 23°C to 30°C and then 37°C. The mechanism of carbon release was analyzed incorporating the experimental results of abiotic release in deionized water. The organic carbon was mainly hydrolyzed by microbes, and the biological release efciencies were at the range of 89.2% to 96.0%. A long-term experiment with a continuous flow reactor with SCS material containing 70% starch was conducted to gain some experience for practical application. When the influent nitrate concentration was in the range of 35.2 to 39.1 mg/L, hydraulic retention time of 4 hr, and operating temperature of 30°C, a nitrogen removal efciency up to94.6% and denitrification rate of 0.217 kg/(m3·day) was achieved. The starch-based materials developed in this study can be used as a solid carbon source for tertiary nitrogen removal from secondary efuent. | Peng Li Jiane Zuo Wei Xing Lei Tang Xiangyang Ye Zaixing Li Lin Yuan Kaijun Wang Hongtao Zhang | 2013 | Journal of Environmental Sciences2013，25，10： | 11 |
| 4 | Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine)Surface Engineering Strategy显示文摘Stenting is currently the major therapeutic treatment for cardiovascular diseases.However,the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response,thrombogenic reactions,smooth muscle cell hyperproliferation accompanied by the delayed arterial healing,and poor reendothelialization,thus leading to restenosis along with late stent thrombosis.To address prevalence critical problems,we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal(copper)-catechol-(amine)(MCA)surface chemistry strategy,leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface heparinization.Apart from the stable nitric oxide(NO)generating rate at the physiological level(2:2×10^(-10) mol/cm^(2)/min lasting for 60 days),this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to∼1μg/cm^(2),which is considerably higher than most of the conventional heparinized surfaces.The resultant coating could create an ideal microenvironment for bringing in enhanced antithrombogenicity,anti-inflammation,anti-proliferation of smooth muscle cells,re-endothelialization by regulating relevant gene expressions,hence preventing restenosis in vivo.We envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis. | Ying Yang Peng Gao Juan Wang Qiufen Tu Long Bai Kaiqin Xiong Hua Qiu Xin Zhao Manfred FMaitz Huaiyu Wang Xiangyang Li Qiang Zhao Yin Xiao Nan Huang Zhilu Yang | 2020 | Research2020，，1： | 8 |
| 5 | Progress in Automotive Transmission Technology显示文摘Much progress has been made in the development of automotive transmissions over the past 20 years,e.g.,an increased speed number,expanded ratio spread and improved efficiency and shift quality.Automotive transmissions are moving toward electrification in response to stringent legislation on emissions and the pressing demand for better fuel economy.This paper reviews progress in automotive transmission technology.Assisted by computer-aided programs,new transmission schemes are constantly being developed.We therefore first introduce the synthesis of the transmission scheme and parameter optimization.We then discuss the progress in the transmission technology of a conventional internal combustion engine vehicle in terms of new layouts;improved efficiency;noise,vibration and harshness technology;and the shifting strategy and control technology.As the major development trend,transmission electrification is subsequently discussed;this discussion includes the configuration design,energy management strategy,hybrid mode shifting control,single-speed and multi-speed electric vehicle transmission and distributed electric drive.Finally,a summary and outlook are presented for conventional automotive transmissions,hybrid transmissions and electric vehicle transmissions. | Xiangyang Xu Peng Dong Yanfang Liu Hui Zhang | 2018 | Automotive Innovation2018，1，3： | 8 |
| 6 | Microbial community structures in an integrated two-phase anaerobic bioreactor fed by fruit vegetable wastes and wheat straw显示文摘The microbial community structures in an integrated two-phase anaerobic reactor(ITPAR)were investigated by 16S r DNA clone library technology.The 75 L reactor was designed with a 25 L rotating acidogenic unit at the top and a 50 L conventional upflow methanogenic unit at the bottom,with a recirculation connected to the two units.The reactor had been operated for 21 stages to co-digest fruit/vegetable wastes and wheat straw,which showed a very good biogas production and decomposition of cellulosic materials.The results showed that many kinds of cellulose and glycan decomposition bacteria related with Bacteroidales,Clostridiales and Syntrophobacterales were dominated in the reactor,with more bacteria community diversities in the acidogenic unit.The methanogens were mostly related with Methanosaeta,Methanosarcina,Methanoculleus,Methanospirillum and Methanobacterium;the predominating genus Methanosaeta,accounting for 40.5%,54.2%,73.6%and 78.7%in four samples from top to bottom,indicated a major methanogenesis pathway by acetoclastic methanogenesis in the methanogenic unit.The beta diversity indexes illustrated a more similar distribution of bacterial communities than that of methanogens between acidogenic unit and methanogenic unit.The differentiation of methanogenic community composition in two phases,as well as pH values and volatile fatty acid(VFA)concentrations confirmed the phase separation of the ITPAR.Overall,the results of this study demonstrated that the special designing of ITPAR maintained a sufficient number of methanogens,more diverse communities and stronger syntrophic associations among microorganisms,which made two phase anaerobic digestion of cellulosic materials more efficient. | Chong Wang Jiane Zuo Xiaojie Chen Wei Xing Linan Xing Peng Li Xiangyang Lu Chao Li | 2014 | Journal of Environmental Sciences2014，26，12： | 6 |
| 7 | A Robust Gaussian Mixture Model for Mobile Robots’ Vision-based Pose Estimation显示文摘In dynamic environments, the moving landmarks can make the accuracy of traditional vision-based pose estimation worse or even failure. To solve this problem, a robust Gaussian mixture model for vision-based pose estimation is proposed. The motion index is added to the traditional graph-based vision-based pose estimation model to describe landmarks’ moving probability, transforming the classic Gaussian model to Gaussian mixture model, which can reduce the influence of moving landmarks for optimization results. To improve the algorithm’s robustness to noise, the covariance inflation model is employed in residual equations. The expectation maximization method for solving the Gaussian mixture problem is derived in detail, transforming the problem into classic iterative least square problem. Experimental results demonstrate that in dynamic environments, the proposed method outperforms the traditional method both in absolute accuracy and relative accuracy, while maintains high accuracy in static environments. The proposed method can effectively reduce the influence of the moving landmarks in dynamic environments, which is more suitable for the autonomous localization of mobile robots. | Chuanqi CHENG Xiangyang HAO Jiansheng LI Peng HU Xu ZHANG | 2019 | Journal of Geodesy and Geoinformation Science2019，2，3： | 4 |
| 8 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 9 | RUVBL2, a novel AS160-binding protein, regulates insulinstimulated GLUT4 translocation显示文摘在脂肪和肌肉房间,刺激胰岛素的葡萄糖举起被葡萄糖 transporter 主要调停 4 (GLUT4 ) ,哪个到响应胰岛素刺激的房间表面的从细胞内部的分隔空间的 translocates。AS160 是 Akt 的底层之一并且在调整胰岛素的 GLUT4 translocation 起重要作用。在这研究,(RUVBL2 ) 象 RuvB 一样蛋白质 2 用与集体 spectrometry 相结合的哺乳动物的双人脚踏车亲密关系纯化(龙头) 作为新 AS160 有约束力的蛋白质被识别。在 3T3-L1 adipocytes, RUVBL2 高度被表示并且在 cytosol 主要是分布式的。在 adipocytes 的 RUVBL2 的弄空通过减少刺激胰岛素的 AS160 phosphorylation 禁止刺激胰岛素的 GLUT4 translocation 和葡萄糖举起。然而,人的 RUVBL2 的介绍能颠倒这禁止的效果。这些数据建议 RUVBL2 通过它和 AS160 的相互作用在刺激胰岛素的 GLUT4 translocation 起一个重要作用。 | Xiangyang Xie Yu Chen Peng Xue Yong Fan Yongqiang Deng Gong Peng Fuquan Yang Tao Xu | 2009 | Cell Research2009，19，9： | 3 |
| 10 | Recent Advances in Microbial Raw Starch Degrading Enzymes显示文摘 | Haiyan Sun Pingjuan Zhao Xiangyang Ge Yongjun Xia Zhikui Hao Jianwen Liu Ming Peng | 2010 | Applied Biochemistry and Biotechnology2010，，4： | 2 |
| 11 | A Novel Electric Dual Motor Transmission for Heavy Commercial Vehicles显示文摘As a vital vehicle part,the powertrain system is undergoing a fast transition towards electrification.The new integrated electric drive system has been widely used,especially for passenger cars.In this work,a novel electric dual motor transmission is proposed for heavy commercial vehicles.The transmission scheme is firstly introduced,which can achieve 9 different operating modes including 5 single motor modes and 4 dual motor modes.Then,the mode shift map with minimum energy consumption is designed based on the motor efficiency map and the proposed energy management strategy.The driving power is appropriately distributed between the two motors in dual motor modes under the condition of minimum power consumption.In addition,a coordinated control strategy is developed for mode shift control without power interruption.The results show that the electric dual motor transmission has advantages in power consumption and power shift ability compared with the conventional single motor automated manual transmission. | Xiangyang Xu Jiajia Liang Qingjun Hao Peng Dong Shuhan Wang Wei Guo Yanfang Liu Zhonghua Lu Jiantao Geng Bin Yan | 2021 | Automotive Innovation2021，4，1： | 2 |
| 12 | The reflexive and anti-reflexive solutions of the matrix equation AHXB = C 显示文摘 | PENG Xiangyang HU Xiyan ZHANG Lei | 2007 | J Comput Appl Math2007，200，： | 1 |
| 13 | Vehicle routing problems with time windows and stochastic travel and services times:models and algorithm显示文摘 | Li Xiangyang Tian Peng Stephen C H | 2010 | Int J Production Economics2010，125，： | 1 |
| 14 | Geographic Information System in Forestry PraCtices, Problems and Prospects 显示文摘 | Lin Hui Peng Changhui Sun Xiangyang | 2000 | Forestry Studies in China2000，2，1： | 1 |
| 15 | New superhard carbon phases between graphite and diamond显示文摘 | Chaoyu He Lizhong Sun Chunxiao Zhang Xiangyang Peng Kaiwang Zhang Jianxin Zhong | 2012 | Solid State Communications2012，，16： | 1 |
| 16 | The reflexive and anti-reflexive solutions of the matrix equation AHXB=C显示文摘 | Peng Xiangyang Hua Xiyan Zhang Lei | 2007 | Journal of Computational and Applied Mathematics2007，200，： | 1 |
| 17 | Detection of diverse viruses in alimentary specimens of bats in Macao显示文摘Bats carry a variety of viruses, and some of them cause public health problems. Macao, which is famous for its gambling industry, has a complex population structure. The globalization in such an international metropolis has enhanced the chance of disease transmission. Therefore, surveillance of zoonotic viruses is necessary for the early warning of potential emerging infectious diseases.Here, we report the first surveillance of bat viruses in Macao. In this study, we collected 1004 samples involving 10 bat species from 7 sites from April 2015 to May 2016, and examined the presence of viruses using nucleic acid-based methods. Coronaviruses, adenoviruses and paramyxoviruses were detected in these samples, with a high prevalence of coronaviruses. While,none was positive for hepatitis A virus, hepatitis E virus or hantavirus. Co-infections are not common in those bat species, but coronavirus HKU6 and adenovirus can be found commonly occurred in Myotis ricketti. | Jie Liang Xing-Lou Yang Bei Li Qi Liu Qin Zhang Hui Liu Hon-Pio Kan Kai-Chin Wong Si-Nga Chek Xiangyang He Xingwen Peng Zheng-Li Shi Yi Wu Libiao Zhang | 2017 | Virologica Sinica2017，32，3： | 1 |
| 18 | Molecular mechanism underlying the subtype-selectivity of competitive inhibitor NF110 and its distinct potencies in human and rat P2X3 receptors显示文摘P2X receptors are a family of extracellular ATP-gated trimeric cation channels that is widely distributed in human tissues. Quite some drug candidates targeting P2X receptors have entered into preclinical or main phases of clinical trials, but many of them failed due to low subtype-selectivity or species differences in pharmacological activities between human and experimental animals. Here, we identified the distinct inhibitory efficacies of NF110, a competitive inhibitor, between the rat(rP2X3) and human(hP2X3) P2X3 receptors. We demonstrated that this difference is determined by two amino acids located in the dorsal fin(DF) domain of P2X3 receptors. As revealed by mutagenesis, metadynamics, and covalent modification, NF110-mediated rP2X3 inhibition may be through a filling in the cavity formed by the DF,left flipper(LF) and lower body(LB) to partially, rather than fully, occupy the ATP-binding pocket.Moreover, substitution of residues located in the DF and/or LF domains of the rP2X2 receptor, a NF110-insensitive subtype, with the equivalent amino acids of rP2X3, bestowed the sensitivity of rP2X2 to NF110. The critical roles of the DF and LF domains in channel gating of P2X and low conservativity in residue sequences of those two domains raise the possibility that small molecules differentially interacting with the residues of the DF and LF domains of different P2X receptors may modulate channel's activity in a subtype-selective manner. However, the possible species-specificity of P2X inhibitors/modulators makes it more complex when interpreting the preclinical data into clinical researches.Nevertheless, our data provide new insights into the subtype-selectivity of competitive inhibitors and their distinct potencies in the human and experimental animals, both of which are extremely important in the drug discovery of P2X receptors. | Bin Li Jin Wang Xiaoyang Cheng Yan Liu Yang Yang Xiaona Yang Changrun Guod Youya Niu Peng Cao Xiangyang Lu Michael X.Zhu Yun Tian Ye Yu | 2018 | Science Bulletin2018，63，24： | 1 |
| 19 | The reflexive and anti-reflexive solutions of the matrixequation 显示文摘 | Peng Xiangyang Hua Xiyan Zhang Lei | 2007 | Journal of Computational and Applied Mathematics2007，，200： | 1 |
| 20 | Relationship among Mechanical Properties Anisotropy,Microstructure and Texture in AA 6111 Alloy Sheets显示文摘We comparatively studied the mechanical properties anisotropy, microstructure and texture of the commercial and the new developed AA6111 alloys through tensile test, optical microscopy, and XRD analysis. The results show that the anisotropy of mechanical properties for the developed AA6111 alloy is lower than that of the commercial alloy. The developed alloy possesses higher r value, lower Δr value and more uniform microstructure, compared with the commercial AA6111 alloy, indicating that the deep drawability of the developed alloy has been improved significantly. The recrystallization textures of the two alloy sheets are also different. The recrystallization texture of the commercial alloy sheet mainly includes Cube and {114}<311> orientations, while the recrystallization texture of developed alloy sheet consists of Cube, Goss and R orientations. The relationships among the deep drawabilities, microstructure and texture were discussed thereafter. | 汪小锋 郭明星 CAO Lingyong PENG Xiangyang ZHANG Jishan ZHUANG Linzhong | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，3： | 1 |
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