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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | The functional role of mussels in the Oosterschelde Estuary显示文摘 | Smaal A C Vonck W Prins T C | 1990 | J Shellfish Res1990，，9： | 1 |
| 3 | The tomato gene Sw-5 is a member of the coiled coil,nucle- otide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco 显示文摘 | Spassova M L Prins T W Folkertsma R T | 2001 | Mol Breed2001，7，2： | 1 |
| 4 | Biomass gasification in near- and super-critical water: Status and prospects显示文摘 | MASTUMURA Y MINOWA T POTIC B KERSTEN S R A PRINS W | 2005 | Biomass Bioenergy2005，29，10： | 1 |
| 5 | On the relationships between the growth of algae and aquatic macrophyte in brackish显示文摘 | VIERSSEN W V PRINS T C | 1985 | A- quatic Botany1985，21，： | 1 |
| 6 | Optimised padlock probe ligation and microarray detection of multiple (non-authorised) GMOs in a single reaction显示文摘 | Prins T W van Dijk J P Beenen H G | 2008 | BMC Genomics2008，9，： | 1 |
| 7 | Pulmonary hypertension secondary to heart failure with preserved ejection fraction显示文摘 | Thenappan T Prins K W Cogswell R | 2015 | Can J Cardiol2015，31，4： | 1 |
| 8 | The functional role of mussels in the Oosterschelde Estuary显示文摘 | Smaal A C Vonck W Prins T C | 1990 | J Shellfish Res1990，9，2： | 1 |
| 9 | Biomass gasification in near-and super-critical water:Status and prospects显示文摘 | MATSUMURA Y MINOWA T POTIC B KERSTEN S R A PRINS W van SWAA1J W P M van de BELD B ELLIOTT D C NEUENSCHWANDER G G KRUSE A ANTAL M J Jr | 2005 | Biomass Bioenergy2005，29，4： | 1 |
| 10 | Differences in epicuticular wax layer in tulip can influence resis- tance to Botrytis tulipae显示文摘 | LEON-REYES A PRINS T W VAN EMPEL J P M VAN YUYL J M | 2004 | Acta Hort2004，673，： | 1 |
| 11 | The functional role of mussels in the osterschelde estuary 显示文摘 | Smaal A C Vonck W Prins T C | 1989 | J Shellfish Res1989，8，2： | 1 |
| 12 | Radiofre- quency ablation of hepatic metastases from thyroid carcinoma 显示文摘 | Wertenbroek M W Links T P Prins T R | 2008 | Thyroid2008，18，： | 1 |
| 13 | Pooling local expert opinions for estimating mammal densities in tropical rainforests显示文摘 | Van Der HOEVEN C A De BOER W F PRINS H H T | 2004 | J Nat Conserv2004，12，4： | 1 |
| 14 | Optimised padlock probe ligation and microarray detection of muhiple (non-authorised) GMOs in a single reaction显示文摘 | PRINS T W DIJK J P BEENEN H G | 2008 | BMC Genomics2008，9，： | 1 |
| 15 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
| 16 | Predictions of the Al-Rich Region of the Al-Co-Ni-Y System Based upon First-Principles and Experimental Data显示文摘 | Golumbfskie W J Prins S N Eden T J | 2009 | Calphad2009，33，1： | 1 |
| 17 | Optimised padlock probe ligation and micrnarray detection of multiple ( non - author- ised) GMOs in a single reaction显示文摘 | PRINS T W VanDIJK J P BEENEN H G | 2008 | BMC Genomics2008，9，： | 1 |
| 18 | The tomato gene Sw-5 is a member of the coiled coil,nucleotide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco显示文摘 | SPASSOVA M PRINS T W FOLKERTSMA R T | 2001 | Molecular Breeding2001，7，： | 1 |
| 19 | The functional role of mussels in the Oosterschelde Estuary显示文摘 | Smaal A C Vonck W Prins T C | 1990 | J Shellfish Res1990，9，2： | 1 |
| 20 | The tomato gene Sw5 is a member of the coiled coil,nucleotide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco显示文摘 | Spassova M I Prins T W Folkertsma R T Klein-Lankhorst R M Hille J Goldbach R W Prins M | 2001 | Molecular Breeding2001，7，2： | 1 |
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