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| 1 | Blood pressure gradients in cerebral arteries:a clue to pathogenesis of cerebral small vessel disease显示文摘rationale The role of hypertension in cerebral small vessel disease is poorly understood.At the base of the brain(the‘vascular centrencephalon’),short straight arteries transmit blood pressure directly to small resistance vessels;the cerebral convexity is supplied by long arteries with many branches,resulting in a drop in blood pressure.Hypertensive small vessel disease(lipohyalinosis)causes the classically described lacunar infarctions at the base of the brain;however,periventricular white matter intensities(WMIs)seen on MRI and WMI in subcortical areas over the convexity,which are often also called‘lacunes’,probably have different aetiologies.Objectives We studied pressure gradients from proximal to distal regions of the cerebral vasculature by mathematical modelling.Methods and results Blood flow/pressure equations were solved in an Anatomically Detailed Arterial Network(ADAN)model,considering a normotensive and a hypertensive case.Model parameters were suitably modified to account for structural changes in arterial vessels in the hypertensive scenario.Computations predict a marked drop in blood pressure from large and medium-sized cerebral vessels to cerebral peripheral beds.When blood pressure in the brachial artery is 192/113 mm Hg,the pressure in the small arterioles of the posterior parietal artery bed would be only 117/68 mm Hg.In the normotensive case,with blood pressure in the brachial artery of 117/75 mm Hg,the pressure in small parietal arterioles would be only 59/38 mm Hg.conclusion These findings have important implications for understanding small vessel disease.The marked pressure gradient across cerebral arteries should be taken into account when evaluating the pathogenesis of small WMIs on MRI.Hypertensive small vessel disease,affecting the arterioles at the base of the brain should be distinguished from small vessel disease in subcortical regions of the convexity and venous disease in the periventricular white matter. | Pablo J Blanco Lucas O Müller J David Spence | 2017 | Stroke & Vascular Neurology2017，2，3： | 9 |
| 2 | Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial显示文摘 | Jonathan M. Spergel Marc E. Rothenberg Margaret H. Collins Glenn T. Furuta Jonathan E. Markowitz George Fuchs Molly A. O’Gorman Juan Pablo Abonia James Young Timothy Henkel H. Jeffrey Wilkins Chris A. Liacouras | 2012 | The Journal of Allergy and Clinical Immunology2012，，： | 3 |
| 3 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH1 , EGFR , and NF1显示文摘 | Roel G.W. Verhaak Katherine A. Hoadley Elizabeth Purdom Victoria Wang Yuan Qi Matthew D. Wilkerson C. Ryan Miller Li Ding Todd Golub Jill P. Mesirov Gabriele Alexe Michael Lawrence Michael O'Kelly Pablo Tamayo Barbara A. Weir Stacey Gabriel Wendy Winckler | 2010 | Cancer Cell2010，，1： | 2 |
| 4 | Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease显示文摘 | Carlos Jose Pirola Tomas Fernández Gianotti Adriana Laura Burgue?o Manuel Rey-Funes Cesar Fabian Loidl Pablo Mallardi Julio San Martino Gustavo Osvaldo Casta?o S Sookoian | 2013 | Gut2013，，9： | 2 |
| 5 | Sorption studies of Zn (Ⅱ) and Cu (Ⅱ) onto vegetal compost used on reactive mixtures for in situ treatment of acid mine drainage 显示文摘 | Gibert O De Pablo J Cortina J L | 2005 | Water Research2005，39，13： | 1 |
| 6 | Western and Eastern Views on Social Net- works 显示文摘 | Pablos P O D | 2005 | The Learning Organisation2005，，5： | 1 |
| 7 | Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance显示文摘 | Rocío García Garza Pablo Sarobe Juana Merino Juan J. Lasarte Delia D’Avola Virginia Belsue José A. Delgado Leyre Silva Mercedes I?arrairaegui Bruno Sangro Jesus J. Sola Fernando Pardo Jorge Quiroga J. Ignacio Herrero | 2013 | Liver Transpl2013，，9： | 1 |
| 8 | Evaluation of Corn Grain Yield and Water Use Efficiency Using Subsurface Drip Irrigation显示文摘 | R. G. Pablo M. K. O’Neill B. D. McCaslin M. D. Remmenga J. G. Keenan B. M. Onken | 2007 | Journal of Sustainable Agriculture2007，，1： | 1 |
| 9 | A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer显示文摘 | Covadonga Huidobro Rocío G. Urdinguio Ramón María Rodríguez Cristina Mangas Vincenzo Calvanese Pablo Martínez-Camblor Cecilia Ferrero Adolfo Parra-Blanco Luis Rodrigo álvaro J. Obaya Laura Suárez-Fernández Aurora Astudillo Henar Hernando Esteban Ballestar | 2011 | European Journal of Cancer2011，，14： | 1 |
| 10 | The utility of low-cost photogrammetry for stiffness analysis and finite-element validation of wood with knots in bending显示文摘 | Pablo G Juan O | 2013 | Biosystems engineering2013，114，： | 1 |
| 11 | 显示文摘 | Peruzzo Pablo J Anbinder Pab!o S Pardini Oscar R | 2011 | Progress in Organic Coatings2011，，72： | 1 |
| 12 | Measuring and reporting structural capital: Lessons from European learning firms 显示文摘 | PABLOS P O | 2004 | Journal of Intellectual Capital2004，5，4： | 1 |
| 13 | Screening analysis of natural gas with respect to methane content by near-infrared spectrometry显示文摘 | Hebertty V. Dantas Mayara F. Barbosa Elaine C.L. Nascimento Pablo N.T. Moreira Roberto K.H. Galv?o Mário C.U. Araújo | 2014 | Microchemical Journal2014，，： | 1 |
| 14 | Aptamers: molecular tools for analytical applications显示文摘 | Teresa Mairal Veli Cengiz ?zalp Pablo Lozano Sánchez Mònica Mir Ioanis Katakis Ciara K. O’Sullivan | 2008 | Analytical and Bioanalytical Chemistry2008，，4： | 1 |
| 15 | Experimental determination of stress corrosion crack rates and service lives in a buried ERW pipeline显示文摘 | PABLO G F JOSE L O | 2007 | International Journal of Pressure Vessels and Piping2007，84，12： | 1 |
| 16 | Measuring and reporting structural capital: Lessons from European learning firms 显示文摘 | DE PABLOS P O | 2004 | Journal of Intellectual Capital2004，5，4： | 1 |
| 17 | Ruthenium-catal- ysed asymmetric transfer hydrogenation of N-(tert-hu- tanesulfinyl) imines显示文摘 | GUIJARRO D PABLO O YUS M | 2009 | Tetrahedron Lett2009，50，38： | 1 |
| 18 | Evaluation of corn grain yield and water use efficiency using subsurface drip irrigation 显示文摘 | Pablo R G O'Neill M K McCaslin B D | 2007 | Journal of Sustainable Agriculture2007，30，1： | 1 |
| 19 | Safety and feasibility of catheter ablation for atrioventricular nodal re-entrant tachycardia without fluoroscopic guidance显示文摘 | Miguel álvarez Luís Tercedor Isabel Almansa Natalia Ros Ricardo S. Galdeano Francisco Burillo Pablo Santiago Rocío Pe?as | 2009 | Heart Rhythm2009，，12： | 1 |
| 20 | Lateral p-n junctions for high-density LED arrays显示文摘 | Pablo O Vaccaro A Vorobev N | 2003 | Microelectronics Journal2003，34，： | 1 |
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