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1Paleomagnetic data from Early Cretaceous volcanic rocks of West Liaoning:Evidence for intracontinental rotation显示文摘Detailed rock magnetic studies of 55 lavas from Yixian and Fuxin area, West Liaoning, show the primary carriers of remanence to be pseudo-single domain ti-tanomagnetite. K/Ar dating indicates that the volcanic sequence spans 93 to 133 Ma. Stepwise thermal demagnetization successfully isolated well-defined characteristic magnetization (ChRM) in all lavas thermal-treated above 250℃ The mean paleodirections are D/I=5.9°/58.8° (α95 = 2.9°) and D/I =179.2°/-59.9° (α95 = 5.2°) for 27 normally magnetized flows and 28 reversibly magnetized flows, respectively. It indicates that since the Early Cretaceous there is no significant horizontal movement and rotation between the Yixian-Fuxin area and Eurasia. However, Korea Peninsula may have undergone a clockwise rotation of 33.9° relative to the Yixian-Fuxin area during the Cretaceous. On the basis of characteristics of hotspot origins (core-mantle boundary or upper mantle), the clockwise rotation of Korea Peninsula relative to Eurasia is assumed to beZHU Rixiang SHAO Ji’an PAN Yongxin SHI Ruiping SHI Guanghai LI Darning 2002Chinese Science Bulletin2002,47,21:31
2Identification of cytokines involved in hepatic differentiation of mBM-MSCs under liver-injury conditions显示文摘AIM: To identify the key cytokines involved in hepatic differentiation of mouse bone marrow mesenchymal stem cells (mBM-MSCs) under liver-injury conditions. METHODS: Abdominal injection of CCl4 was adopted to duplicate a mouse acute liver injury model. Global gene expression analysis was performed to evaluate the potential genes involved in hepatic commitment under liver-injury conditions. The cytokines involved in hepatic differentiation of mBM-MSCs was function-ally examined by depletion experiment using specifi c antibodies, followed by rescue experiment and direct inducing assay. The hepatic differentiation was characterized by the expression of hepatic lineage genes and proteins, as well as functional features. RESULTS: Cytokines potentially participating in hepatic fate commitment under liver-injury conditions were initially measured by microarray. Among the up-regulated genes determined, 18 cytokines known to closely relate to liver growth, repair and development, were selected for further identif ication. The f ibroblast growth factor-4 (FGF-4), hepatocyte growth factor (HGF) and oncostatin M (OSM) were fi nally found to be involved in hepatic differentiation of mBM-MSCs under liver-injury conditions. Hepatic differentiation could be dramatically decreased after removing FGF-4, HGF and OSM from the liver-injury conditioned medium, and could be rescued by supplementing these cytokines. The FGF-4, HGF and OSM play different roles in the hepatic differentiation of mBM-MSCs, in which FGF-4 and HGF are essential for the initiation of hepatic differentiation, while OSM is critical for the maturation of hepatocytes. CONCLUSION: FGF-4, HGF and OSM are the key cytokines involved in the liver-injury conditioned medium for the hepatic differentiation of mBM-MSCs.Dong, Xue-Jun Zhang, Hui Pan, Ruo-Lang Xiang, Li-Xin Shao, Jian-Zhong 2010World Journal of Gastroenterology2010,16,26:20
3SOIL AGGREGATE AND ITS RESPONSE TO LAND MANAGEMENT PRACTICES显示文摘This paper provides a broad review of the existing study on soil aggregate and its responses to land management practices. Soil aggregate is used for structural unit, which is a group of primary soil particles that cohere to each other more strongly than other surrounding particles. The mechanism of soil particle aggregation may be expressed by a hierarchical model, which is based upon the hypothesis that macroaggregates (>250 μm) are collections of smaller microaggregates (<250 μm) held together with organic binding agents. Primary particles form microaggregates and then macroaggregates. Carbon (C)-rich young plant residues form and stabilize macroaggregates, whereas old organic C is occluded in the microaggregates. The interaction of aggregate dynamics with soil organic carbon (SOC) is complex and embraces a range of spatial and temporal processes within macroaggregates and microaggregates. The nature and properties of aggregates are determined by the quantity and quality of coarse residues and humic compounds and by the degree of their interaction with soil particles. The mechanisms resulting in the binding of primary soil particles into stable aggregates vary with soil parent material, climate, vegetation, and land management practices. Land management prac- tices, including tillage methods, residue management, amendments, and soil fertility management, enhance soil aggre- gation. However, there is still much uncertainty in the dynamics of organic matter in macroaggregation and microaggre- gation, and research is still needed to understand further the mechanisms of aggregate formation and its responses to human activities.Chaofu Wei Ming Gao Jingan Shao Deti Xie Genxing Pan 2006China Particuology2006,4,5:17
4MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ显示文摘Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen 2015Chinese Medical Journal2015,,7:15
5A Cross-sectional Survey Assessing Carriage of Streptococcus pneumoniae in a Healthy Population in Xinjiang Uygur Autonomous Region of China显示文摘链球菌 pneumoniae 的车厢率和 serotype 分发(S。pneumoniae ) 在在中国遗体的一张健康人口不清楚。在这研究,我们在 Xinjiang 从 513 个个人收集了 oropharyngeal 拖把,中国。指向 lytA 基因和 12 serotypes 的实时 PCR 被估计识别 S。pneumoniae 马车。S 的全部的车厢率。pneumoniae 是 70.4%(361/513 ) 。最流行的 serotypes 是 19B/F, 18B/C, 5,并且 6A/B。S 的最高的车厢率。pneumoniae 6-10 年(88.6%) 在孩子被注意,它应得进一步的注意。二的合作殖民率或更多的 S。pneumoniae serotypes 是 79.8%(264/331 ) 。这研究试图在中国在健康个人之中调查基线 pneumococcal 马车率改进我们 S 的传染病学的理解。pneumoniae。XIE Na CHEN Zhao Yun CHEN Tao ZHU Bing Qing XU Li GAO Yuan ZHANG Ai Yu ZHAO Pan LIU Ji Wen SHAO Zhu Jun 2018Biomedical and Environmental Sciences2018,31,3:15
6Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation.Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu 2019Cancer Biology & Medicine2019,16,1:14
7Fine mapping of an incom-plete recessive gene for leaf rolling in rice (Oryza sativa L.)显示文摘Genetic analysis and fine mapping of genes controlling leaf rolling were conducted using two back-crossed generations (BC4F2, BC4F3) derived from a cross between QMX, a non-rolled leaf cultivar as a recurrent par-ent, and JZB, a rolled leaf NIL of ZB as a donor parent. Re-sults indicated that leaf rolling was mainly controlled by an incompletely recessive major gene, namely rl(t), and at the same time, affected by quantitative trait loci (QTLs) and/or the environment. A genetic linkage map was constructed using MAPMAKER/EXP3.0 with eight polymorphic mark-ers on chromosome 2, which were screened by BAS method from 500 SSR markers and 15 newly developed inser-tion/deletion (InDel) markers. The position of rl(t) was esti-mated with composite interval mapping (CIM) method using WinQTLcart2.5. Gene rl(t) was mapped between markers InDel 112 and RM3763, and 1.0 cM away from InDel 112 using 241 plants in BC4F2 population. To fine map rl(t), one BC4F3 line with 855 plants was generated from one semi-rolled leaf plant in BC4F2. Four new polymorphic InDel markers were developed, including InDel 112.6 and InDel 113 located between markers InDel112 and RM3763. Based on the information of recombination offered by 191 rolled leaf plants and 185 non-rolled leaf plants from the BC4F3 line ,we mapped rl(t) to a 137-kb region between markers InDel 112.6 and InDel 113. Homologous gene analysis sug-gested that rl(t) was probably related to the process of leaf development regulated by microRNA.SHAO Yuanjia PAN Cunhong CHEN Zongxiang ZUO Shimin ZHANG Yafang PAN Xuebiao 2005Chinese Science Bulletin2005,50,21:13
8NUMERICAL STUDIES ON THE PROPULSION AND WAKE STRUCTURES OF FINITE-SPAN FLAPPING WINGS WITH DIFFERENT ASPECT RATIOS显示文摘An immersed-boundary method is used to investigate the flapping wings with different aspect ratios ranging from 1 to 5.The numerical results on wake structures and the performance of the propulsion are given.Unlike the case of the two-dimensional flapping foil,the wing-tip vortices appear for the flow past a three-dimensional flapping wing,which makes the wake vortex structures much different.The results show that the leading edge vortex merges into the trailing edge vortex,connects with the wing tip vortices and then sheds from the wing.A vortex ring forms in the wake,and exhibits different patterns for different foil aspect ratios.Analysis of hydrodynamic performances shows that both thrust coefficient and efficiency of the flapping wing increase with increasing aspect ratio.SHAO Xue-ming PAN Ding-yi DENG Jian YUZhao-sheng 2010Journal of Hydrodynamics2010,22,2:12
9Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension显示文摘The hypothalamic paraventricular nucleus(PVN) is a crucial region involved in maintaining homeostasis through the regulation of cardiovascular, neuroendocrine, and other functions. The PVN provides a dominant source of excitatory drive to the sympathetic outflow through innervation of the brainstem and spinal cord in hypertension. We discuss current findings on the role of the PVN in the regulation of sympathetic output in both normotensive and hypertensive conditions. The PVN seems to play a major role in generating the elevated sympathetic vasomotor activity that is characteristic of multiple forms of hypertension, including primary hypertension in humans. Recent studies in the spontaneously hypertensive rat model have revealed an imbalance of inhibitory and excitatory synaptic inputs to PVN presympathetic neurons as indicated by impaired inhibitory and enhanced excitatory synaptic inputs in hypertension.This imbalance of inhibitory and excitatory synaptic inputs in the PVN forms the basis for elevated sympathetic outflow in hypertension. In this review, we discuss the disruption of balance between glutamatergic and GABAergic inputs and the associated cellular and molecular alterations as mechanisms underlying the hyperactivity of PVN pre-sympathetic neurons in hypertension.Jing-Jing Zhou Hui-Jie Ma Jian-Ying Shao Hui-Lin Pan De-Pei Li 2019Neuroscience Bulletin2019,35,1:11
10Experimental comparison between aircraft fuel tank inerting processes using NEA and MIG显示文摘Fuel tank inerting technologies are able to reduce the fire risk by injection of inert gas into the ullage or fuel, the former called ullage washing and the latter fuel scrubbing. The Green On-Board Inert Gas Generation System(GOBIGGS) is a novel technology based on flameless catalytic combustion, and owning to its simple structure and high inerting efficiency, it has received a lot of attentions. The inert gas in the GOBIGGS is mainly comprised of CO_2, N_2, and O_2(hereinafter, Mixed Inert Gas(MIG)), while that in the On-Board Inert Gas Generation System(OBIGGS), which is one of the most widely used fuel tank inerting technologies, is NitrogenEnriched Air(NEA). The solubility of CO_2 is nearly 20 times higher than that of N_2 in jet fuels,so the inerting capability and performance are definitely disparate if the inert gas is selected as NEA or MIG. An inerting test bench was constructed to compare the inerting capabilities between NEA and MIG. Experimental results reveal that, if ullage washing is adopted, the variations of oxygen concentrations on the ullage and in the fuel are nearly identical no matter the inert gas is NEA or MIG. However, the ullage and dissolved oxygen concentrations of MIG scrubbing are always higher than those of NEA scrubbing.Lei SHAO Weihua LIU Chaoyue LI Shiyu FENG Chenchen WANG Jun PAN 2018Chinese Journal of Aeronautics2018,31,7:11
11Early evaluation of growth traits of Larix kaempferi clones显示文摘Early selection is an important method to shorten the breeding cycle for tree species, which may differ in the time for early selection.To evaluate the early selected time for Larix kaempferi, tree height and diameter at breast height of 57 L.kaempferi clones were measured over many different growth years.The results indicated that, except for age × clone interaction for diameter at breast height(P = 0.741), there were significant differences among all variation sources(P < 0.01).The coefficient of phenotypic variation ranged from 14.89 to 35.65%for height and from 19.17 to 23.86% for diameter at breast height in different growth years.The repeatability of height and of diameter at breast height among clones was high,ranging from 0.6181 to 0.8531(height) and from 0.8443 to0.8497(diameter at breast height), in different growth years.There were significant positive correlations between all pairs of growth traits except between height in the 2 nd growth year and height in the 30 th growth year; and between height in the 2 nd growth year × diameter at breast height in the 30 th growth year.With a comprehensive evaluation method and a selection ratio of 10%, L65,L1, L62, L9, L15, and L78 were selected as excellent clones in the 30 th growth year.Their average values of height and diameter at breast height were 9.81 and 16.57%higher than the overall average, representing genetic gains of 6.46 and 13.99%, respectively.This study provides a theoretical foundation for the genetic improvement of L.kaempferi.Yanyan Pan Shuchun Li Chenglu Wang Wenjun Ma Guiyou Xu Lili Shao Kailong Li Xiyang Zhao Tingbo Jiang 2018Journal of Forestry Research2018,29,4:10
12Effect of thermal cycling on the mechanical properties of Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5) alloy显示文摘The effect of thermal cycling treatment on mechanical properties and thermal stability of a Zr41Ti14Cu12.5Ni10Be22.5 bulk metallic glass is investigated.The metallic glassy samples are sealed into quartz tubes under high vacuum condition,and liquid nitrogen together with electric furnace are used to control a periodical temperature variation between 196℃ and 150℃.The structure and properties of the tested samples for different thermal cycles have been examined by X-ray diffraction analysis,mechanical properties measurement and thermal analysis.It has been found that the structure and properties of the samples do not show a significant change even after 200 cycles,which suggests Zr41Ti14Cu12.5Ni10Be22.5 alloy as having potential in aerospace environment.WANG Xin SHAO Yang GONG Pan YAO KeFu 2012Science China(Physics,Mechanics & Astronomy)2012,55,12:10
13Using p53-immunostained large specimens to determine the distal intramural spread margin of rectal cancer显示文摘瞄准:决定直肠的癌症的远侧的内部传播(阴间的神) 边缘。方法:直肠的癌症的 61 个 p53 积极的标本被使用。在染色的常规苏木精和曙红(H&E ) 以后,在大标本的直肠的癌症的 DIS 边缘被免疫组织化学检验。病人被划分成 A, B, C,和 D 组。在长期的后续以后,四个组的幸存曲线用寿命表被估计。结果:61 个盒子(83.6%) 中的 51 个有阴间的神。阴间的神的程度变化了 0.11-3.5 厘米;同时,阴间的神的平均数由染色的 H&E 测量了是 0.13 厘米。有效差量在工具之间被发现(t=5.622, P<0.0001 ) 。仅仅, 51 个病人中的 1 个有比 3 厘米大的阴间的神。阴间的神是在很直肠的癌症病人的不到 1.0 厘米。长期的结果显示其阴间的神比 1.0 厘米大的病人的幸存率比其阴间的神是不到 0.5 厘米的病人的低。结论:有比 1.0 厘米大的阴间的神的直肠的癌症病人有差的预后。Zhi-Zhong Pan De-Sen Wan Chang-Qing Zhang Jian-Yong Shao Li-Ren Li Gong Chen Zhi-Wei Zhou Fu-Long Wang 2006World Journal of Gastroenterology2006,12,10:10
14Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia.Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen 2022Journal of Intensive Medicine2022,2,3:9
15Evaluation of ecological sensitivity in Karamay, Xinjiang, China显示文摘Karamay 城市是一个典型采矿城市,依靠油矿探索和开发。在 60 年建设和开发以后, Karamay 在中国成为了第一个大油矿和国家石油和石油化学的工业的一个重要的底。基于空间分析,和地理信息系统( GIS )格子计算和覆盖技术,虽然考虑油矿开发的效果并且在中国的 Xinjiang Uygur 自治区域瞄准了 Karamay 城市的生态的问题,我们在 Karamay 的全面生态的敏感的空间特征上进行了研究。自然环境进化的生态的问题包括土壤侵蚀,陆地 desertification,土壤 salinization,和生物多样性减小。从在这个区域的人的活动的最重要的骚乱因素是油矿利用。这研究执行单个因素的分析生态的问题敏感和综合生态的敏感。研究的结果如下:(1 ) 土壤侵蚀是相对敏感的,特别在 Karamay 区域, Dushanzi 区域, Urho 区域的北方和 Baijiantan 区域的西方,它主要是垂直落下斜坡的结果。(2 ) 陆地 desertification 的主要类型被高、中等的等级敏感代表,并且高、极其高敏感的区域在 Karamay 和 Baijiantan 区域的交叉是分布式的。这由于在这些区域超过降雨的蒸发,并且土壤主要由沙组成并且是很少由植被盖住。(3 ) 土壤 salinizatiion 敏感等级主要中等、高、极其高。高度敏感的区域主要在 Karamay 区域的 Baijiantan 区域,北方和东方和 Urho 区域的东方的东南被散布。主要原因是超过降雨和极端人的活动的蒸发。(4 ) 生物多样性敏感的主要类型是光和中等等级。高度敏感的区域位于 Karamay 区域的东方和南方, Baiyang 河盆的北方和沼泽地区域的部分。(5 ) 油地发展区域是高度生态地敏感,它位于 Urho 区域, Baijiantan 区域的西方的油矿, Karamay dis trict 的西北的油矿和 Dushanzi 的中央油矿的北油矿区域。(6 ) 综合生态的敏感的主要类型高、中等。高、极其高度敏感的区域位于 Baijiantan 区域的 Karamay 区域,和西南的中央、北的部分。评估结果将为计划的未来和发展提供指导,生态的环境的保护和在 Karamay 的和谐社会、经济、生态的开发的实现城市。PAN Feng TIAN Changyan SHAO Feng ZHOU Wei CHEN Fei 2012Journal of Geographical Sciences2012,22,2:9
16Two new saponins from Anemarrhena asphodeloides Bge.显示文摘Two new saponins 3-O-β-D-glucopyranosyl (1→2)-β-D-mannopyranosyl sarsasapogenin, named timosaponin A IV(1) and (5β, 25S)-26-O-β-D-glucopyranosyl-furost-20(22)-en-3,26-diol-3-O-β-D-glucopyranosyl (1→4) glucopyranosyl (1→2)-β-D-galacopyranoside, named timosaponin B IV(2), were isolated by silica gel column chromatography and preparative HPLC from Anemarrhena asphodeloides Bge. Their structures were elucidated by chemical characters and spectroscopic analysis.Ying Peng Yu Jing Zhang Zhi Qiang Ma Wei San Pan Yu Qing Sun Shao Jiang Song 2007Chinese Chemical Letters2007,18,2:7
17Research advances of SAR remote sensing for agriculture applications: A review显示文摘Synthetic aperture radar(SAR) is an effective and important technique in monitoring crop and other agricultural targets because its quality does not depend on weather conditions. SAR is sensitive to the geometrical structures and dielectric properties of the targets and has a certain penetration ability to some agricultural targets. The capabilities of SAR for agriculture applications can be organized into three main categories: crop identification and crop planting area statistics, crop and cropland parameter extraction, and crop yield estimation. According to the above concepts, this paper systematically analyses the recent progresses, existing problems and future directions in SAR agricultural remote sensing. In recent years, with the remarkable progresses in SAR remote sensing systems, the available SAR data sources have been greatly enriched. The accuracies of the crop classification and parameter extraction by SAR data have been improved progressively. But the development of modern agriculture has put forwarded higher requirements for SAR remote sensing. For instance, the spatial resolution and revisiting cycle of the SAR sensors, the accuracy of crop classification, the whole phenological period monitoring of crop growth status, the soil moisture inversion under the condition of high vegetation coverage, the integrations of SAR remote sensing retrieval information with hydrological models and/or crop growth models, and so on, still need to be improved. In the future, the joint use of optical and SAR remote sensing data, the application of multi-band multi-dimensional SAR, the precise and high efficient modeling of electromagnetic scattering and parameter extraction of crop and farmland composite scene, the development of light and small SAR systems like those onboard unmanned aerial vehicles and their applications will be active research areas in agriculture remote sensing. This paper concludes that SAR remote sensing has great potential and will play a more significant role in the various fields of agricultural remote sensing.LIU Chang-an CHEN Zhong-xin SHAO Yun CHEN Jin-song Tuya Hasi PAN Hai-zhu 2019Journal of Integrative Agriculture2019,18,3:7
18Simple fabrication of superhydrophobic PLA with honeycomb-like structures for high-efficiency oil-water separation显示文摘Polylactic acid(PLA) is one of the most suitable candidates for environmental pollution treatment because of its biodegradability which will not cause secondary pollution to the environment after application.However,there is still a lack of a green and facile way to prepare PLA oil-water separation materials.In this work,a water-assisted thermally induced phase separation method for the preparation of superhydrophobic PLA oil-water separation material with honeycomb-like structures is reported.The PLA material shows great ability in application and could adsorb 27.3 times oil to its own weight.In addition,it could also be applicated as a filter with excellent efficiency(50.9 m^3 m^(-2) h^(-1)).Xiaolong Wang Yamin Pan Huan Yuan Meng Su Chunguang Shao Chuntai Liu Zhanhu Guo Changyu Shen Xianhu Liu 2020Chinese Chemical Letters2020,31,2:7
19Histone Deacetylase HDA9 and WRKY53 Transcription Factor Are Mutual Antagonists in Regulation of Plant Stress Response显示文摘Epigenetic regulation of gene expression is important for plant adaptation to environm ental changes.Previous results showed that Arabidopsis RPD3-like histone deacetylase HDA9 is known to function in repressing plant response to stress in Arabidopsis.However,how HDA9 targets to specific chromatin loci and controls gene expression netw orks involved in plant response to stress remains largely unclear.Here,we show that HDA9 represses stress tolerance response by interacting with and regulating the DNA binding and transcriptional activity of WRKY53,which functions as a high-hierarchy positive regulator of stress response.We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites,some of which are removed by HDA9,resulting in inhibition of WRKY53 transcription activity.Conversely,WRKY53 negatively regulates HDA9 histone deacetylase activity.Collectively,our results indicate that HDA9 and WRK53 are reciprocal negative regulators of each other's activities,illustrating how the functional interplay between a chromatin regulator and a transcription factor regulates stress tolerance in plants.Yu Zheng Jingyu Ge Chun Bao Wenwen Chang Jingjing Liu Jingjie Shao Xiaoyun Liu Lufang Su Lei Pan Dao-Xiu Zhou 2020Molecular Plant2020,13,4:6
20Ti-Zr-Be-Fe quaternary bulk metallic glasses designed by Fe alloying显示文摘A series of Ti-Zr-Be-Fe bulk metallic glasses(BMGs)with good glass-forming ability(GFA)and high specific strength have been developed.With different alloying routes and content of Fe,it is found that these alloys exhibit different GFA and mechanical properties.The effects of Fe addition on the GFA and mechanical properties of Ti-Zr-Be alloy are systemically investigated.The possible mechanisms for the improvement or damage to the GFA by addition of Fe can be interpreted in view of the mixing enthalpy,atomic size differences and electronegativity differences of the alloys,while the mechanical properties strongly depend on the Poisson’s ratio and free volume concentration.The experimental results also show that alloying technology is an effective method to improve the GFA and mechanical properties of Ti-Zr-Be glassy alloy.GONG Pan WANG Xin SHAO Yang CHEN Na YAO KeFu 2013Science China(Physics,Mechanics & Astronomy)2013,56,11:6
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