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| 1 | Prospect of the QTL-qSB-9^(Tq) utilized in molecular breeding program of japonica rice against sheath blight显示文摘The major QTL-qSB-9Tq conferring partial resistance to rice (Oryza sativa L.) sheath blight (Rhizoctonia solani Kühn) has been verified on chromosome 9 of the indica rice cultivar, Teqing. In this study, the prospect of this QTL utilized in molecular breeding program of japonica rice for sheath blight resistance was investigated. Most of the japonica rice cultivars showed lower level of sheath blight resistance than the indica rice cultivars. At the corresponding site of qSB-9Tq, nine typical japonica rice cultivars from different ecological regions or countries proved to possess the susceptible allele(s). Introgression of qSB-9Tq into these cultivars enhanced their resistance level by decreasing sheath blight score of 1.0 (0.5–1.3), which indicated that qSB-9Tq had a large potential in strengthening the resistance of japonica rice to sheath blight. The use of the three molecular markers, which were polymorphic between Teqing and many japonica rice cultivars, promotes the application of qSB-9Tq in a concrete molecular breeding program. | Shimin Zuo Li Zhang Hui Wang Yuejun Yin Yafang Zhang Zongxiang Chen Yuyin Ma Xuebiao Pan | 2008 | Journal of Genetics and Genomics2008，35，8： | 14 |
| 2 | From MONEX to the Global Monsoon:A Review of Monsoon System Research显示文摘Substantial progress has been made over the past three decades since the Monsoon Experiments(MONEX) of 1978–79. Here, we review these achievements by highlighting four breakthroughs in monsoon research:(1) The identification of the coupled ocean–land–atmosphere nature of the monsoon in the process of the annual cycle of solar heating;(2) new understanding of the changes in the driving forces of monsoon systems, with anthropogenic factors(climate effects of increased greenhouse gas and aerosol emissions) playing an important role in the regulation of monsoons;(3) detection of the interdecadal- and centennial-scale variability of monsoon systems, and its attribution to the combined impact of global warming and natural(especially oceanic) effects; and(4) the emerging concept of the global monsoon and its long-term variation under the impact of global climate change. All the observational and model-derived evidence demonstrates that the monsoon system, as an important component of the global climate system, has already changed and will continue to change in the future. This picture of an evolving monsoon system poses great challenges for near-term prediction and long-term projection. | DING Yihui LIU Yanju SONG Yafang ZHANG Jin | 2015 | Advances in Atmospheric Sciences2015，32，1： | 14 |
| 3 | Fine mapping of an incom-plete recessive gene for leaf rolling in rice (Oryza sativa L.)显示文摘Genetic analysis and fine mapping of genes controlling leaf rolling were conducted using two back-crossed generations (BC4F2, BC4F3) derived from a cross between QMX, a non-rolled leaf cultivar as a recurrent par-ent, and JZB, a rolled leaf NIL of ZB as a donor parent. Re-sults indicated that leaf rolling was mainly controlled by an incompletely recessive major gene, namely rl(t), and at the same time, affected by quantitative trait loci (QTLs) and/or the environment. A genetic linkage map was constructed using MAPMAKER/EXP3.0 with eight polymorphic mark-ers on chromosome 2, which were screened by BAS method from 500 SSR markers and 15 newly developed inser-tion/deletion (InDel) markers. The position of rl(t) was esti-mated with composite interval mapping (CIM) method using WinQTLcart2.5. Gene rl(t) was mapped between markers InDel 112 and RM3763, and 1.0 cM away from InDel 112 using 241 plants in BC4F2 population. To fine map rl(t), one BC4F3 line with 855 plants was generated from one semi-rolled leaf plant in BC4F2. Four new polymorphic InDel markers were developed, including InDel 112.6 and InDel 113 located between markers InDel112 and RM3763. Based on the information of recombination offered by 191 rolled leaf plants and 185 non-rolled leaf plants from the BC4F3 line ,we mapped rl(t) to a 137-kb region between markers InDel 112.6 and InDel 113. Homologous gene analysis sug-gested that rl(t) was probably related to the process of leaf development regulated by microRNA. | SHAO Yuanjia PAN Cunhong CHEN Zongxiang ZUO Shimin ZHANG Yafang PAN Xuebiao | 2005 | Chinese Science Bulletin2005，50，21： | 13 |
| 4 | Chemical characteristics of size-resolved aerosols in winter in Beijing显示文摘Size-resolved aerosols were continuously collected by a Nano Sampler for 13 days at an urban site in Beijing during winter 2012 to measure the chemical composition of ambient aerosol particles. Data collected by the Nano Sampler and an ACSM(Aerodyne Aerosol Chemical Speciation Monitor) were compared. Between the data sets,similar trends and strong correlations were observed,demonstrating the validity of the Nano Sampler. PM10 and PM2.5concentrations during the measurement were 150.5 ± 96.0 μg/m3(mean ± standard variation)and 106.9 ± 71.6 μg/m3,respectively. The PM2.5/PM10 ratio was 0.70 ± 0.10,indicating that PM2.5dominated PM10. The aerosol size distributions showed that three size bins of 0.5–1,1–2.5 and 2.5–10 μm contributed 21.8%,23.3% and 26.0% to the total mass concentration(TMC),respectively. OM(organic matter) and SIA(secondary ionic aerosol,mainly SO42-,NO3-and NH4+) were major components of PM2.5. Secondary compounds(SIA and secondary organic carbon) accounted for half of TMC(about 49.8%) in PM2.5,and suggested that secondary aerosols significantly contributed to the serious particulate matter pollution observed in winter. Coal burning,biomass combustion,vehicle emissions and SIA were found to be the main sources of PM2.5. Mass concentrations of water-soluble ions and undetected materials,as well as their fractions in TMC,strikingly increased with deteriorating particle pollution conditions,while OM and EC(elemental carbon) exhibited different variations,with mass concentrations slightly increasing but fractions in TMC decreasing. | Kang Sun Yu Qu Qiong Wu Tingting Han Jianwei Gu Jingjing Zhao Yele Sun Qi Jiang Ziqi Gao Min Hu Yuanhang Zhang Keding Lu Stephan Nordmann Yafang Cheng Li Hou Hui Ge Masami Furuuchi Mitsuhiko Hata Xingang Liu | 2014 | Journal of Environmental Sciences2014，26，8： | 9 |
| 5 | Daytime HONO formation in the suburban area of the megacity Beijing, China显示文摘Nitrous acid(HONO),as a primary precursor of OH radicals,has been considered one of the most important nitrogencontaining species in the atmosphere.Up to 30%of primary OH radical production is attributed to the photolysis of HONO.However,the major HONO formation mechanisms are still under discussion.During the Campaigns of Air Quality Research in Beijing and Surrounding Region(CAREBeijing2006)campaign,comprehensive measurements were carried out in the megacity Beijing,where the chemical budget of HONO was fully constrained.The average diurnal HONO concentration varied from 0.33 to 1.2 ppbv.The net OH production rate from HONO,POH(HONO)net,was on average(from 05:00 to 19:00)7.1×106 molecule/(cm3 s),2.7 times higher than from O3 photolysis.This production rate demonstrates the important role of HONO in the atmospheric chemistry of megacity Beijing.An unknown HONO source(Punknown)with an average of 7.3×106molecule/(cm3 s)was derived from the budget analysis during daytime.Punknown provided four times more HONO than the reaction of NO with OH did.The diurnal variation of Punknown showed an apparent photo-enhanced feature with a maximum around 12:00,which was consistent with previous studies at forest and rural sites.Laboratory studies proposed new mechanisms to recruit NO2 and J(NO2)in order to explain a photo-enhancement of of Punknown.In this study,these mechanisms were validated against the observation-constraint Punknown.The reaction of exited NO2 accounted for only 6%of Punknown,and Punknown poorly correlated with[NO2](R=0.26)and J(NO2)[NO2](R=0.35).These results challenged the role of NO2 as a major precursor of the missing HONO source. | YANG Qiang SU Hang LI Xin CHENG YaFang LU KeDing CHENG Peng GU JianWei GUO Song HU Min ZENG LiMin ZHU Tong ZHANG YuanHang | 2014 | Science China Chemistry2014，57，7： | 8 |
| 6 | An online monitoring system for atmospheric nitrous acid(HONO) based on stripping coil and ion chromatography显示文摘A new instrument for measuring atmospheric nitrous acid(HONO) was developed,consisting of a double-wall glass stripping coil sampler coupled with ion chromatography(SC-IC).SC-IC is featured by small size(50 × 35 × 25 cm) and modular construction,including three independent parts:the sampling unit,the transfer and supporting unit,and the detection unit.High collection efficiency(> 99%) was achieved with 25 μmol/L Na2CO3 as absorption solution even in the presence of highly acidic compounds.This instrument has a detection limit of 8 pptv at 15 min time resolution,with a measurement uncertainty of 7%.Potential interferences from NOx,NO2+SO2,NO2+VOCs,HONO+O3,HNO3,peroxyacetyl nitrite(PAN) and particle nitrite were quantified in laboratory studies and were found to be insignificant under typical atmospheric conditions.Within the framework of the 3C-STAR project,inter-comparison between the SC-IC and LOPAP(long path liquid absorption photometer) was conducted at a rural site in the Pearl River Delta.Good agreement was achieved between the two instruments over three weeks.Both instruments determined a clear diurnal profile of ambient HONO concentrations from 0.1 to 2.5 ppbv.However,deviations were found for low ambient HONO concentrations(i.e.< 0.3 ppbv),which cannot be explained by previous investigated interference species.To accurately determine the HONO budget under illuminated conditions,more intercomparison of HONO measurement techniques is still needed in future studies,especially at low HONO concentrations. | Peng Cheng Yafang Cheng Keding Lu Hang Su Qiang Yang Yikan Zou Yanran Zhao Huabing Dong Limin Zeng Yuanhang Zhang | 2013 | Journal of Environmental Sciences2013，25，5： | 5 |
| 7 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 8 | Isolation and characterization of rl_(t), a gene that controls leaf rolling in rice显示文摘Moderate leaf rolling is one of the most important morphological traits in rice breeding for plant ideotype.Previous studies have shown that the rl(t)gene has a high breeding potential for developing hybrid-rice varieties with an ideal ideotype,because it leads to an appropriate leaf rolling index(LRI)of about 30%in the heterozygous state,and had a positive effect on grain yield.In this study,we isolated rl(t)and performed a preliminary investigation of its function in regulating leaf rolling in rice.DNA sequencing identified a single base change(G to T)in the finely mapped region(11 kb)containing rl(t),and this is located in 30-untranslated region(30-UTR)of the only predicted gene,Roc5(Rice outermost cell-specific).The expression level of Roc5 is significantly higher in the rl(t)mutant than in the wild-type.Using RNAi and overexpression analysis,we found that the expression level of Roc5 correlated with LRI and leaf bulliform area,and wasalso associated with leaf abaxial or adaxial rolling.These results confirmed that Roc5 controls leaf rolling in a dosage-dependent manner.Bioinformatics analysis revealed a conserved 17-nt sequence(called the GU-rich element)in the 30-UTR of HD-GL2(Homeodomain-Glabra2)family genes including Roc5.Based on the model of this element in regulating mRNA stability in mammals,we speculate that the single nucleotide change in this element accounts for the higher expression level of Roc5 in the rl(t)mutant compared to the wild-type,which ultimately leads to adaxial rolling of the leaf.This discovery further enhances our knowledge of the molecular mechanisms underlying leaf rolling in rice. | Lei Li Xiang Xue Zongxiang Chen Yafang Zhang Yuyin Ma Cunhong Pan Junkai Zhu Xuebiao Pan Shimin Zuo | 2014 | Chinese Science Bulletin2014，59，25： | 4 |
| 9 | Adjusting the SnZn defects in Cu_(2)ZnSn(S,Se)_(4) absorber layer via Ge^(4+) implanting for efficient kesterite solar cells显示文摘The development of kesterite photovoltaic solar cells has been hindered by large open-circuit voltage(V_(oc))deficit.Recently,Snzn deep point defect and associative defect cluster have been recognized as the main culprit for the Voc losses.Therefore,manipulating the deep-level donor of Snzn antisite defects is crucial for breaking through the bottleneck of present Cu_(2) ZnSn(S,Se)_(4)(CZTSSe)photovoltaic technology.In this study,the Snzn deep traps in CZTSSe absorber layer are suppressed by incorporation of Ge.The energy levels and concentration of Snzn defects measured by deep-level transient spectroscopy(DLTS)decrease significantly.In addition,the grain growth of CZTSSe films is also promoted due to Ge implantation,yielding the high quality absorber layer.Consequently,the efficiency of CZTSSe solar cells increases from 9.15%to 11.48%,largely attributed to the 41 mV Voc increment. | Yueqing Deng Zhengji Zhou Xin Zhang Lei Cao Wenhui Zhou Dongxing Kou Yafang Qi Shengjie Yuan Zhi Zheng Sixin Wu | 2021 | Journal of Energy Chemistry2021，30，10： | 4 |
| 10 | Synthesis of gold/rare-earth-vanadate core/shell nanorods for integrating plasmon resonance and fluorescence显示文摘nanoscale 核心 / 壳 heterostructure 是一个特别地有效的主题联合 plasmonic 材料和稀土元素的混合物的有希望的性质;然而,在那里由于在这二内在地无敌的材料之间的大界面的精力在合成控制仍然是重要挑战。此处,我们报导种 rare-earth-vanadate 的一条合成线路在金 nanorod (AuNR ) 上轰炸核心。在通过表面活化剂交换与油酸盐修改 AuNR 表面以后,包装得好的稀土元素的氧化物(例如, Gd 2 O 3:Eu) 壳由于油酸盐的多重角色在 AuNRs 上被种。而且,壳的作文从氧化物被改变了到 vanadate (用一个阴离子交换方法的 GdVO 4:Eu) 。由于小心地设计的策略, AuNR 核心在合成过程期间维持形态学;因此,最后的 Au/GdVO 4:Eu 核心 / 壳 NR 展出强壮的吸收乐队和高 photothermal 效率。另外, Au/GdVO 4:Eu NR 象 ~ 一样高与量产量展出明亮的 Eu 3+ 荧光 17% ;明亮的 Sm 3+ 和 Dy 3+ 荧光能被改变在氧化物形成做的 lanthanide 也获得。由于 plasmonic 和荧光性质的吸引人的集成,如此的核心 / 壳 heterostructures 将在区域的一个宽数组发现特别应用,从 biomedicine 到精力。 | Jiahong Wang Hao Huang Daquan Zhang Ming Chen Yafang Zhang Xuefeng Yu Li Zhou Ququan wang | 2015 | Nano Research2015，8，8： | 4 |
| 11 | FRACTURAL PROCESS AND TOUGHENING MECHANISM OF LAMINATED CERAMIC COMPOSITES显示文摘基于多层的横梁的模型和假设材料微不同类,把压成薄片的陶器的 composites 的 3D fractural 特征与数字模拟被学习了。在三点的弯曲负担下面,击碎开始,结合,繁殖,调节离开在弱接口和期末考试,破裂被模仿了。声学的排放的空间分发和进化过程也在纸被介绍。模拟验证导致裂缝在那里膨胀并且吸收 fractural 精力的弱接口的主要机制。因此,力量的效果和坚韧上的材料的性质的纪律意义在这篇论文被讨论。 | Zhang Yafang Tang Chun'an Zhang Yongbin Liang Zhenzao | 2007 | Acta Mechanica Solida Sinica2007，20，2： | 3 |
| 12 | Dynamic mechanical loading facilitated chondrogenic differentiation of rabbit BMSCs in collagen scaffolds显示文摘Mechanical signals have been played close attention to regulate chondrogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).In this study,dynamic mechanical loading simulation with natural frequencies and intensities were applied to the 3D cultured BMSCs–collagen scaffold constructs.We investigated the effects of dynamic mechanical loading on cell adhesion,uniform distribution,proliferation,secretion of extracellular matrix(ECM)and chondrogenic differentiation of BMSCs–collagen scaffold constructs.The results indicated that dynamic mechanical loading facilitated the BMSCs adhesion,uniform distribution,proliferation and secretion of ECM with a slight contraction,which significantly improved the mechanical strength of the BMSCs–collagen scaffold constructs for better mimicking the structure and function of a native cartilage.Gene expression results indicated that dynamic mechanical loading contributed to the chondrogenic differentiation of BMSCs with higher levels of AGG,COL2A1 and SOX9 genes,and prevented of hypertrophic process with lower levels of COL10A1,and reduced the possibility of fibrocartilage formation due to down-regulated COL1A2.In conclusion,this study emphasized the important role of dynamic mechanical loading on promoting BMSCs chondrogenic differentiation and maintaining the cartilage phenotype for in vitro reconstruction of tissue-engineered cartilage,which provided an attractive prospect and a feasibility strategy for cartilage repair. | Wanxu Cao Weimin Lin Hanxu Cai Yafang Chen Yi Man Jie Liang Qiguang Wang Yong Sun Yujiang Fan Xingdong Zhang | 2019 | Regenerative Biomaterials2019，6，2： | 3 |
| 13 | Advances in Research of Green Tea Polyphenols in Drug Development显示文摘This paper elaborated the chemical components,biological metabolism,and progress in the field of drug development of green tea polyphenols,mainly in the prevention and treatment of cancer,neurodegenerative diseases,and diabetes.The potential anti-tumor activity of tea polyphenols can be achieved through intervening in various stages of tumor generation,development,and metastasis.However,the development of tea polyphenols as a therapeutic drug still faces many challenges,such as low bioavailability.Nanoparticle-based drug delivery systems have particular advantages over the simple tea polyphenols.Since there are emerging safety issues and potential local drug overdose effects,it is necessary to determine the actual dosage and pharmacological mechanism of the drug after encapsulating the nanoparticles. | Mu ZHANG Erqin DAI Yafang ZHANG Yajun YU Xinqiang SONG | 2020 | Medicinal Plant2020，11，4： | 3 |
| 14 | Identification of New Resistance Loci Against Sheath Blight Disease in Rice Through Genome-Wide Association Study显示文摘Sheath blight(SB) caused by the soil borne pathogen Rhizoctonia solani is one of the most serious global rice diseases. Breeding resistant cultivar is the most economical and effective strategy to control the disease. However, no rice varieties are completely resistant to SB, and only a few reliable quantitative trait loci(QTLs) linked with SB resistance have been identified to date. In this study, we conducted a genome-wide association study(GWAS) of SB resistance using 299 varieties from the rice diversity panel 1(RDP1) that were genotyped using 44 000 high-density single nucleotide polymorphism(SNP) markers. Through artificial inoculation, we found that only 36.5% of the tested varieties displayed resistance or moderate resistance to SB. In particular, the aromatic and aus sub-populations displayed higher SB resistance than the tropical japonica(TRJ), indica and temperate japonica sub-populations. Seven varieties showed similar resistance levels to the resistant control YSBR1. GWAS identified at least 11 SNP loci significantly associated with SB resistance in the three independent trials, leading to the identification of two reliable QTLs, qSB-3 and qSB-6, on chromosomes 3 and 6. Using favorable alleles or haplotypes of significantly associated SNP loci, we estimated that both QTLs had obvious effects on reducing SB disease severity and can be used for enhancing SB resistance, especially in improving SB resistance of TRJ sub-population rice varieties. These results provided important information and genetic materials for developing SB resistant varieties through breeding. | CHEN Zongxiang FENG Zhiming KANG Houxiang ZHAO Jianhua CHEN Tianxiao LI Qianqian GONG Hongbing ZHANG Yafang CHEN Xijun PAN Xuebiao LIU Wende WANG Guoliang ZUO Shimin | 2019 | Rice science2019，26，1： | 3 |
| 15 | Effect of SF6 on Ozone Generation Using Dielectric Barrier Discharge显示文摘The influence mechanism of a small amount of SF6 on ozone generation in oxygen or air discharge is investigated.Some results are obtained by probing into the number of the high-energy electrons,which have the sufficiency energy for generating ozone.Introducing a small amount of SF6 into oxygen sharply decreases the number of high-energy electrons,because the electron density decreases sharply while the mean electron energy remains constant due to higher breakdown voltage and lower discharge power,and some high-energy electrons are consumed by the excitation and attachment of SF6.In contrast,when a small amount of SF6 is added into dry air discharge,despite the consumption of the excitation and attachment of SF6,the number of high energy electrons increases sharply,which is attributed to the higher mean electron energy and electron density resulted from higher breakdown voltage and discharge power.When the volume fraction of SF6 increases from 0 to 2.22%,the ozone mass concentration and the ozone yield increase by 45.7% and 29.7%,respectively.Therefore,though the oxygen source should avoid the presence of SF6,adding a small amount of SF6 can improve the ozone mass concentration and the efficiency of ozone generation. | WEI Linsheng DONG Guopan ZHANG Yafang YUAN Dingkun HU Zhaoji FU Chunyi | 2013 | 高电压技术2013，39，10： | 2 |
| 16 | Visualizing DC morphology and T cell motility to characterize DC-T cell encounters in mouse lymph nodes under mTOR inhibition显示文摘Mammalian target of rapamycin(mTOR),a serine/threonine kinase orchestrating cellular metabolism,is a crucial immune system regulator.However,it remains unclear how mTOR regulates dendritic cell(DC) function in vivo,especially DC-T cell encounters,a critical step for initiating adaptive immune responses.We dynamically visualized DC-T contacts in mouse lymph node using confocal microscopy and established an encounter model to characterize the effect of mTOR inhibition on DC-T cell encounters using DC morphology.Quantitative data showed mTOR inhibition via rapamycin altered DC shape,with an increased form factor(30.17%) and decreased cellular surface area(20.36%) and perimeter(22.43%),which were associated with Cdc42 protein downregulation(52.71%).Additionally,DCs adopted a similar morphological change with Cdc42 inhibition via ZCL278 as that observed with mTOR inhibition.These morphologically altered DCs displayed low encounter rates with T cells.Time-lapse imaging data of T cell motility supported the simulated result of the encounter model,where antigen-specific T cells appeared to reduce arrest in the lymph nodes of rapamycin-pretreated mice relative to the untreated group.Therefore,mTOR inhibition altered DC morphology in vivo and decreased the DC-T cell encounter rate,as well as Cdc42 inhibition.By establishing an encounter model,our study provides an intuitive approach for the early prediction of DC function through morphological quantification of form factor and area. | Qiaoya Lin Zheng Liu Meijie Luo Hao Zheng Sha Qiao Chenlu Han Deqiang Deng Zhan Fan Yafang Lu Zhihong Zhang Qingming Luo | 2019 | Science China(Life Sciences)2019，62，9： | 2 |
| 17 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 18 | Light-induced variation in environmentally persistent free radicals and the generation of reactive radical species in humic substances显示文摘Environmentally persistent free radicals(EPFRs)in humic substances play an essential role in soil geochemical processes.Light is known to induce EPFRs formation for dissolved organic matter in aquatic environments;however,the impacts of light irradiation on the variation of EPFRs in soil humic substances remain unclear.In this study,humic acid,fulvic acid,and humin were extracted from peat soil and then in situ irradiated using simulated sunlight.Electron paramagnetic resonance spectroscopy results showed that with the increasing irradiation time,the spin densities and g-factors of humic substances rapidly increased during the initial 20 min and then gradually reached a plateau.After irradiation for 2h,the maximum spin density levels were up to 1.63×10^17,2.06×10^17,and 1.77×10^×10^17 spins/g for the humic acid,fulvic acid,and humin,respectively.And the superoxide radicals increased to 1.05×10^l4-1.46×10^14spins/g while the alkyl radicals increased to 0.47×10^14-1.76×10^14 spins/g.The light-induced EPFRs were relatively unstable and readily returned back to their original state under dark and oxic conditions.Significant positive correlations were observed between the concentrations of EPFRs and reactive radical species(R2=0.65-0.98,/?<0.05),which suggested that the newly produced EPFRs contributed to the formation of reactive radical species.Our findings indicate that under the irradiation humic substances are likely to be more toxic and reactive in soil due to the formation of EPFRs. | Yafang Shi Yunchao Dai Ziwen Liu Xiaofeng Nie Song Zhao Chi Zhang Hanzhong Jia | 2020 | Frontiers of Environmental Science & Engineering2020，14，6： | 2 |
| 19 | Monoclinic BiVO 4 micro-/nanostructures: Microwave and ultrasonic wave combined synthesis and their visible-light photocatalytic activities显示文摘 | Yafang Zhang Guangfang Li Xiaohui Yang Hao Yang Zhong Lu Rong Chen | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 20 | Krüppel‐like factor 8 contributes to hypoxia‐induced MDR in gastric cancer cells显示文摘 | Hui Zhang Li Sun Xiao Xiao Rougang Xie Changhao Liu Yafang Wang Yanling Wei Hongbo Zhang Lili Liu | 2014 | Cancer Sci2014，，9： | 1 |
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