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| 1 | Genomic landscape of gastric cancer: molecular classification and potential targets显示文摘Gastric cancer imposes a considerable health burden worldwide, and its mortality ranks as the second highest for all types of cancers. The limited knowledge of the molecular mechanisms underlying gastric cancer tumorigenesis hinders the development of therapeutic strategies. However, ongoing collaborative sequencing efforts facilitate molecular classification and unveil the genomic landscape of gastric cancer. Several new drivers and tumorigenic pathways in gastric cancer, including chromatin remodeling genes, Rho A-related pathways, TP53 dysregulation, activation of receptor tyrosine kinases, stem cell pathways and abnormal DNA methylation, have been revealed. These newly identified genomic alterations await translation into clinical diagnosis and targeted therapies. Considering that loss-of-function mutations are intractable, synthetic lethality could be employed when discussing feasible therapeutic strategies. Although many challenges remain to be tackled, we are optimistic regarding improvements in the prognosis and treatment of gastric cancer in the near future. | Jiawei Guo Weiwei Yu Hui Su Xiufeng Pang | 2017 | Science China(Life Sciences)2017，60，2： | 6 |
| 2 | Strategies to improve electrochemical performances of pristine metal‐organic frameworks‐based electrodes for lithium/sodium‐ion batteries显示文摘Metal‐organic frameworks(MOFs)have attracted considerable attention as promising next‐generation active electrode materials for lithium‐ion batteries(LIBs)or sodium‐ion batteries(SIBs)because of ultrahigh specific surface area,uniformly distributed pores,and tunable structure.However,there are some disadvantages inevitably far from meeting commercial requirements,such as low conductivity,inconvenient electron transmission,and unsatisfactory circulation stability.In this review,a comprehensive summary of MOFs‐based electrode materials is presented and discussed.First,the general Li^(^(+))/Na^(+)storage mechanism in MOFs‐based electrode materials,including conversion‐and insertion‐type reactions,are summarized with details of active inorganic/organic ligands.Second,MOFs as anode materials for LIBs/SIBs are emphasized and improved on the electrochemical performances.Furthermore,very few research literature on MOFs‐based cathode materials is also discussed.Finally,opinions and prospects on the current challenge of MOFs‐based electrode materials are provided for future research directions. | Zhoujia Liu Fenfen Zheng Weiwei Xiong Xiaogang Li Aihua Yuan Huan Pang | 2021 | SmartMat2021，2，4： | 3 |
| 3 | Prostate cancer targeted MRI nanoprobe based on superparamagnetic iron oxide and copolymer of poly(ethylene glycol) and polyethyleneimin显示文摘Methoxyl poly (ethylene glycol) (mPEG-OH) was successfully grafted onto branched polyethyleneimine (hy-PEI) to yield a water soluble graft copolymer mPEG-g-PEI. This copolymer may package super- paramagnetic iron oxide (SPIO) by ligand exchange. The SPIO weight percentage in the polymer coated nanoparticles was determined to be 55%, the size and zeta potential of nanoparticles was 50 nm and 12 mV respectively. Antibody fixation onto the complex (mPEI-g-PEG-SPIO) surface layer was achieved by activated single chain monoclonal antibody against prostate stem cell antigen (PSCA). Our study showed that the single chain antibody functionalized nanoprobe (scAbPSCA-PEI-g-PEG-SPIO) with a small size can specifically enter the prostate cancer cells, decreasing MRI T2-weighted signal intensity of prostate cancer cells to 44.76%. Our results revealed that the potential of this magnetic nanoparticulate system promised as a novel MRI nanoprobe for early diagnosis of prostate cancer (PCa). | ZHOU JianHua HUANG Lu WANG WeiWei PANG Jun ZOU Yang SHUAI XinTao GAO Xin | 2009 | Chinese Science Bulletin2009，54，18： | 3 |
| 4 | Nyström-based spectral clustering using airborne LiDAR point cloud data for individual tree segmentation显示文摘The spectral clustering method has notable advantages in segmentation.But the high computational complexity and time consuming limit its application in large-scale and dense airborne Light Detection and Ranging(LiDAR)point cloud data.We proposed the Nyström-based spectral clustering(NSC)algorithm to decrease the computational burden.This novel NSC method showed accurate and rapid in individual tree segmentation using point cloud data.The K-nearest neighbour-based sampling(KNNS)was proposed for the Nyström approximation of voxels to improve the efficiency.The NSC algorithm showed good performance for 32 plots in China and Europe.The overall matching rate and extraction rate of proposed algorithm reached 69%and 103%.For all trees located by Global Navigation Satellite System(GNSS)calibrated tape-measures,the tree height regression of the matching results showed an value of 0.88 and a relative root mean square error(RMSE)of 5.97%.For all trees located by GNSS calibrated total-station measures,the values were 0.89 and 4.49%.The method also showed good performance in a benchmark dataset with an improvement of 7%for the average matching rate.The results demonstrate that the proposed NSC algorithm provides an accurate individual tree segmentation and parameter estimation using airborne LiDAR point cloud data. | Yong Pang Weiwei Wang Liming Du Zhongjun Zhang Xiaojun Liang Yongning Li Zuyuan Wang | 2021 | International Journal of Digital Earth2021，14，10： | 2 |
| 5 | Theoretical and experimental characterizations of gigahertz acoustic streaming in microscale fluids显示文摘Even as gigahertz(GHz) acoustic streaming has developed into a multi-functional platform technology for biochemical applications, including ultrafast microfluidic mixing, microparticle operations, and cellar or vesicle surgery, its theoretical principles have yet to be established. This is because few studies have been conducted on the use of such high frequency acoustics in microscale fluids. Another difficulty is the lack of velocimetry methods for microscale and nanoscale fluidic streaming. In this work, we focus on the basic aspects of GHz acoustic streaming,including its micro-vortex generation principles, theoretical model, and experimental characterization technologies. We present details of a weak-coupled finite simulation that represents our current understanding of the GHz-acoustic-streaming phenomenon. Both our simulation and experimental results show that the GHzacoustic-induced interfacial body force plays a determinative role in vortex generation. We carefully studied changes in the formation of GHz acoustic streaming at different acoustic powers and flow rates. In particular,we developed a microfluidic-particle-image velocimetry method that enables the quantification of streaming at the microscale and even nanoscale. This work provides a full map of GHz acoustofluidics and highlights the way to further theoretical study of this topic. | Weiwei Cui Wei Pang Yang Yang Tiechuan Li Xuexin Duan | 2019 | Nanotechnology and Precision Engineering2019，2，1： | 2 |
| 6 | CpG ODN107 potentiates radiosensitivity of human glioma cells via TLR9-mediated NF-κB activation and NO production显示文摘 | Xiaoli Li Dan Liu Xin Liu Weiwei Jiang Weiying Zhou Wei Yan Yanyan Cen Bin Li Guanqun Cao Guofu Ding Xueli Pang Jianguo Sun Jiang Zheng Hong Zhou | 2012 | Tumor Biology2012，，5： | 1 |
| 7 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 8 | Synthesis and biological evaluation of ^(99m)Tc-HEDTA/HYNIC-MPP4 complex for 5-HT1A receptor imaging显示文摘5-HT1A receptor is associated with a variety of pathophysiology of neuropsychiatric disorders. Accordingly, we have synthesized a new 5-HT1A receptor ligand (HYNIC-MPP4) and labeled it with 99mTc using N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) as coligand. 99mTc-HEDTA/HYNIC-MPP4 was prepared under pH 6 at room temperature. Biodistribution of 99mTc-HEDTA/HYNIC-MPP4 in normal mice showed that this complex had moderate brain uptake (0.60% ID·g-1 at 2 min p.i.) and good retention. The hippocampus had the highest radioactivity uptake at 2 min p.i. (1.84% ID·g-1). The ratio of Hipp/CB was 3.1 at 2 min p.i. and increased to 4.4 at 60 min p.i. After blocking with 8-hydroxy-2-(dipropylamino) tetralin, the uptake of hippocampus was decreased significantly from 1.84% ID·g-1 to 0.53% ID·g-1 at 2 min p.i., while the cerebellum had no significant decrease. This 99mTc complex could be a potent agent for 5-HT1A receptor imaging. | FAN WeiWei*, LIN Yan*, ZHANG XianZhong, PANG Yan, MA Cong, TANG ZhiGang, ZHANG JunBo & WANG XueBin Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China | 2009 | Science China Chemistry2009，52，5： | 1 |
| 9 | The underlying mechanism of variety–water–nitrogen–stubble damage interactions on yield formation in ratoon rice with low stubble height under mechanized harvesting显示文摘Agronomic measures are the key to promote the sustainable development of ratoon rice by reducing the damage from mechanical crushing to the residual stubble of the main crop, thereby mitigating the impact on axillary bud sprouting and yield formation in ratoon rice. This study used widely recommended conventional rice Jiafuzhan and hybrid rice Yongyou 2640 as the test materials to conduct a four-factor block design field experiment in a greenhouse of the experimental farm of Fujian Agricultural and Forestry University, China from 2018 to 2019.The treatments included fertilization and no fertilization, alternate wetting and drying irrigation and continuous water flooding irrigation, and plots with and without artificial crushing damage on the rice stubble. At the same time, a 13C stable isotope in-situ detection technology was used to fertilize the pot experiment. The results showed significant interactions among varieties, water management, nitrogen application and stubble status.Relative to the long-term water flooding treatment, the treatment with sequential application of nitrogen fertilizer coupled with moderate field drought for root-vigor and tiller promotion before and after harvesting of the main crop, significantly improved the effective tillers from low position nodes. This in turn increased the effective panicles per plant and grains per panicle by reducing the influence of artificial crushing damage on rice stubble and achieving a high yield of the regenerated rice. Furthermore, the partitioning of 13C assimilates to the residual stubble and its axillary buds were significantly improved at the mature stage of the main crop, while the translocation rate to roots and rhizosphere soil was reduced at the later growth stage of ratooning season rice. This was triggered by the metabolism of hormones and polyamines at the stem base regulated by the interaction of water and fertilizer at this time. We therefore suggest that to achieve a high yield of ratoon rice with low stubble height under mechanized harvesting, the timely application of nitrogen fertilizer is fundamental,coupled with moderate field drying for root-vigor preservation and tiller promotion before and after the mechanical harvesting of the main crop. | Jingnan Zou Ziqin Pang Zhou Li Chunlin Guo Hongmei Lin Zheng Li Hongfei Chen Jinwen Huang Ting Chen Hailong Xu Bin Qin Puleng Letuma Weiwei Lin Wenxiong Lin | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 10 | 6-44 Studying of Residual Activity Induced by 300 MeV/u Carbon Ion in Copper Target显示文摘Activation of accelerator components due to beam losses is an important issue for a high-energy heavy ion accelerator.The induced components may become a main source of exposure to maintenance workers and a serious access-restriction for“hand-on”maintenance,and also have a certain radiation influence over the environment.In this work,experimental of residual activation induced by 300 MeV/u carbon ions was studied at the deep-therapy terminal of HIRFL. | Xu Junkui Su Youwu Li Wuyuan Pang Chengguo Yan Weiwei Xu Chong Mao Wang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 11 | 6-42 Radiation Safety Report of HIRFL in 2015显示文摘The total operation time of HIRFL is 7 536 h in 2015; the user beam time is about 5 451.5 (from 21 Dec.2014 to 21 Dec. 2015); 4 836 h were used for experiments; 615.5 h were used for accelerator research. There are 26 heavy ions beams were provided by HIRFL in 2015. The highest ions energy provided is 464 MeV/u, the maximum accumulated ion intensity is 1 400 A for carbon ion. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 12 | Application of Energy Saving Technology in Trichlorosilane Distillation Purification Process显示文摘The trichlorosilane(TCS)purification process consumes a significant amount of energy to achieve the high purity requirement for TCS quality(99.9999%).This work proposed a series of energy saving technology to enhance the TCS purification process,including the conventional process,the conventional process coupled with heat-pump(HP),the multi-effect distillation process,and the dividing-wall columns process.All proposed schemes have been conceptually constructed by Aspen Plus.The design and optimization of the processes have been performed by the sensitivity analysis and the response surface methodology.Moreover,the energy consumption and total annual cost(TAC)for these schemes were discussed.The simulation results show that the TAC of the conventional process coupled with the integrated heat pump can reduce 50.5%of energy consumption as compared with the conventional process;the double-effect and three-effect processes can save 15.6%and 33.8%of energy consumption,respectively;the dividing wall column process and that coupled with the heat pump process can reduce by 22.3%and 48.1%of energy consumption,respectively.It can be found that the operating cost can be saved by using the heat pump technology,while the capital cost increases due to the investment in the compressor,when the processes coupled with the heat pump are used.These results demonstrate that the conventional process coupled with the HP technology has advantages over other distillation schemes for TCS purification in terms of the energy saving and economic effects. | Qie Siyuan Pang Weiwei Zhao Ming Huang Zheqing | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，3： | 0 |
| 13 | Manipulation of single cells via a Stereo Acoustic Streaming Tunnel(SteAST)显示文摘At the single-cell level,cellular parameters,gene expression and cellular function are assayed on an individual but not population-average basis.Essential to observing and analyzing the heterogeneity and behavior of these cells/clusters is the ability to prepare and manipulate individuals.Here,we demonstrate a versatile microsystem,a stereo acoustic streaming tunnel,which is triggered by ultrahigh-frequency bulk acoustic waves and highly confined by a microchannel.We thoroughly analyze the generation and features of stereo acoustic streaming to develop a virtual tunnel for observation,pretreatment and analysis of cells for different single-cell applications.3D reconstruction,dissociation of clusters,selective trapping/release,in situ analysis and pairing of single cells with barcode gel beads were demonstrated.To further verify the reliability and robustness of this technology in complex biosamples,the separation of circulating tumor cells from undiluted blood based on properties of both physics and immunity was achieved.With the rich selection of handling modes,the platform has the potential to be a full-process microsystem,from pretreatment to analysis,and used in numerous fields,such as in vitro diagnosis,high-throughput single-cell sequencing and drug development. | Yang Yang Wei Pang Hongxiang Zhang Weiwei Cui Ke Jin Chongling Sun Yanyan Wang Lin Zhang Xiubao Ren Xuexin Duan | 2022 | Microsystems & Nanoengineering2022，8，4： | 0 |
| 14 | 6-22 Radiation Safety Report of HIRFL in 2014显示文摘The total operation time of HIRFL is 7 272 h in 2014, and the user beam time is about 4 964.5 h(from 21stDec.2013 to 21st Dec. 2014). 3 749 h for physics experiment, 332 h for life science research, 883.5 h for materialscience and single particle effect research, and 235 h for machine research. There are 24 heavy ions beams wereprovided by HIRFL in 2014. The highest ions energy provided is 487 MeV/u, and the maximum accumulated ionintensity is 1 000 A. | Su Youwu Xu Junkui Li Zongqiang Mao Wang Li Wuyuan Xu Chong Yan Weiwei Pang Chengguo | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 15 | Template directed perovskite X-ray detectors towards low ionic migration and low interpixel cross talking显示文摘The metal halide perovskites exhibit excellent performance as the direct X-ray detectors owing to their strong absorption capability,long carrier lifetime and diffusion length,radiation ruggedness,etc.For imaging applications,the ionic migration of perovskites and charge sharing effect between the adjacent pixels have a significantly negative impact on the spatial resolution.Herein,for the first time,the porous anodic aluminum oxides(AAO)have been used as a template to grow the CsPbBr2I thick film for the direct X-ray detection.Benefiting from the oxygen passivation effect,the activation energy for ionic migration has been observed to increase to 0.701 eV,whereas the dark current drift(1.01×10^(-5)nA cm^(-1)s^(-1)V^(-1))is one to two orders of magnitude lower than the other lead halide perovskite single crystals and films.Moreover,the AAO insulating wall effectively blocks the charge diffusion effect across a pixel pitch of 10^m.Overall,the findings reported in this study open a new route for reducing the ionic migration and pixel crosstalk,thus,bringing the perovskite X-ray detectors close to the practical applications. | Menghua Zhu Xinyuan Du Guangda Niu Weiwei Liu Weicheng Pan Jincong Pang Wenyu Wang Chao Chen Yadong Xu Jiang Tang | 2022 | Fundamental Research2022，2，1： | 0 |
| 16 | 6 - 32 Radiation Safety Reportof HIRFL in 2012显示文摘 | Su Youwu Li Zongqiang LiWuyuan Xu Junkui Mao Wang Xu Chong Yan Weiwei Pang Chengguo | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
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