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| 1 | Calcium silicate bioactive ceramics induce osteogenesis through oncostatin M显示文摘Immune reactions are a key factor in determining the destiny of bone substitute materials after implantation.Macrophages,the most vital factor in the immune response affecting implants,are critical in bone formation,as well as bone biomaterial-mediated bone repair.Therefore,it is critical to design materials with osteoimmunomodulatory properties to reduce host-to-material inflammatory responses by inducing macrophage polarization.Our previous study showed that calcium silicate(CS)bioceramics could significantly promote osteogenesis.Herein,we further investigated the effects of CS on the behavior of macrophages and how macrophages regulated osteogenesis.Under CS extract stimulation,the macrophage phenotype was converted to the M2 extreme.Stimulation by a macrophage-conditioned medium that was pretreated by CS extracts resulted in a significant enhancement of osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs),indicating the important role of macrophage polarization in biomaterial-induced osteogenesis.Mechanistically,oncostatin M(OSM)in the macrophage-conditioned medium promoted osteogenic differentiation of BMSCs through the ERK1/2 and JAK3 pathways.This in vivo study further demonstrated that CS bioceramics could stimulate osteogenesis better thanβ-TCP implants by accelerating new bone formation at defective sites in the femur.These findings improve our understanding of immune modulation of CS bioactive ceramics and facilitate strategies to improve the in vitro osteogenesis capability of bone substitute materials. | Panyu Zhou Demeng Xia Zhexin Ni Tianle Ou Yang Wang Hongyue Zhang Lixia Mao Kaili Lin Shuogui Xu Jiaqiang Liu | 2021 | Bioactive Materials2021，6，3： | 5 |
| 2 | The influence of mul- tiple modified MMT on the thermal and fire behavior ofpoly (lactic acid) nanocomposites显示文摘 | Liu Jiajia Zhou Keqing Wen Panyue | 2015 | Polymers for Advanced Technologies2015，26，6： | 1 |
| 3 | New Minimally InvasiveOption for the Treatment of Gluteal Muscle Contracture 显示文摘 | Bin Ye Panyu Zhou Yan Xia | 2012 | Orthopedics2012，35，12： | 1 |
| 4 | Knockdown of Burton’s tyrosine kinase confers potent protection against sepsis-induced acute lung injury显示文摘 | Panyu Zhou Bing Ma Shuogui Xu Shijie Zhang Hongtai Tang Shihui Zhu Shichu Xiao Daofeng Ben Zhaofan Xia | 2014 | Cell Biochemistry and Biophysics2014，，2： | 1 |
| 5 | Proper resolutions and Gorensteinness in extriangulated categories显示文摘Let(C,E,s)be an extriangulated category with a proper classξof E-triangles,and W an additive full subcategory of(C,E,s).We provide a method for constructing a proper W(ξ)-resolution(resp.,coproper W(ξ)-coresolution)of one term in an E-triangle inξfrom that of the other two terms.By using this way,we establish the stability of the Gorenstein category GW(ξ)in extriangulated categories.These results generalize the work of Z.Y.Huang[J.Algebra,2013,393:142–169]and X.Y.Yang and Z.C.Wang[Rocky Mountain J.Math.,2017,47:1013–1053],but the proof is not too far from their case.Finally,we give some applications about our main results. | Jiangsheng HU Dondong ZHANG Panyue ZHOU | 2021 | Frontiers of Mathematics in China2021，16，1： | 0 |
| 6 | 机械力诱导MHC-Ⅰ构象变化增强TCR抗原识别及T细胞活化显示文摘CD8+T细胞主要通过T细胞表面受体(T cell recep tor,TCR)识别并与Ⅰ型主要组织性复合物提呈的抗原(pMHC-Ⅰ)相互作用[1]。TCR对刺激型抗原的识别在CD8+T细胞毒性和适应性免疫中发挥着关键作用。许多证据表明机械力可以延长TCR与刺激性pMHC作用的键合时间(bond lifetime)形成抗原特异性逆锁键(catch bond)[2],并且这种逆锁键对抗原识别非常重要。然而,机械力调控TCR抗原识别的具体结构机制仍不清楚。通过分子动力学模拟、单分子生物膜力学探针、磁镊、T细胞活化实验和动物模型对此问题展开了系统的研究[4]。发现作用在TCR-pMHC-Ⅰ复合体上的拉力可以作用在TCR-pMHC-Ⅰ复合体上的拉力可以打破MHC-I分子内部α1-α2和β2结构域间的相互作用,导致α1-α2结构域旋转并发生构象变化。力诱导的MHC-I构象变化可以进一步别构地调节TCR与刺激性抗原肽及α1-α2结构域的构象及相互作用,诱导产生新的氢键,增强TCR-pMHC-Ⅰ之间的键合时间,但并不能增强TCR与抑制性pMHC-Ⅰ之间的作用。当用点突变阻断这些新形成的氢键,或者α1-α2和β2结构域被二硫键锁住时,最佳力诱导的TCR-pMHC-Ⅰ作用的键合时间明显缩短并且T细胞的活化受到抑制。另外,在人TCR和HLA-A2相互作用中发现了类似机制,并且与肿瘤相关的HLA-A2点突变[3]可以通过限制HLA-A2α1--α2和β2结构域之间的构象打开减弱TCR对肿瘤抗原的识别及T细胞的功能。研究结果表明,机械力诱导的MHC-I构象变化对TCR抗原识别和T细胞活化非常重要,进一步地阐明了机械力调控TCR抗原识别机制,为临床肿瘤的免疫治疗和药物设计提供了新思路和新靶点。 | Peng Wu Tongtong Zhang Baoyu Liu Panyu Fei Lei Cui Rui Qin Huaying Zhu Danmei Yao Ryan Martinez Wei Hu Chenyi An Yong Zhang Junwei Liu Weiwei Yin Jie Sun Chun Zhou Xun Zeng Jianan Wang Brian Evavold Cheng Zhu Jizhong Lou Wei Chen | 2019 | 医用生物力学2019，34，A01： | 0 |
| 7 | An efficient approach for the treatment of radioactive waste perfluoropolyether lubricants via a synergistic effect of thermal catalysis and immobilization显示文摘Perfluoropolyether(PFPE)lubricants are a kind of high-molecular polymer with many excellent properties.However,the use of PFPEs in the nuclear industry can lead to partial decomposition and carrying radionuclides,resulting in a large amount of radioactive waste PFPE lubricants annually.Moreover,radioactive waste PFPE lubricants are difficult to be effectively treated due to their high stability,the risk of possible leakage of radionuclides,and hypertoxic fluorine-containing by-products.In this study,without any precedent,a strategy of Mn O_(2)-catalyzed decomposition and Na_(2)CO_(3)-immobilized conversion was proposed for PFPE lubricant decomposition and fluorine immobilization simultaneously based on the Lewis acid-base and oxygen vacancies concept.A high fluorine conversion efficiency of 95.4%was achieved.Meanwhile,the mechanism of decomposition suggested that Mn O_(2)mainly provided Lewis acid sites and attacked the(basic)fluorine or oxygen atoms in PFPE molecules.The decomposition of PFPE chains was proceed down and volatile fluorine-containing gas was released by partial electron transfer,intramolecular disproportionation reaction,and unzipping fashion.Subsequently,gas by-products could be further oxidized and then immobilized into fluoride salts by carbonate solid absorbents.Overall,this study provides a simple,safe,and potentially practical strategy for the harmless conversion of refractory fluorinated organic wastes,especially perfluoropolymers. | Xinhang Du Wenhua Tong Xinyu Zhou Jia Luo Yuqiu Liu Yabo Wang Panyu Li Yongkui Zhang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 8 | A light field measurement system through PSF estimation by a morphology-based method显示文摘Light field imaging technology can obtain three-dimensional(3D)information of a test surface in a single exposure.Traditional light field reconstruction algorithms not only take a long time to trace back to the original image,but also require the exact parameters of the light field system,such as the position and posture of a microlens array(MLA),which will cause errors in the reconstructed image if these parameters cannot be precisely obtained.This paper proposes a reconstruction algorithm for light field imaging based on the point spread function(PSF),which does not require prior knowledge of the system.The accurate PSF derivation process of a light field system is presented,and modeling and simulation were conducted to obtain the relationship between the spatial distribution characteristics and the PSF of the light field system.A morphology-based method is proposed to analyze the overlapping area of the subimages of light field images to identify the accurate spatial location of the MLA used in the system,which is thereafter used to accurately refocus light field imaging.A light field system is built to verify the algorithm’s effectiveness.Experimental results show that the measurement accuracy is increased over 41.0%compared with the traditional method by measuring a step standard.The accuracy of parameters is also improved through a microstructure measurement with a peak-to-valley value of 25.4%and root mean square value of 23.5%improvement.This further validates that the algorithm can effectively improve the refocusing efficiency and the accuracy of the light field imaging results with the superiority of refocusing light field imaging without prior knowledge of the system.The proposed method provides a new solution for fast and accurate 3D measurement based on a light field. | Lingbao Kong Panyu Zhou | 2021 | International Journal of Extreme Manufacturing2021，3，4： | 0 |
| 9 | Intercomparison of multi-model ensemble-processing strategies within a consistent framework for climate projection in China显示文摘Climate change adaptation and relevant policy-making need reliable projections of future climate.Methods based on multi-model ensemble are generally considered as the most efficient way to achieve the goal.However,their efficiency varies and inter-comparison is a challenging task,as they use a variety of target variables,geographic regions,time periods,or model pools.Here,we construct and use a consistent framework to evaluate the performance of five ensemble-processing methods,i.e.,multimodel ensemble mean(MME),rank-based weighting(RANK),reliability ensemble averaging(REA),climate model weighting by independence and performance(ClimWIP),and Bayesian model averaging(BMA).We investigate the annual mean temperature(Tav)and total precipitation(Prcptot)changes(relative to 1995–2014)over China and its seven subregions at 1.5 and 2℃warming levels(relative to pre-industrial).All ensemble-processing methods perform better than MME,and achieve generally consistent results in terms of median values.But they show different results in terms of inter-model spread,served as a measure of uncertainty,and signal-to-noise ratio(SNR).ClimWIP is the most optimal method with its good performance in simulating current climate and in providing credible future projections.The uncertainty,measured by the range of 10th–90th percentiles,is reduced by about 30%for Tav,and 15%for Prcptot in China,with a certain variation among subregions.Based on ClimWIP,and averaged over whole China under 1.5/2℃global warming levels,Tav increases by about 1.1/1.8℃(relative to 1995–2014),while Prcptot increases by about 5.4%/11.2%,respectively.Reliability of projections is found dependent on investigated regions and indices.The projection for Tav is credible across all regions,as its SNR is generally larger than 2,while the SNR is lower than 1 for Prcptot over most regions under 1.5℃warming.The largest warming is found in northeastern China,with increase of 1.3(0.6–1.7)/2.0(1.4–2.6)℃(ensemble’s median and range of the 10th–90th percentiles)under 1.5/2℃warming,followed by northern and northwestern China.The smallest but the most robust warming is in southwestern China,with values exceeding 0.9(0.6–1.1)/1.5(1.1–1.7)℃.The most robust projection and largest increase is achieved in northwestern China for Prcptot,with increase of 9.1%(–1.6–24.7%)/17.9%(0.5–36.4%)under 1.5/2℃warming.Followed by northern China,where the increase is 6.0%(–2.6–17.8%)/11.8%(2.4–25.1%),respectively.The precipitation projection is of large uncertainty in southwestern China,even with uncertain sign of variation.For the additional half-degree warming,Tav increases more than 0.5℃throughout China.Almost all regions witness an increase of Prcptot,with the largest increase in northwestern China. | Huanhuan ZHU Zhihong JIANG Laurent LI Wei LI Sheng JIANG Panyu ZHOU Weihao ZHAO Tong LI | 2023 | Science China Earth Sciences2023，66，9： | 0 |
| 10 | Abelian Hearts of Twin Cotorsion Pairs on Extriangulated Categories显示文摘It was shown recently that the heart of a twin cotorsion pair on an extriangulated category is semi-abelian.In this article,we consider a special class of hearts of twin cotorsion pairs induced by d-cluster tilting subcategories in extriangulated categories.We give a necessary and sufficient condition for such hearts to be abelian.In particular,we can also see that such hearts are hereditary.As an application,this generalizes the work by Liu in the exact case,thereby providing new insights into the triangulated case. | Qiong Huang Panyue Zhou | 2023 | Algebra Colloquium2023，30，3： | 0 |
| 11 | Efficient H_(2)O_(2)Electrosynthesis and Its Electro-Fenton Application for Refractory Organics Degradation显示文摘Hydrogen peroxide(H_(2)O_(2))in situ electrosynthesis by O_(2)reduction reaction is a promising alternative to the conventional Fenton treatment of refractory wastewater.However,O_(2)mass transfer limitation,cathodic catalyst selectivity,and electron transfer in O_(2)reduction remain major engineering obstacles.Here,we have proposed a systematic solution for efficient H_(2)O_(2)generation and its electro-Fenton(EF)application for refractory organic degradation based on the fabrication of a novel ZrO_(2)/CMK-3/PTFE cathode,in which polytetrafluoroethylene(PTFE)acted as a hydrophobic modifier to strengthen the O_(2)mass transfer,ZrO_(2)was adopted as a hydrophilic modifier to enhance the electron transfer of O_(2)reduction,and mesoporous carbon CMK-3 was utilized as a catalyst substrate to provide catalytic active sites.Moreover,feasible mass transfer of O_(2)from the hydrophobic to the hydrophilic layer was designed to increase the contact between O_(2)and the reaction interface.The H_(2)O_(2)yield of the ZrO_(2)/CMK-3/PTFE cathode was significantly improved by approximately 7.56 times compared to that of the co nventional gas diffusion cathode under the same conditions.The H_(2)O_(2)generation rate and Faraday efficiency reached125.98 mg·cm^(-2)·h^(-1)(normalized to 5674.04 mmol·g^(-1)·h^(-1)by catalyst loading)and 78.24%at-1.3 V versus standard hydrogen electrode(current density of-252 mA·cm^(-2)),respectively.The high H_(2)O_(2)yield ensured that sufficient OH was produced for excellent EF performance,resulting in a degradation efficiency of over 96%for refractory organics.This study offers a novel engineering solution for the efficient treatment of refractory wastewater using EF technology based on in situ high-yield H_(2)O_(2)electrosynthesis. | Lei Li Jing Bai Panyu Jiang Yan Zhang Tingsheng Zhou Jiachen Wang Changhui Zhou Jinhua Li Baoxue Zhou | 2023 | Engineering2023，，11： | 0 |
| 12 | Recollements arising from cotorsion pairs on extriangulated categories显示文摘This paper is devoted to constructing some recollements of additive categories associated to concentric twin cotorsion pairs on an extriangulated category.As an application,this result generalizes the work by W.J.Chen,Z.K.Liu,and X.Y.Yang in a triangulated case[J.Algebra Appl.,2018,17(5):1-15].Moreover,it highlights new phenomena when it applied to an exact category.Finally,we give some applications of our main results.In particular,we obtain Krause's recollement whose proofs are both elementary and very general. | Yonggang HU Panyue ZHOU | 2021 | Frontiers of Mathematics in China2021，16，4： | 0 |
| 13 | Complete Cohomology for Extriangulated Categories显示文摘Let(C,E,s)be an extriangulated category with a proper classξof E-triangles.We study complete cohomology of objects in(C,E,s)by applyingξ-projective resolutions andξ-injective coresolutions constructed in(C,E,s).Vanishing of complete cohomology detects objects with finiteξ-projective dimension and finiteξ-injective dimension.As a consequence,we obtain some criteria for the validity of the Wakamatsu tilting conjecture and give a necessary and sufficient condition for a virtually Gorenstein algebra to be Gorenstein.Moreover,we give a general technique for computing complete cohomology of objects with finiteξ-Gprojective dimension.As an application,the relations betweenξ-projective dimension andξ-Gprojective dimension for objects in(C,E,s)are given. | Jiangsheng Hu Dongdong Zhang Tiwei Zhao Panyue Zhou | 2021 | Algebra Colloquium2021，28，4： | 0 |
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