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47篇 您的检索式：作者名="Pearson I M"

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	题名	作者	年代	出处	被引量
1	NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD.	Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley	2011	World Journal of Gastroenterology2011，17，23：	2
2	Active control of helicopter vibration 显示文摘	Pearson J T Goodall R M Lyndon I	1994	Computing & Control Engineering Journal1994，5，6：	1
3	Evidence of nerve sheath differentiation and high grade morphology in sclerosing epithelioid fibrosarcoma显示文摘	Hanson I M Pearson J M Eyden B P	2001	J Clin Pathol2001，54，：	1
4	Rancidity and wamed- over flavour显示文摘	Gray J I Pearson 'A M	1987	Adv Maat Rese1987，3，：	1
5	Effects of synthetic antioxidants (BHA,BHT and PG) on the mutagenicity of IQ-like compounds显示文摘	Chen C Pearson A M Gray J I		0，，：	1
6	Rancidity and warmed-over flavour显示文摘	Gray J I Pearson A M	1987	Adv Meat Rese1987，，3：	1
7	Rancidity and warmed-over flavour显示文摘	Gray J I A M Pearson	1987	Meat Rese1987，3，：	1
8	Evidence of nerve sheath differentiation and high grade morphology in scleresing epithelioid fibresarcoma 显示文摘	Hanson I M Pearson J M Eyden B P	2001	J Clin Pathol2001，54，9：	1
9	Reduction and adsorption kinetics of nitric oxide on cobalt perovskite catalysts显示文摘	Chien M W Pearson I M Nobe K	1975	Ind Eng Chem Prod Res Dev1975，14，2：	1
10	Kinetic and structural characterization of urease active site variants显示文摘	PEARSON M A PARK I SCHALLER R A	2000	Biochemistry2000，39，：	1
11	'Chemical Mixed' catalysts显示文摘	Pearson I M Hwantai 1L Wong W C	1983	Industrial & Engineering Chemistry Product Research and Development1983，22，2：	1
12	Landscape Change and Habitat Availability in the Southern Appalachian High-lands and ()lympie Peninsula 显示文摘	Pearson S M Turner M G I)rake J B	1999	Ecological Applications1999，9，4：	1
13	Rancidity and warmed-o- ver flavour 显示文摘	GRAY J I PEARSON A M	1987	Advances in Meat Research1987，，3：	1
14	THE FOG REMOTE SENSING AND MODELING FIELD PROJECT显示文摘	Gultepe I Pearson G Milbrandt J A Hansen B Platnick S Taylor P Gordon M Oakley J P Cober S G	2009	Bulletin of the American Meteorological Society2009，，3：	1
15	Radical Surgery: What Will Tomorrow's Organizations Look Like? 显示文摘	Mitroff I I Mason R O & Pearson C M	1994	The Academy of Management Executive1994，，8：	1
16	Estrogen receptor gene polymorphisms and endometrial cancer risk 显示文摘	Weiderpass E Pearson I Hahan M	2000	Carcinogeeis2000，21，4：	1
17	CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein Rinases signaling pathways 显示文摘	Castle B E Kehry M R	2001	Int Immunol2001，13，3：	1
18	Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea显示文摘	Amselem J Cuomo C A van Kan J A Viaud M Benito E P Couloux A Coutinho P M de Vries R P Dyer PS Fillinger S Fournier E Gout L Hahn M Kohn L Lapalu N Plummer K M Pradier J M Quévillon E Sharon A Simon A ten Have A Tudzynski B Tudzynski P Wincker P Andrew M Anthouard V Beever R E Beffa R Benoit I Bouzid O Brault B Chen Z Choquer M Collémare J Cotton P Danchin E G Da Silva C Gautier A Giraud C Giraud T Gonzalez C Grossetete S Güldener U Henrissat B Howlett B J Kodira C Kretschmer M Lappartient A Leroch M Levis C Mauceli E Neuvéglise C Oeser B Pearson M Poulain J Poussereau N Quesneville H Rascle C Schumacher J Ségurens B Sexton A Silva E Sirven C Soanes D M Talbot N J Templeton M Yandava C Yarden O Zeng Q Rollins J A Lebrun M H Dickman M	2011	PLoS Genetics2011，7，10：	1
19	Longitudinal changes in bone mineral density during normal pregnancy 显示文摘	Kaur M Pearson D Godber I	2003	Bone2003，32，4：	1
20	Rancidity and Wanned-over Flavour 显示文摘	Gray J I Pearson A M	1987	Adv Meat Rese1987，，3：	1

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