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| 1 | Multimorbidity patterns and association with mortality in 0.5 million Chinese adults显示文摘Background:Few studies have assessed the relationship between multimorbidity patterns and mortality risk in the Chinese population.We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults.Methods:We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years.Multimorbidity was defined as the presence of two or more of the 15 chronic diseases collected by self-report or physical examination at baseline.Multimorbidity patterns were identified using hierarchical cluster analysis.Cox regression was used to estimate the associations of multimorbidity patterns and the number of chronic diseases with all-cause and cause-specific mortality.Results:Overall,15.8%of participants had multimorbidity.The prevalence of multimorbidity increased with age and was higher in urban than rural participants.Four multimorbidity patterns were identified,including cardiometabolic multimorbidity(diabetes,coronary heart disease,stroke,and hypertension),respiratory multimorbidity(tuberculosis,asthma,and chronic obstructive pulmonary disease),gastrointestinal and hepatorenal multimorbidity(gallstone disease,chronic kidney disease,cirrhosis,peptic ulcer,and cancer),and mental and arthritis multimorbidity(neurasthenia,psychiatric disorder,and rheumatoid arthritis).During a median of 10.8 years of follow-up,49,371 deaths occurred.Compared with participants without multimorbidity,cardiometabolic multimorbidity(hazard ratios[HR]=2.20,95%confidence intervals[CI]:2.14-2.26)and respiratory multimorbidity(HR=2.13,95%CI:1.97-2.31)demonstrated relatively higher risks of mortality,followed by gastrointestinal and hepatorenal multimorbidity(HR=1.33,95%CI:1.22-1.46).The mortality risk increased by 36%(HR=1.36,95%CI:1.35-1.37)with every additional disease.Conclusion:Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults. | Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group | 2022 | Chinese Medical Journal2022，，6： | 17 |
| 2 | Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy显示文摘AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine production.METHODS:Human OF were derived from tissues obtained from patients with Graves'ophthalmopathy(GO)and from patients without known thyroid diseases undergoing blepharoplasty.The OF were cultured separately under normoxic and hypoxic conditions.Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed.RESULTS:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions.This was not observed in OF from normal controls.Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures.CONCLUSION:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO.We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process. | Chiaw Ling Chng Oi Fah Lai Charmaine Sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-Chin Khoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 10 |
| 3 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 4 | Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China显示文摘Pneumoconiosis,an interstitial lung disease that occurs from breathing in certain kinds of damaging dust particles,is a major occupational disease in China.Patients diagnosed with occupational pneumoconiosis can avail of free medical treatment,whereas patients without a diagnosis of occupational diseases cannot not claim free medical treatment in most provinces from the government before 2019.This study aimed to analyze the priority of medical facility selection and its influencing factors among patients with pneumoconiosis. | WANG Huan Qiang JIA Jun Lin JIANG Zhao Qiang JIN Qi LI Dong Xia LING Rui Jie LI Ying CUI Ping CHEN Gang ZHAO Hong Yu LI Yan WEN Ke LYU Xiang Pei LOU Jian Lin LI Tao | 2021 | Biomedical and Environmental Sciences2021，34，1： | 9 |
| 5 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 6 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 3 |
| 7 | Synthesis and ferroelectric properties of Nd doped multiferroic BiFeO_3 nanotubes显示文摘Nd doped multiferroic BiFeO3 (Bi0.94Nd0.06FeO3 (BNF)) nanotubes were successfully synthesized by a sol-gel template method.Electron microscopy investigations exhibited that these nanotubes had straight and smooth profile with diameters of about 200 nm and wall thickness of about 20 nm.A perovskite-type structure of BNF was confirmed in the nanotubes by high-resolution transmission electron microscopy and selected area electron diffraction analysis.These nanotubes had high resistivity.The dielectric constant and dielectric loss of the nanotubes were 126 and 0.040 at 1 MHz, respectively.The ferroelectric properties of these BNF nanotubes were demonstrated with a remnant polarization of 48 μC/cm2 and a coercive electric field of 163 kV/cm. | WANG Jing LI MeiYa LIU XiaoLian PEI Ling LIU Jun YU BenFang ZHAO XingZhong | 2010 | Chinese Science Bulletin2010，55，16： | 3 |
| 8 | Pathogenetic effects of platelet activating factor on enterogenic endotoxemia after burn显示文摘INTRODUCTION Previous clinical and experimental studies haveindicated that an early endotoxemia occurred after amajor burn.It is unlikely that burn wound sepsis isthe source of circulating endotoxin in less than 12hour after burn.Increasing evidence demonstratesthat the bacteria and endotoxin in thegastrointestinal tract can pass through the gutbarrier into blood circulation to form enterogenicendotoxemia following burn.However。 | Pei Wu Yu Guang Xia Xiao Wei Ling Fu Jian Cheng Yuan Li Xin Zhou Xiao Jian Qin | 2000 | World Journal of Gastroenterology2000，6，3： | 2 |
| 9 | Methylated TIMP-3 DNA in Body Fluids Is an Independent Prognostic Factor for Gastric Cancer显示文摘 | Yu Jiang-Liu Lv Ping Han Jing Zhu Xin Hong Lian-Lian Zhu Wang-Yu Wang Xin-Bao Wu Yi-Chen Li Pei Ling Zhi-Qiang | 2014 | Archives of Pathology & Laboratory Medicine2014，，11： | 2 |
| 10 | Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing显示文摘The coronavirus disease 2019(COVID-19) is an infection of the respiratory tract which first broke out in Wuhan, China, in December 2019. The etiologic agent of this disease was identified as a betacoronavirus related to severe acute respiratory syndrome coronavirus(SARS-CoV). Thus, the International Committee on Virus Classification named the new coronavirus severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)[1]. | NING Pei Yong YU Ai Ping WANG Yuan GUO Li Ru SHAN Dan KONG Mei YU Ling Qi LYU Li Kun ZOU Ming SU Xu FEI Chun Nan ZHOU Yu Hui WANG Bai Qi | 2020 | Biomedical and Environmental Sciences2020，33，10： | 2 |
| 11 | Associations of muscle mass,strength,and quality with all-cause mortality in China:a population-based cohort study显示文摘Background It remains unclear about the association of muscle mass,strength,and quality with death in the general Chinese population of diverse economical and geographical backgrounds.The present study aimed to comprehensively examine such associations across different regions in China.Methods Based on the China Kadoorie Biobank study,the present study included 23,290 participants who were aged 38 to 88 years and had no prevalent cardiovascular diseases or cancer.Muscle mass and grip strength were measured using calibrated instruments.Arm muscle quality was defined as the ratio of grip strength to arm muscle mass.Low muscle mass,grip strength,and arm muscle quality were defined as the sex-specific lowest quintiles of muscle mass index,grip strength,and arm muscle quality,respectively.Cox proportional hazards models yielded hazard ratios(HRs)and 95%confidence intervals(CIs)for risks of all-cause mortality in relation to muscle mass,strength,and quality.Results During a median follow-up of 3.98 years,739 participants died.The HR(95%CI)of all-cause mortality risk was 1.28(1.08–1.51)for low appendicular muscle mass index,1.38(1.16–1.62)for low total muscle mass index,1.68(1.41–2.00)for low grip strength,and 1.41(1.20–1.66)for low arm muscle quality in models adjusted for sociodemographic characteristics,lifestyle factors,and medical histories.Conclusion Low muscle mass,grip strength,and arm muscle quality are all associated with short-term increased risks of mortality,indicating the importance of maintaining normal muscle mass,strength,and quality for general Chinese adults. | Man Wu Yuxia Wei Jun Lv Yu Guo Pei Pei Jiachen Li Huaidong Du Ling Yang Yiping Chen Xiaohui Sun Hua Zhang Junshi Chen Zhengming Chen Canqing Yu Liming Li 无 | 2022 | Chinese Medical Journal2022，，11： | 2 |
| 12 | (Et_4N)_2[Fe_4(SPh)_10] Stimulated S_(RN)1 Reactions of α-Bromonaphth-alene with Pinacolone Carbanion显示文摘The (Et4N)2[Fe4(SPh)10] stimulated reaction of α-bromonaphthalene with pinacolone carbanion in DMSO leads to the formation of 1-(α-naphthyl)pinacolone. The reaction is suggested in terms of SRN1 mechanism of aromatic nucleophillic substitution and has potential value in synthesis to obtain (-substituted naphthalene derivaties. | Zhao ZHANG1*, Ya Ling GONG1, Yu WANG1, Zhao Bin CHEN1, Pei Lan WANG2 1Department of Chemistry, Shanxi University, Taiyuan 030006 2Test and Analysis Center of Shanxi University, Taiyuan 030006 | 2001 | Chinese Chemical Letters2001，12，2： | 2 |
| 13 | Case Control Study of Impulsivity,Aggression,Pesticide Exposure and Suicide Attempts Using Pesticides among Farmers显示文摘盒子控制研究被进行调查在 organophosphate 杀虫剂(OP ) 之间的协会暴露,侵略, impulsivity,和尝试的自杀。问询表被用来收集信息;impulsivity 和侵略被 Barratt Impulsivity 规模(二度) 和侵略库存(AI ) 测量。很多 OP 症状在为婚姻地位和收入调整以后与一次自杀尝试的一个增加的机会被联系(或 = 1.45;CI 1.14-1.86 ) 。尝试的自杀显著地与高 impulsivity 分数被联系(工具:72.4 对 60.6, P < 0.0001 ) 并且高侵略分数(意味着:38.5 对 26.1, P < 0.0001 ) 。自杀 attempters 比控制有 OP 暴露症状的一个更高的数字并且在 impulsivity 和侵略的规模上更高得分了。 | LYU Chun Ping PEI Jian Ru BESELER L. Cheryl LI Yu Ling LI Jian Hui REN Ming STALLONES Lorann REN Shu Ping | 2018 | Biomedical and Environmental Sciences2018，31，3： | 2 |
| 14 | Exogenous kallikrein enhances neurogenesis and angiogenesis in the subventricular zone and the peri-infarction region and improves neurological function after focal cortical infarction in hypertensive rats显示文摘 | Li Ling Qinghua Hou Shihui Xing Jian Yu Zhong Pei Jinsheng Zeng | 2008 | Brain Research2008，，： | 2 |
| 15 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 1 |
| 16 | Kindlin-2 promotes genome instability in breast cancer cells显示文摘 | Ting Zhao Lizhao Guan Yu Yu Xuelian Pei Jun Zhan Ling Han Yan Tang Feng Li Weigang Fang Hongquan Zhang | 2012 | Cancer Letters2012，，： | 1 |
| 17 | Morphology and microstructure of maize starches with different amylase/amylopectin content显示文摘 | CHEN Pei YU Long CHEN Ling | | 0，，： | 1 |
| 18 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 1 |
| 19 | Cardiac-derived adiponectin induced by long-term insulin treatment ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic mice via AMPK signaling显示文摘 | Haifeng Pei Yan Qu Xiaoyan Lu Qiujun Yu Kun Lian Peilin Liu Wenjun Yan Jingyi Liu Yanzhuo Ma Yi Liu Chengxiang Li Weijie Li Wayne Bond Lau Haifeng Zhang Ling Tao | 2013 | Basic Research in Cardiology2013，，1： | 1 |
| 20 | Development,validation and comparison of multivariable risk scores for prediction of total stroke and stroke types in Chinese adults:a prospective study of 0.5 million adults显示文摘Background and purpose Low-income and middle-income countries have the greatest stroke burden,yet remain understudied.This study compared the utility of Framingham versus novel risk scores for prediction of total stroke and stroke types in Chinese adults.Methods China Kadoorie Biobank(CKB)is a prospective study of 512726 adults,aged 30-79 years,recruited from 10 areas in China in 2004-2008.By 1 January 2018,43234 incident first stroke cases(36310 ischaemic stroke(IS);8865 haemorrhagic stroke(HS))were recorded in 503842 participants with no history of stroke at baseline.We compared the predictive utility of the Framingham Stroke Risk Profile(FSRP)with novel CKB stroke risk scores and included recalibration,refitting,stratifying by study area and addition of other risk factors.Discrimination was assessed using area under the receiver operating characteristic curve(AUC)and calibration was assessed using Greenwood-Nam-D’Agostinoχ^(2) statistics.Results Incidence of total stroke varied fivefold by area in China.The FSRP had good discrimination for total stroke(AUC(95%CI);men:0.78(0.77 to 0.79),women:0.77(95%CI 0.76 to 0.78)),but poor calibration(χ^(2);men:1,825,women:3,053),substantially underestimating absolute risks.Recalibration reducedχ^(2) by>80%,but did not improve discrimination.Refitting the FSRP did not materially improve discrimination,but further improved calibration.Stratification by area improved discrimination(AUC;men:0.82(0.82 to 0.83);women:0.82(0.82 to 0.83)),but not calibration.Adding other risk factors yielded modest,but statistically significant,improvements in the AUCs.The findings for IS and HS were similar to those for total stroke.Conclusions The FSRP reliably differentiated Chinese adults with incident stroke,but substantially underestimated the absolute risks of stroke.Novel local risk prediction equations that took account of differences in stroke incidence within China enhanced risk prediction of total stroke and major stroke pathological types. | Matthew Chun Robert Clarke Tingting Zhu David Clifton Derrick A Bennett Yiping Chen Yu Guo Pei Pei Jun Lv Canqing Yu Ling Yang Liming Li Zhengming Chen Benjamin J Cairns 无 | 2022 | Stroke & Vascular Neurology2022，7，4： | 1 |
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