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| 1 | A FVCOM-Based Unstructured Grid Wave, Current,Sediment Transport Model,I.Model Description and Validation显示文摘An effort was made to couple FVCOM (a three-dimensional (3D),unstructured grid,Finite Volume Coastal Ocean Model) and FVCOM-SWAVE (an unstructured grid,finite-volume surface wave model) for the study of nearshore ocean processes such as tides,circulation,storm surge,waves,sediment transport,and morphological evolution.The coupling between FVCOM and FVCOM-SWAVE was achieved through incorporating 3D radiation stress,wave-current-sediment-related bottom boundary layer,sea surface stress parameterizations,and morphology process.FVCOM also includes a 3D sediment transport module.With accurate fitting of irregular coastlines,the model provides a unique tool to study sediment dynamics in coastal ocean,estuaries,and wetlands where local geometries are characterized by inlets,islands,and intertidal marsh zones.The model was validated by two standard benchmark tests: 1) spectral waves approaching a mild sloping beach and 2) morphological changes of seabed in an idealized tidal inlet.In Test 1,model results were compared with both analytical solutions and laboratory experiments.A further comparison was also made with the structured grid Regional Ocean Model System (ROMS),which provides an insight into the performance of the two models with the same open boundary forcing. | WU Lunyu CHEN Changsheng GUO Peifang SHI Maochong QI Jianhua GE Jianzhong | 2011 | Journal of Ocean University of China2011，10，1： | 15 |
| 2 | Parameters in wind-wave frequency spectra and their bearings on spectrum forms and growth显示文摘The spectrum variance m0, peak frequency ω0 and peakness factor p are expressed in terms of nondimensional fetch and duration by making use of relations which are derived through comparing and analyzing existing empirical formulas for the growth of significant wave height and period. The main features of spectrum growth as specified by these parameters agree with those of the JONS-WAP experiments. For given wind speed and fetch, the high frequency parts beyond the peaks of shallow water spectra almost coincide with that of the corresponding deep water spectrum, whereas the low frequency parts differ appreciably. The method developed in this paper predicts smaller significant wave height as well as smaller wave period for shallow water spectra in contrast to the theoretical result of Kitaigorodskii ef al, in which the peak frequency, and consequently the significant wave period, remains basically unchanged for different water depths. Spectra are further reduced to a form in which only significant wave | Wen Shengchang (S. C. Wen), Zhang Dacuo Guo Peifang, and Chen Bohai Institute of Physical Oceanography, Ocean University of Qingdao (formerly, Shandong College of Oceanography), Qingdao, China | 1989 | Acta Oceanologica Sinica1989，8，1： | 15 |
| 3 | A hybrid model for numerical wave forecasting and its implementation-Ⅰ.The wind wave model显示文摘The authors make an endeavor to explain why a new hybrid wave model is here proposed when several such models have already been in operation and the so- called third generation wave modej is proving attractive. This part of the paper is devoted to the wind wave model. Both deep and shallow water models have been developed, the former being actually a special case of the latter when water depth is great. The deep water model is exceptionally simple in form. Significant wave height is the only prognostic variable. In comparison with the usual methods to compute the energy input and dissipations empirically or by 'tuning', the proposed model has the merit that the effects of all source terms are combined into one term which is computed through empirical growth relations for significant waves, these relations being, relatively speaking, easier and more reliable to obtain than those for the source terms in the spectral energy balance equation. The discrete part of the model and the implementation of the | Wen Shengchang (S.C. Wen)1, Zhang Dacuo, Chen Bohai and Guo Peifang Institute of Physical Oceanography, Ocean University of Qingdao (Formerly, Shandong College of Oceanography), Qingdao, China | 1989 | Acta Oceanologica Sinica1989，8，1： | 14 |
| 4 | Improved form of wind wave frequency spectrum显示文摘The lower frequency part of the theoretical wind wave spectrum proposed by the authors (Wen et al. , 1988a, b,c) has been improved and the form of spectrum is appreciably simplified. In addition to the field data collected in the Bohai Sea region and used in the previous papers, those obtained in the Huanghai Sea, the East China Sea and the South China Sea have been employed so that the improved spectra can be verified on a more extensive observational basis. Computed results agree with the observations well. Further comparisons have been made between the proposed spectra and the JONSWAP spectrum. Though the two types of spectrum are close to each other in form, the former shows, as a whole, better agreement with the observation than the latter. By introducing an improved relation between the peak-ness factor and significant wave steepness, the spectrum contains only significant wave height and period as parameters. For spectra given in this form, the computed peak frequencies coincide approximately | Wen Shengchang (S. C. Wen ), Zhang Dacuo, Guo Peifang, Wang Wei, Chen Bohai and Tai Weitao Institute of Physical Oceanography, Ocean University of Qingdao, China | 1989 | Acta Oceanologica Sinica1989，8，4： | 10 |
| 5 | Interpretation of breast cancer screening guideline for Chinese women显示文摘Breast cancer is the most common malignant tumor in Chinese women.Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients.The peak onset age for breast cancer in Chinese women is considerably younger than those in European and American women.It is imperative to develop breast cancer screening guideline that is suitable for Chinese women.By summarizing the current evidence on breast cancer screening in Chinese women,and referring to the latest guidelines and consensus on breast cancer screening in Europe,the United States,and East Asia,the China Anti-Cancer Association and National Clinical Research Center for Cancer(Tianjin Medical University Cancer Institute and Hospital)have formulated population-based guideline for breast cancer screening in Chinese women.The guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects:age of screening,screening methods,and screening interval.This article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China. | Yubei Huang Zhongsheng Tong Kexin Chen Ying Wang Peifang Liu Lin Gu Juntian Liu Jinpu Yu Fengju Song Wenhua Zhao Yehui Shi Hui Li Huaiyuan Xiao Xishan Hao | 2019 | Cancer Biology & Medicine2019，16，4： | 10 |
| 6 | Responses of the circulation and water mass in the Beibu Gulf to the seasonal forcing regimes显示文摘In the past 20 a, the gulf-scale circulation in the Beibu Gulf has been commonly accepted to be driven by a wind stress or density gradient. However, using three sensitive experiments based on a three-dimensional baroclinic model that was verified by observations, the formation mechanisms were revealed: the circulation in the northern Beibu Gulf was triggered by the monsoon wind throughout a year; whereas the southern gulf circulation was driven by the monsoon wind and South China Sea(SCS) circulation in winter and summer, respectively. The force of heat flux and tidal harmonics had a strong effect on the circulation strength and range, as well as the local circulation structures, but these factors did not influence the major circulation structure in the Beibu Gulf. On the other hand, the Beibu Gulf Cold Water Mass(BGCWM) would disappear without the force of heat flux because the seasonal thermocline layer was generated by the input of heat so that the vertical mixing between the upper hot water and lower cold water was blocked. In addition, the wind-induced cyclonic gyre in the northern gulf was favorable to the existence of the BGCWM. However, the coverage area of the BGCWM was increased slightly without the force of the tidal harmonics. When the model was driven by the monthly averaged surface forcing, the circulation structure was changed to some extent, and the coverage area of the BGCWM almost extended outwards 100%, implying the circulation and water mass in the Beibu Gulf had strong responses to the temporal resolution of the surface forces. | GAO Jingsong SHI Maochong CHEN Bo GUO Peifang ZHAO Dongliang | 2014 | Acta Oceanologica Sinica2014，33，7： | 7 |
| 7 | The equilibrium range of wind wave frequency spectrum显示文摘-Theoretical form of equilibrium range is given on the basis of the wind wave frequency spectra proposed by Wenel al. (1988a,b,c, 1989a,b). The effects of peakness factor and water depth are discussed. In the case of deep water the e-quilibrium range is reduced to the form first proposed by Toba (1973) and the coefficient of the formula is shown to be the function of nondimensional fetch or peak frequency. Results of the present paper have been verified through field data. | Wen Shengchang (S. C. Wen) , Zhang Dacuo, Chen Bohai and Guo Peifang Institute of Physical Oceanography, Ocean University of Qingdao, Qingdao, China | 1990 | Acta Oceanologica Sinica1990，9，1： | 4 |
| 8 | Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy显示文摘Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia(AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor(G-CSF)(low-dose chemotherapy(LDC)/G-CSF). Complete response(CR) after two induction courses was attained in 87.0%(40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy(SDC) for induction(80/94(85.1%) of the patients attained CR after induction Ⅱ, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free(67.4 vs. 70.7%;P = 0.99)and overall(70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell(WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC(11.5 vs. 18.5 d for WBCs(P < 0.001);15.5 vs. 22.0 d for platelets(P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF(n = 9) or SDC(n = 11), all of the mutations were below the reference value(variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML. | Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C. Ribeiro Shaoyan Hu Qian-fei Wang | 2019 | National Science Review2019，6，3： | 3 |
| 9 | A hybrid model for numerical wave forecasting and its implementation-Ⅱ .The discrete part and implementation of the model显示文摘In the first part of the present paper we have explained why we manage to formulate another wave prediction model when so many of them, including the so-called third generation model, have already been in use. The wind-wave part of the proposed model has also been given. Now we proceed to discuss the swell part,the implementation of the model as a prediction method,mumerical experiments done with ideal wind fields and hindcasts made in the Bohai Sea,in the neighboring seas adjacent to China and in the Northwest Pacific. | Zhang Dacuo, Wu Zengmao, Jiang Decai, Wang Wei, Chen Bohai, Tai Weitao, Wen Shengchang,Xu Qichun and Guo Peifang | 1992 | Acta Oceanologica Sinica1992，11，2： | 3 |
| 10 | Injectable melatonin-loaded carboxymethyl chitosan(CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition显示文摘Carboxymethyl chitosan(CMCS)-based hydrogels have antibacterial activity,and have shown the abilities of preventing wound infection,promoting cell proliferation,accelerating collagen deposition,and stimulating hyaluronic acid formation during wound healing.As a hormone produced by the pineal gland in humans and animals,melatonin promotes skin wound healing by regulating the release of inflammatory mediators and accelerating the proliferation and migration of cells,angiogenesis,and collagen deposition.However,the combined effects of CMCS and melatonin on wound healing remain unclear.Injectable CMCS-based hydrogels containing melatonin were prepared,and their healing effects were evaluated using a full-thickness cutaneous wound model in rats.Compared with the control and the hydrogel with no melatonin groups,the melatonin-loaded hydrogel significantly increased the percentage of wound closure,promoted the proliferation of granulation tissue and re-epithelialization,and accelerated collagen deposition.Additionally,the melatonin-loaded hydrogel promoted angiogenesis and vascular endothelial growth factor receptor protein expression and increased the expression of cyclooxygenase-2 and inducible nitric oxide synthase.The melatonin-loaded hydrogel also markedly increased the expression of collagen III,α-smooth muscle actin,and transforming growth factor-β1 proteins and reduced collagen I expression.These results suggest that the melatonin-loaded hydrogel promoted granulation tissue formation and accelerated wound healing by reducing inflammation and promoting angiogenesis and collagen deposition. | Kai Chen Changci Tong Jinge Yang Peifang Cong Ying Liu Xiuyun Shi Xu Liu Jun Zhang Rufei Zou Keshen Xiao Yuyang Ni Lei Xu Mingxiao Hou Hongxu Jin Yunen Liu | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 11 | ANIONIC SPECIES OF SiO_2-CONTAINING SODIUM ALUMINATE SOLUTIONS显示文摘The anionic species of the SiO2-containing sodium aluminate solutions prepared by differentmethods have been investigated by Raman spectra and ultraviolet spectra.It was found thatthese solutions have different SiO2-containing anions.The solution prepared by leaching in-dustrial sinter of soda-lime sintering process contains polvsilicate ions with Si-O-Si radicals. | LIU Miaoxiu ZHOU Peifang CHEN Nianyi Shanghai Institute of Metallurgy,Academia Sinica,Shanghai,ChinaLI Yu Shanghai University of Science and Technology,Shanghai,ChinaKE Jiajun Institute of Chemical Metallurgy,Academia Sinica,Beijing,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，12： | 1 |
| 12 | Composite element algorithm for the thermal analysis of mass concrete: simulation of lift joint 显示文摘 | Chen Shenghong Su Peifang Shahrour I | 2011 | Finite Elements in Analysis and Design2011，，47： | 1 |
| 13 | Composite element algorithm for the thermal analysis of mass concrete: simulation of cooling pipes 显示文摘 | Chen Shenghong Su Peifang Shahrour I | 2011 | International Journal of Numerical Methods for Heat & Fluid Flow2011，21，34： | 1 |
| 14 | Therapeutic effect Of Ginkgo biloba polysaccharide in rats with focal cerebral ischemia/reperfusion (I/R)injury显示文摘 | Yongmei Yang Peifang Liu Lixia Chen | 2013 | Carbohydrate Polymers: Scientific and Technologica Aspects of Industriallv Important Polvsaccharides2013，98，2： | 1 |
| 15 | Theoretical wind wave frequency spectra in shallow water显示文摘 | Wen Shengchang (S. C. Wen) Guo Peifang Zhang Dacuo and Chen Bohai Institute of Physical Oceanography Shandong College of Oceanography Qingdao China | 1988 | Acta Oceanologica Sinica1988，，03： | 1 |
| 16 | Real-time in situ observation of P53-mediated cascade activation of apoptotic pathways with nucleic acid multicolor fluorescent probes based on symmetrical gold nanostars显示文摘T-2 toxin,one of the most dangerous natural pollutants,induces apoptosis through multiple pathways.Amongst,P53 mediated apoptosis pathway,an important collection of molecules,plays a key role in cell vital activity.Real-time monitoring of upstream and downstream activation relationships of P53 mRNA,Bax mRNA,and cytochrome c(Cyt c)in signaling pathways is of great significance for understanding the apoptotic machinery in human physiology.In this work,a novel nucleic acid multicolor fluorescent probe,based on silica-coated symmetric gold nanostars(S-AuNSs@SiO_(2)),was developed for highly sensitive in situ real-time imaging of P53 mRNA,Bax mRNA,and Cyt c during T-2 toxin-induced apoptosis.The nucleic acid chains modified with carboxyl groups were modified on the surface of S-AuNSs@SiO_(2)by amide reaction.The complementary chains of targeted mRNA and the aptamer of targeted Cyt c were modified with different fluorophores,respectively,and successfully hybridized on S-AuNSs@SiO_(2)surface.When targets were present,the fluorescent chains bound to the targets and detached from the material,resulting in the quenched fluorescence being revived.The probes based on S-AuNSs showed excellent performance is partly ascribed to the presence of 20 symmetric“hot spots”.Notably,the amide-bonded probe exhibited excellent anti-interference capability against biological agents(nucleases and biothiols).During the real-time fluorescence imaging of T-2 toxin-induced apoptosis,the corresponding fluorescence signals of P53 mRNA,Bax mRNA,and Cyt c were observed sequentially.Therefore,S-AuNSs@SiO_(2)probe not only provides a novel tool for real-time monitoring of apoptosis pathways cascade but also has considerable potential in disease diagnosis and pharmaceutical medical. | Chenbiao Li Peifang Chen Xiaoyuan Ma Xichi Lin Shan Xu Sobia Niazi Zhouping Wang | 2023 | Nano Research2023，16，4： | 0 |
| 17 | 0D/1D AgI/MoO_(3)Z-scheme heterojunction photocatalyst:Highly efficient visible-light-driven photocatalyst for sulfamethoxazole degradation显示文摘Low dimension nano photocatalysts show great potential in the field of treating contaminated water for their large surface area and size effect.In this study,a 0 D/1 D AgI/MoO_(3)Z-scheme photocatalyst with striking photocatalytic performance was constructed successfully.The one-dimensional MoO_(3)nanobelts were prepared by a simple hydrothermal method,and then it was modified by AgI nanoparticles in a handy deposition approach.When choosing sulfamethoxazole(SMZ)as the target contaminant,the rate constant value of the optimal 0 D/1 D AgI/MoO_(3)composite could hit up to 0.13 min^(-1),which is nearly 22.4 times and 32.5 times as that of pure MoO_(3)(0.0058 min^(-1))and AgI(0.0040 min^(-1)),respectively.A series of detailed characterizations give evidences that the charge transfer in the composite followed Z scheme mechanism.Therefore,efficient separation/transfer and the remained high redox activity of photogenerated carriers played a vital role in the sharply enhanced photocatalytic properties.The possible degradation pathways of SMZ were proposed based on the intermediates detected by high-performance liquid chromatography-mass spectrometry(HPLC-MS).Meanwhile,the magnificent cyclic stability makes the material a promising material in the practical application. | Jing Xu Juan Chen Yanhui Ao Peifang Wang | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 18 | SPECTRAL STUDY OF CARBONIZATION PROCESS IN ALUMINA PRODUCTION显示文摘SPECTRALSTUDYOFCARBONIZATIONPROCESSINALUMINAPRODUCTIONSPECTRALSTUDYOFCARBONIZATIONPROCESSINALUMINAPRODUCTION￥Hong,Mei;Liu,Mia... | Hong, Mei Liu, Miaoxiu Zhang, Weiming Zhao, Peifang Chen, Nianyi | 1994 | 中国有色金属学会会刊:英文版1994，4，2： | 0 |
| 19 | Development and evaluation of the screening performance of a low-cost high-risk screening strategy for breast cancer显示文摘Objective:To develop and evaluate the screening performance of a low-cost high-risk screening strategy for breast cancer in low resource areas.Methods:Based on the Multi-modality Independent Screening Trial,6 questionnaire-based risk factors of breast cancer(age at menarche,age at menopause,age at first live birth,oral contraceptive,obesity,family history of breast cancer)were used to determine the women with high risk of breast cancer.The screening performance of clinical breast examination(CBE),breast ultrasonography(BUS),and mammography(MAM)were calculated and compared to determine the optimal screening method for these high risk women.Results:A total of 94 breast cancers were detected among 31,720 asymptomatic Chinese women aged 45–65 years.Due to significantly higher detection rates(DRs)and suitable coverage of the population,high risk women were defined as those with any of 6 risk factors.Among high risk women,the DR for BUS[3.09/1,000(33/10,694)]was similar to that for MAM[3.18/1,000(34/10,696)],while it was significantly higher than that for the CBE[1.73/1,000(19/10,959),P=0.002].Compared with MAM,BUS showed significantly higher specificity[98.64%(10,501/10,646)vs.98.06%(10,443/10,650),P=0.001],but no significant differences in sensitivity[68.75%(33/48)vs.73.91%(34/46)],positive prediction values[18.54%(33/178)vs.14.11%(34/241)],and negative prediction values[99.86%(10,501/10,516)vs.99.89%(10,443/10,455)].Further analyses showed no significant difference in the percentages of early stage breast cancer[53.57%(15/28)vs.50.00%(15/30)],lymph node involvement[22.73%(5/22)vs.28.00%(7/25)],and tumor size≥2 cm[37.04%(10/27)vs.29.03%(9/31)]between BUS and MAM.Subgroup analyses stratified by breast densities or age at enrollment showed similar results.Conclusions:The low-cost high-risk screening strategy based on 6 questionnaire-based risk factors was an easy-to-use method to identify women with high risk of breast cancer.Moreover,BUS and MAM had comparable screening performances among high risk women. | Yubei Huang Huan Wang Zhangyan Lyu Hongji Dai Peifang Liu Ying Zhu Fengju Song Kexin Chen | 2022 | Cancer Biology & Medicine2022，19，9： | 0 |
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