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| 1 | A pure quasi-human algorithm for solving the cuboid packing problem显示文摘We excavate the wisdom from an old Chinese proverb 'gold corner, silver side and strawy void', and further improve it into 'maximum value in diamond cave' for solving the NP-hard cuboid packing problem. We extract, integrate and formalize the idea by west modern mathematical tools, and propose a pure quasi-human algorithm. The performance of the algorithm is evaluated on two sets of public benchmarks. For 100 strongly heterogeneous difficult benchmarks, experiments show an average packing utilization of 87.31%, which surpasses current best record reported in the literature by 1.83%. For 47 difficult benchmarks without orientation constraint, experiments show an average volume utilization of 92.05%, which improves current best record reported in the literature by 1.05%. | HUANG WenQi HE Kun | 2009 | Science in China(Series F)2009，52，1： | 8 |
| 2 | Deep-learning-based ciphertext-only attack on optical double random phase encryption显示文摘Optical cryptanalysis is essential to the further investigation of more secure optical cryptosystems.Learning-based at-tack of optical encryption eliminates the need for the retrieval of random phase keys of optical encryption systems but it is limited for practical applications since it requires a large set of plaintext-ciphertext pairs for the cryptosystem to be at-tacked.Here,we propose a two-step deep learning strategy for ciphertext-only attack(COA)on the classical double ran-dom phase encryption(DRPE).Specifically,we construct a virtual DRPE system to gather the training data.Besides,we divide the inverse problem in COA into two more specific inverse problems and employ two deep neural networks(DNNs)to respectively learn the removal of speckle noise in the autocorrelation domain and the de-correlation operation to retrieve the plaintext image.With these two trained DNNs at hand,we show that the plaintext can be predicted in real-time from an unknown ciphertext alone.The proposed learning-based COA method dispenses with not only the retrieval of random phase keys but also the invasive data acquisition of plaintext-ciphertext pairs in the DPRE system.Numerical simulations and optical experiments demonstrate the feasibility and effectiveness of the proposed learning-based COA method. | Meihua Liao Shanshan Zheng Shuixin Pan Dajiang Lu Wenqi He Guohai Situ Xiang Peng | 2021 | Opto-Electronic Advances2021，4，5： | 7 |
| 3 | Flow Behaviors of Non-spherical Granules in Rectangular Hopper显示文摘Flow behaviors of four kinds of granular particles(i.e. sphere,ellipsoid,hexahedron and binary mixture of sphere and hexahedron) in rectangular hoppers were experimentally studied. The effects of granular shape and hopper structure on flow pattern,discharge fraction,mean particle residence time and tracer concentration distribu-tion were tested based on the visual observation and particle tracer technique. The results show that particle shape affects significantly the flow pattern. The flow patterns of sphere,ellipsoid and binary mixture are all parabolic shape,and the flow pattern shows no significant difference with the change of wedge angle. The flowing zone be-comes more sharp-angled with the increasing outlet size. The flow pattern of hexahedron is featured with straight lines. The discharge rates are in increasing order from hexahedron,sphere,binary mixture to ellipsoid. The dis-charge rate also increases with the wedge angle and outlet size. The mean particle residence time becomes shorter when the outlet size increases. The difference of mean particle residence time between the maximum and minimum values decreases as the wedge angle increases. The residence time of hexahedron is the shortest. The tracer concen-tration distribution of hexahedron at any height is more uniform than that of binary mixture. The tracer concentra-tion of sphere in the middle is lower than that near the wall,and the contrary tendency is found for ellipsoid particles. | JIN Baosheng TAO He ZHONG Wenqi | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 7 |
| 4 | A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling显示文摘Long noncoding RNAs(lncRNAs)are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development.Liquid–liquid phase separation(LLPS)occurs in a wide range of biological processes,while its role in signal transduction remains largely undeciphered.In this study,we uncovered a lipid-associated lncRNA,small nucleolar RNA host gene 9(SNHG9)as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1(LATS1)and inhibiting the Hippo pathway.Mechanistically,SNHG9 and its associated phosphatidic acids(PA)interact with the C-terminal domain of LATS1,promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation.Loss of SNHG9 suppresses xenograft breast tumor growth.Clinically,expression of SNHG9 positively correlates with YAP activity and breast cancer progression.Taken together,our results uncover a novel regulatory role of a tumor-promoting lncRNA(i.e.,SNHG9)in signal transduction and cancer development by facilitating the LLPS of a signaling kinase(i.e.,LATS1). | Rui-Hua Li Tian Tian Qi-Wei Ge Xin-Yu He Cheng-Yu Shi Jun-Hong Li Zhen Zhang Fang-Zhou Liu Ling-Jie Sang Zuo-Zhen Yang Ya-Zhuo Liu Yan Xiong Qingfeng Yan Xu Li Huai-Qiang Ju Jian Liu Liang-Jing Wang Jian-Zhong Shao Wenqi Wang Tianhua Zhou Aifu Lin | 2021 | Cell Research2021，31，10： | 6 |
| 5 | ZmSRL5 is involved in drought tolerance by maintaining cuticular wax structure in maize显示文摘Cuticular wax is a natural barrier on terrestrial plant organs,which protects plants from damages caused by a variety of stresses.Here,we report the identification and functional characterization of a cuticular-wax-related gene,Zea mays L.SEMI-ROLLED LEAF 5(ZmSRL5).The loss-of-function mutant srl5,which was created by a 3,745 bp in-sertion in the first intron that led to the premature tran-script,exhibited abnormal wax crystal morphology and distribution,which,in turn,caused the pleiotropic pheno-types including increased chlorophyll leaching and water loss rate,decreased leaf temperature,sensitivity to drought,as well as semi-rolled mature leaves.However,total wax amounts showed no significant difference between wild type and semi-rolled leaf5(srl5)mutant.The phenotype of srl5 was confirmed through the generation of two allelic mutants using CRISPR/Cas9.ZmSRL5 encodes a CASPARIAN-STRIP-MEMBRANE-DOMAIN-LIKE(CASPL)protein located in plasma membrane,and highly expressed in developing leaves.Further analysis showed that the expressions of the most wax related genes were not affected or slightly al-tered in srl5.This study,thus,primarily uncovers that ZmSRL5 is required for the structure formation of the cu-ticular wax and could increase the drought tolerance by maintaining the proper cuticular wax structure in maize. | Zhenyuan Pan Min Liu Hailiang Zhao Zengdong Tan Kun Liang Qin Sun Dianming Gong Haijun He Wenqi Zhou Fazhan Qiu | 2020 | Journal of Integrative Plant Biology2020，62，12： | 5 |
| 6 | Research progress of nanoparticles as enzyme mimetics显示文摘Natural enzymes as biological catalysts possess remarkable advantages,especially their highly efficient and selective catalysis under mild conditions.However,most natural enzymes are proteins,thus exhibiting an inherent low durability to harsh reaction conditions.Artificial enzyme mimetics have been pursued extensively to avoid this drawback.Quite recently,some inorganic nanoparticles(NPs) have been found to exhibit unique enzyme mimetics.In addition,their much higher stability overcomes the inherent disadvantage of natural enzymes.Furthermore,easy mass-production and low cost endow them more benefits.As a new member of artificial enzyme mimetics,they have received intense attention.In this review article,major progress in this field is summarized and future perspectives are highlighted. | HU XiaoNa LIU JianBo HOU Shuai WEN Tao LIU WenQi ZHANG Ke HE WeiWei JI YingLu REN HongXuan WANG Qi WU XiaoChun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 4 |
| 7 | A double-filter-structure based COMPASS/INS deep integrated navigation system implementation and tracking performance evaluation显示文摘Beidou or COMPASS is a Chinese GNSS(global navigation satellite system).Like the GPS receiver,the COMPASS receiver also faces the challenge of choosing an optimal bandwidth to satisfy both anti-jamming capability and dynamics adaptation simultaneously.GPS/INS(inertial navigation system)deep integrated navigation system has solved this problem by fusing GPS baseband signal and INS information in a deeply coupled mode.In this study,a COMPASS B3 frequency is considered and a traditional federated GPS/INS deep integration model is used to derive a single-filter-structure based COMPASS/INS deep integration model.Besides,a double-filter-structure based COMPASS/INS deep integration model is proposed.The simulation results show a better carrier tracking performance,especially a better dynamics adaptation.The impact of IMU errors and vehicle’s dynamics on carrier tracking performance of the double-filter-structure based COMPASS/INS deep integrated navigation system are evaluated in simulated and field environments.Simulation and field test results are in accordance with the theory analysis. | LUO Yong WU WenQi BABU Ravindra TANG KangHua HE XiaoFeng | 2014 | Science China(Information Sciences)2014，57，1： | 4 |
| 8 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 9 | Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model显示文摘 | Xiaole Chen Wenqi Zhong Josin Tom Clement Kleinstreuer Yu Feng Xiaopu He | 2016 | Particuology2016，14，5： | 3 |
| 10 | Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection显示文摘The treatment of Alzheimer's disease(AD)is one of the most difficult challenges in neurodegenerative diseases due to the insufficient blood‒brain barrier(BBB)permeability and unsatisfactory intra-brain distribution of drugs.Therefore,we established an ibuprofen and FK506 encapsulated drug co-delivery system(Ibu&FK@RNPs),which can target the receptor of advanced glycation endproducts(RAGE)and response to the high level of reactive oxygen species(ROS)in AD.RAGE is highly and specifically expressed on the lesion neurovascular unit of AD,this property helps to improve targeting specificity of the system and reduce unselective distribution in normal brain.Meanwhile,these two drugs can be specifically released in astrocytes of AD lesion in response to high levels of ROS.As a result,the cognition of AD mice was significantly improved and the quantity of Aβplaques was decreased.Neurotoxicity was also alleviated with structural regeneration and functional recovery of neurons.Besides,the neuroinflammation dominated by NF-κB pathway was significantly inhibited with decreased NF-κB and IL-1βin the brain.Overall,Ibu&FK@RNPs can efficiently and successively target diseased BBB and astrocytes in AD lesion.Thus it significantly enhances intracephalic accumulation of drugs and efficiently treats AD by anti-neuroinflammation and neuroprotection. | Xueqin He Xiaorong Wang Lianyi Yang Zhihang Yang Wenqi Yu Yazhen Wang Rui Liu Meiwan Chen Huile Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 11 | Evaluation of Heavy Metals and Pesticide Residues in Dendrobium officinale Produced in Guangxi显示文摘[Objectives]To establish a method for the determination of heavy metals and pesticide residues in Dendrobium officinale produced in Guangxi and its culture substrate.[Methods]The contents of five heavy metals(Pb,Cd,As,Hg and Cu)were determined by the atomic absorption spectrophotometric(AAS)method;residues of 9 organochlorine pesticides(α-BHC,β-BHC,γ-BHC,δ-BHC,p,p′-DDT,p,p′-DDE,p,p′-DDD,o,p′-DDT and pentachloronitrobenzene)were determined by gas chromatography(GC).[Results]The contents of five heavy metals in the medicinal materials of D.officinale produced in Guangxi were 0.96,0.21,0.021 mg/kg,and not detected,and 0.35 mg/kg.The contents of five heavy metals in the culture substrate were 0.03,0.19,0.21,0.004 and 1.80 mg/kg,respectively;the content of 9 organochlorine pesticide residues in the sample was not detected.[Conclusions]The detection results of heavy metal content and organochlorine pesticide residues in D.officinale produced in Guangxi and its substrate are consistent with the limit requirements of the Chinese Pharmacopoeia.This experiment is expected to provide reliable data reference for ensuring the safety of the drug resources of D.officinale in Guangxi. | Hua ZHU Ruiting HE Piaoling HUANG Wenqi YANG Anda WEI Yuanjing TAO Zhonghua DAI | 2019 | Medicinal Plant2019，10，5： | 3 |
| 12 | Hydrological Simulation Using TRMM and CHIRPS Precipitation Estimates in the Lower Lancang-Mekong River Basin显示文摘Satellite-based products with high spatial and temporal resolution provide useful precipitation information for data-sparse or ungauged large-scale watersheds. In the Lower Lancang-Mekong River Basin, rainfall stations are sparse and unevenly distributed, and the transboundary characteristic makes the collection of precipitation data more difficult, which has restricted hydrological processes simulation. In this study, daily precipitation data from four datasets(gauge observations, inverse distance weighted(IDW) data, Tropical Rainfall Measuring Mission(TRMM) estimates, and Climate Hazards Group InfraRed Precipitation with Stations(CHIRPS) estimates), were applied to drive the Soil and Water Assessment Tool(SWAT) model, and then their capability for hydrological simulation in the Lower Lancang-Mekong River Basin were examined. TRMM and CHIRPS data showed good performances on precipitation estimation in the Lower Lancang-Mekong River Basin, with the better performance for TRMM product. The Nash-Sutcliffe efficiency(NSE) values of gauge, IDW, TRMM, and CHIRPS simulations during the calibration period were 0.87, 0.86, 0.95, and 0.93 for monthly flow, respectively, and those for daily flow were 0.75, 0.77, 0.86, and 0.84, respectively. TRMM and CHIRPS data were superior to rain gauge and IDW data for driving the hydrological model, and TRMM data produced the best simulation performance. Satellite-based precipitation estimates could be suitable data sources when simulating hydrological processes for large data-poor or ungauged watersheds, especially in international river basins for which precipitation observations are difficult to collect. CHIRPS data provide long precipitation time series from 1981 to near present and thus could be used as an alternative precipitation input for hydrological simulation, especially for the period without TRMM data. For satellite-based precipitation products, the differences in the occurrence frequencies and amounts of precipitation with different intensities would affect simulation results of water balance components, which should be comprehensively considered in water resources estimation and planning. | LUO Xian WU Wenqi HE Daming LI Yungang JI Xuan | 2019 | Chinese Geographical Science2019，29，1： | 2 |
| 13 | Olfactory and gustatory dysfunctions of COVID-19 patients in China:A multicenter study显示文摘Introduction:With the spread of the epidemic worldwide,an increasing number of doctors abroad have observed the following atypical symptoms of coronavirus disease 2019(COVID-19):olfactory or taste disorders.Therefore,clarifying the incidence and clinical characteristics of olfactory and taste disorders in Chinese COVID-19 patients is of great significance and urgency.Materials and Methods:A retrospective study was conducted,which included 229 severe acute respiratory syndrome coronavirus 2 confirmed patients,through face-to-face interviews and telephone follow-up.Following the completion of questionnaires,the patients participating in the study,were categorized according to the degree of olfactory and taste disorders experienced,and the proportion of each clinical type of patient with olfactory and taste disorders and the time when symptoms appeared were recorded.Results:Among the 229 patients,31(13.54%)had olfactory dysfunction,and 44(19.21%)had gustatory dysfunction.For the patients with olfactory dysfunction,6(19.35%)developed severe disease and became critically ill.Olfactory dysfunction appeared before the other symptoms in 21.43%of cases.The proportion of females with olfactory and gustatory dysfunction was higher than that of males(P<0.001).Conclusions:The incidence of olfactory and gustatory dysfunction was much lower than that reported abroad;the prognosis of patients with olfactory dysfunction is relatively favorable;olfactory and gustatory dysfunction can be used as a sign for early screening;females are more prone to olfactory and gustatory dysfunction. | Jianhui Li Yi Sun Enqiang Qin Hu Yuan Mingbo Liu Wenqi Yi Zhu Chen Chengcheng Huang Fengjie Zhou Ruiyao Chen Leibo Zhang Ning Yu Qiong Liu Xuejun Zhou Jingjing He Boyu Li Fusheng Wang Changliang Yang Shiming Yang | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，4： | 2 |
| 14 | Recent genome duplications facilitate the phenotypic diversity of Hb repertoire in the Cyprinidae显示文摘Whole-genome duplications(WGDs)are an important contributor to phenotypic innovations in evolutionary history.The diversity of blood oxygen transport traits is the perfect reflection of physiological versatility for evolutionary success among vertebrates.In this study,the evolutionary changes of hemoglobin(Hb)repertoire driven by the recent genome duplications were detected in representative Cyprinidae fish,including eight diploid and four tetraploid species.Comparative genomic analysis revealed a substantial variation in both membership composition and intragenomic organization of Hb genes in these species.Phylogenetic reconstruction analyses were conducted to characterize the evolutionary history of these genes.Data were integrated with the expression profiles of the genes during ontogeny.Our results indicated that genome duplications facilitated the phenotypic diversity of the Hb gene family;each was associated with species-specific changes in gene content via gene loss and fusion after genome duplications.This led to repeated evolutionary transitions in the ontogenic regulation of Hb gene expression.Our results revealed that genome duplications helped to generate phenotypic changes in Cyprinidae Hb systems. | Yi Lei Liandong Yang Haifeng Jiang Juan Chen Ning Sun Wenqi Lv Shunping He | 2021 | Science China(Life Sciences)2021，64，7： | 2 |
| 15 | Flow behavior of non-spherical particle flowing in hopper显示文摘流动在 hopper 的椭圆体的粒子被使用分离元素方法(DEM ) 模仿,并且由多元素方法描述了。为在 hopper 的椭圆体的粒子运动的接触察觉算法和方程被开发。并且模拟结果被实验证实。另外,集体流动率,压力分发和二种粒子的速度分发被检验。结果证明椭圆体的粒子的集体流动率比球形的粒子的小。有在连接的顶的压力落下的最大的价值。而且,压力落下减少,排出的时间增加。球形的粒子的速度比的大椭圆体。 | He TAO Wenqi ZHONG Baosheng JIN | 2014 | Frontiers in Energy2014，8，3： | 2 |
| 16 | Rapid detection of orf virus by loop-mediated isothermal amplification based on the DNA polymerase gene显示文摘 | Jida Li Deguang Song Wenqi He Yingfu Bao Rongguang Lu Gaoli Su Gaili Wang Huijun Lu Kui Zhao Feng Gao | 2013 | Archives of Virology2013，，4： | 2 |
| 17 | The Tribochemical Study of Some N-Containing Heterocyclic Compounds as Lubricating Oil Additives显示文摘 | Zhongyi He Wenqi Rao Tianhui Ren Weimin Liu Qunji Xue | 2002 | Tribology Letters2002，，2： | 1 |
| 18 | The tribochemical study of some N-containing heterocyclic compounds as lubricating oil additives 显示文摘 | Zhongyi He Wenqi Rao Tianhui Ren | 2002 | Tribology Letters2002，13，2： | 1 |
| 19 | Study on the hydrogenation coupling of methane显示文摘 | Bin Dai Xiuling Zhang Lin Zhang Weimin Gong Ren He Wenqi Lu Xinlu Deng | 2001 | Science in China Series B: Chemistry2001，，2： | 1 |
| 20 | Inhibition of porcine hemagglutinating encephalomyelitis virus replication by short hairpin RNAs targeting of the nucleocapsid gene in a porcine kidney cell line显示文摘 | Yungang Lan Kui Zhao Wenqi He Gaili Wang Huijun Lu Deguang Song Feng Gao | 2011 | Journal of Virological Methods2011，，2： | 1 |
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