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| 1 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 2 | Self-organization of unimolecular micelles in beam stream for functional mesoporous metal oxide nanofibers显示文摘The use of linear amphiphilic block copolymers as templates is an important method for the preparation of mesoporous materials.However,the obtained assemblies are usually sensitive to synthetic conditions,which impedes the preparation of such mesoporous materials in certain environments.Herein,we report a universal strategy applying an amphiphilic multiarm triblock copolymer in the preparation of mesoporous metal oxide nanofibers(NFs)using one metal oxide(TiO_(2),ZrO_(2),WO_(3),CeO_(2)),or two(TiO_(2)/WO 3,TiO_(2)/ZrO_(2),TiO_(2)/CeO_(2))and three(TiO_(2)/WO_(3)/CuO)metal oxides as composites.The template consists of modified β-cyclodextrin as the center of the macromolecule which is attached sequentially to a block of polystyrene,poly(acrylic acid),and poly(ethylene oxide).Under electrospinning conditions,stable unimolecular micelles are formed and effectively co-assemble with metal ions to form fibrous nanostructures.As indicated by various characterization methods,the synthesized TiO_(2) and its derived composite NFs maintain a straight and continuous fibrous structure after calcination,and TiO_(2) NFs exhibit uniform mesopores of 10.8 nm in diameter and a large Brunauer-Emmett-Teller surface area of 143.3 m^(2)g^(−1).Benefiting from the characteristic structure,still present after modification,Pt-decorated mesoporous TiO_(2) NFs display excellent ability in the visible-light photocatalytic degradation of tetracycline,which is superior to the commercial P25 catalyst.This study reveals a promising strategy for the preparation of fibrous mesoporous metal oxides. | Chongfei Gu Xiaoshan Fan Guihua Zhu Yuchi Fan Haifeng Wang Tao Zhao Qi Xiao Yuan Fang Xiaopeng Li Wan Jiang Lianjun Wang Pengpeng Qiu Wei Luo | 2022 | Fundamental Research2022，2，5： | 1 |
| 3 | Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer:a case report显示文摘Non-small cell lung cancer(NSCLC) ranks as the leading cause of cancer-related death in the world. Brain metastasis(BM) is a common complication of NSCLC, with 25%–40% of patients developing BM during the course of the disease. A significant strategy of local disease control in the central nervous system is radiation therapy. With the development of precision medicine,the concept of treating lung cancer BM has gradually changed. In this case, we performed a surgical procedure to obtain enough tumor tissue for the detection of the target gene and other related experiments after the patient was informed. Finally, we found that the patient had both hepatocyte growth factor receptor(MET) gene amplification and kinesin light chain 1-anaplastic lymphoma kinase fusion(KLC1-ALK) through next-generation sequencing and showed sensitivity to the targeted therapy of crizotinib. The patient exhibited good response. Our case was successful and underwent targeted therapy with the guidance of precise diagnosis. | Peng Wang Pei Xiao Yingnan Ye Pengpeng Liu Lei Han Li Dong Chunhua She Jinpu Yu | 2017 | Cancer Biology & Medicine2017，14，2： | 1 |
| 4 | Characteristics of Poisoning Cases Admitted to Outpatient and Emergency Department—China,2019显示文摘Summary What is already known about this topic?Poisoning constitutes a significant cause of mortality among individuals aged 1 to 44 in China.Nonetheless,the epidemiological understanding of poisoning incidents within emergency departments remains fragmented across the region. | Xiao Deng Ye Jin Yuan Wang Pengpeng Ye Yuan Yuan Chengye Sun Leilei Duan | 2023 | China CDC weekly2023，5，47： | 1 |
| 5 | Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs显示文摘Dear Editor,Most human genetic diseases arise from mutations such as insertion,deletion,or point mutations(Landrum et al.,2016).CRISPRCas system has been repurposed to correct pathogenic mutations in a variety of genetic diseases(Choi et al.,2022).There are many concerns about using CRISPR-mediated double-stranded DNA breaks(DSBs)for therapeutic purposes,primarily due to off-targeted mutations(Kosicki et al.,2018).Nevertheless,base editing cannot correct deletions,insertions,or some point mutations such as transversion mutations.Prime editing has its advantages of precisely correct point mutations,small insertions,or deletions in animal cells(Anzalone et al.,2019)and plants(Lin et al.,2020).However,prime editing efficiency varies among genomic sites or cell types(Chen et al.,2021;Nelson et al.,2022). | Ying Feng Siyuan Liu Qiqin Mo Pengpeng Liu Xiao Xiao Hanhui Ma | 2023 | Protein & Cell2023，14，4： | 1 |
| 6 | Synergistic lubricating effect of graphene/ionic liquid composite material used as an additive显示文摘We prepared a graphene/ionic liquid(G/IL)composite material by the hybridization of G and an IL for use as a lubricating oil additive.The friction coefficient and wear volume of a base oil containing 0.04 wt%of the G/IL composite was reduced by 45%and 90%,respectively.Furthermore,the base oil containing the G/IL composite exhibited better lubricating properties than the base oil containing G,IL,or a mixture of IL and G at the same mass fraction.A synergistic lubrication mechanism was also revealed.The G/IL composite was adsorbed and deposited on the wear surface,forming a more ordered protective film and a unique tribochemical reaction film during rubbing.Therefore,the G/IL composite exhibited the synergistic lubricating effects of G and IL,which significantly improved the lubricating performance of the base oil.This study also suggested a way to limit the out-of-plane puckering of G at the macroscale. | Lincong LIU Ming ZHOU Youtang MO Pengpeng BAI Qilin WEI Long JIN Shengli YOU Mingyue WANG Liangchuan LI Xin CHEN Xiao LI Yu TIAN | 2021 | Friction2021，9，6： | 1 |
| 7 | Asymmetric epigenome maps of subgenomes reveal imbalanced transcription and distinct evolutionary trends in Brassica napus显示文摘The complexity of the epigenome landscape and transcriptional regulation is significantly increased during plant polyploidization,which drives genome evolution and contributes to the increased adaptability to diverse environments.However,a comprehensive epigenome map of Brassica napus is still unavailable.In this study,we performed integrative analysis of five histone modifications,RNA polymerase Ⅱ CCU-pancy,DNA methylation,and transcriptomes in two B.napus lines(2063A and B409),and established global maps of regulatory elements,chromatin states,and their dynamics for the whole genome(including the An and Cn subgenomes)in four tissue types(young leaf,flower bud,silique,and root)of these two lines.Approximately 65.8% of the genome was annotated with different epigenomic signals.Compared with the Cn subgenome,the An subgenome possesses a higher level of active epigenetic marks and lower level of repressive epigenetic marks.Genes from subgenome-unique regions contribute to the major differences between the An and Cn subgenomes.Asymmetric histone modifications between homeologous gene pairs reflect their biased expression patterns.We identified a novel bivalent chromatin state(with H3K4me1 and H3K27me3)in B.napus that is associated with tissue-specific gene expression.Furthermore,we observed that different types of duplicated genes have discrepant patterns of histone modification and DNA methylation levels.Collectively,our findings provide a valuable epigenetic resource for allopolyploid plants. | Qing Zhang Pengpeng Guan Lun Zhao Meng Ma Liang Xie Yue Li Ruiqin Zheng Weizhi Ouyang Shunyao Wang Hongmeijuan Li Ying Zhang Yong Peng Zhilin Cao Wei Zhang Qin Xiao Yuanling Xiao Tingdong Fu Guoliang Li Xingwang Li Jinxiong Shen | 2021 | Molecular Plant2021，14，4： | 1 |
| 8 | Regulating Phase Junction and Oxygen Vacancies of TiO_(2) Nanoarrays for Boosted Photoelectrochemical Water Oxidation显示文摘In this study,we have provided a facile solution to synthesize well-aligned titanium dioxide nanorods by using hydrothermal reaction.By calcining the materials under different atmospheres and temperatures,a batch of titanium dioxides with excellent oxygen evolution reaction(OER)catalytic efficiency were obtained.This new structured TiO_(2) photoanode material yields a high photocurrent density of 5.69 mA/cm^(2) at 1.23 V vs.reversible hydrogen electrode(RHE)under simulated solar light(100 mW/cm^(2)).Surface photovoltage techniques and other measurements were carried out to confirm that the enhanced photoelectrochemical performances were attributed to the synergistic effect of the phase junction and a certain content of surface states,which accelerate the separation and transmission of the photogenerated charges.This material with phase junction and surface states promises a potential application in the field of photoelectric catalysis under solar light. | ZHANG Xinyu TANG Pengpeng ZHAI Guangyao LIN Xiu ZHANG Qiang CHEN Jiesheng WEI Xiao | 2022 | Chemical Research in Chinese Universities2022，38，5： | 0 |
| 9 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 10 | Sealing functional ionic liquids in conjugated microporous polymer membrane by solvent-assisted micropore tightening显示文摘Porous organic polymers hold great promise for molecular sieving membrane separation.Although the inclusion of functional ionic liquid(IL)in the pores offers a facile way to manipulate their separation properties,the IL leaching during the separation process is difficult to avoid.Herein,we report a strategy to in-situ encapsulate ILs into the micropores of the conjugated microporous polymer membrane via a 6-min electropolymerization and further seal the aperture of the pores to prevent ILs leaching by solvent-assisted micropore tightening(SAMT).Upon screening the binding energy between different ILs and gas molecules,two ILs were selected to be incorporated into the membrane for CO_(2)/CH_(4) and O_(2)/N_(2) gas separations.The resultant separation performances surpass the 2008 Robeson upper bound.Notably,the ILs can be locked in the micropores by a facile high surface tension solvent treatment process to improve their separation stability,as evidenced by a 7-day continuous test.This simple and controllable process not only enables efficient and steady separation performance but also provides an effective strategy for confining and sealing functional guest molecules in the porous solids for various applications. | Mengxi Zhang Anke Yu Xiangyu Wu Pengpeng Shao Xin Huang Dou Ma Xianghao Han Jing Xie Xiao Feng Bo Wang | 2022 | Nano Research2022，15，3： | 0 |
| 11 | Highly selective and efficient photocatalytic NO removal:Charge carrier kinetics and interface molecular process显示文摘The widespread nitrogen oxides(NOx,mainly in NO)in the atmosphere have threatened human health and ecological environment.The dilute NO(ppb)is difficult to efficiently remove via the traditional process due to its characteristics of low concentration,wide range,large total amount,etc.Photocatalysis can utilize solar energy to purify NO pollutants under mild conditions,but its application is limited due to the low selectivity of nitrate and poor activity of NO removal.The underlying reason is that the interface mechanism of NO oxidation is not clearly understood,which leads to the inability to accurately regulate the NO oxidation process.Herein,the recent advances in the photocatalytic oxidation of NO are summarized.Firstly,the common strategies to effectively regulate carrier dynamics such as morphology control,facet engineering,defect engineering,plasma coupling,heterojunction and single-atom catalysts are discussed.Secondly,the progress of enhancing the adsorption and activation of reactants such as NO and O_(2) during NO oxidation is described in detail,and the corresponding NO oxidation mechanisms are enumerated.Finally,the challenges and prospects of photocatalytic NO oxidation are presented in term of nanotechnology for air pollution control.This review can shed light on the interface mechanism of NO oxidation and provide illuminating information on designing novel catalysts for efficient NOx control. | Huan Shang Hongbao Jia Pengpeng Li Hao Li Wenbin Zhang Shuangjun Li Qing Wang Shuning Xiao Ding Wang Guisheng Li Dieqing Zhang | 2024 | Nano Research2024，17，3： | 0 |
| 12 | Comparison of leaf morphological,anatomical,and photosynthetic responses to drought stress among eight apple rootstocks显示文摘The drought resistance of eight commonly used apple rootstocks under natural drought conditions was examined to provide clues for the selection,promotion,and utilization of drought-resistant apple rootstocks.The ultrastructural differences and physiological and biochemical characteristics of the leaves of eight apple rootstocks under drought stress were observed.The index changes were used to rank drought resistance by the membership function method comprehensively.The results showed that the leaf thickness,palisade tissue thickness,sponge tissue thickness,net photosynthetic rate,and chlorophyll content were significantly higher in‘Fupingqiuzi'than those of other rootstocks at various stress conditions.The leaf water content and water use efficiency of'Qingzhen 1'were significantly higher than those of other rootstocks under different stress conditions.The root vigor of‘B.9'was significantly higher than that of other rootstocks.The results of membership function analysis showed that the drought resistance of different rootstocks was in the order:‘Fupingqiuzi'>‘Qingzhen 1'>‘B.9'>‘MM.111'>‘GM256'>‘MM.106'>‘M.26'>‘M.9-Nic29'.‘Fupingqiuzi'had the strongest drought resistance,and‘Qingzhen 1'and‘B.9'were also relatively droughtresistant.These rootstocks can be used as raw materials for drought-resistant apple rootstock breeding and are propagated and utilized in arid areas. | Pengpeng Sun Muhammad Mobeen Tahir Xian Lu Zhimin Liu Xiaoyun Zhang Xiya Zuo Yun Shao Xiangyun Xiao Na An Chao Wang Dong Zhang Weiwei Yang | 2022 | Fruit Research2022，2，1： | 0 |
| 13 | Unintentional Drowning Mortality Among Individuals Under Age 20—China,2013–2021显示文摘ABSTRACT Introduction:This study seeks to elucidate the evolving trend and identify disparities among subgroups in the mortality rate due to unintentional drowning in individuals under the age of 20 from the timeframe of 2013 to 2021 in China. | Zi Li Xiao Deng Ye Jin Leilei Duan Pengpeng Ye | 2023 | China CDC weekly2023，5，47： | 0 |
| 14 | ACLY-induced reprogramming of glycolytic metabolism plays an important role in the progression of breast cancer显示文摘Breast cancer(BC)is the most common malignancy in females and has gradually become an important problem threatening global public health.BC,as a heterogeneous disease,has a great difference in prognosis.Local invasion and distant metastasis are the most important factors affecting the prognosis and treatment outcome of tumors[1].Currently,in the context of advocating precision medicine,one of the ways to address this problem is to identify genes that play specific roles in the occurrence,development and metastasis of BC[2]and to clarify the mechanism of action,thus providing a new idea for the precise treatment of BC. | Yu Lu Liping Tian Chengcheng Peng Jienan Kong Pengpeng Xiao Nan Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，5： | 0 |
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