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| 1 | Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism显示文摘AIM: To explore the mechanism of intra-uterine transmission,the HBV infection status of placental tissue and in vitro cultured placental trophoblastic cells was tested through in vivo and in vitro experiments. METHODS: A variety of methods,such as ELISA,RT- PCR,IHC staining and immunofluorescent staining were employed to test the HBV marker positive pregnant women's placenta and in vitro cultured placental trophoblastic cells. RESULTS: The HBV DNA levels in pregnant women's serum and fetal cord blood were correlated. For those cord blood samples positive for HBV DNA,their maternal blood levels of HBV DNA were at a high level. The HBsAg IHC staining positive cells could be seen in the placental tissues and the presence of HBV DNA detected. After co-incubating the trophoblastic cells and HBV DNA positive serum in vitro,the expressions of both HBsAg and HBV DNA could be detected. CONCLUSION: The mechanism of HBV intra-uterine infection may be due to that HBV breaches the placental barrier and infects the fetus. | Han Bai Lin Zhang Li Ma Xiao-Guang Dou Guo-He Feng Gui-Zhen Zhao | 2007 | World Journal of Gastroenterology2007，13，26： | 30 |
| 2 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 3 | Glucagon-like peptide-1 protects against cardiac microvascular endothelial cells injured by high glucose显示文摘Objective:To investigate the protective effect of glucagon-like peptid-1(GLP-l) against cardiac microvascular endothelial cell(GTFCs) injured by high glucose.Methods:CMECs were isolated and cultured.Superoxide assay kit and dihydroethidine(DHE) staining were used to assess oxidative stress.TENEL staining and caspase 3 expression were used to assess the apoptosis of CMECs.H89 was used to inhibit eAMP/PKA pathway:fasudil was used to inhibit Rho/ROCK pathway.The protein expressions of Rho.ROCK uere examined by Western blol analysis.lesults:High glucose increased the production of ROS.the activity of NADPH.the apoptosis rate and the expression level of Rho/ROCK in CMECs.while GLP- 1 decreased high glucose-induced ROS production.the NADPH activity and the apoptosis rate and the expression level of Rho/ROCK in CMECs,the difference were statistically significant(P<0.05).Conclusions:GLP-1 could protect the cardiac microvessels against oxidative stress and apoptosis.The protective effects of GLP-1 are dependent on downstream inhibition of Rho through a cAMP/PKA-dependent manner,resulting in a subsequent decrease in the expression of NADPH oxidase. | Guang-Hao Ge Hong-Jie Dou Shuan-Suo Yang Jiang-Wei Ma Wen-Bo Cheng Zeng-Yong Qiao Yue-Mei Hou Wei-Yi Fang | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，1： | 11 |
| 4 | Correlation between 1,5-anhydroglucitol and glycemic excursions in type 2 diabetic patients显示文摘背景对在有糖尿病的病人的 glycemic 控制的精确、全面的评价为优化 glycemic 管理并且为提出学习试图在类型 2 糖尿病的 patients.Methods 分析在 1,5-anhydroglucitol ( 1,5-AG )和 glycemic 旅行之间的关联的个性化的糖尿病的治疗 schemes.This 是重要的有类型 2 糖尿病 mellitus 的 71 个门诊病人随机被招募从中国人民的解放军队霍斯皮塔卢辛将军连续葡萄糖 | SUN Jie DOU Jing-tao WANG Xian-ling YANG Guo-qing LU Zhao-hui ZHENG Hua MA Fang-ling LU Ju-ming MU Yi-ming | 2011 | Chinese Medical Journal2011，，22： | 10 |
| 5 | Measurement and assessment of water resources carrying capacity in Henan Province, China显示文摘As demands on limited water resources intensify, concerns are being raised about water resources carrying capacity(WRCC), which is defined as the maximum sustainable socioeconomic scale that can be supported by available water resources and while maintaining defined environmental conditions. This paper proposes a distributed quantitative model for WRCC, based on the principles of optimization, and considering hydro-economic interaction, water supply, water quality, and socioeconomic development constraints. With the model, the WRCCs of 60 subregions in Henan Province were determined for different development periods. The results showed that the water resources carrying level of Henan Province was suitably loaded in 2010, but that the province would be mildly overloaded in 2030 with respect to the socioeconomic development planning goals. The restricting factors for WRCC included the available water resources, the increasing rate of GDP, the urbanization ratio, the irrigation water utilization coefficient, the industrial water recycling rate, and the wastewater reuse rate, of which the available water resources was the most crucial factor. Because these factors varied temporally and spatially, the trends in predicted WRCC were inconsistent across different subregions and periods. | Ming Dou Jun-xia Ma Gui-qiu Li Qi-ting Zuo | 2015 | Water Science and Engineering2015，8，2： | 9 |
| 6 | Establishing a human pancreatic stem cell line and transplanting induced pancreatic islets to reverse experimental diabetes in rats显示文摘The major obstacle in using pancreatic islet transplantation to cure type I and some type II diabetes is the shortage of the donors. One of ways to overcome such obstacle is to isolate and clone pancreatic stem cells as 'seed cells' and induce their differentiation into functional islets as an abundant trans-plantation source. In this study, a monoclonal human pancreatic stem cell (mhPSC) line was obtained from abortive fetal pancreatic tissues. Pancreatic tissues were taken from abortive fetus by sterile procedures, and digested into single cells and cell clusters with 0.1% type IV collagenase. Cultured in modified glucose-low DMEM with 10% fetal bovine serum (FBS), these single cells and cell clusters adhered to culture dishes, and then primary epidermal-like pancreatic stem cells started to clone. After digesting with 0.25% trypsin and 0.04% EDTA, fibroblasts and other cells were gradually eliminated and epithelioid pancreatic stem cells were gradually purified during generations. Using clone-ring selection, the mhPSCs were obtained. After addition of 10 ng/mL epidermal growth factor (EGF) in cell culture medium, the mhPSCs quickly grew and formed a gravelstone-like monolayer. Continuously proliferated, a mhPSC line, which was derived from a male abortive fetus of 4 months old, has been passed through 50 generations. More than 1×109 mhPSCs were cryo-preserved in liquid nitrogen. Karyotype analysis showed that the chromosome set of the mhPSC line was normal diploid. Immunocytochemistry results demonstrated that the mhPSC line was positive for the pdx1, glucagon, nestin and CK19, and negative for the insulin, CD34, CD44 and CD45 protein expression. RT-PCR revealed further that the mhPSCs expressed transcription factors of the pdx1, glucagon, nestin and CK19. Also, in vitro induced with β-mercaptoethanol, the mhPSCs differentiated into nerve cells that expressed the NF protein. Induced with nicotinamide, the mhPSCs differentiated into functional islet-like clusters, as identified by di-thizone staining, which expressed the transcription factor of the insulin and secreted the insulin and C-peptide. Furthermore, the transplantation of mhPSCs-induced pancreatic islets into the subcapsular region of the kidney in streptozotocin-induced diabetic rats could reduce blood glucose levels and prolong the life time. | XIAO Mei AN LiLong YANG XueYi GE Xin QIAO Hai ZHAO Ting MA XiaoFei FAN JingZhuang ZHU MengYang DOU ZhongYing | 2008 | Science China(Life Sciences)2008，51，9： | 9 |
| 7 | Threshold pressure gradient of fluid flow through multi-porous media in low and extra-low permeability reservoirs显示文摘After analyzing many studies of fluid flow theory of multi-porous media in low and extra-low permeability reservoirs and the numerical simulation of non-Darcy flow, we found that a negative flow rate occurs in the existing non-Darcy flow equation, which is unreasonable. We believe that the existing equation can only be considered as a discriminant to judging Darcy flow or non-Darcy flow, and cannot be taken as a fluid flow governing equation of multi-porous media. Our analysis of the experimental results shows that the threshold pressure gradient(TPG) of low and extra-low permeability reservoirs is excessively high, and does not conform to fluid flow through multi-porous media in the actual reservoir situation. Therefore, we present a reasonable TPG ranging from 0.006 to 0.04 MPa/m at the well depth of 1500 m and oil drainage distance of 500 m. The results of our study also indicate that the non-Darcy flow phenomenon will disappear when the TPG reaches a certain value. In addition, the TPG or non-Darcy flow in low and extra-low permeability reservoirs does not need to be considered in the productivity prediction and reservoir numerical simulation. At present, the black oil model or dual-porous media is suitable for simulating low and extra-low permeability reservoirs. | DOU HongEn MA ShiYing ZOU CunYou YAO ShangLin | 2014 | Science China Earth Sciences2014，57，11： | 8 |
| 8 | Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling显示文摘Bone remodeling is precisely coordinated by bone resorption and formation.Apoptotic osteoclasts generate large amounts of apoptotic bodies(ABs)marking the end of the bone resorption phase,whereas the functions of osteoclast-derived ABs remain largely unknown.Here,we identified the molecular profile of ABs derived from osteoclasts at distinct differentiation stages and investigated their corresponding functions.ABs were isolated from apoptotic bone marrow macrophages,preosteoclasts,and mature osteoclasts induced by staurosporine.Proteomic signature analysis with liquid chromatography-tandem mass spectrometry suggested marked protein cargo differences among the different ABs.Further bioinformatic analysis showed that the proteomic signatures of the ABs were highly similar to those of their parental cells.Functionally,pOC-ABs induced endothelial progenitor cell differentiation and increased CD31hiEmcnhi endothelial cell formation in a murine bone defect model via their PDGF-BB cargo.mOC-ABs induced osteogenic differentiation of mesenchymal stem cells and facilitated osteogenesis via RANKL reverse signaling.In summary,we mapped the detailed proteomic landscapes of ABs derived from osteoclasts and showed that their potential biological roles are important in coupling bone formation with resorption during bone remodeling. | Qinyu Ma Mengmeng Liang Yutong Wu Fei Luo Zaisong Ma Shiwu Dong Jianzhong Xu Ce Dou | 2021 | Bone Research2021，9，1： | 8 |
| 9 | SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis显示文摘 | Yong-Feng Han Kun Dou Ze-Yang Ma Su-Wei Zhang Huan-Wei Huang Lin Li Tao Cai She Chen Jian-Kang Zhu Xin-Jian He | 2014 | Cell Research2014，24，12： | 8 |
| 10 | Off-axis multi-wavelength dispersion controllingmetalens for multi-color imaging显示文摘Dispersion control is crucial in optical systems,and chromatic aberration is an important factor affecting imaging quality in imaging systems.Due to the inherent property of materials,dispersion engineering is complex and needs to trade off other aberration in traditional ways.Although metasurface offers an effective method to overcome these limits and results in well-engineered dispersion,off-axis dispersion control is still a challenging topic.In this paper,we design a single-layer metalens which is capable of focusing at three wavelengths(473 nm,532 nm,and 632 nm)with different incident angles(0°,-17°and 17°)into the same point.We also demonstrate that this metalens can provide an alternative for the bulky color synthetic prism in a 3-chips digital micromirror device(DMD)laser projection system.Through this approach,various off-axis dispersion controlling optical devices could be realized. | Kaihua Dou Xin Xie Mingbo Pu Xiong Li Xiaoliang Ma Changtao Wang Xiangang Luo | 2020 | Opto-Electronic Advances2020，3，4： | 7 |
| 11 | Role of endoplasmic reticulum stress in the loss of retinal ganglion cells in diabetic retinopathy显示文摘Endoplasmic reticulum stress is closely involved in the early stage of diabetic retinopathy.In the present study,a streptozotocin-induced diabetic animal model was given an intraperitoneal injection of tauroursodeoxycholic acid.Results from immunofluorescent co-localization experiments showed that both caspase-12 protein and c-Jun N-terminal kinase 1 phosphorylation levels significantly increased,which was associated with retinal ganglion cell death in diabetic retinas.The C/ERB homologous protein pathway directly contributed to glial reactivity,and was subsequently responsible for neuronal loss and vascular abnormalities in diabetic retinopathy.Our experimental findings indicate that endoplasmic reticulum stress plays an important role in diabetes-induced retinal neuronal loss and vascular abnormalities,and that inhibiting the activation of the endoplasmic reticulum stress pathway provides effective protection against diabetic retinopathy. | Liping Yang Lemeng Wu Dongmei Wang Ying Li Hongliang Dou Mark O.M.Tso Zhizhong Ma | 2013 | Neural Regeneration Research2013，8，33： | 7 |
| 12 | Characteristics of volatile compounds removal in biogas slurry of pig manure by ozone oxidation and organic solvents extraction显示文摘Biogas slurry is not suitable for liquid fertilizer due to its high amounts of volatile materials being of complicated composition and peculiar smell. In order to remove volatiles from biogas slurry efficiently, the dynamic headspace and gas chromatography-mass spectrometry were used to clear the composition of volatiles. Nitrogen stripping and superfluous ozone were also used to remove volatiles from biogas slurry. The results showed that there were 21 kinds of volatile compounds in the biogas slurry, including sulfur compounds, organic amines, benzene, halogen generation of hydrocarbons and alkanes, some of which had strong peculiar smell. The volatile compounds in biogas slurry can be removed with the rate of 53.0% by nitrogen stripping and with rate of 81.7% by the oxidization and stripping of the superfluous ozone. On this basis, the removal rate of the volatile compounds reached 99.2% by chloroform and n-hexane extraction, and almost all of odor was eliminated. The contents of some dissolved organic compounds decreased obviously and however main plant nutrients had no significant change in the biogas slurry after being treated. | Yujun Wang Lianshuang Feng Xiaosong Zhao Xiulan Ma Jingmin Yang Huiqing Liu Sen Dou Miping Zhou Zhonglei Xie | 2013 | Journal of Environmental Sciences2013，25，9： | 7 |
| 13 | Phase equilibria for the pseudo-ternary system(NaCl+Na2SO4+H2O)of coal gasification wastewater at T=(268.15 to 373.15)K显示文摘The pseudo-ternary system(Na Cl + Na_2SO_4+ H_2O) of coal gasification wastewater was studied at T =(268.15 to 373.15) K. The solubility and density of the equilibrium liquid phase were determined by the isothermal solution saturation method. The equilibrium solids were also investigated by the Schreinemaker's method of wet residues and X-ray powder diffraction(XRD). According to the experimental data, the phase diagrams were determined. It was found that there was no significant solubility difference on the Na Cl-rich side between the ternary system(Na Cl + Na_2SO_4+ H_2O) in coal gasification wastewater and in pure water. However, the solubility on the Na_2SO_4-rich side of coal gasification wastewater was apparently higher than that of pure water. The increase in the solubility of Na_2SO_4 was most likely caused by the effects of other impurities apart from Na Cl and Na_2SO_4 in coal gasification wastewater. The measured data and phase equilibrium diagrams can provide fundamental basis for salt recovery in coal gasification wastewater. | Haijiao Lu Jingkang Wang Jun Yu Yuefeng Wu Ting Wang Ying Bao Dou Ma Hongxun Hao | 2017 | Chinese Journal of Chemical Engineering2017，25，7： | 7 |
| 14 | Additional laparoscopic gastrectomy after noncurative endoscopic submucosal dissection for early gastric cancer: A single-center experience显示文摘BACKGROUND The necessity of additional gastrectomy for early gastric cancer (EGC) patients who do not meet curative criteria after endoscopic submucosal dissection (ESD) is controversial. AIM To examine the clinicopathologic characteristics of patients who underwent additional laparoscopic gastrectomy after ESD and to determine the appropriate strategy for treating those after noncurative ESD. METHODS We retrospectively studied 45 patients with EGC who underwent additional laparoscopic gastrectomy after noncurative ESD from January 2013 to January 2019 at the Cancer Hospital of the Chinese Academy of Medical Sciences. We analyzed the patients’ clinicopathological data and identified the predictors of residual cancer (RC) and lymph node metastasis (LNM). RESULTS Surgical specimens showed RC in ten (22.2%) patients and LNM in five (11.1%).Multivariate analysis revealed that positive horizontal margin [odds ratio (OR)=13.393, 95% confidence interval (CI): 1.435-125, P=0.023] and neural invasion (OR=14.714, 95%CI: 1.087-199, P=0.043) were independent risk factors for RC. Undifferentiated type was an independent risk factor for LNM (OR=12.000, 95%CI: 1.197-120, P=0.035). Tumors in all patients with LNM showed submucosal invasion more than 500 μm. Postoperative complications after additional laparoscopic gastrectomy occurred in five (11.1%) patients, and no deaths occurred among patients with complications. CONCLUSION Gastrectomy is necessary not only for patients who have a positive margin after ESD, but also for cases with neural invasion, undifferentiated type, and submucosal invasion more than 500 μm. Laparoscopic gastrectomy is a safe, minimally invasive, and feasible procedure for additional surgery after noncurative ESD. However, further studies are needed to apply these results to clinical practice. | Yan-Tao Tian Fu-Hai Ma Gui-Qi Wang Yue-Ming Zhang Li-Zhou Dou Yi-Bin Xie Yu-Xin Zhong Ying-Tai Chen Quan Xu Dong-Bing Zhao | 2019 | World Journal of Gastroenterology2019，25，29： | 6 |
| 15 | 2020 roadmap on pore materials for energy and environmental applications显示文摘Porous materials have attracted great attention in energy and environment applications,such as metal organic frameworks(MOFs),metal aerogels,carbon aerogels,porous metal oxides.These materials could be also hybridized with other materials into functional composites with superior properties.The high specific area of porous materials offer them the advantage as hosts to conduct catalytic and electrochemical reactions.On one hand,catalytic reactions include photocatalytic,p ho toe lectrocatalytic and electrocatalytic reactions over some gases.On the other hand,they can be used as electrodes in various batteries,such as alkaline metal ion batteries and electrochemical capacitors.So far,both catalysis and batteries are extremely attractive topics.There are also many obstacles to overcome in the exploration of these porous materials.The research related to porous materials for energy and environment applications is at extremely active stage,and this has motivated us to contribute with a roadmap on ’porous materials for energy and environment applications’. | Zengxi Wei Bing Ding Hui Dou Jorge Gascon Xiang-Jian Kong Yujie Xiong Bin Cai Ruiyang Zhang Ying Zhou Mingce Long Jie Miao Yuhai Dou Ding Yuan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 5 |
| 16 | Serum vitamin D is associated with non-alcoholic fatty liver disease in Chinese males with normal weight and liver enzymes显示文摘 | Ya-ping HAO Xiao-jing MA Yu-qi LUO Jie NI Jian-xin DOU Ya-qin HU Jia-an ZHU Yu-qian BAO Wei-ping JIA | 2014 | Acta Pharmacologica Sinica2014，35，9： | 5 |
| 17 | Analysis of the Frequency of Clinical Acupoint Use Based on ‘Traditional Chinese Medical Acupuncture-moxibustion Information Databank'显示文摘The frequencies of use of 361 human acupoints in 74 academic journals of traditional Chinese medicine published between 1949 and 2010 are arranged in order using ‘Traditional Chinese Medical Acupuncturemoxibustion Information Databank'. The frequencies of use are divided into five grades: most frequent use, more frequent use, frequent use, less frequent use and infrequent use. The most frequently used acupoints and infrequently used acupoints are summarized and analyzed to help point selection for clinical acupuncture and selection of acupuncture research projects in the future. | Yang Ling Huang Qin-feng Wu Huan-gan Liu Xiao-xu Ding Guang-hong Ma Xiao-peng Feng Xiao-ming Dou Chuan-zi Wang Si-you | 2014 | Journal of Acupuncture and Tuina Science2014，12，2： | 5 |
| 18 | Ru-doped phosphorene for electrochemical ammonia synthesis显示文摘The electrochemical ammonia synthesis has attracted increasing attention due to its energy saving characteristics.However,developing novel electrocatalysts and their mechanism remain great challenges.Here,several transition metal(TM)atoms doped on phosphorene were studied as N2 fixation electrocatalysts by using density functional theory(DFT)calculations.The results demonstrate that single Ru atom doped phosphorene shows an excellent catalytic activity for ammonia synthesis via the enzymatic pattern.A small overpotential of 0.696 V is achieved for this process.The effect of oxidation in the catalyst was also discussed in our work.Oxidation deactivates the catalyst,which should be avoided in the experiment.Our outcomes offer a novel perspective for single-atom catalytic ammonia synthesis with phosphorene as a substrate. | Jian-Dong Liu Zeng-Xi Wei Yu-Hai Dou Yue-Zhan Feng Jian-Min Ma | 2020 | Rare Metals2020，39，8： | 4 |
| 19 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 20 | Two-year clinical outcomes following elective drug-eluting versus bare-metal stent implantation: results from a large single-center database显示文摘响应有 drug-eluting stent (DES ) 的安全的增加的 concem 的背景,试图评估 DES 的长期的安全和功效的现在的学习为一张中国耐心的人口使用了。方法经历了一个索引的所有病人有在到 2006 年 12 月的从 2004 年 4 月的一个单个机构的 DES 或赤裸金属的 stent (BMS ) 的培植的选任的经皮的冠的干预,在分析被包括。匹配技术的一个倾向分数被使用调整并且最小化使因素惊讶的影响。结果外套,有 1465 个病人(20.2%) ,经历了仅仅仅仅 DES 的 BMS,和 5769 个病人(79.8%) 的培植。匹配技术的倾向分数为分析建立了 1321 个病人。stent 血栓的率之间没有重要差别(明确、可能) 二个组(1.06% 对 1.21% , P=-0.8580 ) 。尽管死亡和心肌的梗塞( MI )的率没显著地在2年的后续时期期间不同, death/MI 的率(3.0%对4.5%, P=0.0263 ),目标损害 revascularization ( TLR ,3.2%对 8.5 , P=0.0001 ),目标容器 revascularization ( TVR ,5.8%对9.5%, P < 0.0001 )并且任何 revascularization (10.0%对13.3%, P=0.0066 )比为 BMS 组为 DES 组是显著地更低的。在设备为离开标签指示在被植入的病人之中,倾向分数匹配 stent 血栓,死亡, MI ,和 death/MI 的率不是显著地不同的,当时 TLR 的率, TVR 和任何 revascularization 在后续柱子 stenting 的 2 年期间比为 BMS group.Conclusions 为 DES 组是显著地更低的, DES 使用与 death/MI , TLR , TVR 和任何 revascularization 的更低的率被联系与 BMS 相比,在倾向分数匹配的脊骨在离开标签用法的背景, DES 使用也与类似的优点被联系。 | GAO Run-lin XU Bo CHEN Ji-lin YANG Yue-jin QIAO Shu-bin WANG Yang DOU Ke-fei QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun MA Wei-hua LI Wei | 2009 | Chinese Medical Journal2009，，19： | 4 |
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