|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 3 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 4 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 5 | 灾后民众创伤后应激障碍(PTSD)与事件冲击量表(IES)的发展和应用显示文摘本文简单回顾了国际上在创伤后应激障碍研究中较常使用的自评测量工具——事件冲击量表(IES)及其修改版(IES-R)和儿童版CRIES的发展和应用。并综合报道了在四川绵竹运用IES-R对956名受灾群众进行的测查结果。推论,5·12汶川地震后,将有大约一半的幸存者在一到两个月出现PTSD的主要症状,并具有比较显著的性别差异:女性的分数普遍高于男性,建议及早进行心理危机干预。 | 吴坎坎 张雨青 Peter Tianzhi Chen | 2009 | 心理科学进展2009，17，3： | 31 |
| 6 | Global leaf nitrogen and phosphorus stoichiometry and their scaling exponent显示文摘Leaf nitrogen(N) and phosphorus(P) concentrations constrain photosynthetic and metabolic processes,growth and the productivity of plants. Their stoichiometry and scaling relationships regulate the allocation of N and P from subcellular to organism, and even ecosystem levels, and are crucial to the modelling of plant growth and nutrient cycles in terrestrial ecosystems. Prior work has revealed a general biogeographic pattern of leaf N and P stoichiometric relationships and shown that leaf N scales roughly as two-thirds the power of P. However, determining whether and how leaf N and P stoichiometries, especially their scaling exponents, change with functional groups and environmental conditions requires further verification. In this study, we compiled a global data set and documented the global leaf N and P concentrations and the N:P ratios by functional group, climate zone and continent. The global overall mean leaf N and P concentrations were 18.9 mg g^(-1) and 1.2 mg g^(-1), respectively, with significantly higher concentrations in herbaceous than woody plants(21.72 mg g^(-1) vs. 18.22 mg g^(-1) for N; and 1.64 mg g^(-1) vs. 1.10 mg g^(-1) for P). Both leaf N and P showed higher concentrations at high latitudes than low latitudes. Among six continents, Europe had the highest N and P concentrations(20.79 and 1.54 mg g^(-1)) and Oceania had the smallest values(10.01 and 0.46 mg g^(-1)). These numerical values may be used as a basis for the comparison of other individual studies. Further, we found that the scaling exponent varied significantly across different functional groups,latitudinal zones, ecoregions and sites. The exponents of herbaceous and woody plants were 0.659 and0.705, respectively, with significant latitudinal patterns decreasing from tropical to temperate to boreal zones. At sites with a sample size ≥10, the values fluctuated from 0.366 to 1.928, with an average of 0.841.Several factors including the intrinsic attributes of different life forms, P-related growth rates and relative nutrient availability of soils likely account for the inconstant exponents of leaf N vs. P scaling relationships. | Di Tian Zhengbing Yan Karl J.Niklas Wenxuan Han Jens Kattge Peter B.Reich Yongkai Luo Yahan Chen Zhiyao Tang Huifeng Hu Ian J.Wright Bernhard Schmid Jingyun Fang | 2018 | National Science Review2018，5，5： | 24 |
| 7 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 8 | Isolation and Identification of a Di-(2-Ethylhexyl)Phthalate-Degrading Bacterium and Its Role in the Bioremediation of a Contaminated Soil显示文摘Di-(2-ethylhexyl) phthalate(DEHP) is a high-molecular-weight phthalate ester(PAE) that has been widely used in the manufacture of polyvinylchloride and contributes to environmental pollution.The objectives of the present study were to isolate a DEHP degrader that can utilize DEHP as a carbon source and to investigate its capacity to biodegrade DEHP in both liquid culture and soil.A bacterial strain WJ4 was isolated from an intensively managed vegetable soil,which was contaminated with PAEs.The strain WJ4 was affiliated to the genus Rhodococcus and was able to remove DEHP from soil effectively.A period of only 7 d was required to degrade about 96.4%of DEHP(200 mg L^(-1)) in the liquid culture,and more than 55%of DEHP(1.0 g kg^(-1)) in the artificially contaminated soil was removed within 21 d.Furthermore,Rhodococcus sp.strain WJ4 had a strong ability to degrade DEHP without additional nutrients in liquid minimal medium culture and DEHP-contaminated soil and to degrade the homologue of DEHP in both liquid culture and soil.Strain WJ4 represents a novel tool for removing PAEs from contaminated soils and it may have great potential for application in the remediation of environmental pollution by PAEs. | WANG Jun ZHANG Man-Yun CHEN Ting ZHU Ye TENG Ying LUO Yong-Ming Peter CHRISTIE | 2015 | Pedosphere2015，25，2： | 18 |
| 9 | TREATMENT OF METALS, POLYMER FILMS, AND FABRICS WITHA ONE ATMOSPHERE UNIFORM GLOW DISCHARGE PLASMA(OAUGDP) FOR INCREASED SURFACE ENERGY AND DIRECTIONAL ETCHING显示文摘Direct exposure of samples to the active species of air generated by a One Atmosphere Uniform Glow Discharge Plasma (OAUGDP) has been used to etch and to increase the surface energy of metallic surfaces, photoresist, polymer films, and nonwoven fab- rics. The OAUGDP is a non-thermal plasma with the classical characteristics of a DC normal glow discharge that operates in air (and other gases) at atmospheric pres- sure. Neither a vacuum system nor batch processing is necessary. A wide range of applications to metals, photoresist, films, fabrics, and polymeric webs can be accom- modated by direct exposure of the workpiece to the plasma in parallel-plate reactors. This technolopy is simple, it produces effects that can be obtained in no other way at one atmosphere; it generates minimal pollutants or unwanted by-products; and it is suitable for individual sample or online treatment of metallic surfaces, wafers, films, and fabrics. Early exposures of solid materials to the OAUGDP required minutes to produce rela- tively small increases of surface energy. These durations appeared too long for com- mercial application to fast-moving webs. Recent improvements in OAUGDP gas com- position, power density, plasma quality, recireulating gas flow, and impedance match- ing of the power supply to the parallel plate plasma reactor have made it possible to raise the surface energy of a variety of polymeric webs (PP, PET PE etc.) to levels of 60 to 70 dynes/cm with one second of exposure. In air plasmas, the high surface ener- gies are not durable, and fall to 50 dynes/cm after periods of weeks to months. Here, we report the exposure of metallic surfaces, photoresist, polymeric films, and nonwo- ven fabrics made of PP and PET to an impedance matched parallel plate OAUGDP for durations ranging from one second to several tens of seconds. Data will be re- ported on the surface energy, wettability, wickability, and aging effect of polymeric films and fabrics as functions of time of exposure, and time after exposure; the rate and uniformity of photoresist etching; and the production of sub-micron structures by OAUGDP etching at one atmosphere. | J. Reece Roth and Z. Y Chen (Plasma Sciences Laboratory, Department of Electrical and Computer Engineering, University of Tennessee, Knoxville, TN 37996-2100, USA) Peter P.- Y Tsai (Textiles and Nonwovens Development Center (TANDEC), University of Tenness | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，6： | 18 |
| 10 | Arsenic uptake by arbuscular mycorrhizal maize (Zea mays L.) grown in an arsenic-contaminated soil with added phosphorus显示文摘arbuscular mycorrhizal (AM ) 的效果真菌(血管球 mosseae ) 和砷上的磷(P) 增加(100 mg/kg 土壤)( 作为) 由从污染言论集的土壤的玉米植物(Zea mays L.) 的举起在一个温室被检验 experiment.Non-mycorrhizal 和 zero-P 增加控制被包括。植物生物资源和集中和举起作为, P,和另外的营养素, AMcolonization,根长度,和菌丝的长度密度被决定。结果显示 P 的增加显著地禁止了根殖民和两个都在 thezero-P 处理,而是 AM 植物的射击和根生物资源下面与 mycorrhizal 殖民显著地增加的 extraradicalmycelium.Root 长度和干燥重量的开发被 P application.AM 压抑真菌的接种减少了当没有 P 被增加时,作为集中射击,并且 AM 植物的射击和根 Asconcentrations 与 P 增加, P 的 respectively.Shoot 和根举起, Mn , Cu ,和增加的 Zn 增加了 2.6 和 1.4 次,但是射击 Fe 举起在44.6%减少了与接种,当 Pwas added.P 增加减少了时,射击 P , Fe , Mn , AM 植物的 Cu ,和 Zn 举起,而是增加的根 Fe andMn nonmycorrhizal ones.AM 殖民的举起因此看起来提高植物忍耐到是在低 P 然而,为 As-contaminatedsoil 的 phytostabilization 玷污,并且有一些潜力 P 申请可以由增加土壤 Asmobility 介绍另外的环境风险。 | XIA Yun-sheng CHEN Bao-dong CHRISTIE Peter SMITH F Andrew WANG You-shan LI Xiao-lin | 2007 | Journal of Environmental Sciences2007，19，10： | 18 |
| 11 | Cadmium accumulation and tolerance of two castor cultivars in relation to antioxidant systems显示文摘To investigate the effects of Cd on tolerance and antioxidant activities of castor, two different castor(Ricinus communis L.) cultivars(Zibo No. 5 and Zibo No. 8) were used for a hydroponic experiment(0, 1 and 2 mg/L Cd) and a pot experiment using Cd-contaminated soil(34 mg/kg) with the addition of ethylenedinitrilotetraacetic acid(EDTA). The results indicated that there were significant differences between the two cultivars with respect to Cd uptake in shoots(113–248 mg/kg for Zibo No. 5 and 130–288 mg/kg Zibo No. 8), biomass tolerance indexes(64.9%–74.6% for Zibo No. 5 and 80.1%–90.9% for Zibo No. 8) in the hydroponic experiment and survival rates(0% for Zibo No. 5 and 100% for Zibo No. 8)determined by the addition of EDTA in the pot experiment, suggesting that Zibo No. 8 has higher tolerance than Zibo No. 5. Moreover, the castor cultivars have low bioconcentration factors(4.80% for Zibo No. 5 and 5.43% for Zibo No. 8) and low translocation factors(<1%).Consequently, Zibo No. 8 can participate in Cd phytostabilization in highly Cd-polluted areas. The results indicated that glutathione(GSH) as a non-enzymatic antioxidant, and antioxidant enzymes including superoxide dismutase(SOD), catalase(CAT) and guaiacol peroxidase(GPX), were cultivar- and dose-dependent. The higher tolerance of Zibo No. 8compared with Zibo No. 5 can be attributed to the higher GSH levels in the root and higher GPX activity in the leaf. | Hanzhi Zhang Qingjun Guo Junxing Yang Tongbin Chen Guangxu Zhu Marc Peters Rongfei Wei Liyan Tian Chunyu Wang Deyun Tan Jie Ma Gangming Wang Yingxin Wan | 2014 | Journal of Environmental Sciences2014，26，10： | 15 |
| 12 | Coronavirus disease(COVID-19):The need to maintain regular physical activity while taking precautions显示文摘The on-going Coronavirus disease(COVID-19)outbreak in China has become the world's leading health headline and is causing major panic and public concerns.On January 30,2020,the World Health Organization(WHO)declared that the new coronavirus outbreak is a public health emergency of international concern.1 The virus has already had a direct impact on more than 10 million people in the city of Wuhan and has reached other parts of China as well,posing a health threat of unknown magnitude globally.As of February 8,2020,WHO reported 34,886 confirmed cases of COVID-19 globally,with 34,589 of them occurring in China(including 6101 severe cases and 723 deaths).A total of 288 other confirmed cases(with 1 death)have been reported in 24 countries,including Japan,Australia,Germany,and United States.2 However,these daily estimates are expected to rise even higher as reports from health authorities in China3 are gathered and near real-time updates of the Johns Hopkins virus dashboard are made 4 The outbreak has caused governments in various countries to take swift and protective measures.In China,these included putting cities on lockdown,5 implementing travel wamings/bans and cancellations,6 extending national holidays,and closing schools and postponing classes7. | Peijie Chen Lijuan Mao George P.Nassis Peter Harmer Barbara E.Ainsworth Fuzhong Li | 2020 | Journal of Sport and Health Science2020，9，2： | 15 |
| 13 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 14 | SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells显示文摘Glomerular 矩阵累积是糖尿病的 nephropathy 的一个特点。最近的研究证明抄写因素 SREBP-1 的 overexpression 导致 glomerulosclerosis。TGF1 是 glomerulosclerosis 的一个关键 profibrotic 调停人,但是 SREBP-1 是否调整它的效果,是未知的。在肾 mesangial 房间并且在 vivo, TGF1 激活 SREBP-1。这要求发信号的 SCAP, S1P,和 PI3K/Akt,但是独立于 Smad3。TGF1 应答的记者 plasmid p3TP 勒克司的激活要求 SREBP-1a,然而并非 SREBP-1c,对邻近一个 Smad 有约束力的元素的一个电子盒子有约束力。SREBP-1a overexpression 独自激活 p3TP 勒克司。Smad3 为 SREBP-1a transcriptional 激活被要求, TGF1 导致在二个抄写因素之间的协会。由 acetyltransferase CBP 的 SREBP-1a K333 acetylation 为 Smad3 协会和 SREBP-1 transcriptional 活动被要求,并且也为 Smad3 transcriptional 活动被要求。因此, Smad3 和 SREBP-1a 激活合作地调整 TGF transcriptional 回答。SREBP-1 抑制为糖尿病的肾疾病提供新奇治疗学的策略。 | Guang Chen Tony Wang Lalita Uttarwar Richard vanKrieken Renzhong Li Xing Chen Bo Gao Ayesha Ghayur Peter Margetts Joan C. Krepinsky | 2014 | Journal of Molecular Cell Biology2014，8，6： | 13 |
| 15 | Advances of injectable hydrogel-based scaffolds for cartilage regeneration显示文摘Articular cartilage is an important load-bearing tissue distributed on the surface of diarthrodial joints.Due to its avascular,aneural and non-lymphatic features,cartilage has limited self-regenerative properties.To date,the utilization of biomaterials to aid in cartilage regeneration,especially through the use of injectable scaffolds,has attracted considerable attention.Various materials,therapeutics and fabrication approaches have emerged with a focus on manipulating the cartilage microenvironment to induce the formation of cartilaginous structures that have similar properties to the native tissues.In particular,the design and fabrication of injectable hydrogel-based scaffolds have advanced in recent years with the aim of enhancing its therapeutic efficacy and improving its ease of administration.This review summarizes recent progress in these efforts,including the structural improvement of scaffolds,network cross-linking techniques and strategies for controlled release,which present new opportunities for the development of injectable scaffolds for cartilage regeneration. | Jiawei Li Guojun Chen Xingquan Xu Peter Abdou Qing Jiang Dongquan Shi Zhen Gu | 2019 | Regenerative Biomaterials2019，6，3： | 11 |
| 16 | Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome显示文摘BACKGROUND Polycystic ovary disease(PCOS)may be a risk factor for nonalcoholic fatty liver disease(NAFLD)due to common pathogenetic pathways,including insulin resistance and obesity.Both PCOS and NAFLD are more severe in South Asian women.Data on NAFLD in South Asian women with PCOS are lacking.AIM To investigate prevalence and predictors of NAFLD and liver fibrosis in PCOS patients from South Asia.METHODS We conducted an observational routine screening program by means of transient elastography(TE)with associated controlled attenuation parameter(CAP).NAFLD was defined as CAP≥288 decibels per meter.Significant liver fibrosis(stage 2 and higher out of 4)was defined as TE measurement≥8.0 kilopascals.Elevated alanine aminotransferase(ALT)was defined as ALT>24 IU/L,as per upper limit of normal reported in South Asian women.Biochemical hyperandrogenism was defined as free androgen index>5.Predictors of NAFLD were determined by logistic regression analysis.RESULTS 101 PCOS patients(mean age 36.3 years)with no significant alcohol intake or viral hepatitis were included.Prevalence of NAFLD and significant liver fibrosis was 39.6% and 6.9%,respectively.Elevated ALT was observed in 40%and 11.5%of patients with and without NAFLD,respectively.After adjusting for duration of PCOS and insulin resistance measured by homeostasis model for assessment of insulin resistance,independent predictors of NAFLD were higher body mass index[adjusted odds ratio(aOR)1.30,95% confidence interval(CI):1.13-1.52],hyperandrogenism(aOR:5.32,95%CI:1.56-18.17)and elevated ALT(aOR:3.54,95%CI:1.10-11.47).Lifetime cardiovascular risk was higher in patients with NAFLD compared to those without NAFLD(0.31±0.11 vs 0.26±0.13).CONCLUSION Despite their young age,NAFLD diagnosed by TE with CAP is a frequent comorbidity in South Asian women with PCOS and is strongly associated with higher body mass index and hyperandrogenism.Non-invasive screening strategies could help early diagnosis and initiation of interventions,including counselling on weight loss,cardiovascular risk stratification and linkage to hepatology care where appropriate. | Mohamed Shengir Srinivasan Krishnamurthy Peter Ghali Marc Deschenes Philip Wong Tianyan Chen Giada Sebastiani | 2020 | World Journal of Gastroenterology2020，26，44： | 11 |
| 17 | Tu-San-Qi(Gynura japonica):the culprit behind pyrrolizidine alkaloid-induced liver injury in China显示文摘Herbs and dietary supplement-induced liver injury(HILI)is the leading cause of drug-induced liver injury in China.Among different hepatotoxic herbs,the pyrrolizidine alkaloid(PA)-producing herb Gynura japonica contributes significantly to HILI by inducing hepatic sinusoidal obstruction syndrome(HSOS),a liver disorder characterized by hepatomegaly,hyperbilirubinemia,and ascites.In China,G.japonica has been used as one of the plant species for Tu-San-Qi and is often misused with non-PA-producing Tu-San-Qi(Sedum aizoon)or even San-Qi(Panax notoginseng)for self-medication.It has been reported that over 50% of HSOS cases are caused by the intake of PA-producing G.japonica.In this review,we provide comprehensive information to distinguish these Tu-San-Qi-related herbal plant species in terms of plant/medicinal part morphologies,medicinal indications,and chemical profiles.Approximately 2156 Tu-San-Qi-associated HSOS cases reported in China from 1980 to 2019 are systematically reviewed in terms of their clinical manifestation,diagnostic workups,therapeutic interventions,and outcomes.In addition,based on the application of our developed mechanism-based biomarker of PA exposure,our clinical findings on the definitive diagnosis of 58 PA-producing Tu-San-Qi-induced HSOS patients are also elaborated.Therefore,this review article provides the first comprehensive report on 2214 PA-producing Tu-San-Qi(G.japonica)-induced HSOS cases in China,and the information presented will improve public awareness of the significant incidence of PA-producing Tu-San-Qi(G.japonica)-induced HSOS and facilitate future prevention and better clinical management of this severe HILI. | Lin Zhu Chun-yuan Zhang Dong-ping Li Hu-biao Chen Jiang Ma Hong Gao Yang Ye Ji-yao Wang Peter P.Fu Ge Lin | 2021 | Acta Pharmacologica Sinica2021，42，8： | 9 |
| 18 | Electroacupuncture improves microcirculation and neuronal morphology in the spinal cord of a rat model of intervertebral disc extrusion显示文摘Most studies on spinal cord neuronal injury have focused on spinal cord tissue histology and the expression of nerve cell damage and repair-related genes. The importance of the microcirculation is often ignored in spinal cord injury and repair research. Therefore, in this study, we established a rat model of intervertebral disc extrusion by inserting a silica gel pad into the left ventral surface of T13. Electroacupuncture was used to stimulate the bilateral Zusanli point(ST36) and Neiting point(ST44) for 14 days. Compared with control animals, blood flow in the first lumbar vertebra(L1) was noticeably increased in rats given electroacupuncture. Microvessel density in the T13 segment of the spinal cord was increased significantly as well. The number of normal neurons was higher in the ventral horn of the spinal cord. In addition, vacuolation in the white matter was lessened. No obvious glial cell proliferation was visible. Furthermore, hindlimb motor function was improved significantly. Collectively, our results suggest that electroacupuncture can improve neuronal morphology and microcirculation, and promote the recovery of neurological functions in a rat model of intervertebral disc extrusion. | Dai-xun Jiang Zhi-song Lu Ge-bin Li Sheng-yong Sun Xiang Mu Peter Lee Wu Chen | 2015 | Neural Regeneration Research2015，10，2： | 9 |
| 19 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 20 | The First Case of New Variant COVID-19 Originating in the United Kingdom Detected in a Returning Student—Shanghai Municipality,China,December 14,2020显示文摘On December 14,2020,a 23-year-old female returning from the United Kingdom(UK)via airplane was tested by the laboratory of Shanghai Customs using nose swab to test for coronavirus disease 2019(COVID-19).At 20:30 on December 14,Shanghai CDC received notification from the Shanghai Customs that the patient tested positive for COVID-19.By 22:00,the patient was transported by ambulance from the isolation point to the fever clinic of Jiading District Central Hospital.Due to travel history from the UK and abnormalities in nucleic acid test results. | Hongyou Chen Xiaoyan Huang Xiang Zhao Yang Song Peter Hao Hui Jiang Xi Zhang Chen Fu | 2021 | China CDC weekly2021，3，1： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员